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Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy:Report of a case and a review of the literature

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World Journal of Gastroenterology 2008年第1期14卷 132-135页

作者： Kenichi Hakamada Takuya Miura Akitoshi Kimura Masaki nara Yoshikazu Toyoki Shunij Narumi Mutsuo Sasak Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan

Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis. We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female. A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000. She refused surgery first and delivered her baby uneventfully. During her second pregnancy in 2002, however, she presented hematemesis and underwent urgent distal pancreatectomy, splenectomy and partial resection of the gastric wall where the tumor perforated. A diagnosis of borderline-type mucinous cystic neoplasm with ovarian-like stroma was made. Nine months later, CT visualized a recurrent cystic tumor near the pancreatic stump, which was subsequently resected. Pathology revealed that the tumor was composed of two different components of borderline-type mucinous cystic neoplasm and anaplastic carcinoma. The latter was intensely positive for vimentin, CD68, p53 and focally for cytokeratin, suggesting both sarcomatous and carcinomatous differentiation. She survived four years after the second surgery without tumor recurrence. Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology.

关键词： Mucinous cystic neoplasm Anaplastic carcinoma Pancreatic tumor Ovarian-like stroma Pregnancy

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An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture

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World Journal of Gastroenterology 2008年第7期14卷 1091-1096页

作者： Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki nara Kenosuke Ishido Takuya Miura Norihito Kubo Mutsuo Sasaki Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic ***: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa ***: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely ***: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas.

关键词： Pancreaticojejunostomy Duct-to-mucosa contact method Fast-absorbable suture Irradiated polyglactin 910 Pancreatic fistula

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Impact of microbial self-induced anaerobiosis fermentation(SIAF)on coffee quality

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Food Bioscience 2022年第3期47卷 421-430页

作者： Marcela Caroline Batista da Mota Nádia nara Batista Disney Ribeiro Dias Rosane Freitas Schwan Department of Biology Federal University of LavrasLavrasMGBrazil Food Science Department Federal University of LavrasLavrasMGBrazil

The fermentation of natural(NC)and pulped coffee(PC)was performed with a conventional method(platform)and under self-induced anaerobic fermentation(SIAF).Of the 12 samples analyzed during the fermentation process,the highest temperature was obtained by the SIAF method(30.5℃ for NC and 29.67℃ for PC)with 87 h of *** compounds(36 samples)were evaluated by high-performance liquid *** in the SIAF method contributed to the maximum amount of citric acid(2.534 mg/g)in pulped coffee and acetic acid(6.04 mg/g)and lactic acid(2.533 mg/g)in *** was the primary chemical class detected,followed by ketones and *** coffees(12 samples)were evaluated five times and classified as specialty coffees(>80 points)following Specialty Coffee Association(SCA)*** pulped coffee processed by the SIAF method showed a 2.83-point increase in the sensory score compared to the conventional ***,the SIAF method is accessible to producers,contributes to coffees with differentiated sensory profiles,and increases beverage quality.

关键词： Bioreactor Fermentative process Specialty coffee Anaerobic conditions Natural processing

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Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma

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World Journal of Hepatology 2014年第12期6卷 836-843页

作者： Yoji Kishi Kazuaki Shimada Satoshi nara Minoru Esaki Tomoo Kosuge Hepatobiliary and Pancreatic Surgery Division National Cancer Center Hospital Tokyo 104-0045 Japan

As a result of donor shortage and high postoperative morbidity and mortality after liver transplantation,hepatectomy is the most widely applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy,repeated treatments are advocated provided background liver function is *** treatments including local ablation and transarterial chemoembolization,hepatectomy provides the best long-term outcomes,but studies comparing hepatectomy with other nonsurgical treatments require careful review for selection *** patients with initially unresectable HCC,transarterial chemo-or radio-embolization,and/or systemic chemotherapy can down-stage the tumor and conversion to resectable HCC is achieved in approximately 20%of ***,complete response is rare,and salvage hepatectomy is essential to help prolong patients’*** counter the short recurrence-free survival,excellent overall survival is obtained by combining and repeating different *** is important to recognize hepatectomy as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary approach for patients with HCC,including recurrent or unresectable tumors.

关键词： Hepatocellular carcinoma Hepatectomy Repeat hepatectomy Conversion therapy Multidisciplinary treatment

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Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第9期14卷 1370-1377页

作者： Kenichi Hakamada Norihisa Kimura Takuya Miura Hajime Morohashi Keinosuke Ishido Masaki nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of MedicineJapan

AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body.

关键词： Small hepatocellular carcinoma Hepatic resection Des-gamma-carboxy prothrombin Vascular invasion Prognostic factor

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Formulation development of nifedipine controlled-release coated tablets

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 118-119页

作者： Ananya Ubonratana Sirachaya Choosakul nara Nilnakara Chaisan Sriwichupong Garnpimol Ritthidej Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical Sciences Chulalongkorn University

Due to frequent administration of oral nifedipine tablet, controlled or sustained release of the drug will improve patient compliance, stable blood level and side effect decrement [1,2].Various extended release nifedipine products have been commercially available. In this study, extended release tablets of this drug were formulated using sodium alginate,hydroxypropylmethylcellulose (HPMC) as controlled release matrix materials.

关键词： Nifedipine Extended release tablet Matrix Sodium alginate HPMC

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PARTIMI

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中国制衣 2015年第6期 44-45页

作者： nara Skin

符合生态发展的服装产品不一定是最前卫的。然而,对于一个曾经为John Galliano,Mary Katrantzou,Eley Kishimoto和Anthropologie工作过的伦敦设计师Eleanor Dorrien Smith来说,绝对不是这样。为了证明时尚与生态发展可兼得,Dorrien Smit... 详细信息

符合生态发展的服装产品不一定是最前卫的。然而,对于一个曾经为John Galliano,Mary Katrantzou,Eley Kishimoto和Anthropologie工作过的伦敦设计师Eleanor Dorrien Smith来说,绝对不是这样。为了证明时尚与生态发展可兼得,Dorrien Smith2008年从中央圣马丁学院毕业短短两年后推出了她的成衣品牌PARTIMI,这也让她成为了一个企业家。

关键词：生态发展服装产品圣马丁 PARTIMI 风景照片个人意义西西里岛根西岛康沃尔单位规模

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Macrophage inhibitory cytokine-1 induced by a high-fat diet promotes prostate cancer progression by stimulating tumor-promoting cytokine production from tumor stromal cells

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Cancer Communications 2021年第5期41卷 389-403页

作者： Mingguo Huang Shintaro Narita Atsushi Koizumi Taketoshi nara Kazuyuki Numakura Shigeru Satoh Hiroshi Nanjo Tomonori Habuchi Department of Urology Akita University Graduate School of Medicine1-1-1 HondoAkita 010-8543Japan Department of Clinical Pathology Akita University Graduate School of Medicine1-1-1 HondoAkita 010-8543Japan

Background:Recent studies have indicated that a high-fat diet(HFD)and/or HFD-induced obesity may influence prostate cancer(PCa)progression,but the role of HFD in PCa microenvironment is *** study aimed to delineate the molecular mechanisms of PCa progression underHFDmilieus and define the stromal microenvironment focusing on macrophage inhibitory cytokine-1(MIC-1)***:We investigated the effects of HFD on PCa stromal microenvironment and MIC-1 signaling activation using PC-3M-luc-C6 PCa model mice fed with HFD or control ***,we explored the effect of periprostatic adipocytes derived from primary PCa patients on activation and cytokine secretion of prostate stromal *** patterns and roles of MIC-1 signaling on human PCa stroma activation and progression were also ***:HFD stimulated PCa cell growth and invasion as a result of upregulated MIC-1 signaling and subsequently increased the secretion of interleukin(IL)-8 and IL-6 from prostate stromal fibroblasts in PC-3M-luc-C6 PCa *** addition,periprostatic adipocytes directly stimulatedMIC-1 production from PC-3 cells and IL-8 secretion in prostate stromal fibroblasts through the upregulation of adipose lipolysis and free fatty acid *** increased serum MIC-1 was significantly correlated with human PCa stroma activation,high serum IL-8,IL-6,and lipase activity,advanced PCa progression,and high body mass index of the ***-derived neurotrophic factor receptor α-like(GFRAL),a specific receptor of MIC-1,was highly expressed in both cytoplasm and membrane of PCa cells and surrounding stromal fibroblasts,and the expression levelwas decreased by androgen deprivation therapy and ***:HFD-mediated activation of the PCa stromal microenvironment through metabolically upregulated MIC-1 signaling by increased available free fatty acids may be a critical mechanism of HFD and/or obesity-induced PCa progression.

关键词： macrophage inhibitory cytokine-1 tumor microenvironment high-fat diet prostate cancer metabolism

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Examining effective use of data sources and modeling algorithms for improving biomass estimation in a moist tropical forest of the Brazilian Amazon

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International Journal of Digital Earth 2017年第10期10卷 996-1016页

作者： Yunyun Feng Dengsheng Lu Qi Chena Michael Keller Emilio Moran Maiza nara dos-Santos Edson Luis Bolfe Mateus Batistella The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Key Laboratory of Carbon Cycling in Forest Ecosystems and Carbon Sequestration of Zhejiang ProvinceSchool of Environmental&Resource SciencesZhejiang Agriculture and Forestry UniversityLin AnPeople’s Republic of China Center for Global Change and Earth Observations Michigan State UniversityEast LansingMIUSA Department of Geography University of Hawaii at ManoaHonoluluHIUSA Brazilian Agricultural Research Corporation–Embrapa Informática Agropecuária CampinasBrazil USDA Forest Service International Institute of Tropical ForestryRio PiedrasPRUSA Brazilian Agricultural Research Corporation–Embrapa Secretariat of Intelligence and Macro StrategyBrasíliaBrazil Brazilian Agricultural Research Corporation(Embrapa) BrasíliaBrazil

Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly *** research conducts a comparative analysis of different data sources and modeling approaches in improving AGB ***-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation *** results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges.

关键词： Lidar RapidEye aboveground biomass moist tropical forest support vector regression random forest linear regression stratification

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Intraoperative ultrasound as an educational guide for laparoscopic biliary surgery

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World Journal of Gastroenterology 2008年第15期14卷 2370-2376页

作者： Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki nara Motonari Oohashi Takuya Miura Hiroyuki Jin Syuichi Yoshihara Michihiro Sugai Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To analyze the efficacy of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary tract anatomy, to avoid bile duct injury (BDI) after laparoscopic cholecystectomy (LC), as well as any burden during the learning period. METHODS: A retrospective analysis was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly feasible even in patients with high-grade cholecystitis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by inexperienced surgeons. Incidences of other morbidity, mortality, and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly extended after the educational program began (P < 0.001), and the grade of laparoscopic cholecystitis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly feasible modality, which provided accurate, real- time information about the biliary structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially when performed by less-skilled surgeons.

关键词： Intraoperative ultrasound Cholecystolithiasis Laparoscopic cholecystectomy Bile duct injury Education program

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