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Berberine inhibits inflammatory activation of rat brain microglia

Neural Regeneration Research 2010年第18期5卷 1384-1390页

作者： Kyong Nyon nam Jae-Hong kim Hoon-Ji Jung Jung-Mi Park Sang-Kwan Moon Young-Suk kim Sun Yeou kim Eunjoo H. Lee Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental MedicineKyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Berberine, the effective ingredient of Coptidis Rhizoma and Cortex Phellodendti, has a wide range of pharmacological functions, including anti-inflammatory, anti-atherosclerotic and anti-cancer effects. The neuroprotective potential of berberine has previously been demonstrated. The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases. Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide （LPS）. Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation. Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS. It also reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, and intracellular reactive oxygen species and nuclear factor-kappa activation. Additionally, berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β. These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

关键词： brain inflammation berberine interleukin-1β microglia nuclear factor-kappa nitric oxide prostaglandin tumor necrosis factor-a

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Hemodynamic instability following intravenous dexmedetomidine infusion for sedation under brachial plexus block: Two case reports

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World Journal of Clinical Cases 2023年第30期11卷 7469-7474页

作者： Ye Sull kim Chanhong Lee Jeongmin Oh Seonhwa nam A Ram Doo Department of Anesthesiology and Pain Medicine Jeonbuk National University HospitalJeonju 54907South Korea Department of Anesthesiology and Pain Medicine Jeonbuk National University Medical School and HospitalJeonju 54907South Korea Department of Anesthesiology and Pain Medicine Research Institute of Clinical Medicine-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Dexmedetomidine(DMED)is frequently used as a sedative in several medical *** benefits of DMED include enhanced quality of regional anesthesia,prolonged analgesia,and postoperative opioid-sparing when administered intravenously or perineurally in combination with regional *** hemodynamic complications,such as profound bradycardia and hypotension,can occur after DMED administration in critically ill patients or overdosage;however,there are few reports of complications with DMED administration following brachial plexus block(BPB).CASE SUMMARY We present two cases of hemodynamic instability that occurred following the initial loading of DMED under supraclavicular BPB.A healthy 29-year-old man without any medical history showed profound bradycardia after receiving a loading dose of DMED 0.9μg/kg for 9 *** administration was promptly stopped,and after receiving a second dose of atropine,the heart rate recovered.A 62-year-old woman with a history of cardiomyopathy became hypotensive abruptly,requiring the administration of inotrope and vasopressors after receiving a reduced loading dose of 0.5μg/kg for 10 *** of the recommended loading dose of DMED was administered due to the underlying heart ***-sed blood pressure was maintained despite the intravenous administration of *** continuous infusion of dopamine and norepinephrine,the vital signs were maintained within normal *** and vasopressor support was required for over 6 h after the initial loading dose of *** DMED administration following BPB could trigger hemodynamic instability in patients with decreased cardiac function as well as in healthy individuals.

关键词： Dexmedetomidine Brachial plexus block Profound bradycardia Complication Hypotension Instability Case report

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Dependence of porosity,charge recombination kinetics and photovoltaic performance on annealing condition of TiO2 films

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Frontiers of Optoelectronics 2011年第1期4卷 59-64页

作者： Chang-Ryul LEE Hui-Seon kim nam-Gyu PARK School of Chemical Engineering Department of Energy Science Sungkyunkwan University

Effect of annealing temperature, time of nanocrystalline TiO2film on porosity, electron transport/recombination and photovoltaic performance on dyesensitized solar cell（DSSC） had been investigated in this article. Photocurrent density was slightly higher as annealing at 550°C compared to those of annealing at 450°C and 500°C under the given annealing time of 60 min, which was correlated with the amount of adsorbed dye. Thermogravimetric analysis showed there was a more weight loss between 500°C and 550°C, which revealed there were more sites for dye adsorption. Given the annealing temperature of 550°C, as annealing time varied from 60 to 90 and 120 min, results showed that the average size of pore and surface area decreased with longer annealing time, which deteriorated photocurrent density due to less dye loading. Electron diffusion rate remained almost unchanged regardless of annealing ***, electron recombination was influenced by annealing condition, it became slower with the increase of the annealing temperature under the given annealing time. In the contray, the electron recombination developed faster for the longer annealing time at a given annealing temperature. These results suggested that heat treatment of TiO2film at 550°C for 60 min in air would be the optimal annealing condition to achieve high efficiency DSSC.

关键词： dye-sensitized solar cell (DSSC) annealing conditions surface area porosity electron life time

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Biopeptides of Pyropia yezoensis and their potential health benefits: A review

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 375-384页

作者： Sivakumar Allur Subramaniyan Naziya Begum Sung Jae kim Youn Hee Choi Taek-Jeong nam Institute of Fisheries Sciences Pukyong National UniversityBusan 46041South Korea Department of Chemistry College of Natural and computational sciencesDebre Berhan UniversityDebye BerhanP.O.Box-445 Ethiopia Department of Orthopaedic Surgery Dongtan Sacred Heart HospitalHallym University College of MedicineHwaseongRepublic of Korea Department of Marine Bio-Materials&Aquaculture Pukyong National UniversityBusan 48513South Korea

Pyropia yezoensis(***)is a popular species of red algae that are commercially cultivated and consumed in East Asia,China,Japan,and *** high protein content of *** provides a source of multiple bioactive peptides exhibiting antioxidant,anti-inflammatory,antihypertensive,anticancer,tissue healing,immunomodulatory,and anticoagulant ***,many other biologically active substances in ***,including carbohydrates,lipids,dietary fibers,and polyphenols,have shown potential health benefits and are important in both the food and agriculture *** review provides a detailed summary of researches over the last decade on the biological and medicinal properties of bioactive *** information was extracted from various electronic resources,including Google Scholar,PubMed,MEDLINE,and Google Patents.

关键词： Red algae Pyropia Bioactive peptides Human health

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Tailoring of Mechanical Properties of Indirect Hot Stamping Steel Tubes by Laser Assisted Local Rapid Heating

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Journal of Iron and Steel Research International 2016年第9期23卷 949-954页

作者： Mahmudun Nabi CHOWDHURY Ju-ri kim Sung-tae HONG Jin-wook JUNG Heung-nam HAN Sang-woo SO Schoolof Mechanical Engineering University of Ulsan Ulsan44610 South Korea Department of Materials Science & Engineering and Centre for Iron & Steel Research RIAM Seoul National University Seoul 08826 South Korea Automotive Parts Institute & Centre Ulsan Technopark Ulsan 44412 South Korea

The effect of laser assisted local heating on the mechanical properties of a hot stamping steel tube was in vestigated. A heated region with a spiral shape was generated on the surface of the tube by combining the linear movement of the laser and the rotation of the tube. The results of axial crush tests show that the laser assisted local heating can be effectively used to modify the mechanical performance of the tube. A microstructural analysis confirms that the laser locally induces a martensitic phase transformation in the heated region and results in inhomogeneous microstructures alon- the length of the tube.

关键词： local heating laser hot stamping steel tube

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Brain physiome:A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

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Bioactive Materials 2022年第7期7卷 135-148页

作者： Yoojin Seo Seokyoung Bang Jeongtae Son Dongsup kim Yong Jeong Pilnam kim Jihun Yang Joon-Ho Eom Nakwon Choi Hong nam kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Next&Bio Inc. Seoul02841Republic of Korea Medical Device Research Division National Institute of Food and Drug Safety EvaluationCheongju28159Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea

In the last few decades,adverse reactions to pharmaceuticals have been evaluated using 2D in vitro models and animal ***,with increasing computational power,and as the key drivers of cellular behavior have been identified,in silico models have *** models are time-efficient and cost-effective,but the prediction of adverse reactions to unknown drugs using these models requires relevant experimental ***,the physiome concept has emerged to bridge experimental datasets with in silico *** brain physiome describes the systemic interactions of its components,which are organized into a multilevel *** of the limitations in obtaining experimental data corresponding to each physiome component from 2D in vitro models and animal models,3D in vitro brain models,including brain organoids and brain-on-a-chip,have been *** this review,we present the concept of the brain physiome and its hierarchical organization,including cell-and tissue-level *** also summarize recently developed 3D in vitro brain models and link them with the elements of the brain physiome as a guideline for dataset *** connection between in vitro 3D brain models and in silico modeling will lead to the establishment of cost-effective and time-efficient in silico models for the prediction of the safety of unknown drugs.

关键词： Brain physiome In vitro 3D platform Brain organoid Brain-on-a-chip In silico model

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How Do Phytochromes Transmit the Light Quality Information to the Circadian Clock in Arabidopsis？

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Molecular Plant 2014年第11期7卷 1701-1704页

作者： Miii Yeom Hyunmin kim Junhyun Lim Ah- Young Shin Sunghyun Hong Jeong-II kim Hong Gil nam Division of Molecular and Life Sciences PohangUniversity of Science and Technology Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Integrative Biosciences & Biotechnology in POSTECH Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Department of Molecular Biotechnology and Kumho Life Science Laboratory Chonnam National University Gwangju 500-757 Republic of Korea Center for Plant Aging Research Institute for Basic Science Daegu 711-873 Republic of Korea Department of New Biology DGIST Hyeongpoong-Myun Dalsung-gun Daegu 711-873 Republic of Korea

Dear Editor, Plants use light as an environmental signal to coor- dinate diverse physiological and developmental processes, thereby increasing their fitness. Light quality, quantity, and photoperiod change periodically under natural condi- tions of daily and seasonal cycles. Plants have developed a circadian clock to respond to these predictable, periodic environmental changes, providing plants with the ability to anticipate daily and seasonal environmental changes.

关键词： STABILITY PROTEIN COP1

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Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

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Nano Research 2018年第7期11卷 3582-3592页

作者： Bong Geun Cha Han-Gil Jeong Dong-Wan Kang Myong-Joo nam Chi kyung kim Do Yeon kim In-Young Choi Seul Ki Ki Song I kim Ju hee Han Jaeyun kim Seung-Hoon Lee School of Chemical Engineering Sungkyunkwan University Suwon 16419 Republic of Korea Department of Laboratory of Innovative Nanobiotechnology Biomedical Research Institute Seoul National University Hospital 101 Daehak-ra Jongno-gu Seou103080 Republic of Korea Department of Neurology Seoul National University Hospital 101 Daehak-ro Jongno-gu Seou103080 Republic of Korea Department of Neurology Korea University Guro Hospital and Korea University College of Medicine Seoul 08308 Republic of Korea Department of Health Sdences and Technology Samsung Advanced Institute for Health Science & Technology (SAIHST) Sungkyunkwan University Suwon 16419 Republic of Korea Biomedical Institute for Convergence at SKKU (BICS) Sungkyunkwan University Suwon 16419 Republic of Korea

Intracerebral hemorrhage （ICH）, caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles （CeNPs）, abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanopartide-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebraUy injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH.

关键词： magnetic mesoporous silica nanoparticle ceria nanoparticles intracerebral hemorrhage reactive oxygen species therapeutics imaging

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4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions

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Food Science and Human Wellness 2023年第4期12卷 1287-1299页

作者： Sujin Park YoonA kim Jaewang Lee Hyunsoo Seo Sang-Jip nam Dong-Gyu Jo Dong-Hoon Hyun Department of Life Science Ewha Womans UniversitySeoul 03760South Korea Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419South Korea

Many approaches to neurodegenerative diseases that focus on amyloid-βclearance and gene therapy have not been *** therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases,including mitochondrial *** membrane(PM)redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial *** phytochemicals are known to induce the expression of detoxifying enzymes under stress *** this study,mechanisms of neuroprotective effects of 4-hydroxycinnamic acid(HCA)were examined by analyzing cell survival,levels of abnormal proteins,and mitochondrial functions in two different neuronal *** protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD^(+)/NADH *** cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the *** increased the mitochondrial complexes I and II activities and ATP ***,HCA increased mitochondrial fusion and decreased mitochondrial ***,HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress *** findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

关键词： NADH-quinone oxidoreductase 1(NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions

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Cr/nanodiamond composite plating with cobalt cation additive

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中国有色金属学会会刊：英文版 2009年第4期19卷 975-978页

作者： Viet-Hue NGUYEN Thi-nam HOANG Ngoc-Phong NGUYEN Sik-Chol KWON Man kim Joo-Yul LEE Institute of Materials Science Korea Institute of Materials Science

The effect of cationic additive on Cr/nanodiamond plating was *** plating was performed in Sargent *** of deposit was observed by scanning electron microscope(SEM);microhardness by hardness tester;wear rate by tribometer;amount of diamond in deposit by combustion method and passivity by potentiodynamic *** results show that in the presence of cobalt cation,the amount of nanodiamond particle in the deposit is *** increasing diamond particle amount,the metallurgical,mechanical and electrochemical properties of Cr/nanodiamond deposit are ***,this improvement seems to be *** the presence of 10 g/L of nanodiamond powder and 2.5 g/L of cobalt cation in the bath,the amount of diamond particle in deposit is increased by 4 times;and wear rate of Cr-Co/nanodiamond deposit is decreased by 2-3 times as compared with pure Cr/*** passive current of Cr-Co/nanodiamond composite deposit is decreased from 18 to 8 μ*** morphology of Cr/nanodiamond is smooth remarkably in the presence of cobalt cation.

关键词：纳米金刚石粉复合镀层钴离子镀铬添加剂金刚石颗粒扫描电子显微镜形态观察

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