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Bone mineral density and disorders of mineral metabolism in chronic liver disease

World Journal of Gastroenterology 2009年第28期15卷 3516-3522页

作者： Joe George Hosahithlu k Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana karvat Shobna J Bhatia Samir Shah Padmavathy S Menon nalini Shah Department of Endocrinology Seth G.S. Medical College and KEM Hospital Department of Gastroenterology Seth G.S Medical College and KEM Hospital Department of Gastroenterology Jaslok Hospital

AIM： To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis. METHODS： The study was performed on 72 Indian patients with cirrhosis （63 male, 9 female; aged 〈 50 years）. Etiology of cirrhosis was alcoholism （n = 37）, hepatitis B （n = 25） and hepatitis C （n = 10）. Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C. Secondary causes for metabolic bone disease and osteoporosis were ruled out. Sunlight exposure, physical activity and dietary constituents were calculated. Complete metabolic profiles were derived, and bone mineral density （BMD） was measured using dual energy X ray absorptiometry. Low BMD was defined as a Z score below -2. RESULTS： Low BMD was found in 68% of patients. Lumbar spine was the most frequently and severely affected site. Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass. Calcium intake was adequate, with unfavorable calcium： protein ratio and calcium： phosphorus ratio. Vitamin D deficiency was highly prevalent （92%）. There was a high incidence of hypogonadism （41%）. Serum estradiol level was elevated significantly in patients with normal BMD. Insulin-like growth factor （IGF） 1 and IGF binding protein 3 levels were below the age-related normal range in both groups. IGF-1 was significantly lower in patients with low BMD. Serum osteocalcin level was low （68%） and urinary deoxypyridinoline to creatinine ratio was high （79%）, which demonstrated low bone formation with high resorption. CONCLUSION： Patients with cirrhosis have low BMD. Contributory factors are reduced physical activity, low lean body mass, vitamin D deficiency and hypogonadism and low IGF-1 level.

关键词： Bone mineral density Liver disease Chronic disease Cirrhosis Bone mineral metabolism Hepatic osteodystrophy

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Experience-Based Access Control in UbiComp: A New Paradigm

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Journal of Computer and Communications 2022年第1期10卷 133-157页

作者： nalini A. Mhetre Arvind V. Deshpande Parikshit N. Mahalle Department of Computer Engineering Sinhgad College of Engineering Pune India Department of Computer Engineering Smt. Kashibai Navale College of Engineering Pune India Department of AI and Data Science Vishwakarma Institute of Information Technology Pune India

Experience is a sociological concept and builds over time. In a broader sense, the human-centered equivalents of experience and trust apply to D2D interaction. Ubiquitous computing (UbiComp) embeds intelligence and computing capabilities in everyday objects to make them effectively communicate, share resources, and perform useful tasks. The safety of resources is a serious problem. As a result, authorization and access control in UbiComp is a significant challenge. Our work presents experience as an outcome of history (HI), reliability (RL), transitivity (TR), and Ubiquity (UB). This experience model is easily adaptable to a variety of self-regulating context-aware access control systems. This paper proposes a framework for Experience-Based Access Control (EX-BAC) with all major services provided by the model. EX-BAC extends attribute-based access control. It uses logical device type and experience as context parameters for policy design. When compared with the state-of-the-art, EX-BAC is efficient with respect to response time.

关键词： Access Control Experience-Based Access Control Experience Model History Reliability Transitivity Ubiquitous Computing Ubiquity

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脉络膜新生血管CNV动物模型的评估新方法

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重庆医科大学学报 2011年第2期36卷 192-194页

作者：许琴 nalini S.Bora Puran Bora 贵州遵义医学院附院检验科遵义563003 University of Arkansas

目的:建立C57BL/6小鼠脉络膜新生血管(Choroidal neovascularization,CNV)动物模型的评估方法。方法:①应用氪红激光对小鼠实验性视网膜进行光凝,激光的功率、光凝斑直径和曝光时间分别为250 mW、50μm及0.05 s诱导CNV动物模型。②分别... 详细信息

目的:建立C57BL/6小鼠脉络膜新生血管(Choroidal neovascularization,CNV)动物模型的评估方法。方法:①应用氪红激光对小鼠实验性视网膜进行光凝,激光的功率、光凝斑直径和曝光时间分别为250 mW、50μm及0.05 s诱导CNV动物模型。②分别于光凝后1、3、5、7、10d,用2×106FITC-dextran荧光素灌注小鼠心脏。③mAb特定抗Elastin抗体标记Bruch膜。④视网膜色素上皮(Retinal pigmentepithelium,RPE)-脉络膜-巩膜复合体铺片。⑤激光共聚焦显微镜对RPE-脉络膜-巩膜复合体进行CNV形态进行观察和测量。结果:光凝后3 d可见新生血管及走向清晰可见,光凝后7 d CNV达到高峰。结论:用抗体标记Bruch膜。FITC-dextran荧光素灌注小鼠心脏,激光共聚焦显微镜对RPE-脉络膜-巩膜复合体进行氪红激光诱导C57BL/6小鼠的CNV模型进行评估,直观,可靠。

关键词：脉络膜新生血管动物模型氪红激光共聚焦显微镜评估

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Construction of Genetic Linkage Map of Bread Wheat (Triticum aestivum L.) Using an Intervarietal Cross and QTL Map for Spike Related Traits

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分子植物育种 2007年第2期5卷 219-220页

作者： E. nalini S.G. Bhagwat N. Jawali Molecular Biology Division Trombay Mumbai 400085 India Nuclear Agriculture and Biotechnology Division Bhabha Atomic Research Centre Trombay Mumbai 400085 India

Most often a genetic linkage map is prepared using populations obtained from two highly diverse genotypes. However, the markers from such a map may not be useful in a breeding program as these markers may not

关键词：遗传因素小麦品种种植

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酮症倾向糖尿病综合征

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中国糖尿病杂志 2009年第3期17卷 239-240页

作者： Balasubramanyam A nalini R Hample CS 钱荣立北京大学第一医院内分泌科 100034

众所周知糖尿病是由不同病因与发病机制引起的以糖脂代谢异常为主要表现的临床综合征,随着对其病因与发病机制的研究,对糖尿病的诊断分类在不断进行修订。现行分型基本是ADA于1997年提出,1999年为WHO糖尿病专家委员会确认。这次分型除... 详细信息

众所周知糖尿病是由不同病因与发病机制引起的以糖脂代谢异常为主要表现的临床综合征,随着对其病因与发病机制的研究,对糖尿病的诊断分类在不断进行修订。现行分型基本是ADA于1997年提出,1999年为WHO糖尿病专家委员会确认。这次分型除保留妊娠糖尿病外基本按病因将以往病因明确的继发性糖尿病归为特殊型,而将大多数病因未明的临床糖尿病按其基本发病机制归为T1DM和了2DM。事实上仍有一些病无法明确诊断为T1DM或T2DM,因而近年来一直在探索这类糖尿病的发病机制、临床特点和分型的研究。下面这篇文献对此作了较全面的复习。本期摘译介绍给感兴趣的读者、作者参考。

关键词：酮症倾向糖尿病综合征自身抗体 β细胞功能

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Cyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase Ck2 in pancreatic <i>β</i>-cells

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Journal of Biomedical Science and Engineering 2013年第5期6卷 73-84页

作者： Emilia Heimann Amitabh Sharma nalini Raghavachari Vincent C. Manganiello Lena Stenson Eva Degerman Center for Complex Network Research (CCNR) Department of Physics Northeastern University Boston USA Department of Experimental Medical Science Division for Diabetes Metabolism and Endocrinology Lund University Lund Sweden DNA Sequencing and Genomics Core Genetics and Development Biology Center Pulmonary/Critical Care Medicine Branch National Heart Lung and Blood Institute National Institutes of Health (NIH) Bethesda USA

Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show that osteopontin (OPN) mRNA is increased in a dose-dependent manner in islets from RIP-PDE3B mice, as compared to wild-type islets. In addition, in silico analysis shows that PDE3B and OPN are interacting. Furthermore, OPN interacts with protein kinase Ck2 ina distinct submodule of the protein-protein interaction network. We studied PDE3B and OPN proteins and, in some cases, also PDE1B and PDE4C, under conditions of relevance for insulin secretion. In the presence of forskolin, PDE inhibitors, insulin, or a protein kinase Ck2 inhibitor, similar alterations in protein levels of PDE3B and OPN are shown. In summary, results from using a number of strategies demonstrate a connection between PDE3B and OPNas well as a role for protein kinase Ck2 inpancreatic β-cells.

关键词： Diabetes Mellitus Pancreatic Islets β-Cells cAMP Cyclic Nucleotide Phosphodiesterases PDE Osteopontin Protein kinase Ck2

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卡托普利的新释药系统

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药学进展 1992年第4期16卷 214-216页

作者： Rajinder Singh Matharu nalini M.Sanghavi 郑雪珠沈建中

卡托普利(Captopril)系一种口服血管紧张素转换酶抑制剂,是广泛用于治疗高血压有效的首选药物。然而,该药有两大缺点:(1)临床使用时需日服3次,摄入总量37.5～75mg才能维持6～8h 的作用时间;(2)当与食物同时服用时,其生物利用度明显下降... 详细信息

卡托普利(Captopril)系一种口服血管紧张素转换酶抑制剂,是广泛用于治疗高血压有效的首选药物。然而,该药有两大缺点:(1)临床使用时需日服3次,摄入总量37.5～75mg才能维持6～8h 的作用时间;(2)当与食物同时服用时,其生物利用度明显下降。研究表明,高 pH 条件是使之发生降解的主要原因。

关键词：卡托普利释药系统血管紧张素

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Bidirectional modulation of HIF-2 activity through allosteric ligands

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中国药理学与毒理学杂志 2019年第10期 767-768页

作者： WU Da-lei SU Xiao-yu LU Jing-ping LI Sheng Becky HOOD Stefan VASILE nalini POTLURI DIAO Xiao-tong Young-chang kIM Sepideh kHORASANIZADEH Fraydoon RASTINEJAD State key Laboratory of Microbial Technology Shandong University Sanford Burnham Prebys Medical Discovery Institute 3. Department of Medicine University of California San Diego 4. Argonne National Laboratory 5. Nuffield Department of Medicine University of Oxford

OBJECTIVE Hypoxia-inducible factor-2(HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive subunit HIF-2α subunit and its obligate partner subunit *** HIF-2 activity drives some cancers, while reduced activity causes anemia in chronic kidney disease. Therefore, modulation of HIF-2 activity via direct-binding ligands could provide many new therapeutic benefits. METHODS We explored HIF-2α chemical ligands using combined crystallographic, biophysical, and cell-based functional studies. RESULTS We found chemically unrelated antagonists to employ the same mechanism of *** binding displaced residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization. We also identified first-in-class HIF-2α agonists and found they significantly displaced pocket residue Y281. Its dramatic side-chain movement increases heterodimerization stability and transcriptional *** Our findings show that despite binding to the same HIF-2α PAS-B pocket, ligands can manifest as inhibitors versus activators by mobilizing different pocket residues to al osterical y alter HIF-2α-ARNT heterodimerization.

关键词： hypoxia-inducible factor agonist antagonist allosteric effects

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Impact of TI Programmes Intervention under National AIDS Control Programme among Female Sex Workers in India: Evidence from Integrated Biological and Behavioural Survey, 2014-15

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World Journal of AIDS 2022年第2期12卷 83-96页

作者： Damodar Sahu Varsha Ranjan nalini Chandra Saritha Nair Anil kumar Elangovan Arumugam Bilali Camara Mendu Vishnu Vardhana Rao ICMR-National Institute of Medical Statistics New Delhi India UNAIDS India New Delhi India ICMR-National Institute of Epidemiology Chennai Tamil Nadu India UNAIDS the Hague Netherlands

Background: A better understanding of the impact of Targeted Interventions (TI) services on Female Sex Worker (FSW) behaviours can help in informing and strengthening future TI efforts under National AIDS Control Programme (NACP). Methods: National Integrated Biological and Behavioural Survey (IBBS) 2014-15 has been analysed in the paper. Descriptive statistics and logistic regression analysis were used to understand factors affecting condom use. Propensity score matching (PSM) was done to understand the impact of the TI services on condom use at the last act and consistent condom use in the last three months among FSWs. Results: Younger FSWs aged 15 - 25 years were 1.4 times (95% CI: 1.04 - 1.77) more likely to use consistent condoms in the last three months compared to older over 45 years after controlling for other socio-economic and programme variables. The matched samples estimate ATET i.e. the average treatment effect on treated for consistent condom use in the last three months shows that a 6.0% (CI: 4.7 - 7.3) increase in consistent condom use in the last three months in the FSWs who received information on STI/HIV from peer educator and outreach worker. There is also a 6.0% (4.7 - 7.2) increase in condom use in the last act for FSWs who received the referral services at STI clinics, HIV testing, and detox centres. Conclusions: It is evident that the TI programme has a positive impact on behavior change among FSWs which can prove beneficial to curtail the spread of HIV to the partners and onward transmission to the general population.

关键词： Integrated Biological and Behavioural Survey (IBBS) Female Sex Worker (FSW) Propensity Score Matching (PSM) Targeted Intervention (TI) Evaluation

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Biochemical Composition and Disease Resistance in Newly Synthesized Amphidiploid and Autotetraploid Peanuts

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Food and Nutrition Sciences 2013年第2期4卷 169-176页

作者： krishna Shilpa Gururaj Sunkad Srinivasu kurella Swati Marri kollipara Padmashree Deepak R. Jadhav kanwar Lal Sahrawat nalini Mallikarjuna All India Coordinated Research Project on Groundnut Main Agricultural Research Station University of Agricultural Sciences Raichur India Department of Biotechnology School of Life Sciences University of Hyderabad Hyderabad India. Department of Plant Sciences School of Life Sciences University of Hyderabad Hyderabad India International Crops Research Institute for Semi Arid Tropics (ICRISAT) Patancheru India

Genetic diversity in peanut (Arachishypogaea L.) is narrow due to its evolution and domestication processes. Amphidiploids and autotetraploids (newly synthesized tetraploids) were created to broaden its genetic base. Molecular analysis has shown that the newly synthesized tetraploids had broader genetic base;and were genetically divergent when compared to cultivated peanut. Nutritional composition relative to oil, fatty acid composition, O/L ratio, protein, iodine value and presence of plant proteinase inhibitors such as trypsin and chymotrypsin inhibitors were studied in the synthesized tetraploids. Some of the newly synthesized tetraploids had higher amounts of proteinase inhibitors. Evaluation of newly synthesized tetraploids revealed several lines resistant to late leaf spot (LLS) and peanut bud necrosis disease (PBND).

关键词： Amphidiploid Autotetraploid Biochemical Disease Resistance Fatty Acid Late Leaf Spot Peanut

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