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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu naoki shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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Unveiling the anticancer effect of traditional Chinese herbal medicine

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World Journal of Gastroenterology 2024年第30期30卷 3625-3627页

作者： naoki Asano Division of Carcinogenesis and Senescence Biology Tohoku University Graduate School of MedicineNatori 981-1293MiyagiJapan Division of Cancer Stem Cell Miyagi Cancer Center Research InstituteNatori 981-1293MiyagiJapan

In this issue of World Journal of Gastroenterology,Huang et al reported that Calculus bovis(CB),a traditional Chinese herbal medicine,impedes the growth of liver cancers in *** further in vitro studies,they showed that CB suppressed the M2 polarization of tumor-associated macrophages by suppressing the Wnt signaling pathway,which consequently inhibited the growth of liver *** the effects of traditional Chinese herbal medicine are often not scientifically proven,Huang et al successfully identified the molecular mechanism involved in the anticancer effect of CB,and it is anticipated that the molecular mechanisms involved in the effects of other traditional Chinese herbal medicines will be scientifically elucidated,as demonstrated in this article.

关键词： Calculus bovis Chinese herbal medicine Wnt Hepatocellular carcinoma Liver cancer Tumor-associated macrophages M2 polarization

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Engineering W/O/W pickering emulsion for the enhanced antigen delivery and immune responses

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Particuology 2024年第9期92卷 224-233页

作者： Sihua Wu Xiaonan Huang Yin Ma naoki Asakawa Yufei Xia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Sinovac Biotech Ltd. Beijing100085China School of Chemical Engineering Nanjing Tech UniversityNanjing211816China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Tumor immunotherapy,particularly cancer vaccines,holds promise for combating cancer by harnessing tailored immune responses against malignant ***,conventional approaches face challenges in efficiently delivering antigens for optimal immune *** adjuvants,like MF59,enhance cellular uptake but struggle to induce robust CD8^(+)T cell ***,we introduce a novel strategy employing a water-in-oil-in-water(W/O/W)multiple Pickering emulsion(mPE)for antigen *** mPE,utilizing biocompatible,pH-sensitive particles,encapsulates antigens within the inner water phase,ensuring enhanced intracellular processing and dictating the intracellular fate of antigens for improved *** vitro and in vivo studies demonstrated that mPEs induced robust dendritic cells activation and antigen cross-presentation,leading to a significantly enhanced immune ***,calcium phosphate-stabilized mPE(CaP-mPE)illustrated the more robust IFN-γ^(+)T cell *** comparison with traditional surfactant-stabilized multiple emulsions,CaP-mPE significantly inhibit tumor growth and effectively prolong the survival of tumor-bearing *** innovative approach offers a promising avenue for the development of effective cancer vaccines with potent cellular immune responses.

关键词： Cancer vaccine Multiple pickeringemulsion Adjuvant Antigen delivery Anti-tumor response

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Knockout of a rice K5.2 gene increases Ca accumulation in the grain

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Journal of Integrative Plant Biology 2024年第2期66卷 252-264页

作者： Peitong Wang naoki Yamaji Namiki Mitani-Ueno Jun Ge Jian Feng Ma National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China Institute of Plant Science and Resources Okayama UniversityKurashiki 710-0046Japan

Rice is a staple food for half of the world’s population,but it is a poor dietary source of calcium(Ca)due to the low *** is an important issue to boost Ca concentration in this grain to improve Ca deficiency risk,but the mechanisms underlying Ca accumulation are poorly ***,we obtained a rice(Oryza sativa)mutant with high shoot Ca *** mutant exhibited 26%-53% higher Ca in shoots than did wild-type rice(WT)at different Ca *** concentration in the xylem sap was 36% higher in the mutant than in the *** was no difference in agronomic traits between the WT and mutant,but the mutant showed 25% higher Ca in the polished grain compared with the ***-based cloning combined with a complementation test revealed that the mutant phenotype was caused by an 18-bp deletion of a gene,OsK5.2,belonging to the Shaker-like K+channel ***5.2 was highly expressed in the mature region of the roots and its expression in the roots was not affected by Ca levels,but upregulated by low *** showed that OsK5.2 was mainly expressed in the pericycle of the *** together,our results revealed a novel role for OsK5.2 in Ca translocation in rice,and will be a good target for Ca biofortification in rice.

关键词： accumulation biofortification calcium OsK5.2 pericycle rice translocation

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Nitrogen-based fertilizers differentially affect protist community composition in paddy field soils

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Soil Ecology Letters 2024年第3期6卷 35-44页

作者： Seda Ozer Bodur Solomon Oloruntoba Samuel Kazuki Suzuki naoki Harada Rasit Asiloglu Graduate School of Science and Technology Niigata UniversityNiigataJapan Department of Plant and Microbial Biology North Carolina State UniversityRaleighNCUSA Institute of Science and Technology Niigata UniversityNiigataJapan

Protists are one of the most diverse and dominant microbial groups and they play critical roles in the soil *** nitrogen fertilizers have a profound impact on protist communities,still less is known about how different nitrogen fertilizer types affect protist community composition in different soil *** we investigated the effects of six inorganic nitrogen fertilizers(urea,ammonium nitrate,ammonium sulfate,potassium nitrate,ammonium chloride,and diammonium hydrogen phosphate)and an organic fertilizer(a mixture of rice husk and cow manure)on protist community composition in three paddy field soils using a high-throughput sequencing *** effect of the fertilizers on the functional groups of protists,namely consumers(predators and decomposers),photoautotrophs,and parasites(plant pathogens and animal parasites)was also *** results showed that nitrogen fertilizers had distinctive effects on the beta diversity of the protists,while we also observed that the same fertilizer had slightly different effects depending on the soil *** and Rhizaria were the most affected protist taxonomical groups,while predatory protists were the main functional groups that were affected by nitrogen *** forest analysis showed that most of the fertilizer-affected protists were predators,among which Cercozoa was the most affected *** conclusion,our results provide important insights into the impact of nitrogen fertilizers on soil protist communities.

关键词： nitrogen fertilizer bottom-up paddy field predatory protist soil protist community

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Computer-controlled ultra high voltage amplifier for dielectric elastomer actuators

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Biomimetic Intelligence & Robotics 2024年第1期4卷 14-23页

作者： Ardi Wiranata Zebing Mao Yu Kuwajima Yuya Yamaguchi Muhammad Akhsin Muflikhun Hiroki Shigemune naoki Hosoya Shingo Maeda Department of Mechanical and Industrial Engineering University of Gadjah MadaYogyakarta 55281Indonesia Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Department of Engineering and Science Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Electrical Engineering Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Living Systems Materialogy(LiSM)Research Group International Research Frontiers Initiative(IRFI)Tokyo Institute of TechnologyYokohama 226-8501Japan

Soft robotics is a breakthrough technology to support human-robot *** soft structure of a soft robot can increase safety during human and robot *** of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy *** simple structure of DEAs leads to the easy fabrication of soft *** simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics *** actuation follows the Maxwell-pressure *** pressure produced in the DEAs actuation depends much on the voltage *** DEAs requires high voltage to gain an *** the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be *** commercially available DC-DC converters can convert the volt range to the kV *** order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each *** problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric *** paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft ***-Amp can amplify 12 V to at a maximum of 4 kV *** a demonstration,we used this UHV-Amp to test a single layer of powdered-based *** strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV *** its current state,the UHV-Amp has the potential to achieve approximately 4 *** created a simple platform to control the UHV-Amp from a personal *** near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.

关键词： Dielectric elastomer actuators Electric amplifier Soft actuators Soft robotics Soft actuator education

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Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi Hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

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Evaluation of crustal deformation and associated strong motions induced by the 2022 Paktika earthquake,Afghanistan

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Earthquake Science 2024年第6期37卷 546-557页

作者： A.Bari Jahed Ömer Aydan Takashi Ito naoki Iwata University of Ryukyus Okinawa 903-0213Japan Chuden Engineering Consultants Hiroshima 734-8510Japan

The 2022 Paktika earthquake(moment magnitude:6.2) occurred on June 22,2022,near the border between the Khost and Paktika Provinces of Afghanistan,causing heavy damage and casualties in Paktika *** study evaluated the crustal deformation and associated strong motions induced by the Paktika *** deformations were determined using the Differential Interferometric Synthetic Aperture Radar(DInSAR) technique and three-dimensional finite element method(3DFEM) and the results were *** permanent ground displacements obtained from the DInSAR and 3D-FEM analyses were similar in terms of amplitude and areal *** motions were estimated using the 3D-FEM with and without considering regional *** estimations of maximum ground acceleration,velocity,and permanent ground deformations were compared among each other as well as with those inferred from failures of some simple structures in the Spera and Gayan *** inferred maximum ground acceleration and velocity from the failed adobe structures were more than 300 Gal and 50 cm/s,respectively,nearly consistent with the estimates obtained using empirical *** empirical method yielded a maximum ground acceleration of 347 Gal,whereas the maximum ground velocity was approximately50 cm/*** light of these findings,some surface expressions of crustal deformations and strong ground motions,such as failures of soil and rock slopes and rockfalls,have been *** rock slope failures in the epicentral area were consistent with those observed during various earthquakes in Afghanistan and worldwide.

关键词： Paktika earthquake FEM SAR Afghanistan fault rupture surface deformation slope rockfall

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Benefits of endoscopic gallbladder stenting following percutaneous transhepatic gallbladder drainage

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2902-2909页

作者： Fumitaka Niiya naoki Tamai Masataka Yamawaki Jun Noda Tetsushi Azami Yuichi Takano Fumiya Nishimoto Masatsugu Nagahama Division of Gastroenterology Department of Internal MedicineShowa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACKGROUND Endoscopic transpapillary gallbladder drainage is challenging because of the complexity of the procedure and high incidence of adverse events(AEs).To overcome these problems,endoscopic gallbladder stenting(EGBS)after percutaneous transhepatic gallbladder drainage(PTGBD)can be effective,as it mitigates inflammation and *** To examine the benefits of EGBS after PTGBD to assess its efficacy and impact on *** We retrospectively analyzed data from 35 patients who underwent EGBS after PTGBD at a single center between January 2016 and December *** primary outcomes were technical success and AEs,and the rate of recurrent cholecystitis was *** addition,the reasons for the failure of the procedure were *** Among the 35 patients,the technical success rate was 77.1%and the final contrast of the cystic duct was successful in 97.1%of *** incidence of early AEs was relatively low(11.4%),with no instances of cystic duct *** rate of recurrent cholecystitis was 3.7%,and no other biliary events were *** EGBS after PTGBD may be significantly beneficial,with a substantial success rate and minimal AEs in both short-and long-term follow-ups.

关键词： Endoscopy Gallbladder Stents Drainage Adverse events Cholecystitis Follow-up Cystic duct

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小麦WUS基因亚家族的全基因组鉴定及其在雄蕊和雌蕊中的表达分析

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农业生物技术学报 2024年第11期 2462-2473页

作者：赵若男邹瑞 YAMAMOTO naoki 陈真勇吴一超蒋进彭正松杨在君西华师范大学生命科学学院/西南野生动植物资源保护教育部重点实验室四川省阿坝州农产品质量检验监测中心南充市农业科学院西昌学院农业科学学院

WUSCHEL (WUS)是一种同源结构域转录因子，其作为WOX家族的一个进化分支，可能通过调节特定靶基因的表达，在植物细胞的胚胎发生和芽再生中发挥重要作用。本研究利用生物信息学方法在小麦(Triticum aestivum)的全基因组中一共鉴定出25个... 详细信息

WUSCHEL (WUS)是一种同源结构域转录因子，其作为WOX家族的一个进化分支，可能通过调节特定靶基因的表达，在植物细胞的胚胎发生和芽再生中发挥重要作用。本研究利用生物信息学方法在小麦(Triticum aestivum)的全基因组中一共鉴定出25个WUS基因，不均匀分布在第1、第2、第3和第5同源群染色体上，并且其在第3同源群染色体上发生了串联重复现象。保守结构域分析显示，该家族成员均含有motif 1和motif 3，基因结构和进化树显示，聚类在一起的WUS蛋白具有类似的基因结构。在TaWUSs的启动子区共鉴定出18类激素响应与非生物胁迫类的响应元件。组织表达谱分析显示，25个TaWUSs在小麦中拥有明显的组织表达特异性，且多数在花器官高表达。qRT-PCR结果进一步证实了TaWUS-2A1、TaWUS-3B2、TaWUS-3D2、TaWUS-5A1、TaWUS-5B1和TaWUS-5D1在正常雄蕊中高表达，而TaWUS-3D1在正常雌蕊中高表达。尤其是TaWUS-1A、TaWUS-1B、TaWUS-1D和TaWUS-2D1在雌蕊化雄蕊中高表达，预示其可能在调控小麦同源转化型雄性不育突变体(HTS-1)中雄蕊同源转化为雌蕊性状的形成中发挥作用。本研究为进一步解析小麦WUS亚家族基因的功能提供了理论基础。

关键词：小麦 WUS基因亚家族雄蕊雌蕊

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