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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

World Journal of Gastroenterology 2012年第40期18卷 5771-5778页

作者： Hyun Jung Lee Youn nam kim Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il kim Won Ho kim Chung Mo nam Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April *** also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with *** endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was *** determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were ***:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the *** endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ***,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD *** with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the ***:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD ***,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词： Intestinal Behcet's disease Disease activityindex Colonoscopy Ulcer Endoscopic severity

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A Hybrid Joining Technology for Aluminum/Zinc Coated Steels in Vehicles

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Journal of Materials Science & Technology 2010年第9期26卷 858-864页

作者： C.Y.Choi D.C.kim D.G.nam Y.D.kim Y.D.Park School of Materials Science and Engineering Pusan National UniversityBusan Advanced Welding & Joining R&D Division Institute of Industrial Technology Incheon Dongnam Technology Service Division Korea Institute of Industrial TechnologyBusan Department of Advanced Materials Engineering Dong-Eui UniversityBusan

Currently,in the automotive industry,joining of the aluminum alloys with the steel is a crucial problem to be *** joining techniques including resistance spot and gas metal arc welding are not acceptable for those applications due to a number of metallurgical *** investigation was carried out to develop the hybrid joining process combining the resistance spot welding and *** this study,an attempt was made to apply hybrid process to the joining of dissimilar sheet metals,Al-Mg-Si（6000 series） alloy and low carbon steel *** process（resistance spot weld/brazing） using filler metal was found to be effective to overcome the incompatibility between aluminum alloy and *** hybrid joining process of Al alloy sheet and steel sheet did not produce acceptable bond strength,it was proved to have reasonable interfacial bond layer if the optimal process condition was applied.

关键词： Hybrid joining Aluminum alloy Steel Resistance welding Brazing

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Migration routes and differences in migration strategies of Whooper Swans between spring and autumn

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Avian Research 2023年第3期14卷 345-353页

作者： Ji-Yeon Lee Hyung-kyu nam Jin-Young Park Seung-Gu Kang Nyambayar Batbayar Dong-Won kim Jae-Woong Hwang Otgonbayar Tsend Tseveenmyadag Natsagdorj Jugdernamjil Nergui Tuvshintugs Sukhbaatar Wee-Haeng Hur Jeong-Chil Yoo The Korea Institute of Ornithology and Department of Biology Graduate SchoolKyung Hee University26 Kyungheedae-roDongdaemun-guSeoul02447Republic of Korea National Institute of Biological Resources 42 Hwangyeong-roSeo-guIncheon22689Republic of Korea Endangered Species Research Center National Institute of EcologyYeongyang36351Republic of Korea Wildlife Sciences and Conservation Center of Mongolia Union BuildingB-701UNESCO str.Ulaanbaatar14210Mongolia

Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding ***,several species travel slower in spring owing to environmental influences,such as food availability and wind *** trackers were attached to 17 Whooper Swans(Cygnus cygnus) inhabiting northeastern Mongolia,to determine their migration routes and stopover sites in spring and *** between spring and autumn migrations,migration-influencing parameters,and the effect of spring stopover site temperatures were *** swans completed perfect tours between their wintering and breeding sites,and these data were used for *** migration lasted 57 days,with 49.2 days spent at 3.7 stopover *** migration lasted 21.5 days,with 17.5 days spent at 1.0 stopover ***,the swans traveled more rapidly in autumn than in *** distance,number of stopovers,migration speed,and straightness were important migration determinants in both spring and *** distance,stopover duration,number of stopovers,daily travel speed,travel duration,and migration speed differed significantly between spring and *** spring migration,the temperature at the current stopover sites and that at the future stopover sites displayed significant variations(t=1585.8,df=631.6,p <0.001).These findings are critical for the conservation and management of Whooper Swans and their key habitats in East Asian regions,and the data are anticipated to make a particularly significant contribution toward developing detailed management plans for the conservation of their key habitats.

关键词： Key stopover sites Migration characteristics Migration route Migration strategy Tracking Whooper Swan

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Interstitial tissue-specific gene expression in mouse testis by intra-tunica albuguineal injection of recombinant baculovirus

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Asian Journal of Andrology 2009年第3期11卷 342-350页

作者： Hyun Jung Park Won Young Lee Jin Hoi kim Jae Hwan kim Hun Jong Jung nam Hyung kim Bo kyung kim Hyuk Song Department of Animal Science College of Natural Science Konkuk University Chung-ju 380-701 Korea CHA Stem Cell Institute Graduate School of Life Science and Biotechnology Pochon CHA University Seoul 135-907 Korea Department of Animal Biotechnology College of Animal Biotechnology Konkuk University Seoul 143-701 Korea Occupation and Environment Department Medical School Konkuk University Chung-ju 380-704 Korea Department of Animal Science College of Agriculture Chungbuk National University Choung-ju Chung-buk 361-763 Korea Department of Physiology Medical School Konkuk University Chung-ju 380-701 Korea

The purpose of this study is to establish a gene delivery system for interstitial tissue-specific protein expression in mice testes using modified recombinant baculovirus. Green fluorescent protein （GFP）-expressing recombinant baculovirus （GFP-baculovirus）, in which the insect cell-specific polyhedron promoter was replaced by the cytomegalovirus （CMV）-IE promoter, was used to transfect testicular cells in vitro, and for intra-tunica albuguineal injection of the interstitial tissue of the testis. GFP expression was monitored in frozen testes sections by fluorescence microscopy. Expression of GFP in testicular tissues was also assessed by reverse transcription polymerase chain reaction （RT-PCR）, and protein expression was assessed by Western blot. Testicular cells in vitro were infected efficiently by modified recombinant GFP-baculovirus. lntra-tunica albuguineal injection of GFP- baculovirus into the mouse testis resulted in a high level of GFP expression in the interstitial tissues. RT-PCR analysis clearly showed GFP gene expression in the testis, particularly interstitial tissues. Intra-tunica albuguineal injection of a modified baculovirus that encoded recombinant rat insulin-like growth factor binding protein （IGFBP）-5 resulted in an increase in IGFBP-5 in testis and semen. In conclusion, we have developed an efficient delivery system for gene expression in vivo in testicular cells, particularly cells of the interstitial tissue using intratunica albuguineal injection of a modified recombinant baculovirus. This method will be particularly relevant for application that requires gene delivery and protein expression in the testicular cells of the outer seminiferous tubule of the testis.

关键词： intra-tunica albuguineal injection recombinant baculovirus testis gene delivery

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Extract from Zanthoxylum piperitum Induces Apoptosis of AGS Gastric Cancer Cells through Akt/MDM2/p53 Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第10期27卷 752-759页

作者： Ye Seul Park Gun He nam kyung Jo Jo Hye Won Kawk Sang Yung kim Young Min kim Department of Biological science and Biotechnology College of Life science and Nano TechnologyHannam University1646 Yuseong-daeroYuseong-guDaejeon 34054South Korea Department of Food Science&Bio Technology Shinansan UniversityDeahakro Danwon-guAnsan-CityGyenggi-doKorea

Objective:To determine the effect of Zanthoxylum piperitum extracet(ZPE)on apoptosis and analyze anticancer substances in ZPE,changes in proteins related to apoptosis,and pathological changes in tumors in ***:Fifteen 4-week-old female BALB/c nu/nu mice were divided into 3 groups depending on ZPE dose,with 5 in each *** gastric carcinoma cells(1 x 10^(6) cells/200 jxL)were subcutaneously injected into the flank of each *** week after the injection of AGS cells,ZPE was administered to the skin tissue[10 or 50 mg/(kg-d)]in the low-and high-dose groups,respectively for 20 *** animals were injected with vehicle *** 3 weeks,the tumor was extracted and carried out for immunohistochemistry,the tendency of apoptosis and p53 in the body was checked using TdT-mediated dUTP nick-end labeling(TUNEL)*** 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay,annexin V dead cell staining,cell cycle arrest and Western blotting,AGS gastric carcinoma cells were incubated with various concentrations of ZPE for 24 *** survival rates were analyzed by MTT *** was analyzed using annexin V dead cell staining and cell cycle arrest and measured using Muse cell ***:High performance liquid chromatography(HPLC)analysis showed that ZPE contained organic sulfur compounds such as alliin and *** assay results revealed that ZPE(10-85»xg/mL)could effectively inhibit the growth of AGS gastric cancer cells at higher concentrations(P<0.05,P<0.01).The annexin V&dead cell staining assay and cell cycle arrest assay confirmed a dose-dependent increase in the apoptosis rate and G!phase in ZPE(10-70 jig/mL)*** decreased the expression of anti-apoptotic proteins(p-Akt,p-MDM2,Bcl-2),while increased pro-apoptotic proteins(cleaved PARP,p53,pro-Caspase 3,Bax).TUNEL assays revealed an increase in cell *** staining confirmed the involvement of ***:ZPE decreases AGS cell

关键词： AGS gastric cancer cells Zanthoxylum piperitum apoptosis Akt/MDM2/p53 signaling pathway active compounds

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Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging

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World Journal of Gastroenterology 2012年第31期18卷 4102-4117页

作者： nam kyung Lee Suk kim Gwang Ha kim Dong Uk kim Hyung Il Seo Tae Un kim Dae Hwan Kang Ho Jin Jang Department of Radiology Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Internal Medicine Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Radiology Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Internal Medicine Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Obstetrics and Gynecology Armed Forces Seoul HospitalSeoul 110-200South Korea

Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute *** for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the ***,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and *** previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic *** further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion *** detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance ***,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.

关键词： Magnetic resonance imaging Diffusion-weighted imaging Biliary tract Gallbladder Pancreas

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Plasmonic Ag‑Decorated Few‑Layer MoS2 Nanosheets Vertically Grown on Graphene for Efficient Photoelectrochemical Water Splitting

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Nano-Micro Letters 2020年第12期12卷 159-172页

作者： Dong‑Bum Seo Tran nam Trung Dong‑Ok kim Duong Viet Duc Sungmin Hong Youngku Sohn Jong‑Ryul Jeong Eui‑Tae kim Department of Materials Science and Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea

A controllable approach that combines surface plasmon resonance and twodimensional(2D)graphene/MoS2 heterojunction has not been implemented despite its potential for efficient photoelectrochemical(PEC)water *** this study,plasmonic Ag-decorated 2D MoS2 nanosheets were vertically grown on graphene substrates in a practical large-scale manner through metalorganic chemical vapor deposition of MoS2 and thermal evaporation of *** plasmonic Ag-decorated MoS2 nanosheets on graphene yielded up to 10 times higher photo-to-dark current ratio than MoS2 nanosheets on indium tin *** significantly enhanced PEC activity could be attributed to the synergetic effects of SPR and favorable graphene/2D MoS2 *** Ag nanoparticles not only increased visible-light and near-infrared absorption of 2D MoS2,but also induced highly amplified local electric field intensity in 2D *** addition,the vertically aligned 2D MoS2 on graphene acted as a desirable heterostructure for efficient separation and transportation of photo-generated *** study provides a promising path for exploiting the full potential of 2D MoS2 for practical large-scale and efficient PEC water-splitting applications.

关键词： Photoelectrocatalysis Molybdenum disulfide Graphene Surface plasmon resonance

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Spectrum of mucin-producing neoplastic conditions of the abdomen and pelvis:Cross-sectional imaging evaluation

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World Journal of Gastroenterology 2011年第43期17卷 4757-4771页

作者： nam kyung Lee Suk kim Hyun Sung kim Tae Yong Jeon Gwang Ha kim Dong Uk kim Do Youn Park Tae Un kim Dae Hwan Kang Department of Radiology Pusan National University Hospital Medical Research Institute Pusan National University School of Medicine Pusan National University Department of Surgery Pusan National University Hospital Department of Internal Medicine Pusan National University Hospital Department of Pathology Pusan National University Hospital Department of Radiology Yangsan Pusan National University Hospital Medical Research Institute Pusan National University School of Medicine Department of Internal Medicine Yangsan Pusan National University Hospital

Various mucin-producing neoplasms originate in different abdominal and pelvic *** neoplasms differ from non-mucinous neoplasms because of the differences in clinical outcome and imaging *** carcinoma,in which at least 50%of the tumor is composed of large pools of extracellular mucin and columns of malignant cells,is associated with a worse *** ring cell carcinoma is characterized by large intracytoplasmic mucin vacuoles that expand in the malignant cells with the nucleus displaced to the *** prognosis is also generally *** contrast,intraductal papillary mucinous neoplasm of the bile duct and pancreas,which is characterized by proliferation of ductal epithelium and variable mucin production,has a better prognosis than other malignancies in the pancreaticobiliary *** modalities play a critical role in differentiating mucinous from non-mucinous *** to high water content,mucin has a similar appearance to water on ultrasound(US) ,computed tomography(CT) ,and magnetic resonance imaging,except when thick and proteinaceous,and then it tends to be hypoechoic with fine internal echoes or have complex echogenicity on US,hyperdense on CT,and hyperintense on T1and hypointense on T2-weighted images,compared to ***,knowledge of characteristic mucin imaging features is helpful to diagnose various mucinproducing neoplastic conditions and to facilitate appropriate treatment.

关键词： Mucin Neoplasm Ultrasound Computed tomography Magnetic resonance Abdomen and pelvis

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Effects of tungsten source and tartrate additive on the microstructure and photoluminescence of hydrothermally crystallized ZnWO_(4)

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Tungsten 2019年第4期1卷 266-275页

作者： Mei‑Ting Li Ji‑Guang Li Qi Zhu Byung‑nam kim Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Institute of Ceramics and Powder MetallurgyNortheastern UniversityShenyang 110819China Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305‑0044Japan

Tungstate source and tartrate(Tar^(2−))additive were examined for their influences on the hydrothermal formation and char-acteristics of ZnWO_(4) *** was clearly shown that quasi-equiaxed nanocrystallites of~50-100 nm in diameter and nanorods of~40-50 nm in diameter and up to~700 nm in length can be generated with(NH_(4))_(10)W_(12)O_(41)·5H_(2)O and K_(2)WO_(4)·2H_(2)O as tungsten sources,*** Tar^(2−)into the K_(2)WO_(4)·2H_(2)O reaction system effectively trans-formed the primary crystallites of ZnWO_(4) from nanorods into quasi-equiaxed nanocrystals(~20-50 nm)and then nanoplates(thickness of~20 nm,lateral size of~200 nm)and,meanwhile,aggregated the crystallites into spheroidal clusters(~2-3μm in diameter)with the increasing Tar^(2−)/Zn^(2+)molar ratio up to~*** spectroscopy revealed that the ZnWO_(4) products exhibit broad-band photoluminescence(~425-700 nm)through ^(3)T_(1u)→^(1)A_(1g) transition of the[WO_(6)]^(6−)ligand under short ultraviolet excitation and the nanorods show the best luminescence among all tested *** at 500°C may effectively remove the adsorbed Tar^(2−)species and greatly improve luminescence of the samples synthesized in the presence of Tar^(2−).

关键词： ZnWO_(4) Hydrothermal synthesis Tungsten source Tartrate additive Photoluminescence

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Uterine rupture due to adenomyosis in an adolescent:A case report and review of literature

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World Journal of Clinical Cases 2023年第32期11卷 7888-7894页

作者： Nah Ihm kim Ji Shin Lee Jong Hee nam Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Pathology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Uterine rupture is a fatal medical complication with a high mortality *** cases of uterine rupture occur in late pregnancy or during labor and are mainly related to uterine scarring due to previous surgical *** is a possible risk factor for uterine ***,spontaneous uterine rupture due to severe adenomyosis in a non-gravida-teenaged female has not been reported in the literature to *** SUMMARY A 16-year-old girl was referred to our hospital for acute abdominal pain and hypovolemic shock with a blood pressure of 90/50 *** studies revealed a huge endometrial mass with multiple nodules in the lung,suggesting lung *** patient underwent an emergency total hysterectomy and wedge resection of the lung ***,the uterus showed diffuse adenomyosis with glandular and stromal *** nodules were endometrioma with massive *** demonstrated that the tumor cells were positive for PAX8,ER,and PR expression,leading to a final diagnosis of pulmonary endometriosis and uterine *** surgery,the patient remains in good condition without *** This is the first case of spontaneous uterine rupture due to adenomyosis in a nongravida adolescent.

关键词： Uterus Adenomyosis Malignancy Endometrioma Case report

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