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Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： Jwa hoon kim Jeong Eun kim Yong Sang Hong Sun Young kim Kyu-pyo kim Ki Eun Choi Ji hoon Shin Tae Won kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

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Spatial and spectral measurement of laser-driven protons through radioactivation

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Nuclear Science and Techniques 2023年第12期34卷 30-39页

作者： Yin‑Ren Shou Xue‑Zhi Wu Gwang‑Eun Ahn Seung Yeon kim Seong hoon kim Hwang Woon Lee Jin Woo Yoon Jae Hee Sung Seong Ku Lee Xue‑Qing Yan Il Woo Choi Chang Hee nam Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea School of Physics Peking UniversityBeijing 100871China Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

The simultaneous measurement of the spatial profile and spectrum of laser-accelerated protons is important for further optimization of the beam qualities and *** report a detailed study regarding the underlying physics and regular procedure of such a measurement through the radioactivation of a stack composed of aluminum,copper,and CR-39 plates as well as radiochromic films(RCFs).After being radioactivated,the copper plates are placed on imaging plates(IPs)to detect the positrons emitted by the reaction products through contact *** spectrum and energy-dependent spatial profile of the protons are then obtained from the IPs and confirmed by the measured ones from the RCFs and CR-39 *** also discuss the detection range,influence of electrons,radiation safety,and spatial resolution of this ***,insights regarding the extension of the current method to online measurements and dynamic proton imaging are also provided.

关键词： Laser-driven proton acceleration Proton-induced nuclear reaction Radioactivation measurement Contact imaging

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Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： Jin Myung Park Chang Don Kang Ji Hyun kim Sang hoon Lee Seung-Joo nam Sung Chul Park Sung JoonLee Seungkoo Lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of *** are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal *** associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic *** SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed *** hemostasis could not be achieved,but surgical treatment was ***,we have presented a literature *** Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

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Occurrence and distribution of hydroxylated isoprenoid glycerol dialkyl glycerol tetraethers(OH-GDGTs) in the Han River system, South Korea

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Acta Geochimica 2017年第3期36卷 367-369页

作者： Sujin Kang Kyoung-hoon Shin Jung-Hyun kim Department of Marine Science and Convergence Technology Hanyang University Ansan Korea Korea Polar Research Institute 26 Songdomirae-ro Yeonsugu Incheon Korea

We investigated the occurrence and distribution of terrestrial-derived hydroxylated isoprenoid glycerol dialkyl glycerol tetraethers(OH-GDGTs) in the Han River system and their potential impact on the application of the ring index of OH-GDGTs(RI-OH) as a sea surface temperature(SST) proxy in the eastern Yellow Sea. Thereby, we analyzed various samples collected along the Han River and from its surrounding areas(South Korea, n = 34). The OHGDGTs were found in all samples investigated. OH-GDGT-0 was the dominant OH-GDGT component in the estuary and marine samples while OH-GDGT-2 was generally dominant in the soils, the lake sediments and the river suspended particulate matter(SPM). Our results thus suggests a possible warm bias of the RI-OH-derived summer SSTs in the coastal zone to which a large amount of terrestrial organic matter is being supplied. Further studies are necessary to better assess the applicability of the RI-OH proxy in the eastern Yellow Sea.

关键词： Hydroxylated isoprenoid glycerol dialkyl glycerol tetraethers(OH-GDGTs) Sea surface temperature(SST) Han river Yellow Sea

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gscaLCA in R: Fitting Fuzzy Clustering Analysis Incorporated with Generalized Structured Component Analysis

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Computer Modeling in Engineering & Sciences 2022年第9期132卷 801-822页

作者： Ji hoon Ryoo Seohee Park Seongeun kim Heungsun Hwang Department of Education College of Educational SciencesYonsei UniversitySeoul03722South Korea Psychometrics Department American Board of Internal MedicinePhiladelphia19016USA Department of Educational Research Methodology School of EducationUniversity of North Carolina at GreensboroGreensboro27412USA Department of Psychology McGill UniversityMontrealH3A 0G4Canada

Clustering analysis identifying unknown heterogenous subgroups of a population(or a sample)has become increasingly popular along with the popularity of machine learning *** there are many software packages running clustering analysis,there is a lack of packages conducting clustering analysis within a structural equation modeling *** package,gscaLCA which is implemented in the R statistical computing environment,was developed for conducting clustering analysis and has been extended to a latent variable *** specifically,by applying both fuzzy clustering(FC)algorithm and generalized structured component analysis(GSCA),the package gscaLCA computes membership prevalence and item response probabilities as posterior probabilities,which is applicable in mixture modeling such as latent class analysis in *** a hybrid model between data clustering in classifications and model-based mixture modeling approach,fuzzy clusterwise GSCA,denoted as gscaLCA,encompasses many advantages from both methods:(1)soft partitioning from FC and(2)efficiency in estimating model parameters with bootstrap method via resolution of global optimization problem from *** main function,gscaLCA,works for both binary and ordered categorical *** addition,gscaLCA can be used for latent class regression as *** of profiles of latent classes based on the posterior probabilities is also available in the package *** paper contributes to providing a methodological tool,gscaLCA that applied researchers such as social scientists and medical researchers can apply clustering analysis in their research.

关键词： Fuzzy clustering generalized structured component analysis gscaLCA latent class analysis

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Experimental and Modeling Studies on the Chemical Vapor Infiltration with Respect to the Effects of Thermal Gradient and Other Operating Parameters

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Journal of Wuhan University of Technology(Materials Science) 2018年第3期33卷 525-532页

作者： Kyung Do Joo Do hoon kim Gui Yung Chung Department of Chemical Engineering Hong Ik University

Effects of operating parameters in the thermal gradient chemical vapor infiltration of propane such as thermal gradient, diffusion, infiltrations time, and concentration of propane were studied by focusing on the visualizations of the intrinsic effects of these parameters. A uniform deposition in the preform was obtained with a gradually increasing temperature along the gas flow. The uniformity of deposition through the preform got improved with increasing deposition time. Results of numerical modeling estimated the experimental data very well when the pre-exponential factor of the overall rate of carbon deposition from propane reported by Vaidyaraman[1] was multiplied by 4. The average density of a preform increased by about 3 times from 0.38 to 1.15 g/cm3 after 60 hr deposition with a thermal gradient under the conditions of 3% propane in nitrogen and 840 to 900 ℃.

关键词： TG-CVI propane C/C composites uniform deposition mathematical modeling

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Characteristics of radiation and convection heat transfer in indirect near-infrared-ray heating chamber

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Journal of Central South University 2011年第3期18卷 731-738页

作者： CHOI hoon-ki YOO Geun-jong kim Churl-hwan School of Mechatronics Changwon National University

Numerical study was performed to evaluate the characteristics of combined heat transfer of radiation, conduction and convection in indirect near infrared ray （N/R） heating chamber. The effects of important design parameters such as the shape of heat absorbing cylinder and heat releasing fin on the pressure drop and heat transfer coefficient were analyzed with different Reynolds numbers. The Reynolds numbers were varied from 103 to 3x106, which was defined based on the hydraulic diameter of the heat absorbing cylinder. Analyses were performed to obtain the inner and outer flow and the temperature distributions in the heat absorbing cylinder and the rates of radiation heat transfer and convection heat transfer. As the Reynolds number increases, the convection heat transfer rate is increased while the radiation heat transfer rate is decreased. The average convection heat transfer rate follows a power rule of the Reynolds number. Addition of three-dimensional heat releasing fin to the outside of the heat absorbing cylinder enhances the convection heat transfer.

关键词： near infrared ray indirect near infrared ray heater absorbing cylinder heat releasing fin radiation heat transfer convection heat transfer Reynolds number

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Variations in microstructure and bending formability of extruded Mg–Al–Zn–Ca–Y–MM alloy with precompression and subsequent annealing treatment conditions

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Journal of Magnesium and Alloys 2022年第9期10卷 2475-2490页

作者： Jong Un Lee Sang-hoon kim Dong Hee Lee Hyun Ji kim Young Min kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study, the bending formability of an extruded Mg–9Al–1Zn–0.3Mn–0.9Ca–0.6Y–0.5 MM(AZXWMM91100, wt%) alloy at room temperature is significantly improved through application of a combined precompression and subsequent annealing(PCA) treatment. As the amount of precompression applied along the extrusion direction(ED)(i.e., the total strain) increases from 4% to 6%, the area fraction of ED-oriented grains of the PCA-treated alloy increases, which consequently causes an improvement in its bending formability because these grains accommodate larger tensile strain along the ED during bending. As the temperature of the subsequent annealing treatment increases from 350 ℃ to 450 ℃, both the area fraction of the ED-oriented grains and the average grain size increase, and the residual dislocation density decreases owing to the promotion of boundary migration and occurrence of the recovery process at higher ***, the bending formability of both the 4%-precompressed and the 6%-precompressed samples increases with an increase in the annealing temperature. However, when the precompressed samples are annealed at 300 ℃, their bending formability is lower than that of the extruded alloy because the dislocations formed by precompression remain even after the subsequent annealing at this temperature.

关键词： Magnesium Extrusion Bending Formability Texture

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Direct dynamic-simulation approach to trajectory optimization

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Chinese Journal of Aeronautics 2021年第10期34卷 6-19页

作者： Sung Wook HUR Seong Han LEE Yong Hyeon nam Chang-Joo kim Department of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea

This paper proposes a new direct method for an efficient trajectory optimization using the point that the dynamics of a deterministic system are uniquely determined by initial states and controls imposed over the time horizon of *** effectively implement this concept,the Hermite spline is adopted to interpolate the continuous controls and the system dynamics are integrated with corresponding control parameters in *** a result,the optimal control problem can be transcribed into a nonlinear programming problem which has no dynamic equality constraints and no intermediate states in its design *** addition,the paper proposes an efficient recursive Jacobian estimation technique and introduces a Jacobian transformation matrix to straightforwardly handle the general state *** properties of the present method are thoroughly investigated through its applications to the trajectory optimization for a soft lunar landing from a parking orbit,including the detailed analyses for the de-orbiting *** computed results are compared with those using the pseudo-spectral method to demonstrate an extreme outperformance of the proposed method in the aerospace applications over the traditional direct method.

关键词： Trajectory optimization Direct method Hermite spline interpolation Pseudo-spectral integrator Soft lunar landing

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Preparation of Highly Crystalline Graphitic Nanocarbon for the Electro-Oxidation of Methanol

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Nano Research 2011年第1期4卷 92-102页

作者： Ji Bong Joo nam Dong kim Hyeong Jin Yun Pil kim Jongheop Yi World Class University （WCU） program of Chemical Convergence for Energy ＆ Environment （C2E2） School of Chemical and Biological Engineering Seoul National University Shinlim-dong Kwanak-ku Seoul 151-742 Republic of Korea School of Environmental and Chemical Engineering Specialized Graduate School of Hydrogen and Fuel Cell Engineering Chonbuk National University Jeonju 561-756 Republic of Korea

Highly crystalline graphitic nanocarbons （GNC） have been prepared by the wet-air treatment of hydrothermally- derived graphitic porous carbon. The materials were characterized by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, and electrochemical methods. The experimental results revealed that the treatment temperature has a significant effect on the morphology and degree of graphitic crystallinity. When GNC was treated at 450 ~C under a wet-air atmosphere, the product （GNC-450） consisted of aggregates of silkworm-shaped carbon nanoparticles with enhanced graphitic characteristics. GNC-450 was evaluated as a catalyst support in the electro-oxidation of methanol. The Pt/GNC-450 catalyst contained smaller Pt particles and had a higher electrochemically active surface area than a commercial carbon black-supported Pt catalyst. In the electro-oxidation of methanol, the Pt/GNC-450 catalyst showed the highest performance among the Pt catalysts examined in this study. The superior catalytic performance appears to be closely related to the enhanced graphitic characteristics with highly dispersed Pt nanoparticles on the graphitic layers, which have a positive effect on the electrochemical performance.

关键词： Graphitic nanostructured carbon wet-air treatment enhanced crystallinity Pt catalyst

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