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Effects of Hydro-alcoholic Extract of Launaea acanthodes on Serum Gonadotropin and Testosterone Levels and the Structure of Seminiferous Tubules in Hyperglycemic Rats

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Chinese Journal of Integrative Medicine 2016年第3期22卷 207-213页

作者： Ameneh Mohammadi Morteza Behnam-Rassouli Zeinab Momeni naser mahdavi-shahri Department of Biology Faculty of ScienceFredowsi University of Mashhad

Objective： To investigate the effects of hydro-alcoholic extract of Launaea acanthodes, a blood glucose lowering plant in folk medicine of Iran, on the structure of seminiferous tubules and serum gonadotropin and testosterone levels in hyperglycemic rats. Methods： Twenty-four Wistar rats were randomly allocated into 4 groups （n=6）： control, streptozotocin （STZ）, STZ ＋ insulin [STZ ＋ Ins, 5 IU/（kg·day）], and STZ ＋ Launaea acanthodes extract [STZ ＋ Ext, 150 mg/（kg·day）]. Blood samples were collected at the 2nd and 4th weeks for detection of testosterone, follicle stimulating hormone （FSH） and luteinizing hormone （LH） with enzyme-linked immuno sorbent assay （ELISA）, and the dght testes of rats were removed at the 7th week for the evaluation of diameter and wall thickness of seminiferous tubules and number of Leydig cells using unbiased stereological techniques. Results： in comparison with the control group, at the 2nd week FSH （0.45 vs 0.03, 0.02, 0.02 lUlL in STZ, STZ ＋ Ins and STZ ＋ Ext groups, respectively） and LH （1.02 vs 0.37, 0.2, 0.29 IU/L） showed significant decreases （all P〈0.05） and testosterone （4.2 vs 8.37, 7.78, 11.8 ng/mL） showed a remarkable increase （all P〈0.05）. The levels of these hormones became closer in the STZ ＋ Ext and the STZ ＋ Ins groups to the control at the 4th week. A significant decrease in diameter and wall thickness of seminiferous tubules and number of Leydig cells were observed in the STZ group as compared with the control （P〈0.01）. Conclusions： Administration of Launaea extract demonstrated a beneficial impact on the protection of testis from pathogenic and degenerative effects of hyperglycemia which may be partly due to its potential antioxidative effects.

关键词： hyperglycemia Launaea acanthodes testis gonadotropins testosterone rat

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Down-regulation of Halr1 during induced differentiation of embryonal carcinoma P19 cells

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BIOCELL 2019年第3期43卷 145-154页

作者： ZAHRA HOSSEININIA SARA SOLTANIAN naser mahdavi-shahri HESAM DEHGHANI Division of Biotechnology Faculty of Veterinary MedicineFerdowsi University of MashhadMashhadIran Department of Biology Faculty of SciencesShahid Bahonar University of KermanKermanIran Department of Biology Faculty of SciencesFerdowsi University of MashhadMashhadIran Stem Cells and Regenerative Medicine Research Group Research Institute of BiotechnologyFerdowsi University of MashhadMashhadIran

Maintenance of pluripotency depends to diverse regulatory *** in embryonic stem cells(ESCs)have indicated that large intergenic non-coding RNAs(lincRNAs)are involved in the regulatory network of ***,the presence and function of pluripotency-associated lincRNAs in cancer cells with pluripotency features are *** this study,we used embryonal carcinoma(EC)P19 cell lines to investigate the expression level of Halr1 in pluripotency and retinoic acid(RA)-induced differentiated ***-regulation of pluripotency associated factors such as OCT4,NANOG,SSEA1 and alkaline phosphatase at transcript and protein levels were used to confirm the differentiated status of P19 *** measurement of Halr1 transcript levels revealed a 79% decrease during RA-induced differentiation of P19 *** results indicate that upon exiting the pluripotency state the expression level of Halr1 similar to core pluripotency factors is remarkably reduced.

关键词： Differentiation Halr1 lincRNA Pluripotency P19 cell Retinoic acid

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