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World Journal of Meta-Analysis 2019年第5期7卷 218-223页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima 960-1247Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 960-1247Japan

Autoimmune pancreatitis(AIP)is defined as pancreatitis caused by irregular narrowing of the pancreatic duct accompanied by pancreatic swelling,fibrosis and lymphocyte infiltration,events that are related to autoimmune *** 2010 International Consensus Diagnostic Criteria for AIP defined pancreatitis as“type 1”when increased levels of serum IgG4 were present and other organs were involved;lymphoplasmacytic sclerosing pancreatitis was the main histological *** from surgery,endoscopic ultrasonographyguided fine needle aspiration(EUS-FNA)is the only method for the histological diagnosis of AIP;however,this method is *** use of larger-diameter FNA needles and trucut biopsy did not improve the diagnostic performance of EUS-FNA,but it has improved *** this review,we look back at past efforts to improve the diagnostic performance of EUS-FNA and reveal the present state of EUS-FNA for the histological diagnosis of AIP type 1.

关键词： Autoimmune pancreatitis type 1 Endoscopic ultrasonography-guided fine needle aspiration IgG4-related disease Lymphoplasmacytic sclerosing pancreatitis

Pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis

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World Journal of Meta-Analysis 2019年第5期7卷 249-258页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima CityFukushima Prefecture 960-1295Japan Department of Endoscopy Fukushima Medical University HospitalFukushima CityFukushima Prefecture 960-1295Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)plays a major role in the investigation and treatment of pancreaticobiliary ***,post-ERCP pancreatitis(PEP)is a severe adverse *** meta-analyses have shown that prophylactic PS was useful for preventing ***,abstract reports and patients who underwent endoscopic ampullectomy were included in the previous *** addition,two meta-analyses involved non-randomized controlled trials(RCTs).The efficacy of PS for preventing severe PEP was different in each ***,we performed the current metaanalysis,which included only full-text articles,and added new *** To reveal the efficacy of prophylactic pancreatic stent(PS)placement for preventing *** We searched the MEDLINE,Cochrane Library and PubMed databases for related *** the reports retrieved,11 studies were included in this *** full-text articles were published between 1993 and 2016.A total of 1475 patients were enrolled in the included studies;of these patients,734 had a PS inserted,and 741 did not have a PS *** and severe PEP occurrence were evaluated in this *** PEP was observed in all studies and occurred in 39(5.3%)patients who received a *** the other hand,PEP occurred in 141(19%)patients who did not receive a *** occurrence of PEP was significantly lower in the patients who underwent PS placement than in the patients who did not receive a PS(OR=0.32;95%CI:0.23-0.45;P<0.001).In addition,the occurrence of severe PEP was ***,the occurrence of severe PEP was not observed in the stent group;however,the occurrence of severe PEP was observed in 8(1.3%)patients who did not have a PS *** PEP occurred significantly less often in the stent group than in the no stent group(OR=0.24;95%CI:0.06-0.94;P=0.04).CONCLUSION In conclusion,prophylactic PS placement is useful for preventing PEP and severe PEP.

关键词： Endoscopic retrograde cholangiopancreatography Pancreatic stent Postendoscopic retrograde cholangiopancreatography pancreatitis Meta-analysis

全口无牙颌应用种植固定修复后的咬合力分布研究

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北京口腔医学 2008年第6期16卷 325-328页

作者：温颖郑东翔张振庭楠本直树山田真一首都医科大学口腔医学院修复科 100050 日本国立大阪大学齿学部

目的探讨全口无牙颌患者应用种植固定修复后的咬合力分布特点。方法选择15例全口无牙颌应用种植固定修复的患者作为实验组,15例具有天然牙列的实验者作为对照组,采用咬合力测定仪(FPD-705)测定口腔内的咬合力以及前牙区、双尖牙区和磨... 详细信息

目的探讨全口无牙颌患者应用种植固定修复后的咬合力分布特点。方法选择15例全口无牙颌应用种植固定修复的患者作为实验组,15例具有天然牙列的实验者作为对照组,采用咬合力测定仪(FPD-705)测定口腔内的咬合力以及前牙区、双尖牙区和磨牙区的咬合力分布情况,分析咬合力重心位置的变化。结果种植组全牙列咬合力明显低于天然牙列,磨牙区咬合力也明显低于天然牙列,但是双尖牙区咬合力明显高于天然牙列,咬合力重心位置明显前移,左右牙列咬合力均衡。结论全口无牙颌应用种植固定修复后,双尖牙区承担了更多的咬合力。

关键词：无牙颌种植固定修复咬合力

Diazepam during endoscopic submucosal dissection of gastric epithelial neoplasias

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 80-86页

作者： Yosuke Muraki Shotaro Enomoto Mikitaka Iguchi Toru Niwa Takao Maekita Takeichi Yoshida Kosaku Moribata naoki Shingaki Hisanobu Deguchi Kazuki Ueda Izumi Inoue Hideyuki Tamai Jun Kato Mitsuhiro Fujishiro Masao Ichinose Second Department of Internal Medicine Wakayama Medical University Department of Endoscopy and Endoscopic Surgery Faculty of MedicineUniversity of Tokyo

AIM:To investigate risk factors and adverse events related to high-dose diazepam administration during endoscopic submucosal dissection for gastric ***:Between February 2002 and December 2009,a total of 286 patients with gastric epithelial neoplasia underwent endoscopic submucosal dissection in our *** achieve moderate sedation,5-7.5 mg of diazepam was administered intravenously by *** additional administration of 2.5-5 mg diazepam was performed if uncontrollable body movement of the patient was *** patients were classified into groups based on the required diazepam dose:low-dose (≤ 17.5 mg,n=252) and high-dose (> 17.5 mg,n=79).RESULTS:Differences between the low-and highdose diazepam groups were observed in lifetime alcohol consumption (0.30 ± 0.48 vs 0.44 ± 0.52 tons,P=0.032),body weight (58.4 ± 10.3 vs 62.0 ± 9.9 kg,P=0.006),tumor size (15 ± 10 vs 23 ± 18 mm,P < 0.001),lesion location (P < 0.001) and the presence of ulcerative findings (14/238 vs 18/61,P < 0.001).Multivariate analysis identified all five variables as independently related to required diazepam *** terms of adverse reactions to diazepam administration,paradoxical excitement was significantly more frequent in the high-dose diazepam group (P < 0.001).CONCLUSION:Intermittent administration of diazepam enabled safe completion of gastric endoscopic submucosal dissection except in patients who were alcohol abusers or obese,or who showed complicated lesions.

关键词： Diazepam Endoscopic submucosal dissection Gastric epithelial neoplasias Moderate sedation Non-anesthesiologists

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固溶碳和晶界对超低碳细晶钢应变时效的影响

水钢科技 2017年第4期 53-62页

作者： Yoshihiko ONO Yoshimasa FUNAKAWA Kaneharu OKUDA Kazuhiro SETO naoki EBISAWA Koji INOUE Yasuyoshi NAGAI 首钢水钢技术中心日本JFE钢铁公司钢铁研究实验室贵州六盘水553028 首钢水钢技术中心日本东北大学材料研究所贵州六盘水553028

我们采用碳含量为1～3 ppm、铁素体晶粒尺寸为9．5 um和183 um的含Nb超低碳钢．在70℃-400℃时效条件下，研究了溶质C和晶界对多晶铁素体钢应变时效现象的影响作用。这种钢呈现出两个明显的硬化阶段。无论是细晶粒试样或是粗晶粒试样，... 详细信息

我们采用碳含量为1～3 ppm、铁素体晶粒尺寸为9．5 um和183 um的含Nb超低碳钢．在70℃-400℃时效条件下，研究了溶质C和晶界对多晶铁素体钢应变时效现象的影响作用。这种钢呈现出两个明显的硬化阶段。无论是细晶粒试样或是粗晶粒试样，都有第一个硬化阶段，在这个硬化阶段，屈服点YP的增量（△YP】最高达到30 MPa。根据表观活化能和硬化动力学可知，硬化的原因是由于C原子对位错的钉扎。第二个硬化阶段主要表现在细晶粒试样中，伴随着HaJl—Petch系数的增大，△YP也很大，达到了90 MPa。在时效试样中，用透射电镜（rrEM）和三维原子探4t（3DAP）没有检测到细小的析出物。溶质C向晶界的偏析和晶界上Fe原子的扩散是出现第二个硬化阶段的原因。因此，晶界硬化是多晶铁素体钢应变时效硬化的原因。

关键词：应变时效晶界偏析溶质C 3DAP 析出活化能 Nb钢 Halt-Petch系数 HaU-Petch系数ky

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm

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World Journal of Gastrointestinal Endoscopy 2012年第7期4卷 335-338页

作者： Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose Second Department of Internal Medicine Wakayama Medical University811-1 Kimiidera Wakayama City Wakayama 641-0012 Japan

Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified.

关键词： Chronic pancreatitis Endoscopic ultraso- nography Pseudoaneurysm

Comparison of Survey Results on Subjective Dizziness,Hearing and Tinnitus and Stabilometry Test Results in Yakumo Inhabitant Examination Study (Comparison of 2005, 2007 and 2015, 2017)

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Journal of Health Science 2019年第3期7卷 151-159页

作者： Naomi Katayama Shoko Kondo Yui Nakayama Takafumi Nakada naoki Saji Seiya Goto Satofumi Sugimoto Wakako kinoshita Masaaki Teranisi Michihiko Sone Yasushi Fujimoto Hironao Otake Hirokazu Suzuki Seiichi Nakata Tsutomu Nakashima Yukiharu Hasegawa Nagoya Women’s University Nagoya City 467-8610Japan Graduate School of Nagoya Women’s University Nagoya City 467-8610Japan Department of Otorhinolaryngology Nagoya University Graduate School of MedicineNagoya City 466-8550Japan Watanabe Hospital Mihama TownChita-gun 470-3235Japan National Center for Geriatrics and Gerontology Obu City 474-851Japan Otake Otolaryngology Hospital Kariya City 448-0857Japan Department of Otolaryngology Second Hospital Fujita Health University School of MedicineNagya City 545-8509Japan Ichinomiya Medical Treatment &Habitaiton Center Ichinomiya City 494-0018Japan Department of Occupational Therapy Kansai University of Welfare SciencesOsaka fu 582-0026Japan

Abstract: The Nagoya University Hospital otolaryngology department is doing the prospective cohort study in Yakumo-cho, Hokkaido, Japan from 2005, because this place is a little transfer of the population. Most of inhabitants of Yakumo-cho engage in fishery and agriculture as work mainly. We perform questionary survey using an interview vote. The item is “having feeling of dizziness or not”,“quality of hearing” and “having tinnitus or not”. Furthermore, we go for the examination of stabilometry, too. We compared 2015, 2017 with 2005, 2007 among Yakumo-cho inhabitant examination data this time. As a result, participant with a feeling of conscious dizziness got a bad reputation of the hearing consciously. In addition, participant with a feeling of conscious dizziness had tinnitus consciously. Furthermore, the participant with a feeling of conscious dizziness had bad stabilometry result. As a result of having compared ten years later, we understood that stabilometry result worsened if 60s became in 70s with or without a feeling of dizziness consciously. When there is a feeling of conscious dizziness, it is necessary to perform an examination of stabilometry as routine work. In addition, it is necessary to inspect stabilometry if participants have the bad hearing or tinnitus with a feeling of dizziness in particularly.

关键词： Feeling of dizziness hearing tinnitus stabilometry Yakumo study

基于GMPGIS全球变暖情景下人参未来生态适宜产区变化

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世界中医药 2017年第5期12卷 974-978页

作者：沈亮徐江董林林孟祥霄张乃嘦藤原直树李西文中国中医科学院中药研究所北京100700 中国中医科学院博士后科研流动站北京100700 盛实百草药业有限公司天津300301 日本国株式会社津村生药研发部茨城300-1192

目的:通过开展未来时期人参全球潜在生态适宜产区分析,为其合理规划生产布局提供科学依据。方法:采用"药用植物全球产地生态适宜性区划信息系统"(Global Geographic Information System for Medicinal Plant,GMPGIS),以人参本草文献记... 详细信息

目的:通过开展未来时期人参全球潜在生态适宜产区分析,为其合理规划生产布局提供科学依据。方法:采用"药用植物全球产地生态适宜性区划信息系统"(Global Geographic Information System for Medicinal Plant,GMPGIS),以人参本草文献记载的道地产区、野生分布区以及当前主产区人参生态因子数值为依据,对其在全球范围内的潜在生态分布区进行分析。结果:亚洲东部、北美洲中部及东部、欧洲中南部及大洋洲东部地区是当前人参全球范围内的主要适生区域。随着全球气候变暖,在温室气体排放相对较少的A1b模型和排放较多的A2a模型下,2050年人参潜在生态适宜产区面积约为9 500×10~3km^2,比当前产区适宜面积增加了7.05%~7.12%,增长区域主要分布在亚洲东北部和欧洲北部地区;2100年人参适宜产区面积约为10 800×10~3km^2,比当前产区适宜面积增加了22.89%~27.41%,增长区域主要分布在欧洲北部及亚洲中部及东部地区。结论:气温升高有助于人参适宜产区增加,本研究结果可为人参生产布局规划、引种栽培、规模化种植提供科学依据。

关键词：人参 GMPGIS 生态适宜性全球变暖潜在分布

Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries

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世界胃肠内镜杂志：英文版（电子版） 2016年第3期8卷 186-191页

作者： Hiroyuki Imaeda Kiyokazu Nakajima naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata Department of General Internal Medicine Saitama Medical UniversitySaitama 350-0495Japan Division of Next Generation Endoscopic Intervention Osaka UniversityOsaka 565-0871Japan Center for Diagnostic and Therapeutic Endoscopy School of MedicineKeio UniversityTokyo 160-8582Japan Department of Gastroenterology Ikeda City HospitalOsaka 563-8510Japan Department of Gastroenterology and Hepatology Graduate School of MedicineOsaka UniversityOsaka 565-0871Japan Department of Surgery School of MedicineKeio UniversityTokyo 160-8582Japan Division of Research and Development for Minimally Invasive Treatment Cancer CenterSchool of MedicineKeio UniversityTokyo 160-8582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineKeio UniversityTokyo 160-8582Japan

AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two ***: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG.

关键词： Percutaneous endoscopic gastrostomy Steadypressure automatically controlled endoscopy Carbondioxide