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Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing

World Journal of Stem Cells 2024年第4期16卷 334-352页

作者： Jie-yu Xiang Lin Kang Zi-Ming Li Song-Lu Tseng Li-Quan Wang Tian-Hao Li Zhu-Jun Li Jiu-Zuo Huang nan-ze yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

Wound repair is a complex challenge for both clinical practitioners and *** approaches for wound repair have several *** cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin ***,the use of stem cells in skin regeneration presents several ***,stem cells and biomaterials have been identified as crucial components of the wound-healing *** therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable *** scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the *** scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound *** article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine ***,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement Scaffold characteristics

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Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng Lin Kang Zhu-Jun Li Li-Quan Wang Zi-Ming Li Tian-Hao Li Jie-yu Xiang Jiu-Zuo Huang nan-ze yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical

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Radiation Therapy in Keloids Treatment： History, Strategy,Effectiveness, and Complication

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Chinese Medical Journal 2017年第14期130卷 1715-1721页

作者： Jing Xu Elan Yang nan-ze yu Xiao Long Peking Union Medical College Beijing 100730 China Department of Plastic Surgery Peking Union Medical College Hospital Beijing 100730 China

Objective：Radiation therapy combined with surgical excision was considered as one of the most effective treatment plans for keloid ***,there was no unanimity found over present literatures regarding the issue on optimized treatment strategy for *** here provide a comprehensive review over this issue and emphasize on the influencing *** Sources：The data analyzed in this review were searched from articles included in PubMed and EMBASE *** Selection：The original articles and critical reviews discussing the application of radiation therapy in keloids treatment were selected for this ***：The application of radiation therapy has transitioned from simple superficial X-ray irradiation to ***,several factors including radiation type,dose,fraction,interval,and complications were reviewed,and the results revealed that these factors were significant toward clinical outcome at various ***：Both past and present evidence support the idea that combination therapy of radiation and surgical therapy is safe and ***,the optimization of treatment strategy was based on different radiation types and should take dose,fractions,interval,and complications into consideration,which will then decrease the rate of recurrence and increase the level of satisfaction.

关键词： Combination Therapy: Keloids Radiation Therapy

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Benchmarking visual SLAM methods in mirror environments

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Computational Visual Media 2024年第2期10卷 215-241页

作者： Peter Herbert Jing Wu ze Ji yu-Kun Lai School of Computer Science and Informatics Cardiff UniversityAbacws BuildingSenghennydd RdCardiff CF244AGUK School of Engineering Cardiff UniversityQueen’s BuildingsThe ParadeCardiff CF243AAUK

Visual simultaneous localisation and mapping(vSLAM)finds applications for indoor and outdoor navigation that routinely subjects it to visual complexities,particularly mirror *** effect of mirror presence(time visible and its average size in the frame)was hypothesised to impact localisation and mapping performance,with systems using direct techniques expected to perform ***,a dataset,MirrEnv,of image sequences recorded in mirror environments,was collected,and used to evaluate the performance of existing representative *** ORB-SLAM3 and BundleFusion appear to show moderate degradation of absolute trajectory error with increasing mirror duration,whilst the remaining results did not show significantly degraded localisation *** mesh maps generated proved to be very inaccurate,with real and virtual reflections colliding in the reconstructions.A discussion is given of the likely sources of error and robustness in mirror environments,outlining future directions for validating and improving vSLAM performance in the presence of planar *** MirrEnv dataset is available at https://***/10.17035/d.2023.0292477898.

关键词： visual simultaneous localisation and mapping(vSLAM) mirror localisation mapping reflection datase

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Micro defects formation and dynamic response analysis of steel plate of quasi-cracking area subjected to explosive load

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Defence Technology（防务技术） 2024年第1期31卷 580-593页

作者： Zheng-qing Zhou ze-chen Du Xiao Wang Hui-ling Jiang Qiang Zhou yu-long Zhang yu-zhe Liu Pei-ze Zhang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China School of Mechanical Engineering Nantong UniversityNantong226019China China North Industry Advanced Technology Generalization Institute Beijing100089China China Academy of Ordnance Science China

As the protective component,steel plate had attracted extensive attention because of frequently threats of explosive *** this paper,the evolution of microstructure and the mechanism of damage in the quasi-cracking area of steel plate subjected to explosive load were discussed and the relationships between micro defects and dynamic mechanical response were *** the explosion experiment,five observation points were selected equidistant from the quasi-cracking area of the section of the steel plate along the thickness direction,and the characteristics of micro defects at the observation points were analyzed by optical microscope(OM),scanning electron microscope(SEM) and electron backscattered diffraction(EBSD).The observation result shows that many slip bands(SBs) appeared,and the grain orientation changed obviously in the steel plate,the two were the main damage types of micro *** addition,cracks,peeling pits,grooves and other lager micro defects were appeared in the lower area of the *** stress parameters of the observation points were obtained through an effective numerical *** mechanism of damage generation and crack propagation in the quasicracking area were clarified by comparing the specific impulse of each observation point with the corresponding micro *** result shows that the generation and expansion of micro defects are related to the stress area(*** upper compression area,the neutral plane area,and the lower tension area).The micro defects gather and expand at the grain boundary,and will become macroscopic damage under the continuous action of tensile ***,the micro defects at the midpoint of the section of the steel plate in the direction away from the explosion center(*** horizontal direction) were also *** was found that the specific impulse at these positions were much smaller than that in the thickness direction,the micro defects were only SBs and a few micro cracks,and the those decrea

关键词： Explosive load Quasi-cracking area Micro defects Steel plate Dynamic response Numerical simulation

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Cutibacterium acnes in Atopic Dermatitis:Roles and Potential Therapeutic Applications

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International Journal of Dermatology and Venereology 2024年第1期7卷 12-17页

作者： Tian-ze yu Wei Li Department of Dermatology Shanghai Institute of DermatologyHuashan HospitalFudan UniversityShanghai 200040China

Atopic dermatitis(AD)is a chronic relapsing inflammatory skin *** main initiating mechanisms of AD are disruptions in the skin microbiota,dysfunction of the skin barrier,and predominantly elevated type 2 immune *** acnes(***)is a commensal bacterium that is ubiquitous and predominant in healthy skin and shows intraspecific subtype *** abundance of *** is closely related to the sebum secreted by sebaceous *** has long been considered a proinflammatory skin bacterium that drives the development of acne *** evidence indicates that *** promotes skin microbiota homeostasis and skin barrier maintenance;however,the potential role of *** in AD remains largely *** review provides the latest information on the distribution of *** and its phylotypes in healthy skin and AD as well as an overview of the possible role of *** in the pathophysiological pathways underlying ***,the review focuses on new evidence regarding the protective functions of *** and its metabolites in AD and discusses the potential for therapeutic applications.

关键词： atopic dermatitis skin microbiota probiotic therapy

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Growth of Ag/g-C_(3)N_(4) nanocomposites on nickel foam to enhance photocatalytic degradation of formaldehyde under visible light

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Journal of Environmental Sciences 2024年第3期137卷 432-442页

作者： ze Wang Zhi Huang Jiang yu Xiao Shao Weidong Peng Jie yu Yinying Jiang Department of Environmental Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Institute of New Energy and Low Carbon Technology Sichuan UniversityChengdu 610065China School of Agriculture and Environment University of Western AustraliaPerth 6907Western AustraliaAustralia Yibin Institute of Industrial Technology Sichuan UniversityYibin 644000China

Formaldehyde is a pollutant that significantly affects the indoor air ***,conventional remediation approaches can be challenging to deal with low-concentration formaldehyde in an indoor *** this study,Photocatalysts of Ag/graphitic carbon nitride(g-C_(3)N_(4))/Ni with 3D reticulated coral structure were prepared by thermal polymerization and liquid phase photo-deposition,using nickel foam(NF)as the *** demonstrated that when the Ag concentration was 3%,and the relative humidity was 60%,the Ni/Ag/g-C_(3)N_(4)showed the maximum degradation rate of formaldehyde at 90.19%under visible light irradiation,and the formaldehyde concentration after degradation was lower than the Hygienic standard stated by the Chinese *** porous structure of Ni/Ag/g-C_(3)N_(4)and the formation of Schottky junctions promoted the Adsorption efficiency and degradation of formaldehyde,while the nickel foam carrier effectively promoted the desorption of degradation ***,the degradation rate was only reduced by3.4%after 16 recycles,the three-dimensional porous structure extended the lifetime of the *** study provides a new strategy for the degradation of indoor formaldehyde at low concentrations.

关键词： Graphitic carbon nitride(g-C_(3)N_(4)) Nickel foam(NF) Ag Formaldehyde Photocatalysis

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Centroid Hom-associative Algebras and Centroid Hom-Lie Algebras

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Acta Mathematica Sinica,English Series 2024年第4期40卷 935-961页

作者： yu Xiu BAI Leonid A.BOKUT yu Qun CHEN ze Rui ZHANG Department of Mathematics Teaching Guangzhou Civil Aviation CollegeGuangzhou 510403P.R.China Sobolev Institute of Mathematics Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia School of Mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this article,we construct free centroid hom-associative algebras and free centroid hom-Lie *** also construct some other relatively free centroid hom-associative algebras by applying the Gr?bner-Shirshov basis theory for(unital)centroid hom-associative ***,we prove that the"Poincaré-Birkhoff-Witt theorem"holds for certain type of centroid hom-Lie algebras over a field of characteristic 0,namely,every centroid hom-Lie algebra such that the eigenvectors of the mapβlinearly generates the whole algebra can be embedded into its universal enveloping centroid hom-associative algebra,and the linear basis of the universal enveloping algebra does not depend on the multiplication table of the centroid hom-Lie algebra under consideration.

关键词： Centroid hom-Lie algebra centroid hom-associative algebra Gr?bner-Shirshov basis

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Multiscale spatiotemporal meteorological drought prediction:A deep learning approach

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Advances in Climate Change Research 2024年第2期15卷 211-221页

作者： Jia-Li ZHANG Xiao-Meng HUANG yu-ze SUN Department of Earth System Science Ministry of Education Key Laboratory for Earth System ModellingInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China

Reliable monitoring and thorough spatiotemporal prediction of meteorological drought are crucial for early warning and decision-making regarding drought-related *** utilisation of multiscale methods is effective for a comprehensive evaluation of drought occurrence and progression,given the complex nature of meteorological ***,the nonlinear spatiotemporal features of meteorological droughts,influenced by various climatological,physical and environmental factors,pose significant challenges to integrated prediction that considers multiple indicators and time *** address these constraints,we introduce an innovative deep learning framework based on the shifted window transformer,designed for executing spatiotemporal prediction of meteorological drought across multiple *** formulate four prediction indicators using the standardized precipitation index and the standard precipitation evaporation index as core methods for drought definition using the ERA5 reanalysis *** indicators span time scales of approximately 30 d and one ***-term indicators capture more anomalous variations,whereas long-term indicators attain comparatively higher accuracy in predicting future *** focus on the East Asian region,notable for its diverse climate conditions and intricate terrains,to validate the model's efficacy in addressing the complexities of nonlinear spatiotemporal *** model's performance is evaluated from diverse spatiotemporal viewpoints,and practical application values are analysed by representative drought *** results substantiate the effectiveness of our proposed model in providing accurate multiscale predictions and capturing the spatiotemporal evolution characteristics of *** of the four drought indicators accurately delineates specific facets of the meteorological drought ***,three representative drought events,namely flash drought,sustained drought and severe drought,

关键词： Meteorological drought Spatiotemporal prediction Multiscale Swim transformer Deep learning

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Effect of FeSi additive in dual-chamber sample cup on thermal analysis characteristic values and vermiculating rate of compacted graphite iron

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China Foundry 2024年第1期21卷 91-100页

作者： De-quan Shi ze-yu Liu Gui-li Gao Yi-cheng Feng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Chemical Engineering Harbin University of Science&TechnologyHarbin 150040China School of Mechanical and Energy Engineering Shanghai Technical Institute of Electronics and InformationShanghai 201411China

Thermal analysis plays a key role in the online inspection of molten iron *** solidification process of molten iron can be reflected by thermal analysis curves,and silicon is one of important elements affecting the solidification of molten *** this study,FeSi75 was added in one chamber of the dual-chamber sample cup,and the influences of FeSi75 additive on the characteristic values of thermal analysis curves and vermiculating rate were *** results show that with the increase of FeSi75,the start temperature of austenite formation TALfirstly decreases and then increases,but the start temperature of eutectic growth TSEF,the lowest eutectic temperature TEU,temperature at maximum eutectic reaction rate TEM,and highest eutectic temperature TERkeep always an *** temperature at final solidification point TEShas little *** FeSi75 additive has different influences on the vermiculating rate of molten iron with different vermiculation,and the vermiculating rate increases for lower vermiculation molten iron while decreases for higher *** to the thermal analysis curves obtained by a dual-chamber sample cup with 0.30wt.%FeSi75 additive in one chamber,the vermiculating rate of molten iron can be evaluated by comparing the characteristic values of these *** time differenceΔtERcorresponding to the highest eutectic temperature TERhas a closer relationship with the vermiculating rate,and a parabolic regression curve between the time differenceΔtERand vermiculating rateηhas been obtained within the range of 65%to 95%,which is suitable for the qualified melt.

关键词： FeSi75 additive characteristic value vermiculating rate thermal analysis compacted graphite iron

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