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GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng Ye Yunfei Deng Yue Gu Pengfei Liu Jie Luo Jiangqin Pu Jingyu Chen Yu Huang nanping wang Yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and Yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and Yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

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达格列净对慢性心力衰竭患者血管内皮功能及心功能指标的影响

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药品评价 2024年第2期21卷 238-241页

作者：王南平齐景红乐平市人民医院江西乐平333300 乐平市妇幼保健院江西乐平333300

目的探究达格列净对慢性心力衰竭(CHF)患者血管内皮功能及心功能指标的影响。方法按随机数字表法将2021年2月至2023年2月于乐平市人民医院治疗的86例CHF患者随机分为两组,每组各43例。对照组给予沙库巴曲缬沙坦钠治疗,观察组在对照组... 详细信息

目的探究达格列净对慢性心力衰竭(CHF)患者血管内皮功能及心功能指标的影响。方法按随机数字表法将2021年2月至2023年2月于乐平市人民医院治疗的86例CHF患者随机分为两组,每组各43例。对照组给予沙库巴曲缬沙坦钠治疗,观察组在对照组基础上加用达格列净治疗。两组治疗时长均为2个月。比较两组临床效果,治疗前、后血管内皮功能、心功能指标、心衰标志物水平以及不良反应。结果相较于对照组,观察组治疗总有效率较高(P0.05);观察组治疗后血浆内脑钠肽、N末端脑钠利肽前体水平均较低,差异有统计学意义(P0.05)。结论达格列净用于CHF患者治疗中的效果明确,能够作用于改善患者血管内皮功能,调节其心功能指标与心衰标志物水平,临床用药安全性高,值得推广。

关键词：慢性心力衰竭达格列净血管内皮功能心功能

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阿利西尤单抗联合阿托伐他汀钙治疗急性冠脉综合征的临床效果及对血脂水平的影响

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中国医学创新 2024年第21期21卷 53-57页

作者：陈斌王南平叶兆龙赵海兰乐平市人民医院心血管内科江西乐平333300

目的:探讨采用阿利西尤单抗联合阿托伐他汀钙治疗急性冠脉综合征(ACS)的临床效果及对血脂水平的影响。方法:选取2022年6月—2023年9月乐平市人民医院收治的共计96例ACS患者,以随机数字表法分成研究组(n=48)与对照组(n=48),对照组给予阿... 详细信息

目的:探讨采用阿利西尤单抗联合阿托伐他汀钙治疗急性冠脉综合征(ACS)的临床效果及对血脂水平的影响。方法:选取2022年6月—2023年9月乐平市人民医院收治的共计96例ACS患者,以随机数字表法分成研究组(n=48)与对照组(n=48),对照组给予阿托伐他汀钙治疗,研究组给予阿利西尤单抗联合阿托伐他汀钙治疗,比较两组临床疗效、血脂水平、氧化应激指标、不良反应。结果:统计治疗总有效率,研究组95.83%(46/48)较对照组81.25%(39/48)更高,差异有统计学意义(P0.05)。结论:阿利西尤单抗联合阿托伐他汀钙治疗ACS,可提高临床效果,改善血脂水平,缓解氧化应激反应,安全性较高。

关键词：急性冠脉综合征阿利西尤单抗阿托伐他汀钙血脂水平

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Gaussian fitting in gamma-ray spectral decomposition

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Nuclear Science and Techniques 2010年第4期21卷 214-217页

作者： FU Chen wang nanping Key Laboratory of Geo-detection (China University of Geosciences Beijing) Ministry of Education Beijing 100083 China

In order to extract the information of 662-keV 137Cs spectra from the overlapping peaks with 583-keV 208Tl,609-keV 214Bi,the overlapping peaks are measured by in-situ γ-ray spectrometer using a NaI(Tl) *** spectral model is optimized by the Gaussian fitting algorithm,and the optimized fitting indexes for fitting/original value are from 0.96 to *** fitting verified by experiment is feasible for γ-ray spectrum *** full energy peak of 137Cs is extracted correctly from the overlapping peaks,it is important for in-situ γ-ray spectrometer to estimate contamination of 137Cs in radiated environment and nuclear accident.

关键词：伽玛射线高斯拟合光谱分解 137Cs 拟合算法拟合指数辐射环境重叠峰

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Advanced preparation and application of bimetallic materials in lithium-sulfur batteries:A review

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Journal of Energy Chemistry 2024年第1期88卷 469-512,I0011页

作者： Yongbing Jin nanping Deng Yanan Li Hao wang Meiling Zhang Weimin Kang Bowen Cheng State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China

Lithium-sulfur(Li-S)batteries are considered highly promising as next-generation energy storage systems due to high theoretical capacity(2600 Wh kg^(-1))and energy density(1675 mA h g^(-1))as well as the abundant natural reserves,low cost of elemental sulfur,and environmentally friendly ***,several challenges impede its commercialization including low conductivity of sulfur itself,the severe“shuttle effect”caused by lithium polysulfides(LiPSs)during charge–discharge processes,volume expansion effects and sluggish reaction *** a solution,polar metal particles and their compounds have been introduced as the main hosts for sulfur cathode due to their robust catalytic activity and adsorption capability,effectively suppressing the“shuttle effect”of Li *** alloys and their compounds with multi-functional properties exhibit remarkable electrochemical performance more readily when compared to single-metal ***-designed bimetallic materials demonstrate larger specific surface areas and richer active sites,enabling simultaneous high adsorption capability and strong catalytic *** synergistic effect of the“adsorption-catalysis”sites accelerates the adsorptiondiffusion-conversion process of Li PSs,ultimately achieving a long-lasting Li-S ***,the latest progress and performance of bimetallic materials in cathodes,separators,and interlayers of Li-S batteries are systematically ***,the principles and challenges of Li-S batteries are briefly ***,various mechanisms for suppressing“shuttle effects”of Li PSs are emphasized at the ***,the performance parameters of various bimetallic materials are comprehensively summarized,and some improvement strategies are proposed based on these ***,the future prospects of bimetallic materials are discussed,with the hope of providing profound insights for the rational design and manufacturing of high-performance bimetallic materia

关键词： Bimetallic materials Lithium-sulfur batteries Effectively suppress shuttle effect of LiPSs Significantly improve reaction kinetics Exceptionally long lifespan

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Progress in the application of polymer fibers in solid electrolytes for lithium metal batteries

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Journal of Energy Chemistry 2024年第5期92卷 26-42页

作者： Junbao Kang nanping Deng Bowen Cheng Weimin Kang State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China

Solid state lithium metal batteries(SSLMBs)are considered to be one of the most promising battery systems for achieving high energy density and excellent safety for energy storage in the ***,current existed solid-state electrolytes(SSEs)are still difficult to meet the practical application requirements of *** this review,based on the analysis of main problems and challenges faced by the development of SSEs,the ingenious application and latest progresses including specific suggestions of various polymer fibers and their membrane products in solving these issues are emphatically ***,the inherent defects of inorganic and organic electrolytes are pointed ***,the application strategies of polymer fibers/fiber membranes in strengthening strength,reducing thickness,enhancing thermal stability,increasing the film formability,improving ion conductivity and optimizing interface stability are discussed in detail from two aspects of improving physical structure properties and electrochemical ***,the researches and development trends of the intelligent applications of high-performance polymer fibers in SSEs is *** review intends to provide timely and important guidance for the design and development of polymer fiber composite SSEs for SSLMBs.

关键词： Composite solide lectrolytes Polymer fibers Solid-state lithium metal batteries Solid-stateel ectrolytes Nanofiber membranes

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Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第2期89卷 266-303,I0007页

作者： nanping Deng Xiaofan Feng Yongbing Jin Zhaozhao Peng Yang Feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen Cheng State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage *** widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,*** various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li *** many novel array structured materials are applied to battery for tackling thorny problems mentioned *** this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are ***,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery ***,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are *** hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.

关键词： Array structured materials Preparation methods and structural designs Action mechanism analyses Advanced Li-S batteries Excellent electrochemical performances and safety

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The comparison of the Wnt signaling pathway inhibitor delivered electrospun nanoyarn fabricated with two methods for the application of urethroplasty

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Frontiers of Materials Science 2016年第4期10卷 346-357页

作者： Xuran GUO Kaile ZHANG Mohamed EL-AASSAR nanping wang Hany EL-HAMSHARY Mohamed EL-NEWEHY Qiang FU Xiumei MO State Key Lab for Modification of Chemical Fibers & Polymer Materials College of Chemistry & Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200030 China Polymer Materials Research Department Advanced Technology and New Material Institute City of Scientific Research and Technological Applications (SRTA-City) New Borg El-Arab City Alexandria 21934 Egypt Shanghai Aquatic Product Research Institute Shanghai 200030 China Department of Chemistry College of Science King Saud University Riyadh i 1451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt Shandong International Biotechnology Park Development Co. Ltd. Shanghai 200030 China

Urethral strictures were common disease caused by over-expression of extracellular matrix from fibroblast. In this study, we compare two nanoyarn scaffolds for improving fibroblasts infiltration without inhibition the over-expression of extracellular matrix. Collagenlpoly（L-lactide-co-caprolactone）（ColIP（LLA-CL）） nanoyarn scaffolds were prepared by conjugated electrospinning and dynamic liquid electrospinning, respectively, in addition, co-axial electrospinning technique was combined with the nanoyarn fabrication process to produce nanoyarn scaffolds loading Wntsignaling pathway inhibitor. The mechanical properties of the scaffolds were examined and morphology was observed by SEM. Cell morphology, proliferation and infiltration on the scaffolds were investigated by SEM, MTT assay and H＆E staining, respectively. The release profiles of different scaffolds were determined using HPLC. The results indicated that cells showed an organized morphology along the nanoyarns and considerable infiltration into the nanoyarn scaffolds prepared by dynamic liquid electrospinning （DLY）. It was also observed that the DLY significantly facilitate cell proliferation. The D-DLY could facilitate the infiltration of the fibroblasts and could be a promising scaffold for the treatment of urethra stricture while it may inhibit the collagen production.

关键词： biomaterials nanoyarn electrospinning inhibitor

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Role of peroxisome proliferator-activated receptor-δ on hepatic lipogenesis

Role of peroxisome proliferator-activated receptor-δ on hep...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： nanping wang Institute of Cardiovascular Science Peking University

Nonalcoholic fatty liver disease(NAFLD) is one of the most common forms of chronic liver diseases and is associated with insulin-resistant states such as diabetes and *** proliferator-activated receptor- 5(PPAR-δ) ha...

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健脾疏肝汤联合多潘立酮治疗肝胃不和型功能性消化不良的效果和对胃动力水平的提高观察

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智慧健康 2022年第1期8卷 142-145页

作者：王南萍苏州工业园区星湖医院江苏苏州215000

目的研究健脾疏肝汤联合多潘立酮治疗肝胃不和型功能性消化不良的效果。方法在本文研究中将我院2019年5月-2020年5月收治的肝胃不和型功能性消化不良患者作为研究对象,选取符合该研究纳入标准的60例患者,按照其门诊就诊次序,随机分为观... 详细信息

目的研究健脾疏肝汤联合多潘立酮治疗肝胃不和型功能性消化不良的效果。方法在本文研究中将我院2019年5月-2020年5月收治的肝胃不和型功能性消化不良患者作为研究对象,选取符合该研究纳入标准的60例患者,按照其门诊就诊次序,随机分为观察组30例、对照组30例,观察组予以健脾疏肝汤联合多潘立酮治疗方式、对照组予以单纯口服多潘立酮常规治疗方式,以4周为1疗程,分析并且对比两组各项指标。结果观察组VAS评分(1.02±0.22)分、胃泌素水平(72.23±1.92)103ng/mL与对照组相比具有差异(P0.05),经过治疗后,观察组便溏(2.11±0.16)分、纳少(3.45±1.21)分、胃脘胀痛不适(1.02±0.42)分积分优于对照组(P<0.05);观察组总有效率86.67%高于对照组(P<0.05);观察组食量恢复时间、食欲恢复时间、呕吐恶心消失时间显著优于对照组(P<0.05)观察两组治疗后胃排空率的测定,观察组胃排空率为83.3%,对照组胃排空率为70%,组间有显著性差异(P<0.05)。结论通过对肝胃不和型功能性消化不良患者实施健脾疏肝汤、多潘立酮治疗,取得显著效果。

关键词：健脾疏肝汤多潘立酮肝胃不和型功能性消化

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