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Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

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Hepatoma Research 2020年第3期6卷 41-49页

作者： Takao Shimizu Kaoru Tsuchiya Masayuki Kurosaki Yutaka Yasui Sakura Kirino Keiya Watakabe Leona Osawa Mao Okada Wan Wang Mayu Higuchi Kenta Takaura Shun Kaneko Nobuharu Tamaki Hiroyuki Nakanishi Jun ltakura Yuka Takahashi Tadakazu Hisamatsu namiki lzumi Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan Department of Gastroenterology and Hepatology Kyorin University HospitalTokyo 180-8610Japan

Aim:The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma(HCC)that developed early after the eradication of hepatitis C virus(HCV)by direct-acting antiviral(DAA)***:This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year(DAA-SVR HCC).The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging,including diffusion-weighted imaging(DWI)and T2-weighted imaging(T2WI).For comparison,80 HCC patients with positive HCV RNA(HCV-positive HCC)were *** 42 patients where tumor biopsy was available,histological grade and radiologic findings were ***:The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC(DWI:100%vs.67.5%,P<0.001T2WI:92.6%vs.67.5%,P=0.01).HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC(DWI:69.7%vs.30.3%,P=0.02;T2WI:66.7%vs.27.3%,P=0.03).Conclusion:High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.

关键词： Hepatocellular carcinoma direct-acting antivirals sustained viral response contrast enhanced magnetic resonance imaging

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Prostate-specific antigen-based population screening for prostatecancer： current status in Japan and future perspective in Asia

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Asian Journal of Andrology 2015年第3期17卷 475-480页

作者： Yasuhide Kitagawa Mikio namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan

In Western countries, clinical trials on prostate cancer screening demonstrated a limited benefit for patient survival. In the Asia-Pacific region, including Japan, the rate of prostate-specific antigen （PSA） testing remains very low compared with Western countries, and the benefits of population-based screening remain unclear. This review describes the current status of population screening and diagnosis for prostate cancer in Japan and discusses the efficacy of population screening for the Asian population. Since the 1990s, screening systems have been administered by each municipal government in Japan, and decreases in the prostate cancer mortality rate are expected in some regions where the exposure rate to PSA screening has increased markedly. A population-based screening cohort revealed that the proportion of metastatic disease in cancer detected by screening gradually decreased according to the increased exposure rate, and a decreasing trend in the proportion of cancer with high serum PSA levels after population screening was started. The prognosis of the prostate cancer detected by population screening was demonstrated to be more favorable than those diagnosed outside of the population screening. Recent results in screening cohorts demonstrated the efficacy of PSA. These recent evidences regarding population-based screening in Japan may contribute to establishing the optimal prostate cancer screeninK system in Asian individuals.

关键词： free prostate-specific antigen pro-prostate-specific antigen prostate cancer prostate cancer gene 3 prostate-specificantigen-based population screening serum prostate-specific antigen distribution

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What is appropriate neoadjuvant/adjuvant androgen deprivation for high-risk/locally advanced prostate cancer？

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Asian Journal of Andrology 2011年第4期13卷 624-625页

作者： Mikio namiki Hiroyuki Konaka Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medica Science Ishikawa 920-8640 Japan

The majority of low-risk patients with clinically localized prostate cancer have a high likeliihood of disease-free survival, regardless of the treatment option chosen.

关键词： neoadjuvantladjuvant androgen deprivation prostate

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Origami Folding by Multifingered Hands with Motion Primitives

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Cyborg and Bionic Systems 2021年第1期2021卷 169-183页

作者： Akio namiki Shuichi Yokosawa Graduate School of Engineering Chiba UniversityChibaJapan

Origami,a traditional Japanese art,is an example of superior handwork produced by human *** such extreme dexterity is one of the goals of robotic *** the work described in this paper,we developed a new general-purpose robot system with sufficient capabilities for performing *** decomposed the complex folding motions into simple primitives and generated the overall motion as a combination of these ***,to measure the paper deformation in real-time,we built an estimator using a physical simulator and a depth *** a result,our experimental system achieved consecutive valley folds and a squash fold.

关键词： robot primitive system

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Peginterferon and ribavirin treatment for hepatitis C virus infection

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World Journal of Gastroenterology 2011年第4期17卷 419-432页

作者： Akihito Tsubota Kiyotaka Fujise Yoshihisa namiki Norio Tada Institute of Clinical Medicine and Research Jikei University School of Medicine

Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. This combination therapy has drastically improved the rate of sustained virological response, specifically in difficult-to-treat patients. Recently, individualized treatment, such as response-guided therapy, is being developed based on host-, HCV- and treatment-related factors. Furthermore, modified regimens with currently available medications, novel modified IFNα and ribavirin or combinations with specifically targeted antiviral therapy for HCV agents, are currently being investigated. The purpose of this review is to address some issues and epoch-making topics in the treatment of chronic HCV infection, and to discuss more optimal and highly individualized therapeutic strategies for HCV-infected patients.

关键词： Pegylated interferon α Ribavirin Chronic hepatitis C virus infection Difficult-to-treat patient Individualized treatment Response-guided therapy Specifically targeted antiviral therapy for hepatitis C virus

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Effectiveness and adverse effects of hormonal therapy for prostate cancer： Japanese experience and perspective

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Asian Journal of Andrology 2012年第3期14卷 451-457,I0007,I0008页

作者： Mikio namiki Satoru Ueno Yasuhide Kitagawa Takashi Fukagai Hideyuki Akaza Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan Research Center for Advanced Science and Technology University of Tokyo Tokyo 153-8903 Japan

Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will improve hormonal therapy. On the other hand, there has been an increase in criticism of hormonal therapy, because hormonal therapy is supposed to induce adverse effects such as cardiovascular disease. In this review, we have introduced the Japanese experience of hormonal therapy, because we believe that there may be ethnic differences between Caucasians and Asian people in the efficacy and adverse effects of hormonal therapy. First, we showed that primary hormonal therapy can achieve long-term control of localized prostate cancer in some cases and that quality of life of patients receiving hormonal therapy is rather better than previously thought. Neoadjuvant and adjuvant hormonal therapy in cases undergoing radical prostatectomy or radiotherapy are very useful for high-risk or locally advanced prostate cancer. Further clinical trials are required to confirm the efficacy of neoadjuvant or adjuvant hormonal therapy. We showed that the death from cardiovascular dis- eases in Japanese patients receiving hormonal therapy was not higher than that in the general population. However; efforts should be made to decrease the adverse effects of hormonal therapy, because life-style change may increase the susceptibility to adverse effects by hormonal therapy even in Japan. Managements of endocrine and metabolic dysfunction, such as diabetes mellitus, are essential. New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed.

关键词： adverse effects androgen deprivation therapy hormonal therapy prostate cancer

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Knockout of a rice K5.2 gene increases Ca accumulation in the grain

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Journal of Integrative Plant Biology 2024年第2期66卷 252-264页

作者： Peitong Wang Naoki Yamaji namiki Mitani-Ueno Jun Ge Jian Feng Ma National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China Institute of Plant Science and Resources Okayama UniversityKurashiki 710-0046Japan

Rice is a staple food for half of the world’s population,but it is a poor dietary source of calcium(Ca)due to the low *** is an important issue to boost Ca concentration in this grain to improve Ca deficiency risk,but the mechanisms underlying Ca accumulation are poorly ***,we obtained a rice(Oryza sativa)mutant with high shoot Ca *** mutant exhibited 26%-53% higher Ca in shoots than did wild-type rice(WT)at different Ca *** concentration in the xylem sap was 36% higher in the mutant than in the *** was no difference in agronomic traits between the WT and mutant,but the mutant showed 25% higher Ca in the polished grain compared with the ***-based cloning combined with a complementation test revealed that the mutant phenotype was caused by an 18-bp deletion of a gene,OsK5.2,belonging to the Shaker-like K+channel ***5.2 was highly expressed in the mature region of the roots and its expression in the roots was not affected by Ca levels,but upregulated by low *** showed that OsK5.2 was mainly expressed in the pericycle of the *** together,our results revealed a novel role for OsK5.2 in Ca translocation in rice,and will be a good target for Ca biofortification in rice.

关键词： accumulation biofortification calcium OsK5.2 pericycle rice translocation

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Recent Issues on Nonlinear Effects in Optical Fibers

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光学学报 2003年第S1期23卷 37-38页

作者： Takashi Inoue Osamu Aso Shu namiki FITEL Photonics Lab. Furukawa Electric Co. Ltd. 6 Yawata Kaigan Dori Ichihara Chiba 290-8555 JapanFITEL Photonics Lab. Furukawa Electric Co. Ltd. 6 Yawata Kaigan Dori Ichihara Chiba 290-8555 JapanFITEL Photonics Lab. Furukawa Electric Co. Ltd. 6 Yawata Kaigan Dori Ichihara Chiba 290-8555 Japan

This talk will discuss the types of optical signal degradation due to fiber nonlinearity and review recently invented fibers for suppressing the effects. It also introduces efficiency of highly nonlinear fibers and th... 详细信息

关键词： in high of that Recent Issues on Nonlinear Effects in Optical Fibers been for FWM XPM length on

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Efficacy of Japanese traditional(Kampo) medicine for treating chemotherapy-induced peripheral neuropathy: A retrospective case series study

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World Journal of Clinical Cases 2016年第10期4卷 310-317页

作者： Yumiko Kimata Keiko Ogawa Hideki Okamoto Atsushi Chino Takao namiki Department of Japanese-Oriental(Kampo)Medicine Chiba University School of Medicine Department of Japanese-Traditional(Kampo)Medicine Kanazawa University Hospital Department of Japanese-Oriental(Kampo)Medicine Chiba Central Medical Center

AIM To investigate Japanese traditional(Kampo) medicine's effectiveness on cancer chemotherapy-induced peripheral neuropathy(CIPN), we carried out this retrospective *** By searching our outpatient database of 3154 patients who consulted our outpatient clinic of Japanese-Oriental(Kampo) Medicine at Chiba University Hospital from November 2005 to December 2010, a total of 281 patients diagnosed with cancer were identified. Twentyfour patients out of the 281 patients identified met the following three conditions and were eligible for further investigation of the effectiveness of Kampo treatment: At least one course of cancer chemotherapy had been administered; numbness and pain appeared after the chemotherapy; and CIPN was diagnosed before they were given Kampo *** The 24 patients included 6 males and 18 females and ranged in age from 39 to 86(mean 61.2 ± 11.5) years old. Kampo formulas were individually chosen by Kampo expert doctors based on Kampo-specific diagnostics. Beneficial outcomes were obtained by Kampo treatment in 20 out of the 24 cases(83.3%). Nine out 20 cases had a major response(the numbness and pain showed improvement or reduction by 50% or more), with 7 of 9 cases showing a more than 70% symptom reduction. Eleven out of 20 cases showed a minor response(less than 50% symptom reduction), and 4 out of the 24 cases had no beneficial response. The most frequently used formula was goshajinkigan(GJG), followed by hachimijiogan(HJG) and keishibukuryogan. Thirteen of the 24 cases(54.2%) were prescribed aconite rootcontaining formulas including GJG and HJG. Aconite root has "warming" effects and ameliorates pain and numbness; 21 out of 24 cases(87.5%) in total used warming formulas such as aconite root-containing formulas to reduce *** Our current study suggested that Kampo formulas chosen based on Kampo-specific diagnostics could be for treating CIPN that is refractory to conventional medicine.

关键词： Asian medicine Traditional Chinese medicine Goshajinkigan Keishibukuryogan Hachimijiogan

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Vascular Cambium-Localized AtSPDT Mediates Xylem-to-Phloem Transfer of Phosphorus for Its Preferential Distribution in Arabidopsis

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Molecular Plant 2020年第1期13卷 99-111页

作者： Guangda Ding Gui Jie Lei Naoki Yamaji Kengo Yokosho namiki Mitani-Ueno Sheng Huang Jian Feng Ma institute of Plant Science and Resources Okayama UniversityChuo 2-20-1KurashikiJapan College of Resources and Environment Huazhong Agricultural UniversityWuhan 430070China

During plant growth and development mineral elements are preferentially delivered to different organs and tissues to meet the differential demand. It has been shown that the preferential distribution of mineral nutrients in gramineous plants is mediated by node-based transporters, but the mechanisms of preferential distribution in dicots are poorly understood. Here, we report a distinct mechanism for the preferential distribution of phosphorus (P) in Arabidopsis plants, revealed by detailed functional analysis of AtSPDT/AtSULTR3;4 (SULTR-like P Distribution Transporter), a homolog of rice OsSPDT. Like OsSPDT, AtSPDT is localized at the plasma membrane and showed proton-dependent transport activity for P. Interestingly, we found that AtSPDT is mainly expressed in the rosette basal region and leaf petiole, and its expression is up-regulated by P deficiency. Tissue-specific analysis showed that AtSPDT is mainly located in the vascular cambium of different organs, as well as in the parenchyma tissues of both xylem and phloem regions. Knockout of AtSPDT inhibited the growth of new leaves under low P due to decreased P distribution to those organs. The seed yields of the wild-type and atspdt mutant plants are similar, but the seeds of mutant plants contain – less P. These results indicate that AtSPDT localized in the vascular cambium is involved in preferential distribution of P to the developing tissues, through xylem-to-phloem transfer mainly at the rosette basal region and leaf petiole.

关键词： A rabidopsis thaliana phosphate transporter SPDT phosphorus distribution vascular cambium

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