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Stimulants and donors promote megaplasmid pND6-2 horizontal gene transfer in activated sludge

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Journal of Environmental Sciences 2023年第4期126卷 742-753页

作者： Shan Wang Shanshan Li Dan Du Olusegun KAbass muhammad Salman nasir Wei Yan Department of Environmental Science and Engineering Xi’an Key Laboratory of Solid Waste Recycling and Resource RecoveryXi’an Jiaotong UniversityXi’an 710049China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Structures and Environmental Engineering University of AgricultureFaisalabad 38040Pakistan

The activated sludge process is characterized by high microbial density and diversity,both of which facilitate antibiotic resistance gene *** studies have suggested that antibiotic and non-antibiotic drugs at sub-inhibitory concentrations are major inducers of conjugative gene *** self-transmissible plasmid pND6-2 is one of the endogenous plasmids harbored in Pseudomonas putida ND6,which can trigger the transfer of another co-occurring naphthalene-degrading plasmid ***,to illustrate the potential influence of stimulants on conjugative transfer of pND6-2,we evaluated the effects of four antibiotics (ampicillin,gentamycin,kanamycin,and tetracycline) and naphthalene,on the conjugal transfer efficiency of pND6-2 by filter-mating *** findings demonstrated that all stimulants within an optimal dose promoted conjugative transfer of pND6-2from Pseudomonas putida GKND6 to *** KT2440,with tetracycline being the most effective (100μg/L and 10μg/L),as it enhanced pND6-2-mediated intra-genera transfer by approximately one ***,seven AS reactors were constructed with the addition of donors and different stimulants to further elucidate the conjugative behavior of pND6-2 in natural *** stimulants positively affected the conjugal process of pND6-2,while donors reshaped the host abundance in the *** was likely because stimulant addition enhanced the expression levels of conjugation transfer-related ***,Blastocatella and Chitinimonas were identified as the potential receptors of plasmid pND6-2,which was not affected by donor *** findings demonstrate the positive role of sub-inhibitory stimulant treatment on pND6-2 conjugal transfer and the function of donors in re-shaping the host spectrum of pND6-2.

关键词： Antibiotics Naphthalene Donor Conjugative transfer Host range

SSZ Semail Ophiolite vs mORB masirah Ophiolite: A Perspective from Podiform Chromitites

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Acta Geologica Sinica(English Edition) 2020年第S01期94卷 51-52页

作者： Sobhi nasir UNESCO Chair for Ophiolite Studies Sultan Qaboos University Oman

One of the major topics of debate in ophiolite geology is the original tectonic setting of ophiolites. New studies show that most ophiolites are formed more frequently in a suprasubduction zone(SSZ) environment and that only a very small number of ophiolites have formed in an oceanic range(mOR). The masirah ophiolite is one of the few oceanic ridge ophiolites that have been preserved, and the evidence that was formed in a subduction environment is missing(moseley and Abbotts 1979, Dilek and Furnes, 2011;Rollinson, 2017). masirah Island, the Batain and Ras madrah areas of eastern Oman are almost entirely composed of a well-developed ophiolite, known as the masirah ophiolite(Fig. 1), which is, however, completely unrelated to the nearby Semail Ophiolite in the northern Oman mountains(Fig. 2). The masirah ophiolite is Jurassic in age and represents oceanic lithosphere derived from the Indian Ocean, but is about 15–20 myr later than emplacement of midCretaceous Semail ophiolite in northern Oman. The presence of basaltic to rhyolitic lavas of calc-alkaline affinity and boninites in the lava sequence of the Semail ophiolite led several researchers to propose a back-arc basin model for this ophiolite(e.g. Tamura and Arai, 2006;Godard et al., 2008;Rollinson and Adetunji, 2015). The masirah Ophiolite shows close affinities with mORB peridotites in general. most of the olivine from the masirah harzburgites show Fo contents that are similar to those of olivine from mORB. Both pyroxenes in these harzburgites have similar mg# values, Al2O3 and Cr2O3 contents to those of pyroxenes from mORB peridotites. The observed primitive mantlenormalized REE patterns showing enrichment in LREEs indicate that the masirah peridotites have been modified by fluids or melts enriched in LREEs in a mORB environment. Podiform chromitites housed in ophiolites today interpreted as magmatic deposits formed during the reaction of molten rock in environments spike in the middle of the ocean(mOR) or supra

关键词： masirah ophiolite Semail ophiolite mOR subduction chromitite

Computing and Implementation of a Controlled Telepresence Robot

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Intelligent Automation & Soft Computing 2023年第8期37卷 1569-1585页

作者： Ali A.Altalbe Aamir Shahzad muhammad nasir Khan Prince Sattam Bin Abdulaziz University Al-Kharj11942Saudi Arabia Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah21589Saudi Arabia Department of mechanical Engineering The University of LahoreLahore54000Pakistan Department of Electrical Engineering GC University LahoreLahore54000Pakistan

The development of human-robot interaction has been continu-ously increasing for the last *** this development,it has become simpler and safe interactions using a remotely controlled telepresence robot in an insecure and hazardous *** audio-video communication connection or data transmission stability has already been well handled by fast-growing technologies such as 5G and ***,the design of the phys-ical parameters,e.g.,maneuverability,controllability,and stability,still needs ***,the paper aims to present a systematic,controlled design and implementation of a telepresence mobile *** primary focus of this paper is to perform the computational analysis and experimental implementa-tion design with sophisticated position control,which autonomously controls the robot’s position and speed when reaching an obstacle.A system model and a position controller design are developed with root locus *** design robot results are verified experimentally,showing the robot’s agreement and control in the desired *** robot was tested by considering various parameters:driving straight ahead,right turn,self-localization and complex *** results prove that the proposed approach is flexible and adaptable and gives a better *** experimental results show that the proposed method significantly minimizes the obstacle hits.

关键词： Computing telepresence healthcare system position controller mobile robot

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指数模定理(英文)

自动化学报 2012年第7期38卷 1223-1224页

作者： RAJPOOT nasir Department of Computer Science University of Warwick

Computation of exponential modula when using hashing functions such as Karp-Rabin fingerprints can be quite cumbersome especially when the alphabet size is large. In this paper, we show an interesting result which can... 详细信息

关键词：定理数模哈希函数卡普拉字符集计算指纹

State of Health Estimation of LiFePO_(4) Batteries for Battery management Systems

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Computers, materials & Continua 2022年第11期73卷 3149-3164页

作者： Areeb Khalid Syed Abdul Rahman Kashif Noor Ul Ain Ali nasir Department of Electrical Engineering University of Engineering and TechnologyLahorePakistan Department of Electrical Engineering University of Central PunjabLahorePakistan

When considering the mechanism of the batteries,the capacity reduction at storage(when not in use)and cycling(during use)and increase of internal resistance is because of degradation in the chemical composition inside the *** optimize battery usage,a battery management system(BmS)is used to estimate possible aging effects while different load profiles are requested from the *** is specifically seen in a case when the vehicle is connected to the net(online through BmS).During this process,the BmS chooses the optimized load profiles based on the least aging effects on the battery *** major focus of this paper is to design an algorithm/model for lithium iron phosphate(LiFePO4)*** model of the batteries is based on the accelerated aging test data(data from the beginning of life till the end of life).The objective is to develop an algorithm based on the actual battery trend during the whole life of the *** the analysis of the test data,the complete trend of the battery aging and the factors on which the aging is depending on is identified,the aging model can then be recalibrated to avoid any differences in the production process during cell *** validation of the model was carried out at the end by utilizing different driving profiles at different C-rates and different ambient temperatures.A Linear and non-linear model-based approach is used based on statistical *** parameterization was carried out by dividing the data into small chunks and estimating the parameters for the individual ***-adaptive characteristic map using a lookup table was also *** nonlinear model was chosen as the best candidate among all other approaches for longer validation of 8-month data with real driving data set.

关键词： Aging model state of health lithium-ion cells battery management system state of charge battery modeling

Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation

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Journal of Integrative medicine 2019年第1期17卷 38-45页

作者： Syed nasir Abbas Bukhari Fahad Hussain Hnin Ei Thu Zahid Hussain Department of Pharmaceutical Chemistry College of Pharmacy Aljouf University Institute of molecular Biology and Biotechnology (ImBB) The University of Lahore Department of Pharmacology and Dental Therapeutics Faculty of Dentistry Lincoln University CollegePetaling Jaya 47301 Selangor Malaysia Department of Pharmaceutics Faculty of Pharmacy Universiti Teknologi MARA (UiTM)

Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone ***: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using mC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECm) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also ***: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of mC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECm mineralization(calcium deposition) was also higher in mC3 T3-E1 cells treated with combined *** time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined ***: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.

关键词： Osteoporosis Curcumin Fructus Ligustri Lucidi Combined herbal therapy Cell proliferation Cell differentiation Bone formation

Growth and Physiological Attributes of Tomato (Lycopersicon esculentum mill.) Genotypes as Affected by NaCl Stress

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American Journal of Plant Sciences 2016年第3期7卷 453-460页

作者： m. nasir Khan Department of Biology Faculty of Science University of Tabuk Tabuk Saudi Arabia

High level of salinity adversely affects growth, productivity as well as quality of vegetable crops by reducing photosynthetic capacity, enzyme activities, and by enhanced production of reactive oxygen species (ROS). These ROS cause peroxidation of membrane lipids leading to disintegration of cell membrane with the leakage of electrolytes. All these detrimental effects ultimately contribute to the crop with reduced yield and low nutritive value. The present investigation was carried out to test salt tolerance capacity of ten genotypes of tomato on the basis of growth, physiological and biochemical characteristics. The results show that all the ten tested genotypes of tomato responded differently to 200 mm NaCl stress. Regarding growth parameters, BL-1076 gave higher values, while Queen gave the lowest values for most of the parameters (plant height, number of leaves, leaf area, shoot and root fresh weight and dry weight). Regarding physiological and biochemical parameters, BL-1076 gave higher values for the activities of carbonic anhydrase and nitrate reductase, leaf chlorophyll content, relative water content, and activities of antioxidant enzymes (superoxide dismutase, peroxidase and catalase). However, genotype Queen gave the lowest values for these parameters. On contrary, the least membrane damage (TBARS content) was registered in BL-1076, while the highest in Queen. Overall assessment of results leads to the conclusion that the genotype BL-1076 was found salt tolerant while Queen salt sensitive. The ten genotypes may be arranged on the basis of their salt tolerance capacity in decreasing order as: BL-1076 > Trust > Imperial > Tanshet star > PakmoreVF > L 26 > Plitz > Bonus F1 > Grace > Queen.

关键词： Antioxidant Enzymes Genotypes Growth Stress Tomato

Changes in free amino acids and polyamine levels in Satsuma leaves in response to Asian citrus psyllid infestation and water stress

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Insect Science 2014年第6期21卷 707-716页

作者： nasir S. A. malik Jose L. Perez madhurababu Kunta Joseph m. Patt Robert L. mangan USDA-ARS ERRC 600 E Mermaid lane Wyndmoor PA 19038-8598 USDA-ARS SPARC 2881 F&B Road College Station TX 77845 Texas A&m University-Kingsville Citrus Center 312 North International Blvd Weslaeo TX 78596 U. S. Horticultural Research Laboratory 2001 South Rock Road Fort Pierce FL 34945 Subtropical Horticultural Research Station 13601 Old Coulter Road Miami FL 33158 USDA-ARS 2413 E. Hwy 83 Weslaco TX 78596 USA

The effects of biotic and abiotic stresses on changes in amino acids and polyamine levels in Satsuma orange （Citrus unshiu; cultivar Owari） leaves were inves- tigated. Asian citrus psyllids Diaphorina citri （Kuwayama）（ACP） infestation was used to induce biotic stress while a water deficit was imposed to induce abiotic stress. Potted trees were infested by placing 50 psyllids on 3 citrus leaves enclosed in nylon mesh bags for 5 d. A parallel set of plants were kept water stressed by maintaining the soil at 20% water holding capacity for 5 d. Levels of total free amino acids were higher in water stressed and ACP infested leaves. Polyamine putrescine increased in infested leaves but not in water stressed leaves. Proline was the most abundant amino acid and its levels significantly increased by both biotic and abiotic stresses. Proline levels in infested leaves were significantly higher than the water stressed leaves. Histidine, methionine, asparagine, arginine, serine, and leucine levels also increased significantly in infested leaves, but in water stressed leaves only leucine, methionine, and threonine increased. Levels of amino acids, such as tyrosine, isoleucine, phenylalanine, glutamic acid, and alanine, declined in infested leaves. Under water stress asparagine, phenylalanine, serine, and histidine also declined compared to controls. This indicates that while proteolysis occurred under both stresses, metabolic conversion of amino acids was different under the two stresses. In ACP infested leaves some amino acids may be used as feeding material and/or converted into secondary metabolites for defense.

关键词： amino acids citrus Diaphorina citri polyamines

Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1383-1399页

作者： nasir Uddin Daniel WBinzel Dan Shu Tian-min Fu Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine Division of Pharmaceutics and PharmacologyCollege of Pharmacythe Ohio State UniversityColumbusOH 43210USA Dorothy m.Davis Heart and Lung Research Institute the Ohio State UniversityColumbusOH 43210USA James Comprehensive Cancer Center College of Medicinethe Ohio State UniversityColumbusOH 43210USA Department of Biological Chemistry&Pharmacology College of Medicinethe Ohio State UniversityColumbusOH 43210USA

Exosome is an excellent vesicle for in vivo delivery of therapeutics,including RNAi and chemical *** extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome ***,being composed of a lipidbilayer membrane without specific recognition capacity for aimed-cells,the entry into nonspecific cells can lead to potential side-effects and *** engineering approaches for targeting-capacity to deliver therapeutics to specific cells is *** with chemical modification in vitro and genetic engineering in cells have been reported to decorate exosomes with targeting *** nanoparticles have been used to harbor tumor-specific ligands displayed on exosome *** negative charge reduces nonspecific binding to vital cells with negatively charged lipid-membrane due to the electrostatic repulsion,thus lowering the side-effect and *** this review,we focus on the uniqueness of RNA nanoparticles for exosome surface display of chemical ligands,small peptides or RNA aptamers,for specific cancer targeting to deliver anticancer therapeutics,highlighting recent advances in targeted delivery of siRNA and miRNA that overcomes the previous RNAi delivery *** understanding of exosome engineering with RNA nanotechnology promises efficient therapies for a wide range of cancer subtypes.

关键词： RNA interference RNA nanotechnology Endolysosome trapping Exosome engineering Targeted delivery Chemical drug delivery