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Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

World Journal of Gastroenterology 2015年第46期21卷 13064-13072页

作者： Suk Pyo Shin nam keun kim Ju Hwan kim Ju Ho Lee Jung Oh kim Sung Hwan Cho Hana Park Mi Na kim Kyu Sung Rim Seong Gyu Hwang Department of Internal Medicine CHA Bundang Medical CenterCHA University Institute of Gastroenterology CHA Bundang Medical CenterCHA University Department of Biomedical Science College of Life ScienceCHA University Institute for Clinical Research CHA Bundang Medical CenterCHA University Department of Internal Medicine CHA Gangnam Medical CenterCHA University

AIM: To investigate associations between the tumor necrosis factor alpha(TNF-α)-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A polymorphisms and HCC in ***: Hepatocellular carcinoma(HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms,which are TNF-α-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A. The TNF-α genotype frequencies,genotype combinations and haplotypes were analyzed to disclose the association with ***: None of the TNF-α polymorphisms was significantly associated with HCC. However,nine genotype combinations had associations with increased likelihood of HCC. Among them,TNF-α-1031/-857/-238 TT/CC/GA(AOR = 18.849,95%CI: 2.203-161.246,P = 0.007),TNF-α-1031/-308/-238 TT/GG/GA(AOR = 26.956,95%CI: 3.071-236.584,P = 0.003),and TNF-α-1031/-238 TT/GA(AOR = 21.576,95%CI: 2.581-180.394,P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α-1031/-863/-857/-308/-238 T-C-C-G-A(OR = 25.824,95%CI: 1.491-447.223,P = 0.0005),TNF-α-1031/-857/-308/-238 T-C-G-A(OR = 12.059,95%CI: 2.747-52.950,P < 0.0001),TNF-α-1031/-857/-238 T-C-A(OR = 10.696,95%CI: 2.428-47.110,P = 0.0001),TNF-α-1031/-308/-238 T-G-A(OR = 7.556,95%CI: 2.173-26.280,P = 0.0002) and TNF-α-1031/-238 T-A(OR = 10.865,95%CI: 2.473-47.740,P = 0.0001). Moreover,HCC Okuda stage Ⅲ cases with the TNF-α-1031 CC genotype had better survival than those with the TT genotype(AOR = 5.795,95%CI: 1.145-29.323). CONCLUSION: Although no single TNF-α polymorphism is associated with HCC in this study,some TNF-α genotype combinations and haplotypes are associated with HCC. In addition,HCC Okuda stage Ⅲ cases with the TNF-α-1031 TT genotype may have a better pr

关键词： Tumor necrosis factor-alpha Polymorphism Single nu

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae Taehyun Park Il Tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

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A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue nam‑Young kim Yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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On extensions of matrix rings with skew Hochschild 2-cocycles

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Frontiers of Mathematics in China 2016年第4期11卷 869-900页

作者： Chan Yong HONG nam Kyun kim Tai keun KWAK Yang LEE Department of Mathematics and Research Institute for Basic Sciences Kyung Hee University Seoul 02447 Korea School of Basic Sciences Hanbat National University Daejeon 34158 Korea Department of Mathematics Daejin University Pocheon 11159 Korea Department of Mathematics Pusan National University Pusan 46241 Korea

We study structures of endomorphisms and introduce a skew Hochschild 2-cocycles related to Hochschild 2-cocycle. We moreover define skew Hochschild extensions equipped with skew Hochschild 2-cocycles, and then we examine uniquely clean, Abelian, directly finite, symmetric, and reversible ring properties of skew Hochschild extensions and related ring systems. The results obtained here provide various kinds of examples of such rings. Especially, we give an answer negatively to the question of H. Lin and C. Xi for the corresponding Hochschild extensions of reversible （or semicommutative） rings. Finally, we establish three kinds of Hochschild extensions with Hochschild 2-cocycles and skew Hochschild 2-cocycles.

关键词： Skew Hochschild extensions matrix rings skew triangular matrix rings (uniquely) clean rings symmetric rings

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Duo Property on the Monoid of Regular Elements

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Algebra Colloquium 2022年第2期29卷 203-216页

作者： Chan Yong Hong Hong Kee kim nam Kyun kim Tai keun Kwak Yang Lee Department of Mathematics Kyung Hee UniversitySeoul 02447Korea Department of Mathematics and RINS Gyeongsang National University Jinju 52828Korea School of Basic Sciences Hanbat National UniversityDaejeon 34158Korea Department of Mathematics Daejin UniversityPocheon 11159Korea Department of Mathematics Yanbian UniversityYanjiJilin 133002China Instituteof Basic Science Daejin UniversityPocheon 11159Korea

We study the right duo property on regular elements,and we say that rings with this property are right *** is first shown that the right duo property is preserved by right quotient rings when the given rings are right *** prove that thepolynomial ring over a ring R is right DR if and only if R is *** is also proved that for a prime number p,the group ring KG of a finite p-group G over a field K of characteristic p is right DR if and only if it is right duo,and that there exists a group ring KG that is neither DR nor duo when G is not a p-group.

关键词： right DR ring right duo ring quotient ring (skew)polynomial ring group ring

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On von Neumann Regularity of Commutators

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Algebra Colloquium 2024年第2期31卷 181-198页

作者： nam Kyun kim Tai keun Kwak Yang Lee Sung Ju Ryu Nanqing Ding School of Basic Sciences Hanbat National UniversityDaejeon 34158Korea Department of Data Science Daejin UniversityPocheon 11159Korea Department of Mathematics Yanbian UniversityYanjiJilin 133002China Institute for Applied Mathematics and Optics Hanbat National University Daejeon 34158Korea Department of Mathematics Pusan National UniversityBusan 46241Korea 不详

We study the structure of rings which satisfy the von Neumann regularity of commutators,and call a ring R C-regularif ab-ba ∈(ab-ba)R(ab-ba)for all a,b in *** a C-regular ring R,we prove J(R[X])=N^(*)(R[X])=N^(*)(R)[X]=W(R)[X]■Z(R[X]),where J(A),N^(*)(A),W(A),Z(A)are the Jacobson radical,upper nilradical,Wedderburn radical,and center of a given ring A,respectively,and A[X]denotes the polynomial ring with a set X of commuting indeterminates over A;we also prove that R is semiprime if and only if the right(left)singular ideal of R is *** provide methods to construct C-regular rings which are neither commutative nor von Neumann regular,from any given ***,for a C-regular ring R,the following are proved to be equivalent:(i)R is Abelian;(ii)every prime factor ring of R is a duo domain;(ii)R is quasi-duo;and(iv)R/W(R)is reduced.

关键词： C-regular ring commutator regular ring commutative ring radical singular ideal

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Preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after curative intent surgical resection

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 450-455页

作者： nam Hee kim Hong Joo kim Division of Gastroenterology Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.

关键词： Early recurrence Pancreatic ductal adenocarcinoma Preoperative risk factors C-reactive protein Maximum standardized uptake value

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Shear deformable finite beam elements for composite box beams

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Acta Mechanica Sinica 2014年第2期30卷 223-240页

作者： nam-Il kim Dong-Ho Choi Department of Architectural Engineering Sejong University Department of Civil and Environmental Engineering Hanyang University

The shear deformable thin-walled composite beams with closed cross-sections have been developed for coupled flexural, torsional, and buckling analyses. A theoretical model applicable to the thin-walled laminated composite box beams is presented by taking into account all the structural couplings coming from the material anisotropy and the shear deformation effects. The current composite beam includes the transverse shear and the restrained warping induced shear deformation by using the first-order shear deformation beam theory. Seven governing equations are derived for the coupled axial-flexural-torsional-shearing buckling based on the principle of minimum total potential energy. Based on the present analytical model, three different types of finite composite beam elements, namely, linear, quadratic and cubic elements are developed to analyze the flexural, torsional, and buckling problems. In order to demonstrate the accuracy and superiority of the beam theory and the finite beam elements developed by this study,numerical solutions are presented and compared with the results obtained by other researchers and the detailed threedimensional analysis results using the shell elements of ABAQUS. Especially, the influences of the modulus ratio and the simplified assumptions in stress-strain relations on the deflection, twisting angle, and critical buckling loads of composite box beams are investigated.

关键词： Thin-walled Composite box beam Deflection Twisting angle Buckling load Shear deformation

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Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multiinstitutional analysis (KROG 19-04)

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Cancer Biology & Medicine 2022年第6期19卷 931-944页

作者： Sung Uk Lee Jinsil Seong Tae Hyun kim Jung Ho Im Woo Chul kim Kyubo kim Hae Jin Park Tae Gyu kim Youngkyong kim Bae Kwon Jeong Jin Hee kim Byoung Hyuck kim Taek-keun nam Center for Proton Therapy and Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyang 10408Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13497Korea Department of Radiation Oncology Inha University HospitalInha University School of MedicineIncheon 22332Korea Department of Radiation Oncology Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985Korea Department of Radiation Oncology Hanyang University Medical CenterHanyang University College of MedicineSeoul 04763Korea Department of Radiation Oncology Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Korea Department of Radiation Oncology Kyung Hee University HospitalKyung Hee University College of MedicineSeoul 02447Korea Department of Radiation Oncology Gyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Korea Department of Radiation Oncology Dongsan Medical CenterKeimyung University School of MedicineDaegu 41931Korea Department of Radiation Oncology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University College of MedicineHwasun 58128Korea

Objective:The effectiveness of adjuvant treatments for resected gallbladder carcinoma(GBC)has remained unclear due to lack of randomized controlled trials;thus,the aim of present study was to evaluate the role of adjuvant treatments,including chemoradiotherapy(CRT)and/or chemotherapy(CTx),in patients with resected ***:A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional *** 733 patients,372(50.8%)did not receive adjuvant treatment,whereas 215(29.3%)and 146(19.9%)received adjuvant CTx and CRT,*** locoregional recurrence-free survival(LRFS),recurrence-free survival(RFS),and overall survival(OS)of the adjuvant treatment groups were compared according to tumor stage(stage II *** III–IV).Results:In stage II disease(n=381),the 5-year LRFS,RFS,and OS were not significantly different among the no-adjuvant therapy,CTx,and CRT groups,and positive resection margin,presence of perineural invasion,and Nx classification were consistently associated with worse LRFS,RFS,and OS in the multivariate analysis(P<0.05).For stage III–IV(n=352),the CRT group had significantly higher 5-year LRFS,RFS,and OS than the no-adjuvant therapy and CTx groups(67.8%,45.2%,and 56.9%;37.9%,28.8%,and 35.4%;and 45.0%,30.0%,and 45.7%,respectively)(P<0.05).Conclusions:CRT has value as adjuvant treatment for resected GBC with stage III–IV *** study is needed for stage II disease with high-risk features.

关键词： Gallbladder cancer adjuvant treatment chemoradiotherapy locoregional recurrence-free survival overall survival

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Suppression of gold nanoparticle agglomeration and its separation via nylon membranes

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Chinese Journal of Chemical Engineering 2017年第7期25卷 931-937页

作者： Ayyavoo Jayalakshmi In-Chul kim Young-nam Kwon School of Urban and Environmental Engineering Ulsan National Institute of Sdence and TechnologyUlsan 689-798Korea KIST-UNIST UIsan Center for Convergent Materials UNIST(Ulsan National Institute of Science and Technology)Korea Environment and Resources Research Center Korea Research Institute Chemical TechnologyDaejeon 305-606Korea

Use of ultraporous nylon membrane is one of the most widely employed techniques for removal of hard and soft nanoparticles in the semiconductor industry, and the accurate determination of membrane pore size is necessary in order to avoid manufacturing defects caused by contamination. The gold nanoparticle has several benefits for the evaluation of polymeric membranes; however, the nanoparticles agglomerate easily on the nylon membrane and make it difficult to evaluate the membrane precisely. The properties of 2-amino-2-hydroxymethyl-1,3-propanediol(ADP) ligand in gold nanoparticle solution were systematically investigated, and ADP was utilized for improved evaluation of the nylon membranes. Nylon membrane used in this study was prepared by phase inversion techniques. Ultrathin dense layer on top of the membrane surface and Darcy structures in the microporous membrane support were observed. The gold particle rejection was carried out at various p H values from 4 to14 and higher rejection was observed at p H 4 and 8. The suppression of gold colloid agglomeration using ADP and monodispersity of gold colloids was also analyzed by confocal laser scanning microscopy(CLSM), transmission electron microscopy(TEM), and scanning electron microscopy(SEM). van der Waals interaction energy of the particles was reduced in the addition of ADP. The presence of ADP ligand in the gold solutions prevented the agglomeration of gold nanoparticles and reduced the adsorption of the particles on the nylon membrane surface,leading to precise evaluation of membrane pore sizes.

关键词： Particle size Electron microscopy Gold colloid flock Semiconductor

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