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Journal of Pharmaceutical Analysis 2024年第7期14卷 1091-1094页

作者： Alexander Dombovski Ruben Steigerwald nadine ritter Paul Disse Gunnar Goerges Jana Osthues Isabel Aymanns Carina Dilkaute Julian Schreiber Martina Düfer Guiscard Seebohm Bernhard Wünsch Joachim Jose University of Münster Institute of Pharmaceutical and Medicinal ChemistryPharmacampus48149MünsterGermany University of Münster GRK 2515Chemical Biology of Ion Channels(Chembion)48149MünsterGermany University of Münster Institute for Genetics of Heart Diseases(IfGH)Department of Cardiovascular MedicineUniversity Hospital Münster48149MünsterGermany

Autodisplay of N-methyl-D-aspartate(NMDA)receptor[1]ligand binding domains(LBDs)was done by inserting the coding sequence for each LBD[2]into a plasmid for maximized autotransporter-mediated expression(pMATE)between the coding sequences of signal peptide and translocator domain[3](Figs.1A and S1).Surface display and functionality of LBDs was confirmed by protease accessibility and radioligand binding(Figs.S2 and S3).This is discussed in more detail in the Sections S1.1S1.5 in the Supplementary *** with surface displayed LBDs were applied for a flow cytometry-based binding assay to evaluate fluorescent TCN-201 derivatives[4](Figs.1B,S4,and S5).More detailed information about the structural prerequisites of TCN-201 derivatives for interacting with the modulatory binding site and synthesis of fluorescent derivatives is given in the Sections S1.6 and S1.7 in the Supplementary data.

关键词： compound synthesis sequences

Cas13d-mediated gene knockdown in CAR T cells:towards off-the-shelf cancer treatment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1796-1798页

作者： Midori Johnston nadine Urban Can Dincer FIT Freiburg Centre for Interactive Materials and Bioinspired Technology University of FreiburgFreiburgGermany IMTEK-Department of Microsystems Engineering University of FreiburgFreiburgGermany

In a recent study published in Cell,Tieu et *** RfxCas13d to dynamically enhance performance and longevity of chimeric antigen receptor(CAR)T cells by massively multiplexed gene knockdown and thereby,move the treatmen... 详细信息

关键词： treatment shelf

Electro-Magnetic Control of Vortex Shedding Behind a Circular Cylinder

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Chinese Physics Letters 2006年第1期23卷 154-157页

作者：陈志华范宝春 nadine AUBRY 周本谋 Key Laboratory of Transient Physics Nanjing University of Science and Technology Nanjing 210094 Department of Mechanical Engineering New Jersey Institute of Technology Newark N3 07102 USA

Both open- and closed-loop control algorithms have been developed for suppressing of vortex shedding behind a circular cylinder in an electrically low-conducting fluid. For the open-loop control, the localized Lorentz forces are generated parallel to the cylinder surface, which have the accelerated effect to the fluid. Furthermore, two closed-loop control methods have been derived from the equations of motion capable of determining at all times the intensity of the Lorentz force to control the vortex shedding of a cylinder.

关键词： FORCES WAKE

Effect of hydration on the surface basicity and catalytic activity of Mg-rare earth mixed oxides for aldol condensation

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Journal of Rare Earths 2018年第4期36卷 359-366页

作者： Zheng Wang Pascal Fongarland Guanzhong Lu Wangcheng Zhan nadine Essayem Key Laboratory for Advanced Materials and REsearch Institute of Industrial Catalysis School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Institut de REcherches sur la Catalyse et l'Environnement de Lyon(IRCELYON) CNRS-Universite Lyon 12 Avenue Albert Einstein69626 Villeurbanne CedexFrance

Magnesium and rare earth mixed oxides（Mg3 REOx（RE=La, Y. Ce）） were prepared and characterized by Xray diffraction（XRD）, N_2 adsorption-desorption, infrared spectra and microcalorimetry of CO_2. The results reveal that the Mg_3 CeO_x catalyst is present in the form of Mg-Ce-O solid solution,while the Mg3 LaOx and Mg_3 YO_x catalysts are probably rare earth oxides dispersed on MgO surface. As a result, among the calcined Mg_3 REO_x catalysts, the Mg_3 CeO_x catalyst presents the highest rate constant for acetone aldolization, which is well correlated to its more homogeneous distribution of basic sites. In contrary, the Mg_3 YO_x catalyst exhibit the lowest catalytic activity for acetone aldolization. Upon hydration pre-treatment, the basic properties on the surface of the Mg_3 REO_x catalysts were changed markedly. The Mg_3 YO_x catalyst after hydration treatment shows the highest amount of basic sites on catalyst surface, and then exhibits the highest activity among the hydrated Mg_3 REO_x catalysts. These results make it possible to fine-tune basic sites for acetone aldolization.

关键词： Mg-rare earth mixed oxide Hydration treatment Water tolerance Aldol condensation Solid base catalyst Rare earths

COMPARISON OF TWO METHODS OF OPERATING THEATRE PLANNING:APPLICATION IN BELGIAN HOSPITAL

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Journal of Systems Science and Systems Engineering 2008年第2期17卷 171-186页

作者： Sondes CHAABANE nadine MESKENS Alain GUINET Marius LAURENT LAMIH laboratory Valenciennes University59313 Valenciennes Cedex 09France MAAD Laboratory FUCAM7000 MonsBelgium LIESP Laboratory INSA-Lyon69621 France CHU de TIVOLI 7100 La LouvièreBelgium

Operating Theatre is the centre of the hospital management＇s efforts. It constitutes the most expensive sector with more than 10% of the intended operating budget of the hospital. To reduce the costs while maintaining a good quality of care, one of the solutions is to improve the existent planning and scheduling methods by improving the services and surgical specialty coordination or finding the best estimation of surgical case durations. The other solution is to construct an effective surgical case plan and schedule. The operating theatre planning and scheduling is the two important steps, which aim to make a surgical case programming with an objective of obtaining a realizable and efficient surgical case schedule. This paper focuses on the first step, the operating theatre planning problem. Two planning methods are introduced and compared. Real data of a Belgian university hospital ＂Tivoli＂ are used for the experiments.

关键词： Open scheduling block scheduling operating theatre planning master surgical schedule

In situ Raman imaging of high-temperature solid-state reactions in the CaSO4-SiO2 system

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International Journal of Coal Science & Technology 2019年第2期6卷 247-259页

作者： nadine Bohme Kerstin Hauke Manuela Neuroth Thorsten Geisler Institut fiir Geowissenschaften und Meteorologie Universitat Bonn Poppelsdorfer Schloss Meckenheimer Allee 169 53115 Bonn Germany RWE Power AG F und E Kraftwerk NiederauBem Bergheim Germany

The deposition of mineral phases on the heat transfer surfaces of brown coal power plants may have a negative effect on power plant boilers. The paragenesis of these deposits contains information about the actual temperature prevailed during the combustion of lignite, if the temperature-dependences of distinct mineral transformations or reactions are known. Here, we report results of a sintering study (to ?1100℃) with samples containing anhydrite, quartz, and gehlenite, which are typical components of Rhenish lignite ashes. Thermal decompositions and solid-state reactions were analyzed (1) in situ and (2) both in situ and after quenching using confocal hyperspectral Raman imaging. This novel application of confocal Raman spectroscopy provides temperature-and time-resolved, 2-dimensional information about sintering processes with a micrometer-scale resolution. In the course of the sintering experiments with anhydrite and quartz with a weight ratio of 2:1 both polymorphs wollastonite and pseudowollastonite were identified in situ at about 920 and 1000℃, respectively. The formation of pseudowollastonite was thus observed about 120℃ below the phase transition temperature, demonstrating that it can form metastably. In addition,α′L-Ca2SiO4 was identified at about 1100℃. In samples containing equal weight fractions of anhydrite and quartz that were quenched after firing for 9h at about 1100℃,β-Ca2SiO4 (larnite) crystallized as rims around anhydrite grains and in direct contact to wollastonite. We furthermore observed that, depending on the ratio between quartz and anhydrite, wollastonite replaced quartz grains between 920 and 1100℃., i.e., the higher the quartz content, the lower the formation temperature of wollastonite.

关键词： Ash deposition Calcium silicate Calcium sulfate High-temperature Raman imaging

Advanced pancreatic ductal adenocarcinoma-Complexities of treatment and emerging therapeutic options

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World Journal of Gastroenterology 2017年第13期23卷 2276-2285页

作者： Chandra Diwakarla Katherine Hannan nadine Hein Desmond Yip Department of Medical Oncology The Canberra Hospital The John Curtin School of Medical Research Australian National University ANU Medical School Australian National University

Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental im-provements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel the-rapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.

关键词： Ribosome biogenesis Nucleolar stress RNA polymerase I Pancreatic ductal adenocarcinoma Chemotherapy

Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy

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Journal of Magnesium and Alloys 2019年第1期7卷 47-57页

作者： Samuel Leleu Bertrand Rives Nicolas Causse nadine Pébère CIRIMAT Universitéde ToulouseCNRSINPTUPSENSIACET4 allée Emile Monso BP4436231030 Toulouse cedex 4 France IRT Saint Exupéry 118 route de Narbonne-CS 4424831432 ToulouseFrance

The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)*** all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure *** rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical *** corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series *** data allowed the corrosion mechanisms to be discussed.

关键词： Magnesium alloys Rare-earth elements EIS ICP-OES Interface

Data-driven smart charging for heterogeneous electric vehicle fleets

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Energy and AI 2020年第1期1卷 74-86页

作者： Oliver Frendo Jerome Graf nadine Gaertner Heiner Stuckenschmidt SAP SE Dietmar-Hopp-Allee 16Walldorf 69190Germany University of Mannheim Schloss68131 Mannheim

The ongoing electrification of mobility comes with the challenge of charging electric vehicles(EVs)sufficiently while charging infrastructure capacities are *** charging algorithms produce charge plans for indi-vidual EVs and aim to assign charging capacities fairly and efficiently between vehicles in a *** practice,EV charging processes follow nonlinear charge profiles such as constant-current,constant-voltage(CCCV).Smart charging must consider charge profiles in order to avoid gaps between charge plans and actual EV power *** valid models of charge profiles and their parameters for a diverse set of EVs are not publicly *** this work we propose a data-driven approach for integrating a machine learning model to pre-dict arbitrary charge profiles into a smart charging *** train machine learning models with a dataset consisting of charging processes from the workplace gathered in 2016–2018 from a heterogeneous EV fleet of 1001 EVs with 18 unique *** charging process includes the time series of charging *** pre-processing,the dataset contains 10.595 charging processes leading to 1.2 million data points in *** then compare different machine learning models for charge profile predictions finding that XGBoost yields the most accurate predictions with a mean absolute error(MAE)of 126W and a relative MAE of *** show that smart charging with the integrated XGBoost model leads to a more effective infrastructure usage with up to 21%more energy charged compared to smart charging without considering charge ***,an ablation study on regression model features shows the EV’s model is not a necessary attribute for accurate charge profile ***,charging features are required including the number of phases used for charging.

关键词： Smart charging Electric vehicles Data-driven approach Machine learning

Stiffness increase of red blood cells during storage

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Microsystems & Nanoengineering 2018年第1期4卷 484-489页

作者： Zhensong Xu Yi Zheng Xian Wang nadine Shehata Chen Wang Yu Sun Department of Mechanical and Industrial Engineering University of TorontoTorontoONCanada M5S 3G8 Department of Mechanical Engineering University of MichiganAnn ArborMI48109USA Department of Medicine University of TorontoTorontoONCanada M5G 1X5 Department of Pathology and Laboratory Medicine Mount Sinai HospitalTorontoONCanada M5G 1X5 Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada M5G 1X5 Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada M5S 3G8 Department of Electrical and Computer Engineering University of TorontoTorontoONCanada M5S 3G8

In transfusion medicine,the deformability of stored red blood cells(RBCs)changes during storage in blood *** RBC deformability can reduce the transfusion efficiency or intensify transfusion complications,such as *** paper reports the microfluidic mechanical measurement of stored RBCs under the physiological deformation mode(that is,folding).Instead of using phenomenological metrics of deformation or elongation indices(DI or EI),the effective stiffness of RBCs,a flow velocityindependent parameter,is defined and used for the first time to evaluate the mechanical degradation of RBCs during *** RBCs and RBCs stored up to 6 weeks(42 days)in the blood bank were measured,revealing that the effective stiffness of RBCs increases over the storage *** stored for 1 week started to show significantly higher stiffness than fresh RBCs,and stored RBC stiffness degraded faster during the last 3 weeks than during the first 3 ***,the results indicate that the time points of the effective stiffness increase coincide well with the degradation patterns of S-nitrosothiols(SNO)and adenosine triphosphate(ATP)in RBC storage lesions.

关键词： red blood cell effective stiffness deformability storage lesions microfluidics