检索结果-南通市图书馆

国外农学-杂粮作物 1986年第1期 25-28页

作者： p.K.verma 王富德

为揭示杂种优势的机理,人们已做了许多努力,但是仍未能依遗传学、生理学、生物化学和环境的影响做出综合的说明。某些科学家并不相信那种简单地基于生理、生化原理对杂

关键词：高粱杂交种化原玉米幼苗生化分析酶活性超显性相对优势光合速率出叶生产潜力

污秽绝缘子电气强度、绝缘尺寸设计以及在阿拉伯地区用特殊参数进行绝缘监视

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

电瓷避雷器 1980年第6期 25-30页

作者： M.p.verma 和丕中

本文阐述了系统运行中污秽绝缘存在的有关问题。从污闪机理出发,分析了污闪中泄漏电流的特征,提出了如何把;用于污秽绝缘监视和进行合理绝缘尺寸设计以及选择优良绝缘子造型的方法及实例。最后文中简述了在污秽地区运行的避雷器的主要... 详细信息

本文阐述了系统运行中污秽绝缘存在的有关问题。从污闪机理出发,分析了污闪中泄漏电流的特征,提出了如何把;用于污秽绝缘监视和进行合理绝缘尺寸设计以及选择优良绝缘子造型的方法及实例。最后文中简述了在污秽地区运行的避雷器的主要问题。

关键词：绝缘子碍子电工陶瓷制品泄漏电流污秽闪络污闪故障泄漏距离污秽绝缘监视尺寸设计

Effect of Dietary Lip.ds and Drumstick Leaves (<i>Moringa oleifera</i>) on Lip.d p.ofile &amp.Antioxidant p.rameters in Rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2012年第2期3卷 141-145页

作者： Neveda Oinam Asna Urooj p.eetham p.ul p.illip. narayan p.asad Niranjan Defense Food Research Laboratory Siddharthanagar Mysore India. Dep.rtment of Studies in Food Science & Nutrition University of Mysore Mysore India

The study investigated the influence of dietary vitamin E derived from drumstick leaves (DL, Moringa oleifera) on antioxidant status and p.asma lip.ds in male rats, fed diets based on either p.lm (p.) or p.anut oil (p.). Two control (p. & p.) and three exp.rimental diets (p.DL, p.DL & p.p.DL) differing in dietary fat source sup.lemented with DL p.wder were fed (ad libitum, 8 weeks). The vitamin E content of control diets was 30 IU/kg while the exp.rimental diets p.ovided 60 IU/kg of diet. No significant differences in body weight, liver and adip.se tissue weights were observed between the 5 group., desp.te the difference in the typ./source of fat used in the diets. After 8 weeks, the cholesterol and TBARS levels in the livers of rats fed p.DL diet were lower than the other group.. In all 5 group., p.asma cholesterol decreased after 8 weeks, however, diets sup.lemented with DL p.wder resulted in decreases in both p.asma cholesterol and lip.d p.roxides marked decrease (p.p.red to control group. The increase in p.asma vitamin E levels were not significant. The data suggest that the combination of dietary fat and drumstick leaves as a source of antioxidant was beneficial as it reduced p.asma cholesterol & lip.d p.roxidation.

关键词： Cholesterol Vitamin E Moringa oleifera Antioxidant

Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicap.c, in non-alcoholic liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第23期23卷 4181-4190页

作者： latha p.ka david e smith dawoon jung siobhan mccormack p.ng zhou bin duan jing-song li jiaqi shi yong-jie hao kai jiang michael yamin itzhak d goldberg p.akash narayan Dep.rtment of Research and Develop.ent Angion Biomedica Corp.

To evaluate a calcium activated p.tassium channel (KCa3.1) inhibitor attenuates liver disease in models of non-alcoholic fatty liver disease (NAFLD).METHODSWe have p.rformed a series of in vitro and in vivo studies using the KCa3.1 channel inhibitor, Senicap.c. Efficacy studies of Senicap.c were conducted in toxin-, thioacetamide (TAA) and high fat diet (HFD)-induced models of liver fibrosis in rats. Efficacy and p.armacodynamic effects of Senicap.c was determined through biomarkers of ap.p.osis, inflammation, steatosis and *** of KCa3.1 exp.ession was recorded in TAA-induced and high fat diet-induced liver disease. Treatment with Senicap.c decreased p.lmitic acid-driven Hep.2 cell death. (p.p.orting the finding that Senicap.c reduces lip.d-driven ap.p.osis in Hep.2 cell cultures. In animals fed a HFD for 6 wk, co-treatment with Senicap.c, (1) reduced non-alcoholic fatty liver disease (NAFLD) activity score (NAS) (0-8 scale), (2) decreased steatosis and (3) decreased hep.tic lip.d content (Oil Red O, p.p.c was associated with a decrease in liver fibrosis as evidenced by hydroxyp.oline and Masson’s trichrome staining (p.p.c mitigates both steatosis and fibrosis in liver fibrosis *** data suggest that Senicap.c interrup.s more than one node in p.ogressive fatty liver disease by its anti-steatotic and anti-fibrotic activities, serving as a double-edged therap.utic sword.

关键词： High fat diet Liver Steatosis Fibrosis KCa3.1 channel Senicap.c Inflammation

p.votal roles of tumor-draining lymp. nodes in the abscop.l effects from combined immunotherap. and radiotherap.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2022年第10期42卷 971-986页

作者： Zhaoyun Liu Zhiyong Yu Dawei Chen Vivek verma Chenxi Yuan Minglei Wang Fei Wang Qing Fan Xingwu Wang Yang Li Yuequn Ma Meng Wu Jinming Yu Dep.rtment of Oncology Shandong University Cancer CenterJinanShandong 250117P.R.China Dep.rtment of Radiation Oncology and Shandong p.ovincial Key Laboratory of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Dep.rtment of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030United States Dep.rtment of p.armacy Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Research Unit of Radiation Oncology Chinese Academy of Medical SciencesJinanShandong 250117P.R.China

Background:Currently,due to synergy enhancement of anti-tumor effects and p.tent stimulation of abscop.l effects,combination therap. with irradiation and p.ogrammed cell death p.otein 1/p.ogrammed death-ligand 1(p.-1/p.-L1)immune checkp.int inhibition(immuno-radiotherap.,iRT)has revolutionized the therap.utic *** has been demonstrated that tumor-draining lymp. nodes(TDLN)are essential for effective antitumor immunity induced by radiotherap.,immunotherap.,or *** that the function of TDLN in iRT remains unclear,this study aimed to investigate the function and mechanism of TDLN in iRT-induced abscop.l ***:The function of TDLN was evaluated using unilateral or bilateral MC38 and B16F10 subcutaneous tumor models with or without indicated *** flow cytometry,multip.e immunofluorescence analysis,and NanoString analysis were utilized to detect the comp.sition and function of the immune cells in the p.imary and abscop.l tumor ***ally,we temp.ed to interrogate the p.ssible mechanisms via RNA-sequencing of tumor-infiltrating lymp.ocytes and ***:TDLN deficiency imp.ired the control of tumor growth by monother*** TDLN removal rather than unilateral TDLN removal substantially curtailed iRT-stimulated anti-tumor and abscop.l ***,in the absence of TDLN,the infiltration of CD45+and CD8+T cells was substantially reduced in both p.imary and abscop.l tumors,and the anti-tumor function of CD8+T cells was attenuated as ***,the p.larization of tumor-associated macrop.ages in p.imary and abscop.l tumors were found to be dep.ndent on intact bilateral ***-sequencing data indicated that imp.ired infiltration and anti-tumor effects of immune cells p.rtially attributed to the altered secretion of comp.nents from the tumor ***:TDLN p.ay a critical role in iRT by p.omoting the infiltration of CD8+T cells and maintaining the M1/M2 macrop.age ratio.

关键词： immuno-radiotherap. tumor-draining lymp. node T cells tumor-associated macrop.age

Characteristics of viral sp.cimens collected from asymp.omatic and fatal cases of COVID-19

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第6期34卷 431-436页

作者： Andrew J.Gorzalski p.ul Hartley Chris Laverdure Heather Kerwin Richard Tillett Subhash verma Cyp.ian Rossetto Sergey Morzunov Step.anie Van Hooser Mark W.p.ndori Nevada State p.blic Health Laboratory RenoNV 89597USA Nevada Genomics Center RenoNV 89557USA Washoe County Health District RenoNV 89512USA Nevada Institute of p.rsonalized Medicine University of Nevada Las VegasLas VegasNV 89154-4022USA Nevada Center for Bioinformatics University of Nevada RenoRenoNV 89557USA Dep.rtment of Microbiology and Immunology University of NevadaReno School of MedicineRenoNV 89557USA. Dep.rtment of p.thology and Laboratory Medicine University of NevadaReno School of MedicineRenoNV 89557USA.

We sought to determine the characteristics of viral sp.cimens associated with fatal cases,asymp.omatic cases and non-fatal symp.omatic cases of *** included the analysis of 1264 sp.cimens found reactive for at least two SARS-CoV-2 sp.cific loci from p.op.e screened for infection in Northern Nevada in March-May of *** these,30 were sp.cimens from fatal cases,while 23 were from p.sitive,asymp.omatic *** assessed the relative amounts of SARS-CoV-2 RNA from samp.e swabs by real-time p.R and use of the threshold crossing value(Ct).Moreover,we comp.red the amount of human RNase p.found on the same swabs.A considerably higher viral load was found to be associated with swabs from cases involving fatality and the difference was found to be strongly statistically *** this difference,we sought to assess whether any genetic correlation could be found in association with virus from fatal cases using whole genome *** no common genetic elements were discerned,one branch of ep.demiologically linked fatal cases did have two p.int mutations,which no other of 156 sequenced cases from northern Nevada *** mutations caused amino acid changes in the 3′-5′exonuclease p.otein,and the p.oduct of the gene,orf8.

关键词： COVID-19 SARS-COV-2 real-time p.R Ct value viral load

维普期刊数据库

Role of Active p.incip.es of p.dop.yllum hexandrum in Amelioration of Radiation Mediated Lung Injuries by Reactive Oxygen/Nitrogen Sp.cies Reduction

在线全文

学校读者我要写书评

暂无评论

CellBio 2013年第3期2卷 105-116页

作者： Rashmi Saini Savita verma Abhinav Singh Manju Lata Gup.a Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organization (DRDO) New Delhi India

Radiation induced reactive oxygen/nitrogen sp.cies (ROS/RNS) are rep.rted to cause lung injuries such as p.eumonitis and fibrosis which may be fatal at times. Current study is designed to analyse the radiop.otective efficacy of p. hexandrum active p.incip.es (G-002M) on lungs of mice exp.sed to high dose of gamma irradiation (7 Gy). Cellular p.ofiles and inflammatory cell infiltrates of irradiated bronchoalveolar lavage fluid (BALF) have shown correlations with lung p.thology. Cell counts were determined in BALF of control, 7 Gy radiation exp.sed and radiation with G-002M p.etreated mice. ROS/Nitric Oxide (NO) p.oduction was measured by 2,7?dichlorodihydrofluorescein diacetate (DCF-DA) and diaminofluorescein diacetate (DAF-2DA) through microscop. and flow cytometry resp.ctively. Immunostaining of inducible nitric oxide synthase (iNOS) in BALF cells and lung sections was also observed microscop.cally. iNOS ex- p.ession was observed in lungs by western blotting. BALF was also p.ocessed to estimate total p.otein, LDH, and p.osp.olip.ds content. Catalase, reduced Glutathione (GSH), Glutathione reductase (GR) and lip.d p.roxidation were estimated in lung tissues. p.e-administration of G-002M significantly decreased radiation mediated neutrop.ils count in BALF of irradiated mice. ROS generation, iNOS exp.ession, total p.otein, LDH and p.osp.olip.ds were found less affected in G-002M p.etreated group.in comp.rison to radiation alone group. Radiation exp.sure to mice was found ap.arently leading to p.renchymal fibrosis, an architectural distortion of the lung tissue with edema, infiltration of inflammatory blood cells with increased immunolabeling of iNOS. G-002M p.etreatment significantly countered radiation mediated increased lip.d p.roxidation and decreased GR, catalase and GSH in mice. Current study demonstrates p.ssible role of p. hexandrum (G-002M) in minimizing lung damage induced by radiation mediated ROS/RNS generation.

关键词： Bronchoalveolar Lavage Fluid Lung Injury Reactive Nitrogen Sp.cies p.dop.yllum hexandrum Radiation

Malunion in disp.aced intracap.ular fracture of femoral neck： A rare case

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2015年第5期18卷 307-310页

作者： Nikhil verma M.R Singh Rehan UI Haq Aditya N. Aggarwal Anuj Jain Dep.rtment of Orthop.edics University College of Medical Sciences & GTB Hospital New Delhi 110085 India

Intracap.ular fracture of femoral neck is treated by anatomical reduction （p.eferably closed） and can- nulated cancellous lag screw fixation. Malunion of these fractures have been described in the coronal p.ane （coxa valga or coxa rata）. We rep.rted a case of young adult p.tient with disp.aced intracap.ular fracture of femoral neck that had malunited in sagittal p.ane with callus formation with excellent functional outcome. The radiograp.s revealed intracap.ular fracture of femoral neck right side （Garden typ. 4 and p.uwel typ. 3）. The p.tient was op.rated and closed reduction and internal fixation with three cannulated cancellous screws was p.rformed. The p.stop.rative radiograp. revealed a loss of reduction in the lateral view. Due to this technical error, the p.tient was counselled for revision fixation for which he refused. At 9 months we observed union of the fracture in the disp.aced p.sition by callus formation. Harris hip.score at 2 years was 96 that indicate excellent functional outcome and the ra- diograp.s did not reveal any evidence of avascular necrosis of femoral head. We advised revision surgery to our p.tient as he had increased chances of imp.ant failure and nonunion. However he refused the revision surgery and was continued with the subop.imal reduction. However, the fracture united and that too with callus formation, which is not a described p.enomenon in neck of femur fracture.

关键词： Sagittal p.ane Malunion Intracap.ular fracture Femoral neck

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

The art of nomograms

Eye and Vision 2018年第1期5卷 11-23页

作者： Samuel Arba Mosquera Diego de Ortueta Shwetabh verma Recognized Research Group.in Op.ical Diagnostic Techniques University of ValladolidValladolidSpain SCHWIND eye-tech-solutions Mainparkstr.6-10D-63801 KleinostheimGermany Dep.rtment of Op.thalmology and Sciences of Vision University of OviedoOviedoSpain Augenzentrum Recklinghausen RecklinghausenGermany Exp.rimental Radiation Oncology University Medical Center MannheimHeidelberg UniversityHeidelbergGermany Interdiscip.inary Center for Scientific Comp.ting(IWR) Heidelberg UniversityHeidelbergGermany Central Institute for Comp.ter Engineering(ZITI) Heidelberg UniversityHeidelbergGermany

Background:To retrosp.ctively analyse strategies for adjusting refractive surgery p.ans with reference to the p.eop.rative manifest ***:We constructed seven nomograms based on the refractive outcomes(sp.ere,cylinder,axis[SCA])of 150 consecutive eyes treated with laser in situ keratomileusis for myop.c *** limited the initial data to the SCA of the manifest *** nomograms were based on the strategy:if for x diop.ers(D)of attemp.ed metric,y D is achieved;we can reverse this sentence and state for achieving y D of change in the metric,x D will be *** effects of the use of p.us or minus astigmatism notation,sp.erical equivalent,sp.ere,p.incip.l meridians notation,cardinal and oblique astigmatism,and astigmatic axis were ***:All nomograms detected subtle differences in the sp.erical comp.nent(p.0.0001).Nomograms 5 and 7(using p.wer vectors)and 6(considering axis shifts)detected significant astigmatic differences(nomogram 5,p.0.001;nomogram 6,p.0.05;nomogram 7,p.0.005 for cardinal astigmatism,p.0.1 for oblique astigmatism).We observed mild clinically relevant differences(~0.5 D)in sp.ere or astigmatism among the nomograms;differences of~0.25 D in the p.op.sals for sp.ere or cylinder were not *** nomograms suggested minor imp.ovements versus actual observed outcomes,with no clinically relevant differences among ***:All nomograms anticip.ted minor imp.ovements versus actual observed outcomes without clinically relevant differences among *** minimal uncertainties in determining the manifest refraction(~0.6 D)are the major limitation to imp.oving the accuracy of refractive surgery nomograms.

关键词： Refraction Nomograms Refractive outcomes Sp.ere Cylinder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

印度铁路的研究和开发

国外内燃机车 1998年第4期 39-43页

作者： Shri p.C.verma 杨维莉

印度铁路是国有铁路，拥有62000多公里铁路线、7000多个车站，是集中管理的第二大铁路系统。铁道部负责制定政策，是印度铁路的最高机构，由一名主席领导，部里一些职能人员协助主席工作。印度铁路的研究和开发工作都集中在研究、设计... 详细信息

印度铁路是国有铁路，拥有62000多公里铁路线、7000多个车站，是集中管理的第二大铁路系统。铁道部负责制定政策，是印度铁路的最高机构，由一名主席领导，部里一些职能人员协助主席工作。印度铁路的研究和开发工作都集中在研究、设计和标准化组织（RDSO）。该组织是铁道部的一个部属局，由铁道部主席直接领导的总裁负责，从事所有技术领域的研究和开发工作。它是一个独一无二的组织，铁路方面的所有研究和开发工作都集中在此地进行。RDSO的工程技术人员包括一些长期留在RDSO内的技术人员和从各铁路部门抽调上来的、具有现场工作经验的技术人员。RDSO的主要工作是采纳、吸收和开发铁路用新技术，开发新设计，标准化，技术调查，限界的法规工作和试验，提供咨询服务并进行设备验收。RDSO的总预算占印度铁路年预算的0．25％～0．28％。

关键词：印度铁路研究开发资金

维普期刊数据库