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Journal of Materiomics 2018年第2期4卷 149-156页

作者： Eui-su Kim Ye Chan Kim Jungwoo Park Youngjun Kim sung-Hoon Kim Kwang Jin Kim Jonghwan suhr Youngkwan Lee Seong Hoon Lee Dae-Sik Kim Soo-Hyun Kim Ju-Ho Yun In-Kyung Park Jae-Do nam School of Chemical Engineering Department of Polymer Science and EngineeringSungkyunkwan UniversitySuwon16410Republic of Korea Department of Mechanical Engineering University of NevadaLas Vegas4505 S.Maryland ParkwayLas VegasNV89154United States Department of Energy Science Sungkyunkwan UniversitySuwon16410Republic of Korea Perceived Materials Research Team Hyundai Motor Group18280HwaseongRepublic of Korea Korea Institute of Science and Technology Seoul02792Republic of Korea Korea Automotive Technology Institute Cheonan31214Republic of Korea

Magnesium oxysulfate(MOS)whisker is considered as a promising inorganic material recently attracting a great attention for being used as a reinforcing filler for polymer composites due to high aspect ratio and extremely-low bulk *** this study,the MOS was treated with 3-methacryloyloxypropyl-trimethoxy silane(MPS)via sol-gel condensation reactions,which successfully allowed melt mixing with polypropylene(PP)up to 30 wt%of *** tensile strength at yield and modulus of the MOS/PP composites were substantially increased by 50.8%and 362%,respectively,when compared with the pristine *** a novel finding,the flame retardancy of MOS was proved by identifying water evolution at elevated temperatures giving out 9 wt%of water in 250-320℃and 14 wt%in 350-420℃in two *** work demonstrated that the MOS could be an excellent filler for PP not only increasing the mechanical properties in a great extent but also imposing flame retarding capability.

关键词： Magnesium oxysulfate surface modification Mechanical properties Flame retardant

Pin1 overexpression in colorectal cancer and its correlation with aberrant β-catenin expression

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World Journal of Gastroenterology 2005年第32期11卷 5006-5009页

作者： Chang-Jae Kim Yong-Gu Cho Yong-Gyu Park suk-Woo nam su-Young Kim sug-Hyung Lee nam-Jin Yoo Jung-Young Lee Won-Sang Park Young-Mok Yang Department of PathologyCollege of Medicine The Catholic University of KoreaSeoul 137-701South Korea Department of StatisticsCollege of Medicine The Catholic University of KoreaSeoul 137-701South Korea Genetic Laboratory of Premedical CourseKon-Kuk University College of Medicine Chung-JuSouth Korea

AIM： To investigate clinical significance of Pin1 and β-catenin expression in colorectal cancers and to demonstrate the relationship of their expression. METHODS： The role of Pin1 and β-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and correlation between Pin1 and β-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated. REsuLTS： Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and β-catenin. Overexpression of Pin1 and β-catenin protein was found in 23 （18.54%） and 50 （40.3%） of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and β-catenin protein expression. CONCLUSION： Overexpression of Pin1 and β-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of β-catenin.

关键词： Pin1, Immunohistochemisty β-catenin, survival

Changes in sugar Metabolism and Fruit Quality of Different Pear Cultivars During Cold Storage

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Transactions of Tianjin University 2019年第4期25卷 389-399页

作者： Yanan Zhao Jinhui Geng Ying Zhang Kyongil nam Zhaohui Xue Xiaohong Kou School of Chemical Engineering and Technology Tianjin UniversityTianjin 300354China College of Food Technology Han Dok Su Pyongyang Light Industry UniversityPyongyang 999093Democratic People’s Republic of Korea

This study evaluated the changes in sugar metabolism and fruit quality of diff erent pear cultivars during cold storage using seven major commercial pear cultivars belonging to diff erent Pyrus species, such as P. bretschneideri Rehd.("Huangguan,""Yali"), P. pyrifolia Nakai.("Wonhwang,""Hosui"), P. ussuriensis Maxim.("Jingbai,""Nanguo"), and P. communis L.("Bartlett"). The fi rmness, respiration rate, titratable acidity, total soluble solids, sugar content, and enzyme activity of the seven pear cultivars were investigated. SPSS was used for analyzing the signifi cance of diff erent indexes. Results showed that fructose was the dominant sugar, accounting for > 60% of total sugars, followed by glucose and sucrose. The respiration peak of almost all cultivars appeared within 60 days. The levels of fructose, glucose, sucrose, and total soluble solids increased within 90 days and then generally decreased. Acid invertase showed the highest activity among all pear cultivars, followed by neutral invertase, sucrose synthetase, and sucrose phosphate synthetase during storage.

关键词： Pear cultivar sugar metabolism Enzyme activity Quality change

Deubiquitination of BES1 by UBP12/UBP13 promotes brassinosteroid signaling and plant growth

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Plant Communications 2022年第5期3卷 171-185页

作者： su-Hyun Park Jin Seo Jeong Yu Zhou Nur Fatimah Binte Mustafa nam-Hai Chua Temasek Life Sciences Laboratory National University of Singapore1 Research LinkSingapore 117604Singapore Present address:Wilmar International Limited 28 Biopolis RoadSingapore 138568Singapore

As a key transcription factor in the brassinosteroid (BR) signaling pathway, the activity and expression ofBES1 (BRI1-EMS-suPPRESSOR 1) are stringently regulated. BES1 degradation is mediated by ubiquitinrelated 26S proteasomal and autophagy pathways, which attenuate and terminate BR signaling;however,the opposing deubiquitinases (DUBs) are still unknown. Here, we showed that the ubp12-2w/13-3 doublemutant phenocopies the BR-deficient dwarf mutant, suggesting that the two DUBs UBP12/UBP13 antagonize ubiquitin-mediated degradation to stabilize BES1. These two DUBs can trim tetraubiquitin with K46 and K63 linkages in vitro. UBP12/BES1 and UBP13/BES1 complexes are localized in bothcytosol and nuclei. UBP12/13 can deubiquitinate polyubiquitinated BES1 in vitro and in planta, andUBP12 interacts with and deubiquitinates both inactive, phosphorylated BES1 and active, dephosphorylated BES1 in vivo. UBP12 overexpression in BES1OE plants significantly enhances cell elongation in hypocotyls and petioles and increases the ratio of leaf length to width compared with BES1OE or UBP12OE *** elongation and etiolation result from elevated BES1 levels because BES1 degradation is retardedby UBP12 in darkness or in light with BR. Protein degradation inhibitor experiments show that the majorityof BES1 can be degraded by either the proteasomal or the autophagy pathway, but a minor BES1 fractionremains pathway specific. In conclusion, UBP12/UBP13 deubiquitinate BES1 to stabilize the latter as a positive regulator for BR responses.

关键词： UBP12 UBP13 BES1 deubiquitination brassinosteroid signaling

Mucoid Degeneration of Posterior Cruciate Ligament Leads to Roof Impingement with Anterior Cruciate Ligament: Case Report

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Open Journal of Orthopedics 2018年第2期8卷 46-50页

作者： su Chan Lee Kyung Won Choi Chang Hyun nam Seung Hyun Hwang Hye sun Ahn Joint & Arthritis Research Department of Orthopaedic Surgery Himchan Hospital Seoul Korea

Mucoid degeneration of cruciate ligament is rare cause of knee pain, however there are some cases causing pain and restriction of extension. A 60-year-old man came to our clinic complaining of pain in knee joint on full range of extension about 3 months ago. The range of motion (ROM) was a flexion contracture of 5 degree and a further flexion of 140 degree with pain aggravation by forced extension. Magnetic resonance imaging of the knee joint showed thickened posterior cruciate ligament (PCL) mucoid degeneration. Arthroscopic treatment consists of PCL reduction-plasty by debridement of yellowish material in the PCL fiber and reduces the volume of the hypertrophied PCL. Immediately after surgery, patient gain the full ROM without any symptom of impingement. Enlarged PCL can make impingement in femoral notch with anterior cruciate ligament (ACL). Then, Partial debulking surgery of PCL is an effective treatment to pain relief and restore ROM of knee.

关键词： Mucoid Degeneration Roof Impingement Posterior Cruciate Ligament Anterior Cruciate Ligament

Cyanidine-3-O-Galactoside Enriched <i>Aronia melanocarpa</i>Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells

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Food and Nutrition Sciences 2019年第2期10卷 128-147页

作者： su-Min Lim Jae In Jung nam Young Kim Jung-Shik Bae Hyun Sook Lee Eun Ji Kim Center for Efficacy Assessment and Development of Functional Foods and Drugs Hallym UniversityChuncheonRepublic of Korea R&D Center Wellfine Co.Ltd.ChuncheonRepublic of Korea Department of Food Science&Nutrition Dongseo UniversityBusanRepublic of Korea

Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.

关键词： Obesity Adipocyte Adipogenesis Lipogenesis Transcription Factor Adipocyte Protein 2

Treatment of Bone Defect with Modular Metal Augmentation Using a Downsized Block in Total Knee Arthroplasty: Technical Note and Report of 17 Cases

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Open Journal of Orthopedics 2016年第9期6卷 268-275页

作者： su Chan Lee Chang Hyun nam Seung Hyun Hwang Ji-Hoon Baek Soon Yong Yoo Hye sun Ahn Joint & Arthritis Research Department of Orthopaedic Surgery Himchan Hospital Seoul Korea

In total knee arthroplasty (TKA), a treatment of bone defect varies depending on the location and extent of defect and requires proper surgical procedure. Metal augmentation is readily available for both femoral and tibial bone defects. We report the operative technique of modular metal augmentation using a downsized block for ambiguous proximal tibial and distal femoral bone defects in primary and revision TKA. Regarding bone defects, bone loss can be minimized by using a different size of metal augmentation, and suitable reinforcement for bone defects can be achieved. Once our technique is properly used, it will be very helpful in treating bone defects.

关键词： Total Knee Arthroplasty Bone Defect Metal Augmentation

Photoproduction of the Θ^+ and its vector andaxial-vector structure

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Chinese Physics C 2009年第12期33卷 1279-1284页

作者： H.-Ch. Kim K. Goeke T. Ledwig S. i. nam Department of Physics Inha University Incheon 402-751 Republic of Korea Institut fr Theoretische Physik II Ruhr-Universitt Bochum D-44780 Bochum Germany Institut fr Kernphysik Universitt Mainz D-55099 Mainz Germany Department of Physics Chung-Yuan Christian University (CYCU)

We present recent investigations on the vector and axial-vector transitions of the baryon antidecuplet within the framework of the self-consistent su（3） chiral quark-soliton model, taking into account the 1/No rotational and linear mscorrections. The main contribution to the electric-like transition form factor comes from the wave-function corrections. This is a consequence of the generalized Ademollo-Gatto theorem. It is also found that in general the leading-order contributions are almost canceled by the rotational 1/No corrections. The results are summarized as follows： the vector and tensor K＇NO coupling constants, gK＊N= 0.74--0.87 and fk＊N =0.53--1.16, respectively, and F→KN = 0.71 MeV, based on the result of the KN coupling constant gKne =0.83. We also show the differential cross sections and beam asymmetries, based on the present results. We also discuss the connection of present results with the original work by Diakonov, Petrov, and Polyakov.

关键词： Baryon antidecuplet vector and axial-vector transition form factors chiral quark-soliton model,Photoproduction of the +

The Clinical Characteristics of Combined Deep Vein Thrombosis Prophylaxis of Rivaroxaban and Mechanical Therapy after Total Knee Replacement Arthroplasty

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Open Journal of Orthopedics 2013年第1期3卷 14-19页

作者： su Chan Lee Chang Hyun nam Hye sun Ahn Bo Hyun Hwang Jong Won Kim Ha Young Park Joint & Arthritis Research Department of Orthopaedic Surgery Himchan Hospital Seoul Korea.

Purpose: To investigate the clinical characteristics of combined prophylaxis of rivaroxaban (Xarelto?) and mechanical therapy (foot sole pump, antiembolism stocking) after total knee replacement arthroplasty, for prevention of deep vein thrombosis (DVT). Materials and Methods: The subjects of this study were 110 patients who underwent total knee replacement arthroplasty (TKA) between November 2011 and May 2012, and were prospectively evaluated. They consisted of 13 men (11.8%) and 97 women (88.2%) with the mean age of 68.7 years (±7.9). All of the patients received 10 mg of rivaroxaban once daily for 14 days from Day 1 postoperatively, and used an intermittent pneumatic compression (IPC) pump and compression stockings immediately after the operation. To determine the presence of postoperative DVT, clinical symptoms examination, D-dimer test, color Doppler ultrasound imaging were performed to analyze the risk factors of DVT events. Results: There were a total of 13 patients (11.8%) with DVT in the distal lower limbs among the entire 110 patients. At Day 4 after the operation, a statistically significant difference was seen only in femoral swelling of several clinical symptoms between DVT group and non-DVT group (p = 0.043). D-dimer tests showed no statistically significant difference between the two groups, however with the boundary value of 0.3 mg/L, diagnostic sensitivity, specificity, positive predictability and negative predictability were equivalent to 100%, 8.2%, 12.7% and 100%, respectively. There was no significant difference between the two groups in terms of well-known risk factors including age, gender, obesity, hypertension, diabetes, smoking, and anesthesia method, and no case of pulmonary embolism was observed. Conclusion: A combination of pharmacological therapy (rivaroxaban, Xarelto?) and mechanical therapy (foot sole pump system) after TKA is considered effective for DVT prevention.

关键词： Deep Vein Thrombosis Total Knee Replacement Arthroplasty Rivaroxaban

Comparison of Clinical Results in Deep Vein Thrombosis of Total Knee Arthroplasty with Rivaroxaban and Dalteparin Sodium

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Open Journal of Orthopedics 2015年第2期5卷 17-24页

作者： su Chan Lee Chang Hyun nam Hye sun Ahn Seung Hyun Hwang Nong Kyum Ahn Ha Young Park Joint & Arthritis Research Department of Orthopaedic Surgery Himchan Hospital Seoul Korea

This study was intended to investigate into the incidence rates of deep vein thrombosis (DVT) in patients who used prophylactic antithrombotic medications after total knee arthroplasty (TKA), and to compare clinical results in groups treated with Rivaroxaban versus Dalteparin sodium as prophylactic antithrombotic medications. This prospective study was performed in 300 patients who underwent TKA between November 2011 and December 2012. The prophylactic therapy was given to 150 patients in Rivaroxaban group and Dalteparin sodium group, respectively. In addition, intermittent compression pump and stocking were used in all the groups immediately after TKA. In order to determine the incidence of DVT, color Doppler ultrasonography, D-dimer, and clinical symptom examination were conducted. There were 17 cases (11.3%) of DVT in Rivaroxaban group and 18 cases (12.0%) of DVT in Dalteparin sodium group after TKA, and no significant difference was seen between both groups. Between patients with DVT and those without DVT after TKA at 4 days in both groups, there was a significant difference in the swelling indices. Moreover, a significant difference was observed in the evaluation of bruise. The early signs of DVT after TKA are unknown, however, some initial clinical signs such as swelling have been observed. After using the said prophylactic drugs, the lower incidence of DVT was seen, and there was no difference between the types of drugs. Pharmacological therapy (either Rivaroxaban or Dalteparin sodium) after TKA is considered effective for DVT prevention. There is also a need to consider constant monitoring of clinical symptoms.

关键词： Deep Vein Thrombosis Total Knee Arthroplasty Rivaroxaban Dalteparin Sodium