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Aging impairs the osteocytic regulation of collagen integrity and bone quality

Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna natalia castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

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The present and the future in the diagnosis and management of celiac disease

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Gastroenterology Report 2015年第1期3卷 3-11页

作者： natalia E.castillo Thimmaiah G.Theethira Daniel A.Leffler Division of Gastroenterology Beth Israel Deaconess Medical CenterBostonMAUSA

Celiac disease is an autoimmune enteropathy caused by gluten in genetically predisposed *** celiac disease,adaptive and innate immune activation results in intestinal damage and a wide range of clinical *** the past,celiac disease was thought to result in signs and symptoms solely related to the gastrointestinal ***,more than half of the adult population presents with extra-intestinal manifestations that can also be expected to improve on a gluten-free *** this reason,it is recommended that physicians have a low threshold of suspicion for celiac *** knowledge of the immune pathogenesis of this autoimmune disease has served as a catalyst for the development of novel diagnostic tools and *** the years,highly sensitive and speciﬁc serological assays,in addition to genetic markers,have been found to target speciﬁc steps in the cascade pathway of celiac *** the advent of the gluten challenge has enabled experts to design diagnostic algorithms and monitor clinical responses in clinical *** gluten challenge has provided substantial beneﬁt in the advance of novel therapeutics as an adjuvant treatment to the gluten free ***,a strict gluten-free diet is highly burdensome to patients and can be limited in its efﬁ*** therapies-including gluten modiﬁcation,modulation of intestinal permeability and immune response--could be central to the future treatment of celiac disease.

关键词： celiac disease gluten-free diet autoimmune diseases

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First Report on the Presence of Phyllachora sp. in Corn Crops at Toluca, Estado de Mexico

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American Journal of Plant Sciences 2016年第5期7卷 733-739页

作者： Erika natalia Ríos-Herrera Laila Pamela Partida-Martínez Yisa María Ochoa-Fuentes Ernesto Cerna-Chávez Francisco Daniel Hernández-castillo Alberto Flores-Olivas Víctor Olalde-Portugal Raúl Rodríguez-Guerra Universidad Autónoma Agraria Antonio Narro Saltillo México Department of Genetic Engineering CINVESTAV Irapuato México Department of Agricultural Parasitology Universidad Autónoma Agraria Antonio Narro Saltillo México Department of Biotechnology and Biochemistry CINVESTAV Irapuato México General Terán INIFAP General Terán Nuevo León México

Symptoms of Tar Spot Complex (TSC) in corn appear in the form of black spots surrounded by a chlorotic halo known as fish-eye. The crop with these symptoms was found at San Pablo Autopan, Estado de Mexico. The stromal region of foliar lesions was cut longitudinally, showing perithecia, asci and ascospores typical of Phyllachora maydis. The results were confirmed by PCR-ITS with ITS 1 and ITS4 initiators, cloned by pJET, before being sequenced and compared against NCBI’s data base. Phyllachora identity was confirmed. This is the first report where TSC pathogen has been detected under conditions that had not been previously reported, for instance, at 2600 meters above the sea level.

关键词： Phyllachora maydis Tar Spot Complex ITS

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