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Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 131-138页

作者： naglaa m.el-lakkany Hadeel H.elkattan Alaa E.elsisi Department of Pharmacology Theodor Bilharz Research InstituteWarrak El-HadarImbabaGiza 12411Egypt Department of Pharmacology and Toxicology Faculty of PharmacyTanta UniversityTantaEgypt

Objective:To evaluate the efficacy of ponatinib plus gossypol against colorectal cancer HCT-116 and Caco-2 ***:Cells were treated with ponatinib and/or gossypol at increasing concentrations to evaluate synergistic drug interactions by combination *** viability,FGF19/FGFR4,and apoptotic and autophagic cell death were ***:Ponatinib(1.25-40μm)and gossypol(2.5-80μm)monotherapy inhibited HCT-116 and Caco-2 cell viability in a doseand time-dependent *** combination of ponatinib and gossypol at a ratio of 1 to 2 significantly decreased cell viability(P2-and>4-fold reduction in IC50,respectively,after 24 h and 48 h,as compared to the IC50 of *** combined concentrations showed greater synergism(combination indexmorphological changes in HCT-116and Caco-2 cells,increased beclin-1 and caspase-3,and decreased FGF19,FGFR4,Bcl-2 and p-Akt as compared to treatment with drugs ***:Gossypol enhances ponatinib's anticancer effects against colorectal cancer cells through antiproliferative,apoptotic,and autophagic *** may open the way for the future use of ponatinib at lower doses with gossypol as a potentially safer targeted strategy for colorectal cancer treatment.

关键词： Autophagy Apoptosis Cell viability FGF19/FGFR4 Gossypol Ponatinib HCT-116 Caco-2 Colorectal cancer

Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 348-358页

作者： Sayed H.Seif el-Din Olfat A.Hammam Shahira m.Ezzat Samira Saleh marwa m.Safar Walaa H.el-maadawy naglaa m.el-lakkany Pharmacology Department Theodor Bilharz Research InstituteWarak El-HadarImbaba P.O.Box 30Giza 12411Egypt Pathology Department Theodor Bilharz Research InstituteWarak El-HadarImbaba P.O.Box 30Giza 12411Egypt Pharmacognosy Department Faculty of PharmacyCairo UniversityCairo 11562Egypt Pharmacognosy Department Faculty of PharmacyOctober University for Modern Sciences and ArtsGizaEgypt Pharmacology and Toxicology Department Faculty of PharmacyCairo UniversityCairo 11562Egypt Pharmacology and Biochemistry Department Faculty of PharmacyThe British University in EgyptCairoEgypt

Objective:To evaluate the effect of hydroxysafflor yellow A(HSYA)on thioacetamide-induced liver ***:Thioacetamide was administered to rats intraperitoneally in doses of 200 mg/kg twice a week for 12 ***-intoxicated rats were given silymarin(50 mg/kg)or HSYA(5 mg/kg)orally every day for 8 *** enzymes,fibrosis markers,histological changes as well as immunohistochemistry of TNF-α,IL-6,p21,α-SmA,and caspase-3 were *** effect of HSYA on HSC-T6 activation/proliferation and apoptosis was also determined in ***:HSYA decreased liver enzymes,TNF-α,IL-6,and p21 expressions,hepatic PDGF-B,TImP-1,TGF-β1,and hydroxyproline levels,as well as fibrosis score(S2 vs.S4)compared to the thioacetamide *** also downregulatedα-SmA while increasing caspase-3 ***,at 500μg/mL,HSYA had only a slightly suppressive effect on HSC proliferation,with a 9.5%***,it significantly reduced TGF-β1,inhibitedα-SmA expression,induced caspase-3 expression,and promoted cell ***:HSYA may be a potential therapeutic agent for delaying and reversing the progression of liver *** research on HSYA at higher doses and for a longer period is warranted.

关键词： Hydroxysafflor yellow A Thioacetamide Hepatic stellate cells Inflammatory markers Liver fibrosis p21 α-SmA Apoptosis

Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

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Asian Pacific Journal of Tropical medicine 2017年第5期10卷 423-432页

作者： naglaa m.el-lakkany Walaa H.el-maadawy Sayed H.Seif el-Din Olfat A.Hammam Salwa H.mohamed Shahira m.Ezzat marwa m.Safar Samira Saleh Department of Pharmacology Theodor Bilharz Research InstituteWarak El-HadarImbaba P.O.Box 30Giza 12411Egypt Department of Pathology Theodor Bilharz Research InstituteWarak El-HadarImbaba P.O.Box 30Giza 12411Egypt Department of Immunology Theodor Bilharz Research InstituteWarak El-HadarImbaba P.O.Box 30Giza 12411Egypt Department of Pharmacognosy Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pharmacology and Toxicology Faculty of PharmacyCairo UniversityCairo 11562Egypt

Objective:To investigate the antifibrotic role of rosmarinic acid(RA),a natural polyphenolic compound,on HSCs activation/proliferation and apoptosis in vitro and in vivo. methods:The impact of RA on stellate cell line(HSC-T6) proliferation,activation and apoptosis was assessed along with its safety on primary hepatocytes. In vivo,rats were divided into:(i) normal;(ii) thioacetamide(TAA)-intoxicated rats for 12 weeks;(iii) TAA+silymarin or(iv) TAA+RA. At the end of experiment,liver functions,oxidative stress,inflammatory and profibrogenic markers,tissue inhibitor metalloproteinases type-1(TImP-1) and hydroxyproline(HP) levels were evaluated. Additionally,liver histopathology and immunohistochemical examinations of alpha-smooth muscle actin(α-SmA),caspase-3 and proliferation cellular nuclear antigen(PCNA) were determined. Results:RA exhibited anti-proliferative effects on cultured HSCs in a time and concentration dependent manner showing an IC50 of 276 μg/mL and 171 μg/mL for 24 h and 48 h,respectively,with morphological reversion of activated stellate cell morphology to quiescent form. It significantly improved ALT,AST,oxidative stress markers and reduced TImP-1,HP levels,inflammatory markers and fibrosis score(S1 vs S4). Furthermore,reduction in α-SmA plus elevation in caspase-3 expressions of HSCs in vitro and in vivo associated with an inhibition in proliferation of damaged hepatocytes were recorded. Conclusions:RA impeded the progression of liver fibrosis through inhibition of HSCs activation/proliferation and induction of apoptosis with preservation of hepatic architecture.

关键词： Hepatic fibrosis Hepatic stellate cells Rosmarinic acid Apoptosis Proliferation Profibrogenic markers

Wood By-Products as UV Protection:A Consequence Review

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Journal of Renewable materials 2024年第4期12卷 699-720页

作者： naglaa Salem.el‑Sayed mohamed Hasanin Samir Kamel Cellulose and Paper Department National Research CentreCairo12622Egypt

In recent decades,the ozone layer has suffered considerable damage,increasing the entry of ultraviolet(UV)light into the atmosphere and reaching the earth’s surface,negatively affecting ***,researchers aimed to solve this problem by synthesizing advanced UV-shielding *** the other hand,developing an easy and green strategy to prepare functional materials with outstanding properties based on naturally abundant and environmentally friendly raw materials is highly desirable for sustainable *** biomass-derived materials are sustainable and biodegradable,they present a promising substitute for petroleum-based *** three main structural constituents of the plant biomass-based materials that are naturally available are cellulose,hemicellulose,and *** review details current developments using wood-based products such as cellulose,hemicellulose,and lignin in UV-shielding *** will start with assembling the structure and chemistry of cellulose,hemicellulose,and lignin,followed by their contributions to preparing UV-shielding ***,it will briefly discuss the different processing methods for the design of UV-shielding *** wood by-products offer additional opportunities to use the whole tree harvest.

关键词： UV-shielding wood cellulose lignin hemicellulose sunlight protection

A Hybrid Cybersecurity Algorithm for Digital Image Transmission over Advanced Communication Channel models

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Computers, materials & Continua 2024年第4期79卷 201-241页

作者： naglaa F.Soliman Fatma E.Fadl-Allah Walid el-Shafai mahmoud I.Aly maali Alabdulhafith Fathi E.Abd el-Samie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of electronics and Communications Faculty of EngineeringZagazig UniversityZagazig44519Egypt Security Engineering Lab Computer Science DepartmentPrince Sultan UniversityRiyadh11586Saudi Arabia Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

The efficient transmission of images,which plays a large role inwireless communication systems,poses a significant challenge in the growth of multimedia ***-quality images require well-tuned communication *** Single Carrier Frequency Division multiple Access(SC-FDmA)is adopted for broadband wireless communications,because of its low sensitivity to carrier frequency offsets and low Peak-to-Average Power Ratio(PAPR).Data transmission through open-channel networks requires much concentration on security,reliability,and *** data need a space away fromunauthorized access,modification,or *** requirements are to be fulfilled by digital image watermarking and *** paper ismainly concerned with secure image communication over the wireless SC-FDmA systemas an adopted communication *** introduces a robust image communication framework over SC-FDmA that comprises digital image watermarking and encryption to improve image security,while maintaining a high-quality reconstruction of images at the receiver *** proposed framework allows image watermarking based on the Discrete Cosine Transform(DCT)merged with the Singular Value Decomposition(SVD)in the so-called DCT-SVD *** addition,image encryption is implemented based on chaos and DNA *** encrypted watermarked images are then transmitted through the wireless SC-FDmA *** linearminimummean Square Error(mmSE)equalizer is investigated in this paper to mitigate the effect of channel fading and noise on the transmitted *** subcarrier mapping schemes,namely localized and interleaved schemes,are compared in this *** study depends on different channelmodels,namely PedestrianAandVehicularA,with a modulation technique namedQuadratureAmplitude modulation(QAm).Extensive simulation experiments are conducted and introduced in this paper for efficient transmission of encrypted watermarked *** addition,different variants of SC-FDmA bas

关键词： Cybersecurity applications image transmission channel models modulation techniques watermarking and encryption

Green retrofitting of heritage buildings based on(3Ts)framework:An applied case study

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Frontiers of Architectural Research 2024年第4期13卷 776-798页

作者： Alaa O.Shehata Asmaa m.Hassan merhan m.Shahda naglaa A.megahed Architectural Engineering and Urban Planning Department Faculty of EngineeringPort Said UniversityPort SaidEgypt

Diverse heritage architecture characterizes Port Said in Egypt,reflecting European and Arab *** Canal heritage villas comprise 25%of the total listed heritage buildings in the ***,it is important to retrofit them,aligning with the Sustainable Development Goals(SDGs).By reviewing the previous literature related to the green retrofitting of heritage buildings,the(3Ts)framework can be considered a holistic framework that covers the latest trends due to its three components:targets,tools,and tasks,which help the success of the process through a holistic vision of supporting building information modeling(BIm)technologies and organizing stakeholders’*** paper aims to apply the(3Ts)framework to Suez Canal heritage villas in Port Said,*** applied study is based on how stakeholders perceive their input and decision-making,measuring the climate parameters,proposing several green retrofits,and integrating them into green *** of scenarios is conducted by utilizing the Design Builder simulation ***,the Skelion plugin calculates the photovoltaic system’s(PVs)energy *** results indicated that the total energy savings could reach approximately 12%e74%and nearly 10%e73%CO₂emissions reduction without affecting heritage values.

关键词： Green retrofitting Heritage buildings BIm BES Suez Canal heritage villas Port Said/Egypt

Bone marrow microRNA-34a is a good indicator for response to treatment in acute m.eloid leukemia

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Oncology Research 2024年第3期32卷 577-584页

作者： mONA SA BDelLATEIF naglaa mHASSAN mAHmOUD mKAmel YOmNA mel-melIGUI Department of Cancer Biology Medical Biochemistry and Molecular BiologyNational Cancer InstituteCairo UniversityCairo11976Egypt Department of Cinical Pathology National Cancer InstituteCairo UniversityCairo11976Egypt

Background:microRNA 34a(miR 34a)had been reported to have a diagnostic role in acute m.eloid leukemia(AmL).However,its value in the bone marrow(Bm)of AmL patients,in addition to its role in response to therapy is still *** current study was designed to assess the diagnostic,prognostic,and predictive significance of miR 34a in the Bm of AmL ***:The miR.34a was assed in Bm aspirate of 82 AmL patients in relation to 12 normal control subjects using *** data were assessed for correlation with the relevant dinical critenia,response to therapy,disease-free survival(DFS),and overall survival(OS)***:miR.34a was significantly downregulated in AmL patients[0.005(3.3×10^(-6)-1.32)],compared to the control subjects[0.108(3.2× 10^(-4)-1.64),p=0.021].*** relative quantification(RQ)of miR-34a was 0.106(range;0-32.12).The specifaity,sensitivity,and area under the curve(AUC)for the diagnosis of AmL were(58.3%,69.5%,0.707,respectively,p=0.021).patients with upregulated miR-34a showed decreased platelets countmplete remission(CR,p=0.031,p=0.044,respectively).Similarly,patients who were refractory to therapy showed decreased miR 34a levels in comparison to those who achieved CR[0.002(0-0.01)and 0.12(0-32.12),respectively,p=0.002].Therefore,miR 34a could significantly identify patients with CR with a specificity of 75%and sensitivity of 100%at a cut-off of 0.014(AUC=0.927,p=0.005).There was no considerable association between miR-34a expression and survival rates of the induded AmL ***:miR-34a could be a beneficial diagnostic biomarker for AmL *** addition,it serves as a good indicator for response to therapy,which could possibly identify patients who are refractory to treatment with 100%sensitivity and 75%specificity.

关键词： AmL miR 34a microRNA Leukemia

Correlation between DKK-1 Level and Bone Density Status in Children on maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： manal Abd el-Salam marwa mohamed Anwar Rasha mahmoud Gouda naglaa Abou el Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BmD) with a Z-score of under -2.0. Eighteen of these patients had low BmD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BmD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BmD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BmD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-mBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

Evaluation of phosphorus bioavailability in el mex Bay and Lake mariut sediments

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International Journal of Sediment Research 2017年第3期32卷 432-441页

作者： naglaa F.Soliman Gehan m.el Zokm mohamed A.Okbah Department of Environmental Studies Institute of Graduate Studies and Research University of Alexandria National Institute of Oceanography and Fisheries

Phosphorus(P) fractions and their bioavailability in the sediments from.el mex Bay and Lake mariut in Egypt were investigated using different chemical extraction methods. Sodium bicarbonate(NaHC03)extractable P(Olsen-P) was the largest fraction(14.42%), followed by algal available P(AAP)(3.56%),water soluble P(WSP)(0.79%), and readily desorbable P(RDP)(0.06%) for el mex Bay. While AAP contributed 9.94% to total P in sediments from Lake mariut, Olsen-P 8.53%, WSP 4.11%, and RDP 0.92%.Summation of the bioavailable P fractions didn’t exceed the sediment quality guidelines, and, therefore, P doesn’t represent a danger to marine organisms. Correlation coefficients showed that no apparent relations between total P(TP) and iron(Fe), aluminum(Al), and calcium(Ca) in the sediments. Furthermore, Fe:P ratio was less than 15 indicting that there was not enough Fe in surface sediments to bind to P at most of the sampling sites. The positive correlation between TP and organic matter(Om) for Lake mariut and el mex Bay sediments indicated that the organic matter content of the sediment was a useful predictor of the total phosphorus content. Data from this study constitute a baseline of phosphorus bioavailability in sediments from.el mex Bay and Lake mariut and could be used as a reference for future studies on the changes of bioavailable and residual phosphorus fractions over time.

关键词： Phosphorus bioavailability Sediments el mex Bay Lake mariut

An Efficient GCD-Based Cancelable Biometric Algorithm for Single and multiple Biometrics

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Computers, materials & Continua 2021年第11期69卷 1571-1595页

作者： naglaa F.Soliman Abeer D.Algarni Walid el-Shafai Fathi E.Abd el-Samie Ghada m.el Banby Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia Department of electronics and Communications Faculty of EngineeringZagazig UniversityZagazig44519Egypt Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Industrial electronics and Control Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

Cancelable biometrics are required in most remote access applications that need an authentication stage such as the cloud and Internet of Things(IoT)*** objective of using cancelable biometrics is to save the original ones from hacking attempts.A generalized algorithm to generate cancelable templates that is applicable on both single and multiple biometrics is proposed in this paper to be considered for cloud and IoT *** original biometric is blurred with two co-prime ***,it can be recovered as the Greatest Common Divisor(GCD)between its two blurred *** changes if induced in the biometric image prior to processing with co-prime operators prevents the recovery of the original biometric image through a GCD ***,the ability to change cancelable templates is guaranteed,since the owner of the biometric can pre-determine and manage the minimal change induced in the biometric ***,we test the utility of the proposed algorithm in the single-and multi-biometric *** multi-biometric scenario depends on compressing face,fingerprint,iris,and palm print images,simultaneously,to generate the cancelable *** metrics such as Equal Error Rate(EER)and Area and Receiver Operator Characteristic curve(AROC)are *** results on single-and multi-biometric scenarios show high AROC values up to 99.59%,and low EER values down to 0.04%.

关键词： Cloud IoT cancelable biometrics GCD single-and multi-biometrics security applications