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A Case of Huge Fibroma in the Palate

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Open Journal of Clinical Diagnostics 2018年第4期8卷 52-59页

作者： Sayaka Yoshiba Koki Takamatsu Shinsuke Nakamura Junichiro Chikuda naoko Kawachi Tatsuo Shirota Department of Dental and Oral Surgery Showa University Northern Yokohama Hospital Tokyo Japan Department of Oral and Maxillofacial Surgery Showa University School of Dentistry Tokyo Japan Department of Dental and Oral Surgery Health Park Clinic Gunma Japan

Fibroma-like lesions occur with relatively high frequency in oral soft tissues, but represent reactive proliferation against chronic irritation. True fibromas are rare. Tumor size is often seen to range from the mass of a red bean to a soybean. We encountered a case of huge fibroma in the palate with a long history of more than 30 years. The patient was a 60-year-old man who became aware of a tumor in the right palate about 30 years earlier. The mass had tended to increase in size in recent years, and was introduced to our department for the first visit. As an intraoral finding, a pedicled mass measuring 29 × 27 mm was found in the right palate. We also considered the possibility of verrucous carcinoma, and performed biopsy, obtaining a diagnosis of fibroma. Right palatectomy was performed under general anesthesia in October 2016. We performed immunohistochemical examination of the surgical specimen, obtaining a definitive diagnosis of fibroma. As of 1 year postoperatively, no recurrence has been identified and the course has been good.

关键词： Huge Fibroma Immunohistological Examination

编码日本梨树(Pyruspyrifolia )花粉类β-1,3-葡聚糖酶蛋白的cDNA克隆与核苷酸序列(英文)

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农业生物技术学报 2004年第4期12卷 374-379页

作者：周跃钢,naoko Norioka,李绍良,Shigemi Norioka 重庆工学院生物工程学院日本大阪大学蛋白质研究所日本大阪大学蛋白质研究所日本大阪大学蛋白质研究所重庆400050 中国大阪府吹田市565 日本大阪府吹田市565 日本大阪府吹田市565 日本

构建了日本梨树（Pyruspyrifolia）花粉cDNA文库, 发现了一个编码花粉管分泌的类β-1,3-葡聚糖酶蛋白（BGN-1）的cDNA（bgn-1 ）并测定了其序列。bgn-1由1408 bp组成, 包括47 bp的5’-非翻译区, 由1194 bp组成并编码了397个氨基酸的ORF... 详细信息

构建了日本梨树（Pyruspyrifolia）花粉cDNA文库, 发现了一个编码花粉管分泌的类β-1,3-葡聚糖酶蛋白（BGN-1）的cDNA（bgn-1 ）并测定了其序列。bgn-1由1408 bp组成, 包括47 bp的5’-非翻译区, 由1194 bp组成并编码了397个氨基酸的ORF和167 bp的3'-非翻译区。3'-非翻译区含有1个NUE（AATTAA）和3个似FUE的基序, 分别位于1369～1374（AAT-TAA）、1320～1325、1327～1332（TTTTTA）和1363～1368（TTTGGA）。 bgn-1编码的蛋白（BGN-1）与DDBJ中的植物β-1,3-葡聚糖酶的序列相似性范围为37%59%, 与3D结构已知的大麦β-1, 3-葡聚糖酶（GⅡ）的序列相似性为39.7%。对GⅡ与BGN-1进行的疏水簇分析（HCA同源分为87.1%, >75%的一般标准）和使用3D-PSSM软件进行的分析暗示, BGN-1的3D结构与大麦GⅡ同源性最大（≧95%的肯定度）。BGN-1的信号肽长度为22 aa, 成熟的BGN-1（375 aa）的理论分子量为4 0723 D, 理论pI值为9.59, 诊断氨基酸残基模式（D, L, S, L）与禾谷类的与生长相关的亚家族D的诊断氨基酸残基模式（D, L, S, Q）极相似。在BGN-1的C-端延伸区的位点352～367之间发现了1个功能不清, 重复出现的ProXXPro结构。

关键词： cDNA β-1,3-葡聚糖酶花粉梨树

Causal relationships between survival rates, dietary and lifestyle habits, socioeconomic status and physical, mental and social health in elderly urban dwellers in Japan: A chronological study

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Health 2013年第8期5卷 1303-1312页

作者： Tanji Hoshi Motoyuki Yuasa Suwen Yang Sugako Kurimori naoko Sakurai Yoshinori Fujiwara Department of Health Promotion Tokyo Metropolitan Institute of Gerontology Tokyo Japan Graduate School of Medicine Juntendo University Tokyo Japan Graduate School of Nursing Ibaraki Church University Ibaraki Japan Graduate School of Urban System Science Tokyo Metropolitan University Tokyo Japan School of Nursing Tokyo Jikeikai Medical College Tokyo Japan

Life expectancy was well known to associate with lifestyle habits, socioeconomic condition, and three health-related dimensions (physical, mental and social health status). However, the causal effect relationship among these variables remains unclear. The purpose of this study was to determine the causal relationships among health and life conditions, socioeconomic status, dietary and lifestyle habits and three health-related dimensions in elderly urban dwellers in Tokyo, Japan. Of 16,462 eligible elderly individuals aged 65 years and older, 13,195 participants responded to the questionnaire survey conducted in September 2001 (a response rate of 80.2%). A follow-up survey was conducted in September 2004 and a total of 8162 survivors were followed until the end of August 2007 through the municipal resident's registry. Exploratory factor analysis defined five latent variables based on the 13 observed variables. From a cross-lagged effects variation model using structural equation modeling, causal relationships were analyzed using longitudinal data obtained at the 2001 and 2004 survey and the number of survival days between 2004 and 2007. After estimating a best-fit model, we discovered that health and life conditions were not determined by current dietary and lifestyle habits, which many studies showed. However, the conditions were more directly affected by three health-related dimensions three years earlier, and indirectly affected by educational attainment and previous annual income as well. The current model suggests that it might be of great importance for elderly individuals to emphasize the maintenance of psychological well being, physical activity, social communication and participation, as well as income, rather than focusing on improvements in diet and health-related lifestyles per se.

关键词： Survival Rate Food Habits Life Style Socioeconomic Status Aged Japan

Gait speed may predict development of Type 2 diabetes: A pilot study among elderly Japanese

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Journal of Diabetes Mellitus 2014年第1期4卷 38-43页

作者： Shuhei Nakanishi Gen Takezawa Yasuyuki Taooka Katsuko Kikkawa naoko Matsumoto Toru Hidaka Department of Internal Medicine Aki-Ota Hospital Hiroshima Japan Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Surgery Aki-Ota Hospital Hiroshima Japan Fitness Club Company Hiroshima Japan Welfare Division Health and Social Welfare Department Aki-Ota Town Government Hiroshima Japan

Aims: Epidemiologic evidence suggests that physical activity is associated with reduced risk of Type 2 diabetes. Walking is simple, effective, and by far the most prevalent physical activity among older adults. However, it is difficult to recognize and evaluate performance-based parameters of physical activity. The purpose of this study was to evaluate the importance of performance-based gait speed among several physical measurements in the development of Type 2 diabetes using long-term community-based data on elderly Japanese persons. Methods: 10 baseline physical measurements, including habitual (HGS) and fast (FGS) gait speed, were examined in 102 elderly Japanese persons living independently in the community (mean age: 71.1 years old) who were not previously diagnosed with diabetes. The subjects then participated in a daily exercise program consisting of walking, stretching, muscle strengthening, and balance exercises and were followed for an average of 4.16 years. Using Cox proportional hazards models with adjustment for age, sex, and category of fasting glucose status, we investigated whether gait speed and/or other physical measurements are associated with development of Type 2 diabetes. Results: 9 subjects developed Type 2 diabetes. Among the 10 physical parameters examined, prolongation of HGS and FGS per second was the only statistically significant factors, with hazard ratios 1.83 (1.15 - 2.89, P = 0.010) and 2.93 (1.43 - 6.03, P = 0.003), respectively. Conclusions: We found a negative association between the development of Type 2 diabetes and gait speed among elderly Japanese people. We conclude that encouraging physical activity and preserving walking capacity may be beneficial for preventing Type 2 diabetes.

关键词： Gait Speed Type 2 Diabetes Japanese Elderly Population

RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND MENTAL HEALTHFOR JAPANESE CHILDREN

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RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND MENTAL HEALTHFOR ...

The aternatively spliced EDA segment regulates fibronectin promoted cell cycle progression and mitogenlc signal transduction

3～(rd) International Congress Asian-South Pacific Association of Sport Psychology

作者： Hiroaki Uechi Koji Takenaka Koichiro Oka naoko Matsuo MA.Waseda University Graduate School of Human Sciences 2-579-15 Mikajima Tokorozawa Saitama 359-1192 Japan Ed.D.Waseda University Graduate School of Human Sciences 2-579-15 Mikajima Tokorozawa Saitama 359-1192 Japan Ph.D.Waseda University Graduate School of Human Sciences 2-579-15 Mikajima Tokorozawa Saitama 359-1192 Japan MA.Waseda University Graduate School of Human Sciences 2-579-15 Mikajima Tokorozawa Saitama 359-1192 Japan

＜正＞ INTRODUCTION Many evidences indicate that physical activity is an important contributor to the short-and long-term health. For example, physical activity confers significant protection from chronic diseases such as cardiovascular diseases and non-insulin-dependent diabetes mellitus and it appears to reduce the risk of osteoporosis and some cancers. The Physical

关键词： physical activity mental health children

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The aternatively spliced EDA segment regulates fibronectin p...

Urban-Rural Comparison of Nutrient Intake by Adult Women in Shaanxi Province, China

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Ri-ichiroh Manabe naoko Oh-e Kiyotoshi Sekiguchi Research Institute Osaka Medical Center for Maternal and Child Health840 MurodoIzumiOsaka 594-1101Japan

Fibronectin (FN) comprises multiple isoforms arising from alternative splicing of a single gene transcript. One of the alternatively spliced segments, EDA, is prominently expressed in embryonic development, malignant

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Biomedical and Environmental Sciences 1999年第4期12卷 270-284页

作者： HARUO NAKATSUKA ZHANG ZUO-WEN QU JIANG-BIN GAO WEI-PIN DENG YI-JUAN SHINICHIRO SHIMBO TAKAO WATANABE naoko INOGUCHI-MATSUDA KAE HIGASHIKAWA AND MasAYUKI IKEDA(Miyagi University, Taiwa-cho 981-3298, Japan)(Department of Food and Nutrition, Kyoto Wome Miyagi Univeristy 日本 Kyoto Women's University 日本山东医科大学公共卫生学院山东济南 250012 陕西省卫生防疫站陕西西安 710054 陕西省卫生防疫站陕西西安 Miyagi University of Education 日本 Kyoto Industrial Health Association 日本

Triplet surveys were conducted in the city of Xi'an and two villages (one in the vicinity and the other at a distance) in Shaanxi fuvince in China in October-November (when agricultural activitis were low), 1997, to elucidate nutrient intakes with a focus on possible urban-rural differences. Total food duplicate samples were collected from non-smoking and non-habitually dhnking adult healthy women (ahout 50 subjects per site and 149 in total). The nutrient intakes were estimated from the weight of food items in reference to national food composition tables. On average, the women took 1873 kcal energy, 54 g protein and 37 g lipid per day, with a lipid eneny ratio of 18.4%. Both excess and insufficient energy intake was observed as a result of food intake analysis and body mass index determination. With regard to minor nutrient intakes, insufficiency was serious in the case of calcium, vitamin A and vitamin B2, but not with iron. Whereas dependency on plant foods for sources of energy and protein was common to the three regions, Xi' an people consumed more animal foods than those in the villages. Intake of fish and shellfish was quite low throughout the three regions. Among the four types of cereals, wheat was consumed most substantially in the three regions and in three meals (except for the village where people essentially did not take lunch in reflection of low agricultural activities), whereas rice was consumed more in Xi'an than in the two villages. Maize consumption was higher in the two villages (especially for breakfast) than in the *** contrast, foxtail millet (although in small amounts) was taken primarily in Xi'an and ouly at the time of breakfast.

关键词： ab Chen Urban-Rural Comparison of Nutrient Intake by Adult Women in Shaanxi Province China

Comparing Oncotype DX Recurrence Score Categories with Immunohistochemically Defined Luminal Subtypes

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Journal of Cancer Therapy 2016年第3期7卷 223-231页

作者： Yoshio Mizuno Hiromi Fuchikami naoko Takeda Junichi Yamada Yuko Inoue Hiroshi Seto Kazuhiko Sato Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Inoue Ladies Clinic Tokyo Japan Department of Clinical Pathology Tokyo-West Tokushukai Hospital Tokyo Japan Seto Hospital Saitama Japan

Background: At the 13th St Gallen International Breast Cancer Conference in 2013, a new definition of luminal A-like and luminal B-like breast cancer was proposed, involving the expression of estrogen receptor (ER), progesterone receptor (PgR), and Ki-67. We examined the rate of concordance between the risk groups using the Oncotype DX recurrence score (RS) and the previous and newly proposed luminal subtypes with the standardized Ki-67 assessment. Method: The relationship between a previously and newly proposed, immunohistochemically defined luminal A and B subtype with the Oncotype DX RS of 41 cases of T1-2 N0-1 M0 (ER positive, HER2 negative) breast cancer was assessed. We first classified the patients into the previously defined luminal A and B subtypes, according to the level of Ki-67 as either “low” (<14%) or “high” (≥14%), as assessed by local pathologists. Next, to consider the necessity for standardizing Ki-67 measurement methods, we re-examined Ki-67 with a central review. By introducing PgR positivity (≥20%), we classified these patients to newly proposed luminal subtypes and compared them with the risk groups stratified by Oncotype DX RS. Results: In the previously proposed luminal subtypes, the concordance rate between luminal A and the low RS category was 76.5% according to local pathologists and 90.1% by central review, whereas the rate between luminal B and the intermediate to high RS category was 46.7% and 45.8%, respectively. In newly proposed luminal subtypes, the concordance rate between luminal A and low RS category was 100% and between the luminal B and intermediate to high RS category was 53.6%. Conclusions: Although this study was based on a retrospective chart review of a small sample size, the newly proposed luminal subtypes including addition of PgR positivity with the standardized Ki-67 assessment appeared to improve the concordance rate especially between luminal A and low RS category.

关键词： Breast Cancer Oncotype DX Ki-67 Standardized Assessment

The Effect of Masseter Activity Patterns during Chewing on Suprahyoid Activity in Subsequent Chewing Cycles

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Journal of Behavioral and Brain Science 2014年第2期4卷 69-74页

作者： Yozo Miyaoka Ichiro Ashida Hajime Iwamori Shin-ya Kawakami Takako Yamazaki naoko Ito Department of Health and Nutrition Niigata University of Health and Welfare Niigata Japan Department of Health and Nutrition University of Niigata Prefecture Niigata Japan

Few studies have evaluated the effects of activity patterns of the jaw closing muscles assessed by specific parameters on jaw opening in subsequent cycles during the chewing of food. The objective of this study was to quantitatively analyze the effect of the masseter (jaw closer) activity patterns on suprahyoid (jaw opener) activity during subsequent cycles. The assessments were performed while participants naturally chewed six test foods that differed in size dimensions and textural properties. Surface electromyograms of the masseter (on the habitual working side) and suprahyoid muscles were recorded in ten healthy young adults, each of whom randomly received one of the six test foods. The activity patterns were assessed using three parameters specifically developed for their quantification. Changes in suprahyoid activity during each of the subsequent chewing cycles were examined by three amplitudinal (minimum, maximum, and net values of the integrated suprahyoid electromyogram) parameters and one durational (active duration) parameter. The main finding was that two of the three activity pattern parameters had a statistically significant effect only on the three amplitudinal parameters in three of the six test foods. These results suggest that masseter activity patterns partially affect suprahyoid activity during subsequent chewing cycles and that the effect is food dependent. A possible neural mechanism responsible for this effect is presented.

关键词： Masseter Activity Pattern Suprahyoid Textural Property Chewing Adult