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Target morphology and cell memory:a model of regenerative pattern formation

Neural Regeneration Research 2015年第12期10卷 1901-1905页

作者： Nikolai Bessonov Michael Levin nadya morozova Natalia Reinberg Alen Tosenberger Vitaly Volpert Institute of Problems of Mechanical Engineering Russian Academy of Sciences Department of Biology Tufts Center for Regenerative & Developmental BiologyTufts University Laboratoire Epigénétique et Cancer Institut des Hautes Etudes Scientiques Unité de Chronobiologie Théorique Faculté des SciencesUniversité Libre de BruxellesCampus Plaine Institut Camille Jordan UMR 5208 CNRSUniversity Lyon 1

Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical structure following damage.A key question is how regenerating systems know when to stop growth and remodeling-what mechanisms implement recognition of correct morphology that signals a stop condition？In this work,we review two conceptual models of pattern regeneration that implement a kind of pattern *** the first one,all cells communicate with each other and keep the value of the total signal received from the other *** a part of the pattern is amputated,the signal distribution *** difference fromthe original signal distribution stimulates cell proliferation and leads to pattern regeneration,in effect implementing an error minimization process that uses signaling memory to achieve pattern *** the second model,we consider a more complex pattern organization with different cell *** tissue contains a central（coordinator）cell that controls the tissue and communicates with the other central *** of them keeps memory about the signals received from other central *** values of these signals depend on the mutual cell location,and the memory allows regeneration of the structure when it is *** purpose of these models is to suggest possible mechanisms of pattern regeneration operating on the basis of cell memory which are compatible with diverse molecular implementation mechanisms within specific organisms.

关键词： target morphology pattern regeneration cell memory morphogenesis cell signaling mathematical modeling agent-based model

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