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Chemical composition of Mentha suaveolens and Pinus halepensis essential oils and their antibacterial and antioxidant activities

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Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 117-122页

作者： Abdelhakim Bouyahya Omar Belmehdi Jamal Abrini nadia Dakka Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed V University in Rabat Biology and Health Laboratory Department of BiologyFaculty of SciencesAbdelmalek Essaadi University

Objective: To determin the chemical compounds of Mentha suaveolens(M. suaveolens) and Pinus halepensis(P. halepensis) essential oils(Eos) and evaluate their antioxidant and antibacterial activities. Methods: The chemical composition of P. halepensis and M. suaveolens EOs was determined by GC-MS analysis. The antioxidant activity was evaluated using DPPH,ABTS and FRAP assays. The antibacterial effect was tested against 6 bacterial strains using the well diffusion method and micro-dilution assay. Results: The major components of P. halepensis EOs were β-caryophyllene(28.04%),myrcene(23.81%) and α-pinene(12.02%). However,piperitenone oxid(56.28%),piperitenone(11.64%) and pulegone(6.16%) were the major components of M. suaveolens EOs. M. suaveolens EOs showed remarkable antioxidant activities compared with P. halepensis EOs,showing antioxidant capacity values of IC50=(64.76±2.24) μg/mL,IC50=(82.73±3.34) μg/mL,and IC50=(93.35±4.45) μg/mL,revealed by DPPH,ABTS and FRAP assays,respectively. However,P. halepensis EOs showed interesting antibacterial effects against all bacterial strains. The most sensible strains to P. halepensis EOs were Staphylococcus aureus [(34.00±0.50) mm],Listeria monocytogenes [(31.00±1.50)] mm and Proteus mirabilis [(29.00±2.25)mm]. Furthermore,the lowest minimal inhibitory concentration(MIC) and minimal bactericidal concentration(MBC) values were revealed by P. halepensis EOs against Staphylococcus aureus [MIC=MBC=0.125%(v/v)] and Listeria monocytogenes [MIC=MBC=0.25%(v/v)]. Conclusions: P. halepensis and M. suaveolens EOs contain bioactive compounds that could have potential applications against bacterial infections and oxidative stress related diseases as well as for food conservation. However,further investigations are necessary to isolate and investigate the action mechanisms of these bioactive compounds.

关键词： Mentha suaveolens Pinus halepensis Essential oil Antioxidant effect Antibacterial activity

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X-ray Structure and Density Functional Theory Investigations of 4-((2R)-2-(3,4-dibromophenyl)-1-fluoro cyclopropyl)-N-(o-tolyl)benzamide Compound

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Chinese Journal of Structural Chemistry 2020年第9期39卷 1601-1614,1554页

作者： BENELHADJ-DJELLOUL Yamina BOUKABCHA Nourdine BENHALIMA nadia YAHIAOUI Salem CHOUAIH Abdelkader ZANOUN Abdelouahab Laboratory of Technology and Solid Properties(LTPS) Abdelhamid Ibn Badis University of MostaganemMostaganem 27000Algeria Département de Génie des Procédés UniversitéAhmed Zabana de RelizaneRelizane 48000Algeria Département de Physique Facultédes SciencesUniversitéDr.Moulay Tahar de SaidaSaida 20000Algeria Ecole Normale Supérieure de Mostaganem Mostaganem 27000Algeria

In this work,the structure of 4-((2R)-2-(3,4-dibromophenyl)-1-fluorocyclopropyl)-N-(o-tolyl)benzamide(DBFB)has been determined at room temperature using single-crystal X-ray diffraction *** structure of the compound was solved using 1464 observed reflections with I≥2σ(I).It crystallizes in monoclinic space group P21 with a=20.0820(10),b=10.2770(10),c=4.860(2)?,β=95.9600(10)°,V=997.6(4)?3,Z=2,Dc=1.675 g/m3,F(000)=500,Μr=503.18,μ=4.09 mm-1 and the final R=*** molecular packing of the title compound exhibits C–H???O and C–H???F hydrogen bonds forming a supramolecular ***,conformational analysis has been performed in order to confirm the most stable conformer of the title *** parameters of the keto conformer in the ground state have been obtained using density functional theory(DFT)method with B3LYP/6-31G(d,p)level of *** general,a good agreement between the calculated and experimental results was *** normal modes of vibration,molecular boundary orbitals(HOMO and LUMO),reactivity descriptors,Mullikan atomic charges and molecular electrostatic potential for the title compound have been evaluated and discussed.

关键词： C23H18Br2FNO insecticide crystal structure DFT HOMO-LUMO

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Efficacy of Silene arenosa extract on acetylcholinesterase in Bungarus sindanus(krait) venom

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Journal of Traditional Chinese Medicine 2021年第3期41卷 349-354页

作者： Adil Shah Mushtaq Ahmed Naila Sher nadia Mushtaq Rahmat Ali Khan Fozia Midrarullah Department of Biotechnology Faculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPK-Pakistan Department of Botany Faculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPK-Pakistan Department of Biochemistry KMU Institute of Medical SciencesKohat 26000Pakistan Department of Biotechnology Saheed Benazir Bhutto UniversitySheringalDir UpperKPK-Pakistan

OBJECTIVE:To examine the efficacy of Silene arenosa extract on acetylcholinesterase (AChE) of krait (Bungarus Sindanus) snake ***:The present project designed to evaluate the inhibition of AChE by following standard ***:Statistical analysis of the results showed that Silene arenosa exerted 73%inhibition against the krait venom acetylcholinesterase at fixed substrate acetylcholine (ACh) concentration (0.5 mM).Kinetic analysis using the Lineweaver Burk plot revealed that Silene arenosa caused a competitive type of inhibition i.e.K_(m) values increased from 26.6 to 93.3 mM (26.6%to 93.3%) and V_(max)remained constant in a concentration-dependent *** arenosa competes with the substrate to bind at the active site of the *** K_(mapp)of venom AChE for Silene arenosa increased from 60%to 81.6%and the V_(maxapp)remains constant.K_(i)(inhibition constant was estimated to be 48μg for snake venom);while the K_(m)(Michaelis-Menten constant of AChE-substrate into AChE and product) was estimated to be 0.5 *** IC_(50)of AchE calculated for Silene arenosa was 67μ***:The present results suggest that Silene arenosa extract can be considered as an inhibitor of snake venom AChE.

关键词： acetylcholinesterase snake venoms silene arenosa competitive inhibition

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作者： nadia Dalbuono.

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作者： nadia Dalbuono.

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Light-controlled mass formation of aggregates of molecules in organic compounds

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Chinese Optics Letters 2009年第9期7卷 823-825页

作者： Tariel D.Ebralidze nadia A.Ebralidze Giorgi A.Mumladze Enriko S.Kitsmarishvili Institute of Cybernetics Georgian Academy of Sciences

During the mass formation of aggregates of molecules in a gelatin film dyed with the mixture of chrysophenine and acridine yellow dyes, photo-reorientation, photo-disorientation, and photo-orientation of the molecules... 详细信息

关键词： Light-controlled mass formation of aggregates of molecules in organic compounds

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Mechanisms underlying lineage commitment and plasticity of human yo T cells

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Cellular & Molecular Immunology 2013年第1期10卷 30-34页

作者： nadia Caccamo Matilde Todaro Guido Sireci Serena Meraviglia Giorgio Stassi Francesco Dieli Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi Universita degli Studi di Palermo Palermo Italy Dipartimento di Discipline Chirurgiche ed Oncologiche Universita degli Studi di Palermo Palermo: Italy

Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells. Upon antigen stimulation, y T cells differentiate into two major types of memory T cells： central memory cells, which patrol the blood and secondary lymphoid organs, and effector memory cells, which migrate to peripheral tissues, y T cells display in vitroa certain degree of plasticity in their function that is reminiscent of that which is observed in conventional CD4 T cells. Similar to CD4 T cells, in which a plethora of specialized subsets affect the host response, y8 T cells may readily and rapidly assume distinct Thl-, Th2-, Th17-, TFH and T regulatory-like effector functions, suggesting that they profoundly influence cell-mediated and humoral immune responses. In addition to differences in cytokine repertoire, y~ T cells exhibit diversity in homing, such as migration to lymph node follicles, to help B cells versus migration to inflamed tissues. Here, we review our current understanding of y T-cell lineage heterogeneity and flexibility, with an emphasis on the human system, and propose a classification of effector y T cells based on distinct functional phenotypes.

关键词： cytokines effector and memory cells y T cells lineage-specifying factors T-cell subsets

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Synthesis, Spectral, Thermal and Biological Studies of Mn（ll）, Co（ll）, Ni（ll） and Cu（ll） Complexes with 1-（（（5-Mercapto- 1 H-1,2,4-triazol-3-yl）imi no）-methyl） naphthalene-2-ol

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Chinese Journal of Chemistry 2012年第3期30卷 547-556页

作者： Issa,Raafat Mostafa Gaber,Mohammed Al-Wakiel,nadia Abd-Elhamed Fathalla,Shaimaa Kamal Chemistry Department Faculty of ScienceTanta University31527 TantaEgypt

Mn（Ⅱ）, Co（Ⅱ）, Ni（Ⅱ） and Cu（Ⅱ） complexes of 5-mercapto-1,2,4-triazol-3-imine-2＇-hydroxynaphthaline have been synthesized and characterized by elemental analysis, IR, IH NMR, EI-mass, UV-Vis, and ESR （electron spin resonance） spectra, molar conductance, magnetic moment measurements, DC conductivity and thermogravimetric analysis. IR spectra confirm that the ligand molecule existed in both thione and thiole forms. The molar conduc- tance values indicate the complexes are nonelectrolyte. The magnetic moment values of the complexes display paramagnetic behavior. All studies confirm the formation of an octahedral geometry for complex 1 and the other complexes have tetrahedral geometrical structures. The structures of the complexes have also been theoretically studied by using the molecular mechanic calculations by the hyperchem. 8.03 molecular modeling program which confirm the proposed structures. The Schiff-base ligand and its metal complexes have also been screened for their antimicrobial activities.

关键词： inorganic chemistry spectral thermal biological studies conductance triazole Schiffbase

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Thyroid and Pregnancy

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Reproductive and Developmental Medicine 2018年第3期2卷 162-170页

作者： nadia Belmahi Said Boujraf Hanan El Ouahabi Department of Endocrinology and Metabolism University Hospital of FezFez 30000Morocco Department of Biophysics and Clinical MRI Methods Faculty of Medicine and Pharmacy of FezFez 30000Morocco

Thyroid diseases are common in women of childbearing *** factors of maternal thyroid function occur during pregnancy;therefore,guidelines recommend trimester-specific pregnancy reference range for thyroid-stimulating ***,thyroid dysfunctions have deleterious obstetrical and neonatal ***,an adequate treatment is important to prevent adverse pregnancy ***,iodine deficiency during pregnancy could originate maternal and fetal ***,scientific organizations recommend prenatal iodine supplementation for all pregnant ***,treatment of thyroid autoimmunity is intriguing,but adequately powered randomized controlled trials are *** aim of this article was to summarize the reported results of the literature related to the management of thyroid disease during pregnancy in order to help endocrinologists in decision-making processes.

关键词： Autoimmunity Hyperthyroid Hypothyroid Pregnancy Screening Thyroid

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Medicinal plant products targeting quorum sensing for combating bacterial infections

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 795-809页

作者： Abdelhakim Bouyahya nadia Dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesMohammed V UniversityRabatMorocco Biology and health Laboratory Department of BiologyFaculty of ScienceAbdelmalek Essaadi UniversityTetouanMorocco

Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances.

关键词：察觉到的治安法官 Biofilms 细菌的抵抗自然混合物

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