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World Journal of Gastroenterology 2021年第18期27卷 2193-2204页

作者： Chang Seok Ko nam Ryong Choi Byung Sik Kim Jeong Hwan Yook Min-Ju Kim Beom su Kim Department of surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been *** best anastomosis technique for LTG has not been *** To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled *** We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December *** and oncological outcomes were compared between groups using propensity score *** addition,we analyzed the risk factors associated with postoperative *** Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),Psurvival between *** analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early ***,age was associated with≥3 Clavien-Dindo classification and EJrelated *** Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and *** should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages.

关键词： Laparoscopic surgery Gastrectomy Anastomosis Stomach neoplasms Totally laparoscopic total gastrectomy

Pin1 overexpression in colorectal cancer and its correlation with aberrant β-catenin expression

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World Journal of Gastroenterology 2005年第32期11卷 5006-5009页

作者： Chang-Jae Kim Yong-Gu Cho Yong-Gyu Park suk-Woo nam su-Young Kim sug-Hyung Lee nam-Jin Yoo Jung-Young Lee Won-Sang Park Young-Mok Yang Department of PathologyCollege of Medicine The Catholic University of KoreaSeoul 137-701South Korea Department of StatisticsCollege of Medicine The Catholic University of KoreaSeoul 137-701South Korea Genetic Laboratory of Premedical CourseKon-Kuk University College of Medicine Chung-JuSouth Korea

AIM： To investigate clinical significance of Pin1 and β-catenin expression in colorectal cancers and to demonstrate the relationship of their expression. METHODS： The role of Pin1 and β-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and correlation between Pin1 and β-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated. REsuLTS： Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and β-catenin. Overexpression of Pin1 and β-catenin protein was found in 23 （18.54%） and 50 （40.3%） of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and β-catenin protein expression. CONCLUSION： Overexpression of Pin1 and β-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of β-catenin.

关键词： Pin1, Immunohistochemisty β-catenin, survival

Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

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World Journal of Gastroenterology 2013年第1期19卷 97-102页

作者： Goh Eun Chung nam Ju Heo Min Jung Park su Jin Chung Hae Yeon Kang Seung Joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL subjects after adjust

关键词： Helicobacter pylori Seropositivity Microalbuminuria Atherosclerosis Diabetes

Risk Evaluation and Development of Soil Quality Level of Cd and Pb using Biotic Ligand-Based Model in Former Smelter Area

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Risk Evaluation and Development of Soil Quality Level of Cd ...

Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation

2012年环境污染与大众健康学术会议

作者： Kyung Yang Jinsung An Eun Hea jho Boyoung Jeong Kyoungphile nam Department of Civil and Environmental Engineering Seoul National University Seoul Korea Korea Basic Science Institute Seoul Korea

ISBN: (纸本)9781618960108

In this study, the risk of Cd and Pb in a former smelter area was evaluated using the toxicity predicting tool based on the Biotic Ligand Model and the sensitivity of Vibrio fischeri. The evaluated toxicities show that all the areas on the site have high risks due to the presence of Cd in soil, while Pb in soil does not pose risk. The site specific soil quality levels （SQLs） of Cd and Pb were suggested based on the same tool, and compared with the Korean soil regulatory level. The suggested SQLs of Cd were much lower than the Korean soil regulatory level;while the suggested SQLs of Pb were higher than the regulatory level. The total concentrations of Cd or Pb in soil determined and the suggested SQLs were compared. At all areas of the site, the total concentration of Cd in soil exceeded the site specific SQL;however, for Pb, the risk pollution level exceeded 1 only for one sample among 51 samples. The huge difference of suggested SQLs and the present standards of Cd could be explained by the low sensitivity of V. fischeri for Cd.

关键词： Biotic ligand model cadmium lead risk pollution level

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Science Bulletin 2017年第13期62卷 943-949页

作者： Hee Jin Kim Bibi Ruqia Mi sung Kang su Bin Lim Ran Choi Ki Min nam Won Seok Seo Gaehang Lee Sang-Il Choi Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Department of Chemistry KAIST Department of Chemistry Mokpo National University Department of Chemistry Sogang University Korea Basic Science Institute(KBSI) and University of Science and Technology

Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical ***,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic *** we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt ***-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst.

关键词： Platinum Nanocube Shape-control Kinetic product Methanol oxidation

CREEP BEHAVIOR OF Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu ALLOY

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Acta Mechanica Solida Sinica 2008年第4期21卷 308-311页

作者： Ji Young Kim Kwang su Na Yong Duck Kim Ji Hui Kim Kwon Yeong Lee Ki nam Kim Seon Jin Kim Division of Advanced Materials Science and Engineering Hanyang University133-791Korea Technical Research Center Sheet Products Design TeamHyundai Steel CompanyKodae-RiSongak-MyeonDangjin-GunChungnam167-32Korea

Creep behavior of the Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu alloy sheet is investigated from 300℃ to 400℃ in the stress range from 50 MPa to 180 MPa along the rolling direction. The measured strain rates range from 8.8 × 10^-10 s^-1 to 4.7 × 10^-7 s^-1. The activation energies are estimated to assess the creep deformation mechanisms in this alloy. The strain rate is slightly different at low stress, while it shows a distinct difference at high stresses. Stress exponents of this alloy increase with increasing applied stress at all testing temperatures. It is concluded that the creep deformation of the Zr-1.5Nb-0.4Sn-0.1Fe-0. 1 Cu alloy is controlled by the diffusion creep at low stress region and by the climbing of dislocations at high stress region.

关键词： creep zirconium alloy nuclear cladding

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim sung Hyun Tag Eunjoo nam suji Ham sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee Young-su Yang Seung Eun Lee Yong Sik Kim Il-Joo Cho Kwang Pyo Kim su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Rapid delivery of Cas9 gene into the tomato cv.‘Heinz 1706’through an optimized Agrobacterium-mediated transformation procedure

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BIOCELL 2021年第1期45卷 199-215页

作者： BEEMNET MENGESHA KASSAHUN BEUM-CHANG KANG su-JI BAE YE JIN nam GRETEL FONSECA MUNDO GA-HUI KANG KYOUNGOOK KIM JEUNG-suL HAN Department of Horticulture Kyungpook National UniversityDaegu41566Korea Center for Genome Engineering Institute for Basic ScienceDaejeon34047Korea School of Water Energyand EnvironmentCranfield UniversityCranfieldMK430ALUK Institute of Agricultural Science and Technology Kyungpook National UniversityDaegu41566Korea

Solanum lycopersicum‘Heinz 1706’is a pioneer model cultivar for tomato research,whose whole genome sequence valuable for genomics studies is ***,a genetic transformation procedure for this cultivar has not yet been ***,various genome editing technologies such as transfection of clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)ribonucleoprotein complexes into cells are in the *** the Cas9-expressing genotype possessing a reference genome can simplify the verification of an off-target effect,resolve the economic cost of Cas9 endonuclease preparation,and avoid the complex assembly process together with single-guide RNA(sgRNA)in the transfection ***,this study was designed to generate Cas9-expressing‘Heinz 1706’lines by establishing an Agrobacterium tumefaciens-mediated transformation(ATMT)***,we report a rapid and reproducible transformation procedure for‘Heinz 1706’by finetuning various factors:*** strain,pre-culture and co-culture durations,a proper combination of phytohormones at each step,supplementation of acetosyringone,and shooting/rooting ***,through eluding subculture and simultaneously inducing shoot elongation and rooting from leaf cluster,we achieved a short duration of three months for recovering the transgenic plants expressing *** presence of the Cas9 gene and its stable expression were confirmed by PCR and qRT-PCR analyses,and the Cas9 gene integrated into the T_(0) plant genome was stably transmitted to T_(1) ***,we anticipate that our procedure appears to ease the conventional ATMT in‘Heinz 1706’,and the created Cas9-expressing‘Heinz 1706’lines are ultimately useful in gene editing via unilateral transfection of sgRNA into the protoplasts.

关键词： Transgenic plant Phytohormone Acetosyringone Gene editing

Changing trends and characteristics of peptic ulcer disease:A multicenter study from 2010 to 2019 in Korea

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World Journal of Gastroenterology 2023年第44期29卷 5882-5893页

作者： Yoon Jin Choi Tae Jun Kim Chang Seok Bang Yong Kang Lee Moon Won Lee su Youn nam Woon Geon Shin Seung In Seo Department of Internal Medicine National Cancer CenterGoyang-si 13620South Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chuncheon Sacred Heart HospitalChuncheon 24253South Korea Department of Internal Medicine National Health Insurance Service Ilsan HospitalGoyang-si 10444South Korea Department of Internal Medicine Pusan National University School of MedicineBusan 50463South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University Chilgok HospitalDaegu 41404South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul 05355South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon 24253South Korea Division of Gastroenterology Department of Internal MedicineKangdong Sacred Heart HospitalSeoul 05355South Korea

BACKGROUND The clinical trend and characteristics of peptic ulcer disease(PUD)have not fully been investigated in the past *** To evaluate the changing trends and characteristics of PUD according to age and METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and *** classified patients with PUD who underwent rapid urease tests or Helicobacter pylori(***)serology into three groups:***-related,drug[nonsteroidal anti-inflammatory drugs(NSAIDs)or aspirin]-related,and idiopathic(***/NSAID/aspirin-negative)PUD and compared the yearly trends and characteristics among the three *** We included 26785 patients in 7 databases,and the proportion of old age(≥65 years)was 38.8%.The overall number of PUD exhibited no decrease,whereas PUD in old age revealed an increasing trend(P=0.01 for trend).Of the 19601 patients,41.8%had ***-related,36.1%had drug-related,and 22.1%had idiopathic *** PUD exhibited a decreasing trend after 2014(P=0.01),drug-related PUD demonstrated an increasing trend(P=0.04),and idiopathic PUD showed an increasing trend in the old-age group(P=0.01)during 10 *** with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic *** idiopathic PUD group had a significantly higher number of patients with chronic liver *** With the aging population increase,the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced *** studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.

关键词： Peptic ulcer disease Drug Idiopathic Trend Characteristics

Characteristics of Algal succession Following Rock Scraping at Imwon Area in the East Coast of Korea

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Journal of Ocean University of China 2016年第6期15卷 1087-1093页

作者： Young Dae Kim Jung Kwan Alan Myung Mo nam Chu Lee Hyun Il Yoo su Yeoung Yeon Young Hwan Kim Jang Kyun Kim Jae suk Choi East Sea Fisheries Research Institute National Fisheries Research & Development Institute Gangneung 210-860Republic of Korea Korea National Park Service National Park Research Institute Yeosu 550-833 Republic of Korea Seaweed Research Center 1rational Fisheries Research & Development lnstituie Mokpo 530-831 Republic of Korea Department of Biology Chungbuk National University Chongju 361-763 Republic Of Korea Department of Marine Science School of Natural Sciences Incheon National University 22012 Yeonsu-gu Incheon Korea Department of Marine Sciences University of Connecticut 06901 Stamford Connecticut USA Division of Bioindustry Silla University Sasang-gu Busan 617-736 Republic of Korea

Abstract This study was conducted to clarify the characteristics high-pressure water sprayer in the period from June 2010 to April 2011 of algal succession following rock scraping using hoe or We divided the research area off the eastern coast of Korean near Imwon into 3 categories depending upon the severity of the barren ground, i.e., the urchin barren-affected, urchin bar- ren-ongoing and urchin barren-free areas. In April 2011, in the urchin barren-affected area with 25 seaweed species, the cover per- centage and importance value （IV） of erustose coralline algae were higher than those of other species. In the urchin barren-ongoing area with 33 seaweed species, crustose coralline algae （mean IV=62%） as well as Sargassum sp. （mean IV=28%）, and Gelidium amansii （mean IV= 19%） were observed following rock scraping. In the urchin barren-free area where seaweed communities were relatively abundant with 42 species, a variety of algal species including G. amansii （mean IV = 32%） underwent algal succession. Overall, it was observed that, as an aspect of algal succession, the weaker the barren ground severity was, the more frequent and di- verse the seaweeds were, and the more complex the succession pattern was in the study. As an aspect of recovering algal community, rock scraping using hoe was shown to be superior to the method using high-pressure water spraying. Therefore, we conclude that rock scraping using hoe is a very effective strategy for recovering the algal community in urchin barren-ongoing area.

关键词： algal succession sea-urchin barren ground rock scraping subtidal zone