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Serum albumin predicts survival in patients with hilar cholangiocarcinoma

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gastroenterology Report 2017年第1期5卷 62-66,I0003页

作者： Abhijeet Waghray Anastasia Sobotka Carlos Romero Marrero Bassam Estfan Federico Aucejo KV narayanan Menon Department of Medicine MetroHealth Medical CenterClevelandOHUSA Department of gastroenterology and Hepatology Cleveland Clinic FoundationClevelandOHUSA Department of Hepatobiliary and Transplant Surgery Cleveland Clinic FoundationClevelandOHUSA

Background and aims:Hilar cholangiocarcinoma is a devastating malignancy with incidence varying by geography and other risk *** progression of disease and delays in diagnosis restrict the number of patients eligible for curative *** objective of this study was to determine prognostic factors of overall survival in all patients presenting with hilar ***:All adult patients with histologically confirmed hilar cholangiocarcinoma from 2003 to 2013 were evaluated for predictors of survival using demographic factors,laboratory data,symptoms and radiological characteristics at ***:A total of 116 patients were identified to have pathological diagnosis of hilar cholangiocarcinoma and were included in the *** with a serum albumin level>3.0 g/dL(Pgen 19-9≤200U/mL(P=0.03),carcinoembryonic antigen≤10g/L(Pgreater length of overall survival.A serum albumin level>3.0 g/dL was identified as an independent predictor of overall survival(hazard ratio 0.31;95%confidence interval 0.14–0.70)with a survival benefit of 44 ***:This study was the largest analysis to date of prognostic factors in patients with hilar cholangiocarcinoma.A serum albumin level>3.0 g/dL conferred an independent survival advantage with a significantly greater length of survival.

关键词： hilar cholangiocarcinoma prognostic factors survival albumin

Disposition and tissue distribution of imatinib in a liposome formulation after intravenous bolus dose to mice

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药学学报 2010年第7期45卷 901-908页

作者： MOO Kai Shing RADHAKRISHNAN Shantini TEOH Magdalene narayanan Prasad BUKHARI Nadeem Irfan SEgARRA Ignacio Department of Pharmaceutical Technology School of Pharmacy and Health SciencesInternational Medical University(Malaysia)

Imatinib is an efficacious anticancer drug with a spectrum of potential antitumour applications limited by poor biodistribution at therapeutic concentrations to the tissues of *** assess the pharma-cokinetic and tissue distribution profile of imatinib in a liposome *** single dose(6.25 mg·kg-1) in a liposome formulation was administered iv to male *** concentration was measured in plasma,spleen,liver,kidney and brain using a HPLC ***-compartmental pharmacokinetic approach was used to assess the disposition *** plasma disposition profile was biphasic with a plateau-like second *** AUC0→∞ was 11.24 μg·h·mL-1,the elimination rate constant(kel) was 0.348 h-1 and the elimination half life(t1/2) was 2.0 *** mean residence time(MRT) was 2.59 h,VSS was 1.44 L·kg-1 and clearance was 0.56 L·h·*** achieved the highest tissue exposure:CMAX = 18.72 μg·mL-1;AUC0→∞ = 58.18 μg·h·mL-1 and longest t1/2(4.29 h) and MRT(5.31 h).Kidney and spleen AUC0→∞ were 47.98 μg·h·mL-1 and 23.46 μg·h·mL-1,***-life was 1.83 h for the kidney and 3.37 h for the *** penetrated into the brain reaching ～1 μg·*** correction by organ blood flow the spleen showed the largest uptake *** imatinib presented extensive *** drug uptake kinetics showed mechanism differences amongst the *** findings encourage the development of novel imatinib formulations to treat other cancers.

关键词： imatinib pharmacokinetics liposome tissue distribution

Enhanced cytotoxic effect on human lung carcinoma cell line(A549) by gold nanoparticles synthesized from Justicia adhatoda leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2018年第11期8卷 540-547页

作者： D.Latha P.Prabu C.Arulvasu R.ManikANDan S.Sampurnam V.narayanan Department of Inorganic Chemistry University of Madras Guindy Campus Department of Zoology Pachaiyappa's College for Men Kanchipuram Department of Zoology University of Madras Guindy Campus Chennai

Objective: To synthesize bio-inspired gold nanoparticles(AuNPs) using the leaf extract of Justicia adhatoda and evaluate the anti-cancer activity on human lung cancer cell line(A549).Methods: Synthesis of AuNPs was done using an aqueous leaf extract of Justicia adhatoda as a green route. The bio-synthesized AuNPs were confirmed and characterized by using various spectral studies such as UV-Vis spectrum, Scanning Electron Microscope with EDAX, Transmission Electron Microscope, Fourier Transmission Infrared Spectroscope analysis and Surface Enhanced Raman Spectroscopy. The cell viability was determined by MTT reduction assay. In addition, cytomorphology and the nuclear morphological study of A549 cell line was observed under fluorescence microscope. Results: UV-Vis spectrum showed surface plasmon resonance peak at 547 nm, scanning electron microscope and transmission electron microscope studies showed the monodispersed spherical shape and its average size in the range of 40.1 nm was noticed. Fourier Transmission Infrared Spectroscope analysis confirmed that the C=O group of amino acids of proteins had strong ability to bind with the surface of nanoparticle. Interestingly, our results also demonstrated inhibited proliferation of A549 cell line by MTT(IC50 value: 80 μg/mL). Cell morphology was observed and cell death was caused by apoptosis as revealed by propidium iodide staining. Conclusions: The current study proves the anticancer potential of bio-synthesized AuNPs. Thus, synthesized AuNPs can be used for the treatment of human lung cancer cell(A549) and it can be exploited for drug delivery in future.

关键词： Justicia adhatoda Leaf extract AuNPs Cytotoxicity A549 cell line

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锌-三氧化二铬复合镀层的特性(英文)

电镀与涂饰 2011年第9期30卷 12-15页

作者： KARTHIKEYAN S VENKATACHALAM g narayanan S SRINIVASAN K N Materials Division SASVIT UniversityVellore-632014India

采用由氧化锌 12 g/L、氢氧化钠 94 g/L、2-氨基-3-羧基吡啶 4.2 g/L、四乙烯五胺 17 g/L、三乙醇胺 2 g/L、专利表面活性剂0.5 g/L及碳三氧化二铬(粒径2 μm)0 ～ 11 g/L组成的镀液,于温度 50 °C、pH 6.5 和电流密度 4 A/dm2的条件下... 详细信息

采用由氧化锌 12 g/L、氢氧化钠 94 g/L、2-氨基-3-羧基吡啶 4.2 g/L、四乙烯五胺 17 g/L、三乙醇胺 2 g/L、专利表面活性剂0.5 g/L及碳三氧化二铬(粒径2 μm)0 ～ 11 g/L组成的镀液,于温度 50 °C、pH 6.5 和电流密度 4 A/dm2的条件下,在低碳钢上电镀 Zn-Cr2O3复合镀层。其显微硬度采用维氏硬度计测量,耐磨性用 Taber 磨耗试验机测量,表面形貌和显微组织采用扫描电镜(SEM)、X 射线衍射(XRD)及 X 射线光电子能谱(XPS)进行分析,在 3.5%(质量分数)NaCl 溶液中的耐蚀性以电化学阻抗谱(EIS)评价。证实了锌基体中存在团聚的 Cr2O3颗粒。与纯锌镀层相比,Zn-Cr2O3复合镀层的机械性能及耐蚀性能更好。

关键词：锌三氧化二铬复合镀层耐蚀性显微硬度耐磨性

The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

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Neural Regeneration Research 2019年第11期14卷 1950-1960页

作者： Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven g. Meuth Department of Neurology with Institute of Translational Neurology Westfalische Wilhelms-UniversitatMunsterGermany Institute of Physiology I Westfalische Wilhelms-UniversitatMunsterGermany Novartis Institutes of Biomedical Research BaselSwitzerland

Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with german and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010.

关键词： multiple sclerosis focal experimental autoimmune encephalomyelitis cortical grey matter white matter BAF312 neuroaxonal damage neuroprotection

Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis

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World Journal of Cardiology 2017年第2期9卷 182-190页

作者： Mahesh Anantha narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David g Benditt ganesh Raveendran Division of Cardiovascular Diseases University of Minnesota Medical Center Division of Cardio-vascular Diseases Mayo ClinicRochester

AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart *** Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P gnificantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF.

关键词： Ivabradine Heart failure

Validation of Foreground Emission Model using gALEX Medium Observations

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Research in Astronomy and Astrophysics 2023年第6期23卷 228-237页

作者： Nimmi narayanan Shivashankar S.Menon N.V.Sujatha Department of Physics St.Xavier's College for WomenAluva 683101India Department of Physics Sree Sankara CollegeKaladyErnakulam 683574India CSIS BITS Pilani K.K.Birla Goa CampusZuarinagarGoa 403726India

The study of diffuse ultraviolet(UV)background radiation is vital in the investigation of stellar and galactic ***-based UV observations are comprised of both foreground and background *** foreground emission in an observation is a result of solar contamination in the direction of *** our previous work,we modeled airglow(one of the major constituents of the foreground emission)as a function of10.7 cm Solar Flux and Sun Angle with great accuracy using gALEX deep *** adopt a similar methodology to validate the obtained model and run equivalent experiments here using far-UV(FUV)and nearUV(NUV)gALEX medium imaging surveys(MIS)with a total exposure time greater than 3300 *** obtained a predictive model having excellent compatibility with the earlier *** analysis shows that the total foreground emission varies between 59 and 295 photon units in FUV whereas in NUV,it varies between 671 and1195 photon units depending upon the date and time of *** also noticed a strong correlation between the background emission and optical depth both in FUV and NUV,especially in the low density *** clearly indicates that the major contributor in diffuse background radiation is the starlight scattered by interstellar dust grains.

关键词： instrumentation:detectors Sun:activity ultraviolet:ISM atmospheric effects

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镍-磷-硫酸钡化学复合镀层的研制(英文)

电镀与涂饰 2011年第3期30卷 31-34页

作者： S. Karthikeyan g. Venkatachalam K. N. Srinivasan S. narayanan Materials Division School of Advanced Sciences VIT University Vellore-632014 Tamilnadu India Design Division School of Mechanical and Building Sciences VIT University Vellore-632014 Tamilnadu India IMF Division Central Electrochemical Research Institute (CECRI) Karaikudi-630006 Tamilnadu India Manufacturing Division School of Mechanical and Building Sciences VIT University Vellore-632014 India

在由硫酸镍31g/L、次磷酸钠22g/L、乙醇酸30g/L、乙酸钠13g/L、二甲胺0.8g/L、全氟乙基碘化铵0.1g/L及重晶石(即硫酸钡)0～25g/L组成的稳定镀液中,采用化学镀的方法在低碳钢上制备了Ni–P–BaSO4复合镀层。其表面形貌采用扫描电镜进行分... 详细信息

在由硫酸镍31g/L、次磷酸钠22g/L、乙醇酸30g/L、乙酸钠13g/L、二甲胺0.8g/L、全氟乙基碘化铵0.1g/L及重晶石(即硫酸钡)0～25g/L组成的稳定镀液中,采用化学镀的方法在低碳钢上制备了Ni–P–BaSO4复合镀层。其表面形貌采用扫描电镜进行分析,耐蚀性以动电位极化及电化学阻抗谱测试。镍–磷合金基体中掺入硫酸钡,提高了化学镀层的显微硬度。相对于纯Ni–P合金镀层,Ni–P–BaSO4复合镀层具有更小的磨损率。硫酸钡颗粒的存在使得复合镀层的耐蚀性明显降低。

关键词：化学镀镍磷合金硫酸钡复合镀层耐蚀性显微硬度耐磨性

A Comparative Study on the Utilization of Corn Pericarp and Peanut Hull in the Production of Ethanol and the Impact on Food Economics

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Food and Nutrition Sciences 2016年第11期7卷 1010-1020页

作者： J. L. Herring V. C. narayanan Department of Food & Animal Sciences Alabama A&M University Normal AL USA

Corn pericarp and peanut hull (lignocellulosic materials) which are food industry by-products were used as substrates in this study. Alkaline hydrogen peroxide (H2O2) pretreatments at 0%, 2.5% and 5% were used for the removal of lignin. Simultaneous Saccharification and Fermentation (SSF) and Separate Hydrolysis and Fermentation (SHF) were conducted using Aspergillus niger (strain 201201) and Saccharomyces cerevisiae (strain 26603). Aspergillus niger was added on day 1 to all samples with inoculation treatments of S. cerevisiae at one-day intervals (A = Day 1, B = Day 2, C = Day 3 and D = Day 4). Pretreatment with 2.5% H2O2 was more beneficial in the removal of lignin for both substrates. Corn pericarp yielded an ethanol concentration of 22.2 g/L in C and 21.78 g/L in D of 2.5% H2O2 pretreatment. Peanut hull with 2.5% H2O2 pretreatment in D yielded a higher concentration at 10.38 g/L compared to other inoculation treatments. The highest ethanol yielded on a percentage basis for corn pericarp was 45.04% in C of 2.5% H2O2 pretreatment and 24.6% in D of 2.5% H2O2 pretreatment for peanut hull.

关键词： Ethanol Peanut Hull Corn Pericarp Alkaline Pretreatment Fermentation