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Determinants of Early Survival of Breast Cancer Patients in Yaoundé-Cameroon

Open Journal of Obstetrics and Gynecology 2024年第3期14卷 487-501页

作者： Um Esther Meka Ngo Junie Annick Metogo Ntsama Kodoumé Motolouze naomi marie laurene ndtoungou schouame Obalemba Etienne Atenguena Claude Cyrille Noa Ndoua Robinson Enow Mbu Faculty of Medicine and Biomedical Sciences The University of Yaoundé 1 Yaoundé Cameroon Yaoundé Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon Hospital Center for Research and Application in Endoscopic Surgery and Human Reproduction Yaoundé Cameroon Yaoundé General Hospital Yaoundé Cameroon

Introduction: Breast cancer is one of the leading causes of death worldwide. We carried out this study with the aim of evaluating the determinants of early survival of women with breast cancer in two hospitals in the city of Yaoundé. Methodology: This was an analytical cross-sectional study with retrospective and prospective data collection of breast cancer patients during 6 years in two Hospitals of Yaoundé from January 2017 to December 2022. We consulted the files in search of epidemiological, clinical, paraclinical, therapeutic and survival variables. We completed the survival data directly from the patients or their relatives after their consent. We analyzed the data using SPSS version 23.0 software. Survival analysis was done using the Kaplan-Meier method and survival curves were compared using the Log Rank test. Factors influencing survival were evaluated using the Cox model. The significance threshold (P value) was set at 0.05 at 95% confidence interval. The study was approved by the ethics committees. Results: We included 500 patients whose ages varied between 22 and 83 years with a mean age of 47.19 ± 11.61 years. The most represented age group was 30 to 45 years old (45.8%). Less than half (41.6%) were postmenopausal. The most frequent reason for consultation was a breast lump (79.9%). The most common clinical stage at presentation was stage-3 (47.6%). Infiltrating ductal carcinoma was the most represented histological type (84.7%). The most represented histological grade was grade 2 (40.2%). Immunohistochemistry was performed in 34.20% of cases. The most represented molecular subtype was triple negative (41.8%) followed by Luminal A (30%). Concerning treatment, 17.2% did not receive any, 45% had surgery, 79.4% had chemotherapy, 34.2% hormone therapy, and 14.6% radiotherapy. The survival of patients with breast cancer at 1, 2, 3, 4 and 5 years was respectively 90.6%;83.1%;74.2%;69.8% and 59.2%. The median survival was not reached;however, the first quartil

关键词： Determinants Early Survival Breast Cancer Yaoundé

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Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

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Nano Research 2015年第3期8卷 774-789页

作者： Mohammed Jamshad Vinciane Grimard Ilaria Idini Tim J. Knowles Miriam R. Dowle naomi Schofield Pooja Sridhart Yupin Lin Rachael Finka Mark Wheatley Owen R. T. Thomas Richard E. Palmerr Michael Overduin Cedric Govaerts Jean-marie Ruysschaert Karen J. Edler Tim R. Dafforn School of Biosciences University of Birmingham Edgbaston Birmingham B 15 2TT UK Universite Libre de Bruxelles SFMB - CP206/2 Bd. du Triomphe Acces 2 1050 Bruxelles Belgium Department of Chemistry University of Bath Claverton Down Bath BA2 7AY UK School of Cancer Studies University of Birmingham Edgbaston Birmingham B 15 2 TT UK Nanoscale Physics Research Laboratory and PSIBS School of Physics and Astronomy University of Birmingham Edgbaston Birmingham B 15 2TT UK School of Chemical Engineering University of Birmingham Edgbaston Birmingham B 15 2TT UK

In the past few years there has been a growth in the use of nanoparticles for stabilizing lipid membranes that contain embedded proteins. These bionanoparticles provide a solution to the challenging problem of membrane protein isolation by maintaining a lipid bilayer essential to protein integrity and activity. We have previously described the use of an amphipathic polymer （poly（styrene-co-maleic add）, SMA） to produce discoidal nanoparticles with a lipid bilayer core containing the embedded protein. However the structure of the nanoparticle itself has not yet been determined. This leaves a major gap in understanding how the SMA stabilizes the encapsulated bilayer and how the bilayer relates physically and structurally to an unencapsulated lipid bilayer. In this paper we address this issue by describing the structure of the SMA lipid particle （SMALP） using data from small angle neutron scattering （SANS）, electron microscopy （EM）, attenuated total reflection Fourier transform infrared spectroscopy （ATR-FTIR）, differential scanning calorimetry （DSC） and nuclear magnetic resonance spectroscopy （NMR）. We show that the particle is disc shaped containing a polymer ＂bracelet＂ encircling the lipid bilayer. The structure and orientation of the individual components within the bilayer and polymer are determined showing that styrene moieties within SMA intercalate between the lipid acyl chains. The dimensions of the encapsulated bilayer are also determined and match those measured for a natural membrane. Taken together, the description of the structure of the SMALP forms the foundation for future development and applications of SMALPs in membrane protein production and analysis.

关键词： nanoparticles lipid polymer membrane proteins structure detergent

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Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation

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Journal of Molecular Cell Biology 2022年第9期14卷 54-67页

作者： Zhaofei Wu M.Elena Martinez Victoria DeMambro marie Francois Arturo Hernandez MaineHealth Institute for Research Center for Molecular MedicineMaineHealthScarboroughME 04074USA Graduate School of Biomedical Science and Engineering University of MaineOronoME 04469USA naomi Berrie Diabetes Center Division of Molecular GeneticsColumbia University Irving Medical CenterNew YorkNY10032USA Department of Medicine Tufts University School of MedicineBostonMA 02111USA

Thyroid hormone excess secondary to global type 3 deiodinase(DIO3)deficiency leads to increased locomotor activity and reduced adiposity,but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict *** distinguish the underlying contributions to the energy balance phenotype of Dlo3 deficiency,we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin(POMC)-expressing cells via cell-specific DIO3 *** mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression,hyperphagia,and increased activity in brown adipose tissue,with adiposity and serum levels of leptin and thyroid hormones remained *** male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a(BMPR1A),which has been shown to cause similar phenotypes when inactivated in PoMC-expressing *** results indicate that developmental overexposure to thyroid hormone in PoMC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BMPR1A expression.

关键词： thyroid hormone type 3 deiodinase(DIO3) bone morphogenetic receptor 1a(BMPR1A) pro-opiomelanocortin(POMC) hyperphagia brown adipose tissue corticosterone

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