检索结果-南通市图书馆

Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2077-2096页

作者： Cheng Qian Yueke Zhou Teng Zhang Guanglu Dong Mengyao Song Yu Tang Zhonghong Wei Suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.choi Juming Yan Chongjin Zhong Li Wan Jia Li Aiyun Wang Yin Lu Yang Zhao Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Centre for Inflammation Faculty of ScienceCentenary InstituteSchool of Life SciencesUniversity of Technology SydneySydney NSW 2050Australia Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Experimental Demonstration Center for Basic Medicine EducationXuzhou Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004China Department of General Surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Macquarie Medical School Faculty of MedicineHuman Health SciencesMacquarie UniversitySydney NSW 2109Australia

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor ***,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic *** was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to ***,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial *** importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent *** findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.

关键词： Salvianic acid A Tumor vascular normalization PKM2 β-Catenin Claudin-5 Endothelial glycolysis Tight junctions Doxorubicin

Osteotomy Protocol for Implant Insertion of One Day Biotech: One Drill, One Implant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2024年第5期14卷 255-277页

作者： Jin Hwan Kim Jaehyun Song Jaegyun choi Jose Francisco Ballester Ireh Kim Santiago Jose Ballester Private Practice Seul South Korea Private Practice Valencia Spain Seul South Korea

Background: Four factors determine the quality of an implantology kit: 1) Heat generated by the drills;2) Morphology of the osteotomy according to the diameter of the implant;3) Efficiency of collecting autologous bone;and 4) Osteotomy execution time. Materials and Methods: This article examines the heat produced by drills during osteotomy, focusing on the effect of the following factors: drilling technique;volume of autologous bone harvested;drilling time;implant primary stability;and the percentage of osseointegrated implants after primary healing. Discussion: The four factors mentioned above are analyzed based on the data obtained for sequential, biological, and One Drill milling techniques. Conclusions: 1) One Drill is the fastest technique for performing the osteotomy;2) All techniques stay within the biological temperature range of living bone, with the lowest increase in temperature achieved using One Drill with irrigation;3) The bone harvested showed no statistically significant differences between biological milling and the One Drill technique, both far superior to the sequential technique;and 4) There is no statistically significant difference in the number of osseointegrated implants among the three techniques analyzed.

关键词： Dental Implant Bur Primary Stability Drilling Time Osteotomy Irrigation Bone Collected

3D engineered tissue models for studying human-specific infectious viral diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第3期21卷 576-594页

作者： Kyeong Seob Hwang Eun U Seo Nakwon choi Jongbaeg Kim Hong nam Kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea

Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ *** on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin *** these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent *** infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is ***,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were ***,recent studies have shown that these models can recapitulate infection-associated *** this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral ***,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection ***,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection ***,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.

关键词： 3D engineered tissue model Infectious viral disease Infection route Pathology In vivo-mimicking

Automorphism groups of some algebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2009年第2期52卷 323-328页

作者： PARK Hong Goo LEE Jeongsig choi Seul Hee nam Ki-Bong Department of Mathematics Hanyang UniversitySeoul 133-791 Korea Department of General Studies and Education SamYuk University Cheongnyangi P.O.Box 118Seoul 130-650 Korea Department of Mathematics University of JeonjuChon-ju 560-759 Korea Department of Mathematics and Computer Sciences University of Wisconsin-WhitewaterWhitewater WI53190 USA

The automorphism groups of algebras are found in many papers. Using auto-invariance, we find the automorphism groups of the Laurent extension of the polynomial ring and the quantum n-plane (respectively, twisting polynomial ring) in this work. As an application of the results of this work, we can find the automorphism group of a twisting algebra. We define a generalized Weyl algebra and show that the generalized Weyl algebra is simple. We also find the automorphism group of a generalized Weyl algebra. We show that the generalized Weyl algebra Am,m+n is the universal enveloping algebra of the generalized Witt algebra W(m,m + n).

关键词： Laurent extension quantum n-plane (generalized) Weyl algebra automorphism auto-invariant 17B40 17B56

Predicting rock size distribution in mine blasting using various novel soft computing models based on meta-heuristics and machine learning algorithms

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第3期12卷 458-472页

作者： Chengyu Xie Hoang Nguyen Xuan-nam Bui Yosoon choi Jian Zhou Thao Nguyen-Trang School of Environment and Resources Xiangtan UniversityXiangtan 411105China Institute of Research and Development Duy Tan UniversityDa Nang 550000Viet Nam Department of Surface Mining Mining FacultyHanoi University of Mining and Geology18 Pho VienDuc Thang wardBac Tu Liem districtHanoi 100000Viet Nam Center for Mining Electro-Mechanical researchHanoi University of Mining and Geology18 Pho VienDuc Thang wardBac Tu Liem districtHanoi 100000Viet Nam Department of Energy Resources Engineering Pukyong National UniversityBusan 48513Republic of Korea School of Resources and Safety Engineering Central South UniversityChangsha 410083HunanChina Division of Computational Mathematics and Engineering Institute for Computational ScienceTon Duc Thang UniversityHo Chi Minh City 700000Viet Nam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh City 700000Viet Nam

Blasting is well-known as an effective method for fragmenting or moving rock in open-pit *** evaluate the quality of blasting,the size of rock distribution is used as a critical criterion in blasting operations.A high percentage of oversized rocks generated by blasting operations can lead to economic and environmental ***,this study proposed four novel intelligent models to predict the size of rock distribution in mine blasting in order to optimize blasting parameters,as well as the efficiency of blasting operation in open ***,a nature-inspired algorithm(i.e.,firefly algorithm-FFA)and different machine learning algorithms(i.e.,gradient boosting machine(GBM),support vector machine(SVM),Gaussian process(GP),and artificial neural network(ANN))were combined for this aim,abbreviated as FFA-GBM,FFA-SVM,FFA-GP,and FFA-ANN,***,predicted results from the abovementioned models were compared with each other using three statistical indicators(e.g.,mean absolute error,root-mean-squared error,and correlation coefficient)and color intensity *** developing and simulating the size of rock in blasting operations,136 blasting events with their images were collected and analyzed by the Split-Desktop *** which,111 events were randomly selected for the development and optimization of the ***,the remaining 25 blasting events were applied to confirm the accuracy of the proposed ***,blast design parameters were regarded as input variables to predict the size of rock in blasting ***,the obtained results revealed that the FFA is a robust optimization algorithm for estimating rock fragmentation in bench *** the models developed in this study,FFA-GBM provided the highest accuracy in predicting the size of fragmented *** other techniques(i.e.,FFA-SVM,FFA-GP,and FFA-ANN)yielded lower computational stability and ***,the FFA-GBM model can be used as a powerful

关键词： Mine blasting Rock fragmentation Artificial intelligence Hybrid model Gradient boosting machine Meta-heuristic algorithm

Cardiac metastasis from colorectal cancer:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第21期15卷 2675-2678页

作者： Pyong Wha choi Chul nam Kim Sun Hee Chang Woo Ik Chang Chang Young Kim Hyun Min choi Department of Surgery Ilsan Paik HospitalInje University College of Medicine Department of Diagnostic Pathology Ilsan Paik HospitalInje University College of Medicine Department of Chest Surgery Ilsan Paik HospitalInje University College of Medicine Department of Internal Medicine Ilsan Paik HospitalInje University College of Medicine

The heart is an unusual site of metastasis from any malignancy. We report a case of cardiac metastasis from colorectal cancer. A 70-year-old woman was referred with a presumptive diagnosis of sigmoid colon cancer with cardiac myxoma. Two-dimensional echocardiography showed a 4 cm x 4.5 cm mobile mass on the lateral right atrial wall, and computed tomography revealed a low attenuated Iobulating mass in the right atrium. The patient underwent anterior resection for sigmoid colon cancer （T4N2）. Thereafter, she experienced progressive shortness of breath. Therefore, a cardiac operation was performed 2 wk after the colorectal operation. Histological examination revealed adenocarcinoma, which was identical to the primary lesion. Although two- dimensional echocardiography has become the diagnostic test of choice for detecting cardiac tumors, in patients with colorectal cancer showing a cardiac mass, further diagnostic evaluation such as a magnetic resonance imaging might be necessary.

关键词： Heart Cardiac metastasis Colorectalcancer Atrial myxoma Magnetic resonance imaging

Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1556-1565页

作者： Hong Ju Lee Da Hee Jung nam Kwen Kim Hwa Kyoung Shin Byung Tae choi Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanRepublic of Korea Graduate Training Program of Korean Medicine for Healthy Aging Pusan National UniversityYangsanRepublic of Korea Department of Korean Ophthalmology Otolaryngology and DermatologySchool of Korean MedicinePusan National UniversityYangsanRepublic of Korea

Neural/glial antigen 2(NG2)-expressing cells has multipotent stem cell activity under cerebral *** study examined the effects of electroacupuncture(EA)therapy(2 Hz,1 or 3 mA,20 minutes)at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic *** stimulation alleviated motor deficits caused by ischemic stroke,and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control treatment with edaravone,a free radical *** properties of NG2-expressing cells were altered with 1 mA EA stimulation,enhancing their survival in perilesional brain tissue via reduction of tumor necrosis factor alpha *** stimulation robustly activated signaling pathways related to proliferation and survival of NG2-expressing cells and increased the expression of neurotrophic factors such as brain-derived neurotrophic factor,tumor growth factor beta,and neurotrophin *** the perilesional striatum,EA stimulation greatly increased the number of NG2-expressing cells double-positive for oligodendrocyte,endothelial cell,and microglia/macrophage markers(CC1,CD31,and CD68).EA therapy also greatly activated brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase kinase 3 beta *** results indicate that EA therapy may prevent functional loss at the perilesional site by enhancing survival and differentiation of NG2-expressing cells via the activation of brain-derived neurotrophic factor-induced signaling,subsequently ameliorating motor *** animal experiments were approved by the Animal Ethics Committee of Pusan National University(approval ***2019-2199 and PNU2019-2884)on April 8,2019 and June 19,2019.

关键词： brain-derived neurotrophic factor differentiation electroacupuncture motor function neural/glial antigen 2 perilesional striatum stroke survival

COVID-19 Stay-At-Home Orders and Older Adults’ Cognitive Health — United States, June 2018–February 2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2022年第45期4卷 1002-1006,I0003页

作者： nam Sun choi Tianzi Li Jingxiang Pan Selena Yue Jing Li Department of Population Health Sciences Weill Cornell Medical CollegeCornell UniversityNew YorkNYU.S. The Comparative Health Outcomes Policy and Economics(CHOICE)InstituteSchool of PharmacyUniversity of WashingtonSeattleWAU.S.

What is already known about this topic?Lack of social activities is known to negatively impact cognitive functioning and increase risk of cognitive impairment,including dementia,among older *** is added by this report?Coronavirus disease 2019(COVID-19)stay-at-home orders implemented in the *** during the pandemic were not found to negatively affect cognitive functioning of older *** are the implications for public health practice?There may have been no severe,unintended consequences of the COVID-19 stay-at-home orders in terms of their impact on cognitive functioning and risk of dementia among older adults,lending further support to use of such orders.

关键词： impairment consequences COV

Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2017年第13期62卷 943-949页

作者： Hee Jin Kim Bibi Ruqia Mi Sung Kang Su Bin Lim Ran choi Ki Min nam Won Seok Seo Gaehang Lee Sang-Il choi Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Department of Chemistry KAIST Department of Chemistry Mokpo National University Department of Chemistry Sogang University Korea Basic Science Institute(KBSI) and University of Science and Technology

Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical ***,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic *** we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt ***-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst.

关键词： Platinum Nanocube Shape-control Kinetic product Methanol oxidation