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SERS-ba.ed la.era. flow immunoa.sa. of troponin I by using ga.enha.ced Ra.a. ta.s

Na.o Resea.ch 2019年第2期12卷 413-420页

作者： Boris N. Khlebtsov Da.iil N. Bra.a.hov nadezhda a. byzova Boris B. Dza.tiev Nikola. G. Khlebtsov Institute of Biochemistry a.d Physiology of Pla.ts a.d Microorga.isms Russian Academy of Sciences Saratov 410049 Russia Sa.a.ov Sta.e University Saratov 410012 Russia a. N. Ba.h Institute of Biochemistry Research Centre of Biotechnology Russian Academy of Sciences Moscow 119071 Russia

The la.era. flow immuno a.sa. (LFIa. ha. emerged a. a.powerful tool for ra.id scree ning owing to its simplicity a.d flexibility for detection of va.ious bioma.kers. However, conventiona. LFIa.strips ha.e severa. disa.va.ta.es, including limits in qua.tita.ive a.a.ysis a.d low sensitivity. Here we developed a.novel surfa.e-e nha.ced Ra.a.n sca.teri ng LFIa.ba.ed on non spherica. ga.-e nha.ced Ra.a. ta.s (GERTs), with Ra.a. molecules (RMs) embedded in a.1-nm ga. between a. na.orod core a.d a. shell. Such ta.s ha.e a.strong a.d uniform surfa.e-enha.ced Ra.a.n sca.tering (SERS) resp on se, a. order of ma. nitude higher tha. tha. of other comm on SERS ta.s such a. a. na.o rods, na.o sta.s, a. na.o shells with surfa.e-a.sorbed RMs, or spherica. GERTs with embedded RMs. The fea.ibility of the ta.s wa. dem on stra.ed by the semiqua.ntita.ive a.d sen sitive detecti on of the hea.t disea.e bioma.ker ca.dia. tropo nin I (cTnI). GERTs were conjuga.ed with mono clona. a.tibodies a.d used for LFIa.in the sa.e wa. a. ordina.y functiona.ized colloida. gold. The presenee of the ta.get a.tigen, cTnI, wa. identified by Ra.a. microscopy ma.ping of the test zone. With the SERS-ba.ed LFIa. the limit of cTnI detection wa. a.out 0.1 ng/mL. This va.ue is within the dia.nostic ra.ge of cTnI in the blood serum of pa.ients with hea.t infa.ction a.d is 30 times lower tha. tha. of the colorimetric LFIa.test using the sa.e a.tibodies a.d either GERTs or colloida. gold a. la.els.

关键词： surfa.e-enha.ced Ra.a. sca.tering (SERS) la.era. flow immunoa.sa. a. core/shell na.orods ga.-enha.ced Ra.a. ta.s ca.dia. troponin I

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a.SPECIa. MODULUS OF CONTINUITY a.D THE K-FUNCTIONa.

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a.ta.Ma.hema.ica.Scientia 2016年第5期36卷 1531-1540页

作者： nadezhda DOLMa.OVA Institute of Ma.hema.ics University of Wroc law

We consider the questions connected with the a.proxima.ion of a.rea. continuous 1-periodic functions a.d give a.new proof of the equiva.ence of the specia. Boma.-Sha.iro modulus of continuity with Peetre’s K-function... 详细信息

关键词： modulus of continuity K-functiona. Ja.kson's theorem

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Modeling of Lea.ha.e Propa.a.ion in a.Municipa. Solid Wa.te La.dfill Founda.ion

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Fluid Dyna.ics & Ma.eria.s Processing 2024年第6期20卷 1407-1424页

作者： nadezhda Zubova.a.drey Iva.tsov Institute of Continuous Media.Mecha.ics of the Ura. Bra.ch Russian Academy of SciencePerm614013Russia

The study dea.s with the numerica. modeling of lea.ha.e distribution in the porous medium loca.ed under a.municipa. solid wa.te disposa. la.dfill(MSWLF).The considered three-la.er system is ba.ed on geologica. da.a.obta.ned from field *** simplicity,the problem is investiga.ed by a.suming a.two-component ***,the hea. produced by la.dfills due to biologica. a.d chemica. processes a.d the therma. diffusion mecha.ism contributing to pollution tra.sport a.e ta.en into *** numerica. modeling of the propa.a.ion of lea.ha.e in the considered la.ered porous medium is implemented for pa.a.eters corresponding to na.ura. soil a.d for the ca.e where disruption of the porous medium structure is due to cra.ks forma.ion or *** la.ter is a.compa.ied by a. increa.e in rock *** this ca.e,the emergence of multi-vortex flow in the la.er of high permea.ility is observed to substa.tia.ly influence the bottom la.ers a.d ca.se intensifica.ion of the lea.ha.e *** effects should be ta.en into a.count when estima.ing the pa.a.eters a.d properties of ma.eria.s required for the construction of solid wa.te disposa. fa.ilities.

关键词： Three-la.er porous medium bina.y mixture diffusion therma. diffusion

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Influence of a.ricultura. development a.d clima.e cha.ges on the dra.na.e va.ley density of the southern ha.f of the Russia. Pla.n

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Interna.iona. Journa. of Sediment Resea.ch 2017年第1期32卷 60-72页

作者： Va.entin Golosov nadezhda Iva.ova.Sa.iya.Kurba.ova Ka.a. Federa. University Lomonosov Moscow Sta.e University

The southern ha.f of the Russia. Pla.n is cha.a.terized by a.rela.ively short history of intensively ploughed *** dura.ion va.ies from a.proxima.ely three centuries in the southern pa.t of the forest zone to less tha. one century in some pa.ts of the steppe *** wa. found tha. a.ter cultiva.ion,on more tha. 40%of la.ds in river ba.ins the dra.na.e va.ley density(Ddv) decrea.ed by 15-58%in a.l la.dsca.e *** the first sta.e,the Ddvdecrea.e wa. mostly a.socia.ed with increa.ing surfa.e runoff coefficient a.ter cultiva.ion of virgin la.ds with proportiona. decrea.es in groundwa.er *** the second sta.e,usua.ly a.ter rea.hing a.ea. of a.a.le la.ds in river ba.ins > 60%,the volume of eroded sediments entering sma.l river cha.nels exceeded the tra.sport ca.a.ities of the perma.ent *** a.result,the river cha.nels completely *** la.er sta.es,the sediment redistribution ca.ca.e within the sma.l river ba.ins of the Russia. Pla.n sta.ilized beca.se of the increa.ing proportion of sediment eroded from the ba.in a.ea. a.d re-deposited before entering the river cha.nels beca.se of the increa.ing a.ea.of sediment sinks due to the increa.e in dry va.ley lengths a.d tota. *** morphologica. pa.a.eters of sma.l va.leys a.d groundwa.er discha.ges a.e the key pa.a.eters tha. a.fect the intensity of sma.l river a.gra.a.ion on the regiona. sca.e.

关键词： Soil erosion Sediment redistribution Clima.e cha.ge La.d use cha.ge Europea. Russia

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Compa.ison of fa.ty a.id contents a.d composition in ma.or lipid cla.ses of la.va. a.d a.ults of mosquitoes （Diptera. Culicida.） from a.steppe region

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Insect Science 2013年第5期20卷 585-600页

作者： nadezhda N. Sushchik Yuri a. Yurchenko Micha.ll. Gla.yshev Olga.E. Belevich Ga.ina.S. Ka.a.hova.a.gelika.a. Kolma.ova Institute of Biophysics of Siberia. Bra.ch of Russia. a.a.emy of Sciences Akademgorodok 50/50 Krasnoyarsk Russia Institute of Funda.enta. Biology a.d Biotechnology Siberian Federal University Krasnoyarsk Russia Institute of Systema.ics a.d Ecology of a.ima.s of Siberia. Bra.ch of Russia. a.a.emy of Sciences Novosibirsk Russia

Emerging a.ua.ic insects, including mosquitoes, a.e known to tra.sfer to terrestria. ecosystems specific essentia. biochemica.s, such a. polyunsa.ura.ed fa.ty a.ids （PUFa.. We studied fa.ty a.id （Fa. composition a.d contents of domina.t mosquito popula.ions （Diptera. Culicida.）, tha. is, a.opheles messea., Ochlerota.us ca.pius, Oc. fla.escens, Oc. euedes, Oc. subdiversus, Oc. ca.a.hylla. a.d a.des cinereus, inha.ited a.steppe wetla.d of a.tempera.e clima.e zone to fill up the ga. in their lipid knowledge. The pola. lipid a.d tria.ylglycerol fra.tions of la.va. a.d a.ults were compa.ed. In most studied mosquito species, we first found a.d identified a.number of short-cha.n PUFa. for exa.ple, prominent 14：2n-6 a.d 14：3n-3, which were not ea.lier documented in living orga.isms. These PUFa. a.though occurred in low levels in a.ult mosquitoes, ca. be potentia.ly used a. ma.kers of mosquito bioma.s in terrestria. food webs. We hypothesize tha. these a.ids might be synthesized （or retroconverted） by the mosquitoes. Using Fa.trophic ma.kers a.cumula.ed in tria.ylglycerols, trophic rela.ions of the mosquitoes were a.cessed. The la.va. diet comprised green a.ga., cryptophytes, a.d dinofla.ella.es a.d provided the mosquitoes with essentia. n-3 PUFa. linolenic, a.d eicosa.enta.noic a.ids. a. a.result, both la.va. a.d a.ults of the studied mosquitoes ha. compa.a.ively high content of the essentia. PUFa. Compa.ison of Fa.proportions in pola. lipids versus stora.e lipids shown tha. during mosquito meta.orphosis tra.sfer of essentia. eicosa.enta.noic a.d a.a.hidonic a.ids from the reserve in stora.e lipids of la.va. to functiona. pola. lipids in a.ults occurred.

关键词： a.phibiotic insects essentia. fa.ty a.ids meta.orphosis mosquitoes,short-cha.n polyunsa.ura.ed fa.ty a.ids

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miR 204-5p inhibits a.optosis in da.a.ba.ine-trea.ed mela.oma.cells

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Oncology Resea.ch 2021年第6期29卷 393-400页

作者： nadezhda Pa.KINa.EKa.ERINa.SERGEEVa.Ta.Ia.a.RUKSHA Kra.noya.sk Sta.e Medica. University Krasnoyarsk660022Russian Federation

Mela.oma.is one of the most a.gressive types of ma.igna.t tumors,commonly a.fecting young *** trea.ment of meta.ta.ic tumors rema.ns obscure due to the resista.ce of tumor cells to drugs media.ed by va.ious *** a.quisition of a.resista.t phenotype is a.socia.ed with both genetic a.d epigenetic a.tera.ions in ca.cer ***,the current study a.med to investiga.e whether microRNa.miR)-204-5p could promote a.tera.ions in the cell cycle a.d a.optosis of da.a.ba.ine(DTIC)-trea.ed mela.oma.*** rea. time PCR showed tha. tra.sfection of DTIC-trea.ed SK-MEL-2 mela.oma.cells with miR-204-5p mimics signiﬁca.tly upregula.ed ***,ﬂow cytometric a.a.ysis revea.ed tha. the proportion of cells in different pha.es of the cell cycle rema.ned ***,the proportion of ea.ly a.optotic cells wa. nota.ly enha.ced following cell trea.ment with DTIC,a.compa.ied by a.profound increa.e in Ki-67 nega.ive cells,a. veriﬁed by a. immunoﬂuorescence ***,miR-204-5p overexpression reduced the percenta.e of ea.ly a.optotic DTIC-trea.ed mela.oma.*** proportion of Ki-67 nega.ive cells wa. only increa.ed by 3%.Overa.l,the results of the current study indica.ed tha. miR-204-5p overexpression could mostly a.tenua.e cell a.optosis in DTIC-trea.ed cells ra.her tha. promote their tra.sition from the G0 pha.e of the cell cycle in response to chemothera.eutic a.ent-induced stress.

关键词： Cell cycle senescence Ki-67 microRNA

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Clima.e cha.ge evidence in tree growth a.d sta.d productivity a. the upper treeline ecotone in the Pola. Ura. Mounta.ns

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Forest Ecosystems 2020年第1期7卷 76-91页

作者： nadezhda M.Devi Vla.imir V.Kuka.skih Аrina.a.Ga.imova.Va.eriy S.Ma.epa.a.drey a.Grigoriev Institute of Pla.t a.d a.ima. Ecology Ural BranchRussian Academy of Sciences8 Marta202/3Ekaterinburg 620144Russia

Ba.kground:Recent wa.ming is a.fecting species composition a.d species a.ea. distribution of ma.y ***,a.though most treeline studies ha.e estima.ed the ra.es of forest expa.sion into tundra.still little is known a.out the long-term dyna.ic of sta.d productivity a. the forest-tundra.***,we ma.e use of tree-ring da.a.from 350 la.ch(La.ix sibirica.Ledeb.)a.d spruce(Picea.obova.a.Ledeb.)sa.pled a.ong the singula. a.titudina. treeline ecotone a. the Pola. Ura.s to a.sess the dyna.ic of sta.d esta.lishment a.d productivity,a.d link the results with meteorologica. observa.ions to identify the ma.n environmenta. ***:The a.a.ysis of sta.d insta.ment indica.ed tha. more tha. 90%of the living trees a.pea.ed a.ter *** this period,the sta.d beca.e denser a.d moved 50m upwa.d,while in recent deca.es the trees of both species grew *** ma.imum a.foresta.ion occurred in the la.t deca.es of the twentieth century,a.d the la.ge number of encountered sa.lings indica.es tha. the forest is still *** upwa.d shift coincided with a.slight increa.e of Ma.-a.gust a.d nea.ly doubling of September-a.ril precipita.ion while the increa.e in growth ma.ched with a. ea.ly growth sea.on wa.ming(June+0.27°C per deca.e since 1901).This increa.e in ra.ia. growth combined with the sta.d densifica.ion led to a.6-90 times increa.e of bioma.s since ***:Tree-ring ba.ed twentieth century reconstruction a. the treeline ecotone shows a. ongoing forest densifica.ion a.d expa.sion a.compa.ied by a. increa.ed *** cha.ges a.e driven by clima.e cha.ge mecha.ism,whereby the lea.ing fa.tors a.e the significa.t increa.e in Ma.-June tempera.ures a.d precipita.ion during the dorma.t *** of phytoma.s a.cumula.ion mecha.isms within treeline ecotone is va.ua.le for improving our understa.ding of ca.bon dyna.ics a.d the overa.l clima.e ba.a.ce in current treeline ecosystems a.d for predicting how these will be a.tered by globa. ch

关键词： Pola. Ura.s Treeline Productivity Clima.e cha.ge Ra.ia. growth Recruitment La.ch Spruce

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Improved proper motion determina.ions for 15 open clusters ba.ed on the UCa.4 ca.a.og

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Resea.ch in a.tronomy a.d a.trophysics 2016年第7期16卷 39-46页

作者： a.exa.der Kurtenkov nadezhda Dimitrova.a.exa.der a.a.a.ov Teodor D.a.eksiev Depa.tment of a.tronomy University of Sofia5 James Bourchier Blvd.1164 SofiaBulgaria Institute of a.tronomy a.d Na.iona. a.tronomica. Observa.ory Bulgarian Academy of Sciences72 Tsarigradsko Shose Blvd.1784 SofiaBulgaria a.glo-a.erica. School of Sofia 1 Siyanie Str.1138 SofiaBulgaria Geo Milev High School of Ma.hema.ics Storgozia5802 PlevenBulgaria Sofia.High School of Ma.hema.ics 61 Iskar Str.1000 SofiaBulgaria

The proper motions of 15 nea.by（d 〈 1 kpc） open clusters（OCs） were reca.cula.ed using da.a.from the UCa.4 ca.a.og. Only evolved or ma.n sequence sta.s inside a.certa.n ra.ius from the center of the cluster were used. The results significa.tly differ from the ones presented by Dia. et a..（2014）. This could be expla.ned by a.different a.proa.h in which we ta.e the field sta. conta.ina.ion into a.count. The present work a.ms to empha.ize the importa.ce of a.plying photometric criteria.for the ca.cula.ion of OC proper motions.

关键词： proper motions Ga.a.y open clusters a.d a.socia.ions genera.

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Recent a.va.ces in na.opa.ticle genera.ion in liquids by la.ers:Revea.ing forma.ion mecha.isms a.d ta.loring properties

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Science China.Physics,Mecha.ics & a.tronomy) 2022年第7期65卷 115-117页

作者： a.exa.der V.Bulga.ov nadezhda M.Bulga.ova HiLa.E Centre Institute of Physics of the Czech Academy of SciencesDolni Brezany 25241Czech Republic S.S.Kuta.ela.ze Institute of Thermophysics of the Siberia. Bra.ch of the Russia. a.a.emy of Sciences Novosibirsk 630090Russia

When Fojtik a.d Henglein [1] submitted in 1992 the first scientific pa.er on genera.ion of na.opa.ticles(NPs) by la.er a.la.ion in liquids, the a.thors proba.ly could not rea.ize how it will revolutionize the na.opa.ticle science a.d technology. In 2017, ma.king a.qua.ter century of this pioneering study, a.endola.a.d Ba.cikowski [2] pointed out tha. the simple a.d bright idea.of Henglein a.d Fojtik wa. a. inspira.ion to hundreds of scientists worldwide over 25 yea.s a.d opened a.wa. to use la.ers in synthesis of colloids.

关键词： liquids hundreds genera.ion

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a.plica.ion of the Principles of “Green Chemistry” for the Synthesis of 10-Undecylenic a.ipha.ic Esters with a.timicrobia. a.tivity

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Journa. of Renewa.le Ma.eria.s 2020年第6期8卷 675-686页

作者： Dra.omir Va.silev nadezhda Petkova.Yulia. Tumba.ski Milena.Koleva.Pa.teley Denev Depa.tment of Physics Chemistry and EcologyTechnical University of GabrovoGabrovo5300Bulgaria Depa.tment of Inorga.ic a.d Orga.ic Chemistry University of Food TechnologiesPlovdiv4002Bulgaria Depa.tment of Microbiology University of Food TechnologiesPlovdiv4002Bulgaria

Undenicylic a.id(10:1)is known a. a. a.tifunga. a.ent a.d a. a.tive ingredient of ma.y topica. medicines[1–6].The present resea.ch investiga.es the prepa.a.ion of a.ipha.ic esters of 10-undecylic a.id with buta.ol a.d i-a.yl a.cohol by the conventiona. a.d ultra.ound-a.sisted syntheses a. well a. the structura. elucida.ion of the resulting compounds,by FTIR a.d NMR *** a.timicrobia. properties of the obta.ned 10-undecylenic esters were tested a.a.nst Gra.-positive ba.teria.Sta.hylococcus a.reus;Enterococcus fa.ca.is;Listeria.monocytogenes),Gra.-nega.ive ba.teria.Escherichia.coli;Sa.monella.sp.)a.d fila.entous fungi(Penicillium sp.;a.pergillus niger;Fusa.ium moniliforme)using the conventiona. a.a.-well diffusion *** results demonstra.ed tha. a.l esters ha. insignifica.t a.tiba.teria. a.tivity.i-a.yl-10-undecylena.e a.d t-butyl-10-undecylena.e showed a.tivity a.a.nst both Gra.-positive a.d Gra.-nega.ive ba.teria.while i-butyl-10-undecylena.e a.d n-butyl-10-undecylena.e were effective only a.a.nst Gra.-positive ba.teria.*** contra.t,a.l 10-undecylenic esters demonstra.ed high a.tifunga. a.tivity,which wa. most pronounced in ***,the obta.ned products ca. be successfully used a. promising a.tifunga. a.ents for va.ious pha.ma.eutica. formula.ions a. well a. biocontrol mea.s a.a.nst pla.t pa.hogens.

关键词： 10-undecylena.e a.kyl esters FTIR a.d NMR spectroscopy a.timicrobia. a.tivity

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