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Laser-assisted direct roller imprinting of large-area microstructured optical surfaces

Microsystems & Nanoengineering 2024年第1期10卷 257-266页

作者： Keisuke nagato Ken Takahashi Yuki Yajima Masayuki Nakao Department of Mechanical Engineering Graduate School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

In this study,a high-throughput fabrication method called laser-assisted direct roller imprinting(LADRI)was developed to lower the cost of nanoimprinting large-area polymer films and to address problems associated with nanoimprinting,namely,microstructural damage and precision in flatness of entire *** LADRI,the laser directly heats the microstructured surface of the roller mold,which heats and melts the surface of a polymethyl methacrylate(PMMA)film to replicate the microstructures on the mold *** this study,the effects of laser power density,scanning speed,size of the microstructures,and contact pressure on the replication speed were investigated *** replication speed increased as the power and scanning speed ***,because the film required heating until it filled the entire depth of the microstructure,an appropriate replication speed was *** result was supported by simulation of the temperature distribution inside the mold and the PMMA using transient heat conduction *** demonstrate the applications of LADRI,two different optical surfaces were replicated:an antireflection(AR)structure with conical structures sized several hundred nanometers and a lightextraction structure with a microlens array(MLA)comprising 10μm lenses,for display and illumination,*** replication degree of the MLA was governed by the contact *** flow simulation indicated that the heat conduction and flow speeds of the melted PMMA surface were comparable within several tens of *** addition,the reflectivity of the AR structure decreased from 4 to 0.5%,and the light intensity of the light-extraction structure increased by a factor of 1.47.

关键词： microstructure roller conduction

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Critical Current and Fracture Behavior of Nb3Al Superconducting Strands under Cyclic Electromagnetic Force

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材料科学与工程（中英文版） 2011年第2期5卷 121-127页

作者： Yoshihide Wadayama Kyohei Natsume Toshiyuki Mito Shinji Hamaguchi nagato yanagi Kazuya Takahata Shinsaku Imagawa Department of Fusion Science School of Physical Science The Graduate University for Advanced Studies Toki-city Gifu 509-5292 Japan National Institute for Fusion Science Toki-city Gifu 509-5292 Japan

To obtain basic information on fracture behavior and its critical current properties in superconducting strands with long-term periodic excitation, a unique experiment of cyclic strain loading was carried out. The strain was applied to a superconducting filament directly at 4.2 K using an electromagnetic (Lorenz) force instead of the usual mechanical load. The sample strands were Jelly-roll process Nb3Al with a copper ratio of 2.1. A new magnet system to evaluate long-term cyclic strain loading was set up. It was able to generate external fields up to 14 T with 58 mm bore. Cyclic strain was applied by the sample current control: 500 A, 0.1 Hz. In the experiment, critical current measurements and applied cyclic strain were carried out in alternation and the variation of critical current was obtained during the cyclic test. In this paper, the experimental results of cyclic strain loading on the critical current of Nb3Al strand and mirostructural observation of fracture surface of the filaments is described. Our results show that degradation of critical current properties was not observed at cycle number n = 1500 under the applied axial strain of 0.17%. A noxious sample, from which the outside copper stabilizer was deliberately removed, broke after n = 10, and crack propagation was observed at the fracture surface of the Nb3Al filaments. Under a microstructural observation of the break sample, the fracture points of the filaments were seen to be different in a longitudinal direction. A striped pattern like a beach mark due to crack propagation was also observed at the Nb3Al fracture surface. It was found that the cross-sectional homogeneity of the strand is important to avoid the damage and breaking from cyclic loading.

关键词： Superconducting strand mechanical strength Nb3Al jelly-roll cyclic strain microstructure

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Long-term treatment with proton pump inhibitor is associated with undesired weight gain

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World Journal of Gastroenterology 2009年第38期15卷 4794-4798页

作者： Ichiro Yoshikawa Makiko nagato Masahiro Yamasaki Keiichiro Kume Makoto Otsuki Third Department of Internal Medicine University of Occupational and Environmental HealthJapanSchool of Medicine

AIM:To examine the effects of long-term proton pump inhibitor (PPI) therapy on body weight (BW) and body mass index (BMI) in patients with gastroesophageal reflux disease (GERD).METHODS: The subjects were 52 patients with GERD and 58 sex-and age-matched healthy controls. GERD patients were treated with PPI for a mean of 2.2 years (range, 0.8-5.7 years), and also advised on lifestyle modifications (e.g. selective diet, weight management). BW, BMI and other parameters were measured at baseline and end of ***: Twenty-four GERD patients were treated daily with 10 mg omeprazole, 12 with 20 mg omeprazole, 8 with 10 mg rabeprazole, 5 with 15 mg lansoprazole, and 3 patients with 30 mg lansoprazole. At baseline, there were no differences in BW and BMI between reflux patients and controls. Patients with GERD showed increases in BW (baseline: 56.4±10.4 kg, end: 58.6±10.8 kg, mean±SD, P<0.0001) and BMI (baseline: 23.1±3.1 kg/m2, end: 24.0±3.1 kg/m2, P<0.001), but no such changes were noted in the control group. Mean BW increased by 3.5 kg (6.2% of baseline) in 37 (71%) reflux patients but decreased in only 6 (12%) patients during ***: Long-term PPI treatment was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to manage BW through lifestyle modifi cations.

关键词： Gastroesophageal reflux disease Protonpump inhibitor Body weight

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Preventing pancreatic fistula after distal pancreatectomy: An invagination method

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World Journal of Gastroenterology 2017年第8期23卷 1507-1512页

作者： nagato Katsura Yasuhiro Kawai Takashi Gomi Kenji Okumura Takahiko Hoashi Seijun Fukuda Katsushi Takebayashi Kenji Shimizu Masugi Satoh Department of Surgery Misugikai Otokoyama Hospital Department of Surgery Misugikai Satoh HospitalYobuhigashimachi Hirakata

Following an increase in the use of the GIA stapler for treating a pancreatic stump, more techniques to prevent postoperative pancreatic juice leakage have been required. We describe one successful case using our new technique of invaginating the cut end of the pancreas into the stomach to prevent a pancrea-tic fistula(PF) from occurring. A 50-year-old woman with pancreatic cancer in the tail of the pancreas underwent distal pancreatectomy, causing a grade A PF. We resected the distal pancreas without additional reinforcement to invaginate the stump into the gastric posterior wall with single layer anastomosis using a 3-0 absorbable suture. The drain tubes were removed on the third postoperative day. Although a grade A PF was noted, the patient was discharged on foot on the eleventh postoperative day. Our technique may be a suitable method for patients with a pancreatic body and tail tumor.

关键词： Amylases Pancreatectomy Pancreatic fistula Pancreatic juice Neoplasms

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Hydrogen and methane gases are frequently detected in the stomach

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World Journal of Gastroenterology 2006年第19期12卷 3088-3091页

作者： Yoshihisa Urita Susumu Ishihara Tatsuo Akimoto Hiroto Kato Noriko Hara Yoshiko Honda Yoko Nagai Kazushige Nakanishi nagato Shimada Motonobu Sugimoto Kazumasa Miki Department of General Medicine and Emergency Care Toho University School of Medicine Omori HospitalTokyoJapan Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University School of MedicineOmori HospitalTokyoJapan

AIM： To investigate the incidence of bacterial overgrowth in the stomach by using a new endoscopic method in which intragastric hydrogen and methane gases are collected and analyzed. METHODS： Studies were performed in 490 consecutive patients undergoing esophagogastroscopy, At endoscopy, we intubated the stomach without inflation by air, and 20 mL of intragastric gas was collected through the biopsy channel using a 30 mL syringe, Intragastric hydrogen and methane concentrations were immediately measured by gaschromatography, H pylori infection was also determined by serology. RESULTS： Most of intragastric hydrogen and methane levels were less than 15 ppm （parts per million）. The median hydrogen and methane values （interquartile range） were 3 （1-8） ppm and 2 （1-5） ppm, respectively. The high hydrogen and methane levels for indication of fermentation were decided if the patient had the values more than 90 percentile range in each sample. When a patient had a high level of hydrogen or methane in one or more samples, the patient was considered to have fermentation. The overall incidence of intragastric fermentation was 15.4% （73/473）, Intragastric methane levels were higher in the postoperative group than in other groups. None of the mean hydrogen or methane values was related to Hpylori infection. CONCLUSION： Hydrogen and methane gases are more frequently detected in the stomach than expected, regardless of the presence of abdominal symptoms. Previous gastric surgery influences on the growth of methaneproducing bacteria in the fasting stomach.

关键词： Intragastric gases Hydrogen Methane Helicobacter pylori

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Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowth

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World Journal of Gastroenterology 2006年第19期12卷 3092-3095页

AIM： To investigate non-invasively the incidence of absorption of carbohydrates in diabetic patients during an oral glucose tolerance test （OGTT） and to determine whether malabsorption may be associated with insulin secretion and insulin resistance. METHODS： A standard 75-g OGTT was performed in 82 diabetic patients. The patients received 75 g of anhydrous glucose in 225 mL of water after an overnight fasting and breath samples were collected at baseline and up to 120 rain after ingestion. Breath hydrogen and methane concentrations were measured. Blood glucose and serum insulin concentrations were measured before ingestion and at 30, 60, 90, 120 rain post-ingestion. RESULTS： When carbohydrate malabsorption was defined as subjects with an increase of at least 10 ppm （parts per million） in hydrogen or methane excretion within a 2-h period, 28 （34%） had carbohydrate malabsorption. According to the result of increased breath test, 21 （75%） patients were classified as small bowel bacterial overgrowth and 7 （25%） as glucose malabsorption. Patients with carbohydrate malabsorption were older and had poor glycemic control as compared with those without carbohydrate malabsorption. The HOMA value, the sum of serum insulin during the test and the AinsulinlAglucose ratio were greater in patients with carbohydrate malabsorption. CONCLUSION： Insulin resistance may be overestimated by using these markers if the patient has carbohydrate malabsorption, or that carbohydrate malabsorption may be present prior to the development of insulin resistance. Hence carbohydrate malabsorption should be taken into account for estimating insulin resistance and β-cell function.

关键词： 75-g OGTT Carbohydrate malabsorption Bacterial overgrowth Breath test Insulin resistance

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Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study

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World Journal of Clinical Cases 2019年第12期7卷 1393-1402页

作者： Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takahiro Sato Ikutaka Takemoto Sho Kijima Tadashi Maeda Takamasa Ishii Taito Miyazaki Yoshiko Honda nagato Shimada Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of Medicine

BACKGROUND Acute right colonic diverticulitis (ARCD) is an important differential diagnosis of acute appendicitis (AA) in Asian countries because of the unusually high prevalence of right colonic diverticula. Due to qualitative improvement and the high penetration rate of computed tomography (CT) scanning in Japan, differentiation of ARCD and AA mainly depends on this modality. But cost, limited availability, and concern for radiation exposure make CT scanning problematic. Differential findings of ARCD from AA are based on several small studies that used univariate comparisons from Korea and Taiwan. Previous studies on clinical and laboratory differences between AA and ARCD are limited. AIM To determine clinical differences between AA and ARCD for differentiation of these two diagnoses by creating a logistic regression model. METHODS We performed an exploratory single-center retrospective case-control study evaluating 369 Japanese patients (age ≥ 16 years), 236 (64.0%) with AA and 133 (36.0%) with ARCD, who were hospitalized between 2012 and 2016. Diagnoses were confirmed by CT images. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant (RLQ) pain, nausea/vomiting, diarrhea, anorexia, medical history, body temperature, blood pressure, heart rate, RLQ tenderness, peritoneal signs, leukocyte count, and levels of serum creatinine, serum C-reactive protein (CRP), and serum alanine aminotrans-ferase. We subsequently performed logistic regression analysis for differentiating AA from ARCD based on the results of the univariate *** In the AA and ARCD groups, median ages were 35.5 and 41.0 years, respectively (p=0.011);median onset-to-visit intervals were 1 [interquartile range (IQR): 0-1] and 2 (IQR: 1-3) days, respectively (P < 0.001);median leukocyte counts were 12600 and 11500/mm3, respectively (P = 0.002);and median CRP levels were 1.1 (IQR: 0.2-4.1) and 4.9 (IQR: 2.9-8.5) mg/dL, respectively (P < 0.001). In th

关键词： Abdominal pain Acute abdomen Appendicitis Clinical difference Creactive protein Diverticulitis Right lower quadrant pain

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Clinical prediction of complicated appendicitis:A case-control study utilizing logistic regression

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World Journal of Clinical Cases 2020年第11期8卷 2127-2136页

作者： Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takeshi Suzuki Ikutaka Takemoto Sho Kijima Tadashi Maeda Taito Miyazaki Yoshiko Honda Hiroaki Zai nagato Shimada Kimihiko Funahashi Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of MedicineOta-kuTokyo 143-8541Japan Department of General and Gastroenterological Surgery Toho University Omori Medical CenterOtakuTokyo 143-8541Japan

BACKGROUND Since high-quality evidence on conservative treatment of acute appendicitis using antibiotics has increased,differentiation of patients with complicated appendicitis(CA)from those with simple appendicitis(SA)has become increasingly *** studies have revealed that male gender,advanced age,comorbid conditions,prehospital delay,fever,and anorexia are risk factors of perforated *** serum C-reactive protein(CRP)level and hyponatremia have also been reported as predictive biomarkers of ***,confounding between various factors is problematic because most previous studies were limited to univariate *** To evaluate non-laboratory and laboratory predictive factors of CA using logistic regression *** We performed an exploratory,single-center,retrospective case-control study that evaluated 198 patients(83.9%)with SA and 38 patients(16.1%)with *** were confirmed by computed tomography images for all *** compared age,sex,onset-to-visit interval,epigastric/periumbilical pain,right lower quadrant pain,nausea/vomiting,diarrhea,anorexia,medical history(of previous non-surgically treated appendicitis,diabetes,hypertension,dyslipidemia,liver cirrhosis,hemodialysis,chronic lung diseases,malignant tumors,immunosuppressant use,and antiplatelet use),vital signs,physical findings,and laboratory data to select the explanatory variates for logistic *** on the univariate comparisons,we performed logistic regression for clinical differentiation between CA and SA using only nonlaboratory factors and also including both non-laboratory and laboratory *** The 236 eligible patients consisted of 198 patients(83.9%)with SA and 38 patients(16.1%)with *** median ages were 34 years old[interquartile ranges(IR),24-45 years]in the SA group and 49 years old(IR,35-63 years)in the CA group(P<0.001).The median onset-to-visit interval was 1 d(IR,0-1)and 1 d(IR,1-2)in the SA and CA groups,respectively

关键词： Acute abdomen Abscess Appendicitis C-reactive protein Forecasting Intestinal perforation

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横过JR Tokaido干线下的屏蔽化学灌浆

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探矿工程译丛 1998年第3期 36-38页

作者： nagato,N 木石

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水稻和大麦颖果培养中胚形成初期3H-尿苷和3H-亮氨酸的掺入

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核农学通报 1981年第1期 44-47页

作者： Yasuo nagato 吴刚明日本东京大学农学系植物育种研究室

在高等植物形态发生中RNA和蛋白质起着重要作用,可是到目前为止对于胚形成初期RNA和蛋白质合成的知识仍然很少。有关RNA合成的研究主要集中在萌发的胚上。前已报道,在球形胚中出现许多激烈的发育变化,指数生长和双重节律生长开始于球形... 详细信息

在高等植物形态发生中RNA和蛋白质起着重要作用,可是到目前为止对于胚形成初期RNA和蛋白质合成的知识仍然很少。有关RNA合成的研究主要集中在萌发的胚上。前已报道,在球形胚中出现许多激烈的发育变化,指数生长和双重节律生长开始于球形胚100—200细胞阶段,这些发育的变化反映了RNA和蛋白质代谢方面质和量的变化。本试验测定了水稻和大麦胚形成初期3H-尿苷和3H-亮氨酸的掺入情况。

关键词：颖果子房壁大麦胚水稻亮氨酸白氨酸

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