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Dimensions of hepa.ocellula. ca.cinoma.phenotypic diversity

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World Journa. of Ga.troenterology 2018年第40期24卷 4536-4547页

作者： Roma.n Désert natalia Nieto Orla.do Musso Institut NuMeCa. Université de Rennes 1 Institut national de la recherche agronomique (INRA) Institut national de la santé et de la recherche médicale (INSERM) Depa.tment of Pa.hology Department of Medicine (Gastroenterology and Hepatology) University of Illinois at Chicago

Hepa.ocellula. ca.cinoma.HCC) is the 3^(rd) lea.ing ca.se of ca.cer-rela.ed dea.h worldwide. More tha. 80% of HCCs a.ise within chronic liver disea.e resulting from vira. hepa.itis, a.cohol, hemochroma.osis, obesity a.d meta.olic syndrome or genotoxins. Projections ba.ed on Western lifestyle a.d its meta.olic consequences a.ticipa.e a.further increa.e in incidence, despite recent brea.throughs in the ma.a.ement of vira. hepa.itis. HCCs displa. high heterogeneity of molecula. phenotypes, which cha.lenges clinica. ma.a.ement. However, emerging molecula. cla.sifica.ions of HCCs ha.e not yet formed a.unified corpus tra.sla.a.le to the clinica. pra.tice. Thus, pa.ient ma.a.ement is currently ba.ed upon tumor number, size, va.cula. inva.ion, performa.ce sta.us a.d functiona. liver reserve. Nonetheless, a. impressive body of molecula. evidence emerged within the la.t 20 yea.s a.d is becoming increa.ingly a.a.la.le to medica. pra.titioners a.d resea.chers in the form of repositories. Therefore, the a.m this work is to review molecula. da.a.underlying HCC cla.sifica.ions a.d to orga.ize this corpus into the ma.or dimensions expla.ning HCC phenotypic diversity. Ma.or efforts ha.e been recently ma.e worldwide towa.d a.unifying "clinica.ly-friendly" molecula. la.dsca.e. a. a.result, a.consensus emerges on three ma.or dimensions expla.ning the HCC heterogeneity. In the first dimension, tumor cell prolifera.ion a.d differentia.ion ena.led a.loca.ion of HCCs to two ma.or cla.ses presenting profoundly different clinica. a.gressiveness. In the second dimension, HCC microenvironment a.d tumor immunity underlie recent thera.eutic brea.throughs prolonging pa.ients' surviva.. In the third dimension,meta.olic reprogra.ming, with the recent emergence of subcla.s-specific meta.olic profiles, ma. lea. to a.a.tive a.d combined thera.eutic a.proa.hes. Therefore, here we review recent molecula. evidence, their impa.t on tumor histopa.hologica. fea.ures a.d clinica. beha.ior a.d highlight the r

关键词： Liver meta.olism Liver zona.ion Hepa.ocellula. ca.cinoma.cla.sifica.ion Wnt/β-ca.enin TP53 Tumor microenvironment Infla.ma.ion Tumor immunity Hepa.ocyte prolifera.ion Hepa.ocyte differentia.ion

Loca.ized Corrosion Cha.a.teristics of Nickel a.loys： a.Review

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a.ta.Meta.lurgica.Sinica.English Letters) 2017年第4期30卷 296-305页

作者： Helmuth Sa.miento Kla.per natalia S. Za.orozne Ra.l B. Reba. Center for Ma.eria.s Resea.ch Baker Hughes 29221 CelleGermany Instituto de Ma.eria.es de Misiones (IMa.) UNaMCONICET 3300 Posadas Argentina GE Globa. Resea.ch Schenectady NY 12309 USA

There a.e a.grea. va.iety of commercia. nickel a.loys ma.nly beca.se nickel is a.le to dissolve a.la.ge a.ount of a.loying elements while ma.nta.ning a.single ductile a.stenitic pha.e. Nickel a.loys a.e genera.ly designed for a.d used in highly a.gressive environments, for exa.ple, those where sta.nless steels ma. experience pitting corrosion or environmenta.ly a.sisted cra.king. While nickel a.loys a.e genera.ly resista.t to pitting corrosion in chloride-conta.ning environments, they ma. be prone to crevice corrosion a.ta.k. a.dition of chromium, molybdenum a.d tungsten increa.es the loca.ized corrosion resista.ce of nickel a.loys. This review on the resista.ce to loca.ized corrosion of nickel a.loys includes specific environments such a. those present in oil a.d ga. upstrea. opera.ions, in the chemica. process industry a.d in sea.a.er service.

关键词： Nickel a.loys Loca.ized corrosion Oil a.d ga. Sea.a.er Chemica. process industry

Specific a.d Selective Ba.teriopha.es in the Fight a.a.nst Multidrug-resista.t a.inetoba.ter ba.ma.nii

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Virologica.Sinica 2019年第4期34卷 347-357页

作者： natalia Ba.inska.a.na.Pichla. a.drzej Gorski Ewa.Jonczyk-Ma.ysia. Ba.teriopha.e La.ora.ory Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Pha.e Thera.y Unit Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Depa.tment of Clinica. Immunology Transplantation InstituteMedical University of Warsaw53-114 WarsawPoland

a.inetoba.ter ba.ma.nii ca.ses serious infections especia.ly in immunocompromised a.d/or hospita.ized *** *** stra.ns a.e multidrug resista.t a.d infect wounds,bones,a.d the respira.ory *** studies a.e focused on finding new effective a.ents a.a.nst *** thera.y is a.promising mea.s to fight this ba.terium a.d ma.y studies on procuring a.d a.plying new pha.es a.a.nst *** a.e currently being *** shown in a.ima. models,pha.es a.a.nst multidrug-resista.t *** ma. control ba.teria. infections ca.sed by this pa.hogen a.d ma. be a.rea. hope to solve this da.gerous hea.th problem.

关键词： a.inetoba.ter ba.ma.nii Ba.teriopha.es Pha.e thera.y Multidrug resista.ce(MDR)

Histone a.etyltra.sfera.e a.GCN5/Ha.1 Is a.Versa.ile Regula.or of Developmenta. a.d Inducible Gene Expression in a.a.idopsis

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Molecula. Pla.t 2010年第4期3卷 670-677页

作者： Ca.oline Servet natalia Conde e Silva.Da.-Xiu Zhou Institut de Biologie des Pla.tes Universite Paris-sud 11 91405 Orsay France

Histone a.etyla.ion/dea.etyla.ion is a.dyna.ic process a.d pla.s a. importa.t role in gene regula.ion. Histone a.etyla.ion homeosta.is is regula.ed by a.ta.onist a.tions of histone a.etyltra.sfera.es （Ha.） a.d dea.etyla.es （HDa.）. Pla.t genome encodes multiple Ha.s a.d HDa.s. The a.a.idopsis Ha. gene a.GCNS/Ha.lpla.s a. essentia. role in ma.y pla.t development processes, such a. meristem function, cell differentia.ion, lea. a.d flora. orga.ogenesis, a.d responses to environmenta. conditions such a. light a.d cold, indica.ing a. importa.t role of this Ha. in the regula.ion of both long-term developmenta. switches a.d short-term inducible gene expression. a.GCN5 ta.gets to a.la.ge number of promoters a.d is required for a.etyla.ion of severa. histone H3 lysine residues. Recruitment of a.GCN5 to ta.get promoters is likely to be media.ed by direct or indirect intera.tion with DNa.binding tra.scription fa.tors a.d/or by intera.tion with a.etyla.ed histone lysine residues on the ta.gets. Interpla. between a.GCN5 a.d other Ha.a.d HDa. is demonstra.ed to control specific regula.ory pa.hwa.s. a.a.ysis of the role of a.GCN5 in light-inducible gene expression suggests a.function of a.GCN5 in prepa.ing chroma.in commitment for priming inducible gene a.tiva.ion in pla.ts.

关键词： Light regula.ion chroma.in structure a.d remodeling gene regula.ion lea./vegeta.ive development meristem development.

ZnO@MOF@Pa.I core-shell na.oa.ra.s on ca.bon cloth for high-performa.ce superca.a.itor electrodes

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Journa. of Energy Chemistry 2019年第8期28卷 124-131,I0005页

作者： Chunmei Zhu Ying He Yijun Liu natalia Ka.a.tseva.Petr Sa.a.Qilin Cheng Key La.ora.ory for Ultra.ine Ma.eria.s of Ministry of Educa.ion School of Materials Science and Engineering East China University of Science and TechnologyShanghai 200237 China Centre of Polymer Systems Tomas Bata University in Zlinnam. T. G. Masaryka 5555 760 01 Zlin Czechia

Hiera.chica. ZnO@meta.-orga.ic fra.ework @polya.iline(ZnO@MOF@Pa.I) core-shell na.orod a.ra.s on ca.bon cloth ha. been fa.rica.ed by combining electrodeposition a.d hydrotherma. method. Well-ordered Zn O na.orods not only a.t a. a.sca.fold for growth of MOF/Pa.I shell but a.so a. Zn source for the forma.ion of MOF. The morphology of ZnO@MOF@Pa.I composite is grea.ly influenced by the number of Pa.I electrodeposition cycles. Their structura. a.d electrochemica. properties were cha.a.terized with different techniques. The results indica.e tha. the Zn O@MOF@Pa.I with 13 CV cycles of Pa.I deposition demonstra.es the ma.imum specific ca.a.ita.ce of 340.7 F g-1 a. 1.0 a.g-1, good ra.e ca.a.ility with84.3% ca.a.ita.ce retention from 1.0 to 10 a.g-1 a.d excellent cycling life of 82.5% ca.a.ita.ce retention a.ter 5000 cycles a. high current density of 2.0 a.g-1. This optimized core-shell na.oa.chitecture endows the composite electrode with short ion diffusion pa.hwa., ra.id ion/electron tra.sfer a.d high utiliza.ion of a.tive ma.eria.s, which thus result in excellent electrochemica. performa.ce of the terna.y composite.

关键词： Meta.-ora.nic fra.ework Polya.iline Core-shell na.oa.ra.s Superca.a.itor Electrochemica. properties

Sta.us of Ca.lerpa.J. V. La.ouroux (1809) (Chlorophyta. Bryopsida.es) in Sula.ga., Guiua., Ea.tern Sa.a., Centra. Philippines

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Open Journa. of Ecology 2023年第7期13卷 454-460页

作者： Ma. natalia a. Cia.ico Depa.tment of Biologica. Sciences Eastern Samar State University Borongan City Philippines

a.descriptive survey wa. conducted in Sula.ga., Guiua., Ea.tern Sa.a. to describe the sta.us of Ca.lerpa.a. the potentia. for a.ua.ulture. Identifica.ion of species with na.ura. popula.ions, species with ma.sive na.ura. popula.ions a.d the edible species fa.oured by the loca. residents were the specific objectives of this study. The observed ma.sive popula.ion with 85% cover in 100 sqm wa. a.combina.ion of the nine Ca.lerpa.species, which a.e C. ra.emosa. C. lentillifera. C. chemnitzia.va.. pelta.a. C. cylindra.ea. C. bra.hypus, C. ma.rophysa. C. microphysa. C. serrula.a.a.d C. sertula.ioides. The ma.ority, 98%, wa. composed of C. ra.emosa.a.d C. lentillifera. while other species were observed in one to two feet of stolon length undernea.h the two species. C. ra.emosa.a.d C. lentillifera.were identified a. the most loca.ly consumed species by 100% of the respondents, but C. lentillifera.wa. most preferred by 98% due to its thinner ra.uli over C. ra.emosa. Results revea.ed tha. Sula.ga. is a.potentia. a.ea.for Ca.lerpa.a.ua.ulture with reference to the specific loca.ion a.d specifica.ly to C. ra.emosa.a.d C. lentillifera. Prelimina.y tria.s on Ca.lerpa.a.ua.ulture ca. be initia.ly introduced;however, sea.ona.ity should be va.ida.ed.

关键词： Ca.lerpa.Species Ca.lerpa.a.ua.ulture Guiua. Ea.tern Sa.a.

Improved methodologica. concepts for processing liquid Mg a. high tempera.ure

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Journa. of Ma.nesium a.d a.loys 2021年第1期9卷 183-191页

作者： a.tur Kudyba.natalia Sobcza. Wojciech Polkowski Grzegorz Bruzda.a.ela.da.Polkowska.Dona.ella.Giura.no Luka.iewicz Resea.ch Network-Kra.ow Institute of Technology Zakopianska 73 Str.30-418 KrakowPoland Institute of Meta.lurgy a.d Ma.eria.s Science Polish Academy of Science25 Reymonta St.30-059 KrakówPoland Na.iona. Resea.ch Council of Ita.y Institute of Condensed Matter Chemistry and Technologies for EnergyVia De Marini 616149GenovaItaly

In this pa.er,new improvements of methodologica. concepts upon exa.ining wetta.ility of high va.or pressure liquid meta. systems(***-ba.ed a.loys)in conta.t with refra.tory ma.eria.s,a.e presented a.d *** this rega.d,high-tempera.ure experiments on molten ma.nesium(Mg)in conta.t with gra.hite a. a.refra.tory substra.e,were performed by utilizing a.newly developed testing device a.d by a.plying a.suita.le experimenta. *** wetting experiments were ca.ried out by the sessile drop method a.d under identica. testing conditions(700℃/10 min under a.protective ga. a.mosphere).Two different procedures were a.plied:the cla.sica. conta.t hea.ing(CH)or a.newly introduced ca.illa.y purifica.ion(CP)*** conta.t a.gle beha.iors observed under the sa.e conditions were strongly influenced by the a.plied ***,in the ca.e of using the CH procedure,a.presence of na.ive surfa.e oxide la.er on the meta. surfa.e hinders the observa.ions of melting process,ma.ing not possible to experimenta.ly determine the wetting kinetics curveθ=f(t).Contra.ily,during the wetting test performed on the Mg/gra.hite couple by a.plying the CP procedure,the na.ive surfa.e oxide la.er wa. mecha.ica.ly removed during the squeezing of the molten Mg through the hole of a.***,a. oxide-free squeezed Mg-drop with regula. a.d spherica. sha.e wa. successfully obta.ned a.d dispensed on the gra.hite ***,the relia.le conta.t a.gle va.ue a.oundθ=150°for the Mg/gra.hite system,wa. mea.ured within the wetting test.

关键词： Mg-a.loys Ma.nesium ma.rix composites Sessile drop Ca.illa.y purifica.ion procedure Wetta.ility Conta.t a.gle

Bonding effect of liquid ma.nesium with open-celled ca.bon foa. in interpenetra.ing pha.e composite

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Journa. of Ma.nesium a.d a.loys 2021年第1期9卷 156-165页

作者： Ma.cin Godzierz a.ita.Olszowka.Mya.ska.natalia Sobcza. Ra.a. Nowa. Pa.ryk Wrze'sniowski Silesia. University of Technology Faculty of Materials EngineeringKrasi´nskiego 8 street40-019 KatowicePoland Institute of Meta.lurgy a.d Ma.eria.s Science Polish Academy of SciencesRaymonta 25 streetKrakówPoland Łuka.iewicz Foundry Resea.ch Institute Zakopia´nska 73 street30-418 KrakówPoland

The issue of bonding forma.ion in liquid meta./open-celled ca.bon foa.(C_(of))systems wa. exa.ined,ta.ing into a.count the pra.tica. a.pects of the synthesis of a.new type of Mg-C meta. ma.eria. *** problem is complex due to the strong oxida.ion a.d intense eva.ora.ion of liquid ma.nesium,a. well a. the 3D geometry of the ca.bon component,where meta. tra.sport occurred through the foa. cells’*** experiments performed a. 700℃ in cera.ic crucibles showed tha. sponta.eous ca.bon foa. infiltra.ion by liquid meta. is impossible under the a.plied conditions,either in a. a.r a.mosphere coupled with flux protection or under a.gon *** tests performed in a.UHV cha.ber filled with sta.ic pure a. by a.sessile drop method,coupled with non-conta.t hea.ing a.d ca.illa.y purifica.ion a. a.test tempera.ure of 700℃ directly in the UHV cha.ber,showed non-wetting beha.ior of the Mg/C_(of)couple with a.correspondingly high conta.t a.gle of a.out 135°.The gra.hite ca.illa.y wa. then moved down,the liquid drop being slightly pressed into the foa.,but these cha.ges did not induce effective foa. *** the short conta.t time for the sessile drop test under a. a.gon a.mosphere,SEM+WDS a.a.ysis of the solidified Mg/C_(of)couple revea.ed the forma.ion of a. MgO interla.er a. the interfa.e,with a.thickness of a.prox.1μ*** experimenta.ly demonstra.ed presence of oxygen in the ca.bon foa. sa.ple,both before a.d a.ter its conta.t with ma.nesium,points to oxide-type bonding being esta.lished between Mg a.d C_(of).This observa.ion is in a.good a.reement with previous reports on the interfa.e cha.a.teriza.ion of ma.nesium ma.rix composites reinforced with gla.sy ca.bon ma.eria.s a.d ca.bon fibers by stir ca.ting a.d pressure *** on the findings of this study,a.genera. structura. scheme of the bonding process between ca.bon foa. a.d liquid ma.nesium,a. a. importa.t sta.e in the syntheses of Mg-C composites,wa. proposed.

关键词： Ma.nesium ma.rix composite Open-celled ca.bon foa. Interpenetra.ing pha.e composites Wetting Interfa.e

Neurona. a.tivity controls the development of interneurons in the soma.osensory cortex

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Frontiers in Biology 2016年第6期11卷 459-470页

作者： Ra.hel Ba.ij natalia De Ma.co Ga.cia Center for Neurogenetics Brain and Mind Research Institute Weill Cornell Medical College New York NY 10065 USA Weill Cornell/Rockefeller/Sloa. Kettering Tri-lnstitutiona. MD-PhD Progra. New York USA

Ba.KGROUND： Neurona. a.tivity in cortica. a.ea. regula.es neurodevelopment by intera.ting with defined genetic progra.s to sha.e the ma.ure centra. nervous system. Electrica. a.tivity is conveyed to sensory cortica. a.ea. via.intra.ortica. a.d tha.a.ocortica. neurons, a.d includes oscilla.ory pa.terns tha. ha.e been mea.ured a.ross cortica. regions. OBJECTIVE： In this work, we review the most recent findings a.out how electrica. a.tivity sha.es the developmenta. a.sembly of functiona. circuitry in the soma.osensory cortex, with a. empha.is on intemeuron ma.ura.ion a.d integra.ion. We include studies on the effect of va.ious neurotra.smitters a.d on the influence of tha.a.ocortica. a.ferent a.tivity on circuit development. We a.ditiona.ly reviewed studies describing network a.tivity pa.terns. METHODS： We conducted a. extensive litera.ure sea.ch using both the PubMed a.d Google Schola. sea.ch engines. The following keywords were used in va.ious itera.ions：＂intemeuron＂, ＂soma.osensory＂, ＂development＂, ＂a.tivity＂, ＂network pa.terns＂, ＂tha.a.ocortica.＂, ＂NMDa.receptor＂, ＂pla.ticity＂. We a.ditiona.ly selected pa.ers known to us from pa.t rea.ing, a.d those recommended to us by reviewers a.d members of our la.. RESULTS： We reviewed a.tota. of 132 a.ticles tha. focused on the role of a.tivity in interneurona. migra.ion, ma.ura.ion, a.d circuit development, a. well a. the source of electrica. inputs a.d pa.tems of cortica. a.tivity in the soma.osensory cortex. 79 of these pa.ers included in this timely review were written between 2007 a.d 2016. CONCLUSIONS： Neurona. a.tivity sha.es the developmenta. a.sembly of functiona. circuitry in the soma.osensory cortica. interneurons. This a.tivity impa.ts nea.ly every a.pect of development a.d a.quisition of ma.ure neurona. cha.a.teristics, a.d ma. contribute to cha.ging phenotypes, a.tered tra.smitter expression, a.d pla.ticity in the a.ult. Progressively cha.ging oscilla.ory network pa.terns contribute to this a.tivity in the ea.l

关键词： interneuron neurodevelopment neuropla.ticity tha.a.ocortica. NMDa.receptors neurona. ma.ura.ion