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Surgical Management of a Collision Tumor: The Association of Intracranial Meningioma and Macroadenoma

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Spheno-Temporal Langerhans Cell Histiocytosis: A Case Report

Open Journal of Modern Neurosurgery（现代神经外科学进展） 2024年第1期

作者： Salma Abbas Yao Christian Hugues Dokponou Thameen Jaradat Mahjouba Boutarbouch nadia cherradi Hafsa El Ouazzani Abdessamad El Ouahabi

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Open Journal of Modern Neurosurgery 2020年第2期10卷 260-266页

作者： Christine Milena Sayore Nda Bankole Loubna Rifi nadia cherradi Adyl Melhaoui Abdessamad Elouahabi Department of Neurosurgery Mohamed V University Rabat Morocco Department of Histopathology Mohamed V University Rabat Morocco

Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells with inflammatory cells, characterized by the activation of histiocytic cells or their proliferation that affects structures of the human body, including the temporal bone which localization is rare in children. The objective of this study is to illustrate the clinical presentation, management and prognosis of this disease, and to compare our case with previously reported series. We report the case of a young 4-year-old patient with a history of otorrhea and recurrent otalgia, with left axillary non-blowing exophthalmia progressive since 5 months associated with indurated left temporal swelling and also an indurated swelling of posterior face of the left shoulder on pathological fracture. A cerebro-orbital MRI performed at home showed an extra-conical process with extension at the temporal fossa. The patient, then, underwent an open-air biopsy of the temporal mass and the pathological analysis returned to favor Langerhans cell histiocytosis. The diagnosis was made by immunohistochemical findings of the S-100 protein and/or the CD1 antigen. The child was treated by chemotherapy with a good outcome. Our results concord with literature. The prognosis is different and better in children with unifocal bone disease than those with a multifocal disease with a survival rate of 65% - 100%.

关键词： Langerhans Cell Histocytosis Temporal Sphenoid Exophthalmia

Extracranial Metastasis of an Anaplastic Ependymoma, RELA Fusion-Positive: A Rare Occurrence

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Open Journal of Modern Neurosurgery 2020年第1期10卷 9-18页

作者： Christine Milena Sayore Nabil Adio Mousse Mohammed Yassaad Oudrhiri nadia cherradi Adyl Melhaoui Abdessamad El Ouahabi Department of Neurosurgery Mohamed V University Rabat Morocco Department of Histopathology Mohamed V University Rabat Morocco

Primary intracranial ependymomas originate from ependymal cells. They may migrate mainly in the spinal cord but rarely metastasize outside the central nervous system. Metastases outside the central nervous system are rare. Metastatic diffusion from the central nervous system is low due to the unique interaction of the brain and the tumor with the blood-brain barrier. Nevertheless, three main hypotheses have been mentioned in the literature, the tumor growth, the surgical manipulation (which may be considered to be the case in our patient), and the aggressiveness of the tumor according to the Ki67 index. We report the case of a 16-year-old female, who underwent complete surgical removal of a left occipital 2007 WHO grade II ependymoma. 3 years later, the patient presented multiple cervical and occipital indurated masses. MRI showed a left hemispheric meningeal infiltration, with multiple nodules located on the neck, occiput and mastoid. Histopathological study of a left temporal surgical biopsy and resection of an occipital subcutaneous nodule turned to be metastases of an anaplastic ependymoma. The ependymoma considered as a benign tumor could very quickly turn into malignancy by its metastatic potential. Early diagnosis and longer follow-up of patients would be recommended for a rapid management.

关键词： Anaplastic Ependymoma Extracranial Metastasis Extraneural RELA Fusion

Pediatric Nasopharyngeal Rhabdomyosarcoma: About a Case and Review of Literature

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Journal of Cancer Therapy 2021年第1期12卷 10-18页

作者： Dohoué Patricia Eliane Agbanglanon Imane M’barki Oswald Houessou Gaël Kietga Siham Jaba Hafsa Elouazzani Séka Evrard Narcisse Hanan Elkacemi nadia cherradi Sanaa Elmajjaoui Noureddine Benjaafar Department of Radiotherapy Oncology National Institute of Oncology Rabat Morocco Department of Pathological Anatomy Laboratory Specialties Hospital Rabat Morocco

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the head and neck location accounting for up to 40% of cases. The embryonal and alveolar histologic variants are more commonly seen in pediatric patients. The treatment is multimodal and the prognosis of this clinical entity is always gloomy. We report the case of nasopharyngeal rhabdomyosarcoma in a 7-year-old boy child with a good response to early post-therapy. Case Presentation: The patient was diagnosed with nasopharyngeal RMS revealed by a congested nose, ptosis and bilateral blindness, and who received induction chemotherapy followed by concurrent radiotherapy followed by adjuvant chemotherapy. The evolution is marked by a good clinical course but persistence of bilateral blindness

关键词： Rhabdomyosarcoma Nasopharyngeal Pediatric Chemotherapy Radiotherapy

Pediatric Nasopharyngeal Rhabdomyosarcoma: About a Case and Review of Literature

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