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[Advances in molecular networking technology for discovering emerging contaminants and transformation products]

Se pu = Chinese journal of chromatography 2025年第1期43卷 33-42页

作者： Xiao-Mei Tan yu-Wei Zhang Zhao-yu Jiao nan-yang yu Si Wei State Key Laboratory of Pollution Control & Resource Reuse School of Environment Nanjing University Nanjing 210046 China.

Emerging contaminants and their transformation products are widely distributed in the environment. These pollutants carry unknown risks owing to their persistence, migration, and toxicity. The wide variety and complex structures of these substances render them difficult to identify using only target analysis. Suspect screening analysis can identify more substances than target analysis in a single run. However, this analysis method is based on limited data and cannot meet the growing demand for compound identification, especially for emerging contaminants and their transformation products with unknown information. The development of high-resolution mass spectrometry technology has promoted the applications of nontarget analysis in the environmental field, especially for identifying unknown transformation products. At present, the challenges of nontarget analysis include the difficulty of finding compounds of interest and their transformation products from complex data. Molecular networking calculates the similarity between mass spectra based on an improved cosine similarity algorithm. This method can cluster molecular families with similar structures, achieve visualization and a collection of massive mass spectral datasets, and promote the annotation of pollutants through networks and communities. Molecular networking can globally organize and systematically interpret complex tandem mass spectral datasets, providing a new direction for nontarget analysis. This technology was first used in proteomics and gradually introduced into metabolomics for the discovery of new natural products. Recently, it has been introduced into the environmental field for the study of various man-made chemicals, particularly for the discovery of emerging contaminants and their transformation products. In this paper, we introduce a molecular networking analysis method based on high-resolution tandem mass spectrometry and describe its applications in the nontargeted screening of emerging cont

关键词： emerging contaminants high-resolution tandem mass spectrometry molecular networking transformation products

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Implementation of Dynamic Matrix Control on Field Programmable Gate Array

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Journal of Shanghai Jiaotong university(Science) 2011年第4期16卷 441-446页

作者：兰建李德伟杨楠席裕庚 Department of Automation Shanghai Jiaotong University Key Laboratory of System Control and Information ProcessingMinistry of Education

High performance computer is often required by model predictive control(MPC) systems due to the heavy online computation *** extend MPC to more application cases with low-cost computation facilities, the implementation of MPC controller on field programmable gate array(FPGA) system is *** the dynamic matrix control(DMC) algorithm,the main design idea and the implemental strategy of DMC controller are introduced based on a FPGA’s embedded *** performance tests show that both the computation efficiency and the accuracy of the proposed controller can be satisfied due to the parallel computing capability of FPGA.

关键词： model predictive control(MPC) dynamic matrix control(DMC) quadratic programming(QP) active set programmable logic device field programmable gate array(FPGA)

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng Gong yangping Zhuang Jiali Wu yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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公共图书馆职能管理与项目管理并行的难点与对策——以佛山市图书馆为例

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图书馆论坛 2017年第2期37卷 62-67页

作者：李楠杨玉麟谷秀洁西安科技大学图书馆西北大学公共管理学院西安工程大学图书馆

在梳理职能管理与项目管理各自运行模式的基础上,分析二者在公共图书馆管理过程中的差异性,认为职能管理与项目管理在并行环境下会出现一些难点。结合佛山市图书馆项目管理实践,总结出难点主要表现在组织结构、资源分配、评分机制、多... 详细信息

在梳理职能管理与项目管理各自运行模式的基础上,分析二者在公共图书馆管理过程中的差异性,认为职能管理与项目管理在并行环境下会出现一些难点。结合佛山市图书馆项目管理实践,总结出难点主要表现在组织结构、资源分配、评分机制、多重角色、部门协调等方面;针对难点提出对策。

关键词：公共图书馆项目管理职能管理佛山市图书馆

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脊柱侧凸特定运动疗法治疗轻度青少年特发性脊柱侧凸患者的疗效观察

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中华物理医学与康复杂志 2016年第12期38卷 927-932页

作者：周璇杜青梁菊萍陈楠杨晓颜于虹上海交通大学医学院附属新华医院康复医学科上海200092

目的探讨以脊柱侧凸特定运动疗法为核心的康复干预对轻度特发性脊柱侧凸患者的疗效。方法将30例轻度特发性脊柱侧凸患者分为观察组及康复治疗组。观察组患者给予常规健康宣教，康复治疗组患者给予脊柱侧凸特定运动疗法治疗，每周训练2—... 详细信息

目的探讨以脊柱侧凸特定运动疗法为核心的康复干预对轻度特发性脊柱侧凸患者的疗效。方法将30例轻度特发性脊柱侧凸患者分为观察组及康复治疗组。观察组患者给予常规健康宣教，康复治疗组患者给予脊柱侧凸特定运动疗法治疗，每周训练2—3次，每次治疗60min，共治疗12周。比较治疗前、后2组患者躯干旋转角度、冠状面Cobb角、椎体旋转角度、静态平衡功能（跌倒指数）、骨强度[包括桡骨远端声速（SOS）、Z值、百分位等指标]、竖脊肌表面肌电信号、肺功能[用力肺活量（FVC）、第一秒用力呼气量（FEV1）、用力肺活量占预计值百分比（FVC／Pred％）、第一秒用力呼气容积占预计值百分比（FEVlpred％）、用力呼气量占用力肺活量比值（FEV1／FVC％）]、生活质量改善情况等。结果与治疗前比较，观察组患者治疗后最大Cobb角显著增大（P〈O．01），治疗前、后躯干旋转角度、椎体旋转角度、跌倒指数、SOS、Z值、百分位、FVC、FEVl、FVCpred％、FEVlpred％、FEV1／FVC％及生活质量各维度得分差异均无统计学意义（P〈O．05），治疗前、后顶椎水平竖脊肌凹侧激活率均显著小于凸侧激活率（P〈O．01）。康复治疗组治疗前、后躯干旋转角、最大Cobb角、椎体旋转角度、跌倒指数差异均无统计学意义（P〉O．05），治疗后骨强度SOS、Z值、百分位、FVC、FEVl、功能活动维度得分均显著优于治疗前水平（P〈O．05），治疗前顶椎水平竖脊肌凹侧激活率小于凸侧（P〈0．05），治疗后双侧顶椎水平竖脊肌激活率间差异无统计学意义（P〉O．05）。结论早期进行以脊柱侧凸特定运动疗法为核心的康复治疗可阻止轻度青少年特发性脊柱侧凸患者侧凸畸形进展，提高骨强度，改善肺功能，减少双侧竖脊肌肌肉运动控制差异，提高患者生活质量，该疗法值得临床推广、应用。

关键词：青少年特发性脊柱侧凸轻度脊柱侧凸特定运动疗法康复

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Embedded reservoir and constructed wetland for drinking water source protection:Effects on nutrient removal and phytoplankton succession

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Journal of Environmental Sciences 2020年第1期32卷 260-271页

作者： Changtao yang Jing nan Huaiyong yu Jianhua Li College of Environmental Science and Engineering Tongji University

An embedded reservoir that provides an efficient nutrient removal system protects drinking ***,embedded reservoirs are rarely used in eutrophic shallow lakes because of their undetermined nutrient retention efficiency and unknown effects by the phytoplankton *** this study,we aim to investigate the nutrient retention and algae succession in an embedded reservoir and adjacent wetland from April 2017 to September 2018 in the eastern part of Lake Taihu,*** than 40%of total phosphorus(TP)and 45%of particulate phosphorous entering the reservoir were retained semiannually,and the highest TP removal efficiency was achieved in the reservoir during autumn with an average value of 53.3%±9.9%.The overall nitrogen retention efficiency(21.7%±37.8%)was lower than that of TP(41.8%±27.8%).Similar trends were obtained in the wetland *** important pathway for phosphorus removal is through particulate matter *** study revealed that nutrient retention mechanisms in the reservoir were primarily via macrophyte absorption,particulate substance sedimentation,and prolonged water residence ***,the phytoplankton biomass(Chl-a)in the reservoir decreased(from 48.0 to 25.2μg/L)and water transparency improved,due to the decreased P level and transformation of the phytoplankton group into simple structures with good ecological ***,the combination of embedded reservoir and constructed wetland ecosystem can be used successfully to protect surface *** results will be advantageous to groups seeking to preserve drinking water sources.

关键词： Drinking water source Eutrophication Embedded reservoir Constructed wetland Nutrient retention Phytoplankton succession

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High-fidelity numerical simulation of unsteady cavitating flow around a hydrofoil

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Journal of Hydrodynamics 2023年第1期35卷 1-16页

作者： nan Xie yu-meng Tang yang-wei Liu School of Energy and Power Engineering Beihang UniversityBeijing100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing100191China

Cavitation is a widespread and detrimental phenomenon in hydraulic machinery, therefore, it requires to be accurately predicted. In this study, large eddy simulation (LES), scale-adaptive simulation (SAS) and grid-adaptive simulation (GAS) are employed to investigate the unsteady cavitating flow around a NACA0009 hydrofoil. The prediction accuracy of GAS, SAS, both using the shear-stress transport (SST) k — ω model as baseline turbulence model, is validated by comparing with experimental and LES results. The cavity behaviors and turbulence fields are analyzed systematically. Results show that the GAS gives a more reasonable turbulent viscosity and accurately predicts the periodic evolution of typical vortical structures of cavitating flow, such as tip leakage vortex cavitation, tip separation vortex cavitation, leading-edge cavitation, and trailing-edge vortex. The time-averaged cavity volume, volume fluctuation amplitude, and characteristic frequencies of cavities predicted by the GAS are very closed to the LES, while the SAS fails to accurately capture these cavity characteristics. Furthermore, the local trace criterion is applied to extract the vortical structures and to analyze the swirling patterns of the tip leakage vortex. Multi-scale vortical structures in LES are well identified by local trace criterion. The prediction accuracy of the SAS method for small-scale vortical structures, such as the vortex shedding on the suction side and the vortex rope around the tip leakage vortex, is obviously insufficient, while the GAS has a higher accuracy in predicting vortex shedding. The tip leakage vortex and induced vortex extracted from GAS are also closer to that of LES in both swirling patterns and scale.

关键词： Tip leakage vortex cavitation leading-edge cavitation large eddy simulation(LES) grid-adaptive simulation scale-adaptive simulation

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基于PCIE接口的IPSec加速SoC设计

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计算机工程与设计 2017年第5期38卷 1212-1215,1257页

作者：杭彦希徐金甫南龙梅杨宇航王周闯信息工程大学河南郑州450001

为达到IPSec实现的高速性、灵活性以及安全性,设计一个IPSec加速SoC。引入高速PCIE接口突破主机与SoC通信速度瓶颈;采取多核设计技术和层次化存储结构,构建以交叉存储为主的高速数据交换区和以邮箱为主的引擎间状态通信区;采用指令级并... 详细信息

为达到IPSec实现的高速性、灵活性以及安全性,设计一个IPSec加速SoC。引入高速PCIE接口突破主机与SoC通信速度瓶颈;采取多核设计技术和层次化存储结构,构建以交叉存储为主的高速数据交换区和以邮箱为主的引擎间状态通信区;采用指令级并行和流水线并行技术,对IPSec协议中算法进行多核映射。实验结果表明,该SoC对于IPSec中典型分组密码算法AES的吞吐率可达1Gbps,对于认证算法SM3可达2Gbps,较好地满足了高速网络处理需求。

关键词： IPSec协议 SoC 高速多核 PCIE接口

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Open reading frame 3 protein of hepatitis E virus:Multi-function protein with endless potential

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World Journal of Gastroenterology 2021年第20期27卷 2458-2473页

作者： Yong-Lin yang yu-Chen nan Department of Infectious Diseases Taizhou People's HospitalThe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300Jiangsu ProvinceChina Department of General Practice Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Preventive Veterinary Medicine Northwest A&F UniversityYangling 712100Shaanxi ProvinceChina

Hepatitis E virus (HEV), a fecal-orally transmitted foodborne viral pathogen,causes acute hepatitis in humans and is responsible for hepatitis E outbreaksworldwide. Since the identification of HEV as a zoonotic agent, this virus has beenisolated from a variety of hosts with an ever-expanding host range. HEV-openreading frame (ORF) 3, the smallest ORF in HEV genomes, initially had beenperceived as an unremarkable HEV accessory protein. However, as novel HEVORF3function has been discovered that is related to the existence of a putativethird virion structural form, referred to as “quasi-enveloped” HEV particles, HEVis challenging the conventional virion structure-based classification scheme,which assigns all viruses to two groups, “enveloped” or “non-enveloped”. In thisreview, we systematically describe recent progress that has identified multiplepathogenic roles of HEV-ORF3, including roles in HEV virion release, biogenesisof quasi-enveloped virus, regulation of the host innate immune response, andinterference with host signaling pathways. In addition, implications of HEVORF3-associated quasi-enveloped virions are discussed to guide futuredevelopment of improved vaccines against zoonotic HEV infection.

关键词： Hepatitis E virus Zoonosis Quasi-enveloped virion Hepatitis E virus-open reading frame 3 Innate immunity

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高压下Fe_(2)S的相变及热力学性质的第一性原理研究

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原子与分子物理学报 2025年第5期42卷 102-107页

作者：余柏树焦亩鑫杨学楠曾召益重庆师范大学物理与电子工程学院重庆401331

本文采用基于密度泛函理论的赝势平面波方法研究了高压下Fe_(2)S的结构相变、弹性性质和热力学性质.计算表明,当压强增加到124±10 GPa时,Fe_(2)S(Co_(2)P型)的晶格常数发生了突变,轴向比c/a从1.20跃迁到1.35,向C37结构(Co_(2)Si型)转变... 详细信息

本文采用基于密度泛函理论的赝势平面波方法研究了高压下Fe_(2)S的结构相变、弹性性质和热力学性质.计算表明,当压强增加到124±10 GPa时,Fe_(2)S(Co_(2)P型)的晶格常数发生了突变,轴向比c/a从1.20跃迁到1.35,向C37结构(Co_(2)Si型)转变.弹性模量的计算结果也证实了Fe_(2)S的这一结构相变.根据弹性模量,获得了高压下Fe_(2)S的声速,相对于纯Fe,S元素提升了纵波声速.通过准谐德拜模型预测了200 GPa,2000 K范围内Fe_(2)S的热力学性质.

关键词：相变弹性性质热力学性质第一性原理

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