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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko Hyun Woo Lee Won Joon Oh hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

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Biomimetic Fe_(7)S_(8)/Carbon electrocatalyst from[FeFe]-Hydrogenase for improving pH-Universal electrocatalytic hydrogen production Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 451-459页

作者： Dohun kim Subramani Surendran Sejin Im Jaehyoung Lim Kyoungsuk Jin Ki Tae nam Uk Sim Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science&Technology(DGIST)DaeguRepublic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Department of Chemistry Korea UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

Efficient and cost-effective electrocatalysts that can operate across a wide range of pH conditions are essential for green hydrogen *** by biological systems,Fe_(7)S_(8)nanoparticles incorporated on polydopamine matrix electrocatalyst were synthesized by co-precipitation and annealing *** resulting Fe_(7)S_(8)/C electrocatalyst possesses a three-dimensional structure and exhibits enhanced electrocatalytic performance for hydrogen production across various pH ***,the Fe_(7)S_(8)/C electrocatalyst demonstrates exceptional activity,achieving low overpotentials of 90.6,45.9,and 107.4 mV in acidic,neutral,and alkaline environments,*** impedance spectroscopy reveals that Fe_(7)S_(8)/C exhibits the lowest charge transfer resistance under neutral conditions,indicating an improved proton-coupled electron transfer ***-wave electron paramagnetic resonance results confirm a change in the valence state of Fe from 3+to 1+during the hydrogen evolution reaction(HER).These findings closely resemble the behavior of natural[FeFe]-hydrogenase,known for its superior hydrogen production in neutral *** remarkable performance of our Fe_(7)S_(8)/C electrocatalyst opens up new possibilities for utilizing bioinspired materials as catalysts for the HER.

关键词： biomimetic electrocatalyst hydrogen production renewable energy

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Importance of dietary supplementation of soluble and insoluble fibers to sows subjected to high ambient temperatures during late gestation and effects on lactation performance

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Animal Nutrition 2024年第1期16卷 73-83页

作者： Seung Min Oh Abdolreza Hosseindoust Sang hun Ha Jun Young Mun Joseph Moturi Habeeb Tajudeen Yo Han Choi Su Hyup Lee Jin Soo kim Gyeongbuk Livestock Research Institute Department of Animal Industry Convergence Kangwon National University Swine Division National Institute of Animal Science Rural Development Administration Department of Swine Science Korea National University of Agriculture and Fisheries

Heat stress adversely affects sows' performance, which can be improved by applying proper nutritional strategies. This study was conducted to investigate the interactive effects of dietary fiber levels and sources on sows' reproductive performance, metabolic response during gestation, and the carry-over influence on litter performance in the lactation period during heat stress(average room temperature of 27.1°C). Fifty-four multiparous sows(Landrace × Yorkshire; initial body weight of 236.3 ± 16 kg; 2, 3and 4 parities) at d 90 of gestation were assigned to a 2 × 3 factorial arrangement(9 sows/treatment),involving 2 dietary fiber levels(4.5% and 6% crude fiber) and 3 dietary fiber sources(wheat bran [WB],palm kernel meal [PK], and beet pulp [BP]). Sows fed the BP diet had highest(P namic acid, iron, linoleic acid, glycerol, ketone, and formamide were increased(P < 0.05) in the BP treatment compared with the WB. The BP treatment with high soluble fiber content improved the constipation index, farrowing duration, and litter performance, while high insoluble fibers increased sows comfort and reduced stress factors including respiratory rate and rectal

关键词： Soluble fiber Insoluble fiber Beet pulp Wheat bran Palm kernel Metabolites

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Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

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Energy & Environmental Materials 2024年第6期7卷 230-237页

作者： Jong-Woon Ha Seung hun Eom Bo Kyung Cha Seyeong Song Hyeong Ju Eun Jong H.kim Jong Mok Park BongSoo kim Byoungwook Park Seo-Jin Ko Sung Cheol Yoon Changjin Lee In Hwan Jung Do-Hoon Hwang Department of Chemistry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea Division of Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Electro-Medical Device Research Center Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate School of Carbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Molecular Science and Technology Ajou UniversitySuwon 16449Korea Research Center for Advanced Specialty Chemicals Korea Research Institute of Chemical TechnologyUlsan 44412Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Organic and Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency ***,this is quite challenging because of the heavy weight of the scintillator and silicon *** weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic *** study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone and highly soluble molecular structure of *** ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A W−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D_(sh)^(*)=2.18×10^(13)Jones in the organic *** organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit D_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)and falling(0.29 s)response times upon X-ray *** reliability is also proven by linear response of the X-ray detector,and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray

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Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho Son Ha Kyung Park Dae-Hwan kim Jin-Kyu Kang Shi-Joon Sung Dae-Kue Hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo kim Sang-Hoon nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae kim Seung Hyun kim Jae-Il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun Yun Su-Hyeon Cho Kil-nam kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk kim Sung Yong Han Suk kim nam Kyung Lee Seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek nam Jung-El Ryu Tae Hoon Eom Seung Ju kim Jun Min Suh Seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo kim Sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park Sung Hwan Cho Hyuk Jin kim Sang Eon Jun Tae Hyung Lee Yeong Jae kim Jae Young kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

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Realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun nam Yong-Jae Jung Jong Ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch Jung Young Cho Won-Seon Seo Jong Wook Roh Sang-il kim Soonil Lee Kyu Hyoung Lee Hyun Sik kim Weon Ho Shin Leibniz Institute for Solid State and Materials Research Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic Materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University Department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

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Data driven computational design of stable oxygen evolution catalysts by DFT and machine learning:Promising electrocatalysts

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Journal of Energy Chemistry 2024年第4期91卷 645-655页

作者： Hwanyeol Park Yunseok kim Seulwon Choi Ho Jun kim Department of Display Materials Engineering Soonchunhyang UniversityAsanChung-nam 31538Republic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang Uni-versityAsanChungnam 31538Republic of Korea Department of Mechanical Engineering Hanyang University ERICA Campus55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

The revolutionary development of machine learning(ML),data science,and analytics,coupled with its application in material science,stands as a significant milestone of the scientific community over the last *** active,stable,and cost-efficient catalysts is crucial for oxygen evolution reaction owing to the significance in a range of electrochemical energy co nversion *** this work,we have demonstrated an efficient approach of high-throughput screening to find stable transition metal oxides under acid condition for high-performance oxygen evolution reaction(OER)catalysts through density functional theory(DFT)calculation and a machine learning algorithm.A methodology utilizing both the Materials Project database and DFT calculations was introduced to assess the acid stability under specific reaction *** upon this,OER catalytic activity of acid-stable materials was examined,highlighting potential OER catalysts that meet the required *** identified IrO_(2),Fe(SbO_(3))_(2),Co(SbO_(3))_(2),Ni(SbO_(3))_(2),FeSbO_(4),Fe(SbO_(3))4,MoWO_(6),TiSnO_(4),CoSbO_(4),and Ti(WO_(4))_(2)as promising catalysts,several of which have already been experimentally discovered for their robust OER performance,while others are novel for experimental exploration,thereby broadening the chemical scope for efficient OER *** of the bond length of TM-O and the first ionization energy were used to unveil the OER activity *** the calculated results,guidance has been derived to effectively execute advanced high-throughput screenings for the discovery of catalysts with favorable ***,the intrinsic correlation between catalytic performance and various atomic and structural factors was elucidated using the ML *** these approaches,we not only streamline the choice of the promising electrocatalysts but also offer insights for the design of varied catalyst models and the discovery of superior c

关键词： Transition metal oxides Oxygen evolution reaction High-throughput screening First-principles calculation Machine learning

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