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Advantages and disadvantages of nuclear reactions used in reactors or cyclotrons,in addition to a theoretical study based on photodisintegration on natural indium for^(111)Ag production

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Nuclear Science and Techniques 2022年第2期33卷 1-13页

作者： Khaled m.El-Azony nader m.a.m.ham.d dalal A.Aloraini Radioactive Isotopes and Generators department Hot Labs.CenterEgyptian Atomic Energy AuthorityP.O.Box 13759CairoEgypt Reactors department Egyptian Atomic Energy AuthorityP.O.Box 13759CairoEgypt Physics department College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadhKingdom of Saudi Arabia

Production routes were recorded on available reactions for^(111)Ag production from nuclear reactors or cyclotrons using a natural palladium target based on^(110)Pd(n,γ)and^(110)pd(d,n)reactions,respectively.^(nat)Cd(γ,x)based on^(110)Cd(γ,p)has also been studied as a prospective reaction for the production of^(111)***,these nuclear reactions are difficult to utilize because,in some cases,they reduce the specific activity of^(111)*** is a consequence of the stable silver isotopes produced in high *** isotopes include^(107,109)Ag and,in other cases,the high impurity of silver radioisotopes,such as^(110)m,^(106)m,^(105)Ag,that are produced during parallel nuclear *** to a scarcity of data regarding the(γ,α)reaction,the gamma reaction on natural indium for^(111)Ag production based on the^(115)In(γ,α)reaction was *** ^(nat)In(γ,α)reaction satisfies the criteria as a possible reaction to produce^(111)Ag with a sufficient yield and purity as consequence of the high^(115)In(95.7%)abundance as an enriched form and a relatively soft background caused by the parallel nuclear reactions.

关键词： Silver-111 Nuclear data Natural cadmium Natural palladium Natural indium

multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2089-2102页

作者： mélanie Robert Bastien Laperrousaz diana Piedrahita Emilie-Fleur Gautier Travis Nemkov Florian dupuy Elie nader Virginie Salnot Patrick mayeux Angelo d’Alessandro Catherine Lavazec Philippe Joly Alexander Scheer Philippe Connes Agnès Cibiel Erytech Pharma Lyon 69008France Laboratoire interuniversitaire de Biologie de la motricité(LIBm)EA7424 Team«Vascular Biology and Red Blood Cell»Universite´Claude Bernard Lyon 1Universite´de LyonLyon 69008France Labex GR-Ex Paris 75015France 3P5 proteom’IC facility Universitéde ParisInstitut CochinINSERMCNRSParis 75014France University of Colorado Anschutz Medical CampusAuroraCO 80045USA Omix Technologies Inc.AuroraCO 80045USA Inserm U1016 CNRS 8104Universitéde ParisInstitut CochinParis 75014France Laboratoire de Biochimie et de Biologie moléculaire UF de biochimie des pathologies e´rythrocytairesCentre de Biologie et de Pathologie EstHospices Civils de LyonBron 69500France

Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many *** RBCs integrity and lifespan is important for the efficacy of RBCs as drug *** investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and *** parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed *** RBCs were less hydrated and displayed a reduction of intracellular *** observed a change in the metabolomic but not in the proteomic profile of processed *** process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles *** a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic *** RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free *** study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function.

关键词： Red blood cells drug carrier Hypotonic dialysis L-Asparaginase Omics Rheology morphology Senescence markers

Time-varying materials in the presence of dispersion:plane-wave propagation in a Lorentzian medium with temporal discontinuity

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Photonics Research 2021年第9期9卷 1842-1853页

作者： dIEGO m.SOLíS RAPHAEL KASTNER nader ENGHETA department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Tel Aviv University Tel Aviv 69978Israel

We study the problem of a temporal discontinuity in the permittivity of an unbounded medium with Lorentzian dispersion. more specifically, we tackle the situation in which a monochromatic plane wave forward-traveling in a(generally lossy) Lorentzian-like medium scatters from the temporal interface that results from an instantaneous and homogeneous abrupt temporal change in its plasma frequency(while keeping its resonance frequency constant). In order to achieve momentum preservation across the temporal discontinuity, we show how, unlike in the well-known problem of a nondispersive discontinuity, the second-order nature of the dielectric function now gives rise to two shifted frequencies. As a consequence, whereas in the nondispersive scenario the continuity of the electric displacement d and the magnetic induction B suffices to find the amplitude of the new forward and backward wave, we now need two extra temporal boundary conditions. That is, two forward and two backward plane waves are now instantaneously generated in response to a forward-only plane wave. We also include a transmission-line equivalent with lumped circuit elements that describes the dispersive time-discontinuous scenario under consideration.

关键词： discontinuity plane wave

Lignocellulosic micro and Nanofibrillated Cellulose Produced by Steam Explosion for Wood Adhesive Formulations

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Journal of Renewable materials 2022年第2期10卷 263-271页

作者： Saad nader Felipe Guzman Raphael Becar Cesar Segovia Cecilia Fuentealba miguel Peirera Evelyne mauret Nicolas Brosse Laboratoire d’Etude et de Recherches sur le materiau Bois-Green Process For Wood(LERmaB-GP4W) Facultedes Sciences et TechnologiesUniversitede LorraineVandœuvre-les-NancyFrance Laboratoire de Genie des Procedes Papetiers(LGP2) Saint Martin D’HèresFrance Unidad de desarrollo Tecnologico(UdT) Universidad de ConcepcionCoronelChile Centre d’Essais TEchnique LORrain(CETELOR) EpinalFrance

The reinforcing impact of Lignocellulosic micro and nanofibrillated cellulose(L-mNFCs)obtained from Eucalyp-tus Globulus bark in Urea-Formaldehyde UF adhesive was tested.L-mNFCs were prepared by an environmentally friendly,low-cost process using a combination process involving steam explosion followed by refining and ultra-fine *** L-mNFCs showed a web-like morphology with some aggregates and lignin *** present a mixture of residual fibers and fine elements with a width varying between 5 nm to 20μm,*** effects of the addition of low amounts of L-mNFCs(1%wt.)on the properties of three different adhe-sives(Urea-Formaldehyde UF,Phenol-Formaldehyde PF,and Tannin-Hexamine TH)were studied by the evolution of the pH,the viscosity,and the mechanical *** showed that the viscosity of PF and UF adhesives increased with the addition of L-mNFCs,unlike ***,the addition led to better mechan-ical behavior for the three *** were then prepared using modified UF with L-mNFCs and *** showed that an amount of 1%*** L-mNFCs was sufficient to increase the internal bonding by≈67%,the modulus of elasticity by≈43%,and the modulus of rupture by≈29%.

关键词： Lignocellulosic microfibrils Eucalyptus globulus bark wood adhesives steam explosion wood panels

deep learning acceleration of multiscale superresolution localization photoacoustic imaging

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Light(Science & Applications) 2022年第6期11卷 1166-1177页

作者： Jongbeom Kim Gyuwon Kim Lei Li Pengfei Zhang Jin Young Kim Yeonggeun Kim Hyung ham Kkim Lihong V.Wang Seungchul Lee Chulhong Kim departments of Electrical Engineering Mechanical EngineeringConvergence IT Engineeringand Interdisciplinary Bioscience and BioengineeringGraduate School of Artificial IntelligenceMedical Device Innovation CenterPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 E.California Blvd.MC 138-78PasadenaCA 91125USA School of Precision Instruments and Optoelectronics Engineering Tianjin University92 Weijin RoadNankai DistrictTianjin 300072China Opticho 532CHANGeUP GROUND87 Cheongam-roNam-guPohangGyeongsangbuk 37673Republic of Korea

A superresolution imaging approach that localizes very small targets,such as red blood cells or droplets of injected photoacoustic dye,has significantly improved spatial resolution in various biological and medical imaging ***,this superior spatial resolution is achieved by sacrificing temporal resolution because many raw image frames,each containing the localization target,must be superimposed to form a sufficiently sampled high-density superresolution ***,we demonstrate a computational strategy based on deep neural networks(dNNs)to reconstruct high-density superresolution images from far fewer raw image *** localization strategy can be applied for both 3d label-free localization optical-resolution photoacoustic microscopy(OR-PAm)and 2d labeled localization photoacoustic computed tomography(PACT).For the former,the required number of raw volumetric frames is reduced from tens to fewer than *** the latter,the required number of raw 2d frames is reduced by 12 ***,our proposed method has simultaneously improved temporal(via the dNN)and spatial(via the localization method)resolutions in both label-free microscopy and labeled ***-learning powered localization PA imaging can potentially provide a practical tool in preclinical and clinical studies requiring fast temporal and fine spatial resolutions.

关键词： deep frames networks

Synthesis of Novel 3-Substituted Pyridothienopyrimidinederivatives with Biological Evaluation as Antimicrobial Agents

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Chemical Research in Chinese Universities 2016年第6期32卷 967-972页

作者： Farag A. E1-Essawy nader m. Boshta Ayman K. EI-Sawaf Areal A. Nassar mohamed S. Khalafalah Preparatory Year deanship Basic Science Department Prince Sattam Bin Abdulaziz University KSA Chemistry department Faculty of Science Menoufia University Shebin EI-Koam Egypt Collage of Science and Humanitles Prince Sattam Bin Abdulaziz University KSA Faculty of Education for Girls Prince Sattam Bin Abdulaziz University KSA

Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′：4,5]thieno[3,2-d]pyrimidin-3（4H）-yl}acetohydrazide（5） with a variety of activereagents and chemicals. Structures of the newly synthesized compounds were established based on spectral *** resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some ofthem represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayedthe highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in mIC range of 0.12--1.95 μg/mL.

关键词： Nitrogen-containing heterocycle Pyridothienopyrimidine Thieno[2,3-b]pyridine Antimicrobial

On the mHd squeeze flow between two parallel disks with suction or injection via ham and HPm

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Frontiers of mechanical Engineering 2014年第3期9卷 270-280页

作者： d. d. GANJI m. ABBASI J. RAHImI m. GHOLAmI I. RAHImIPETROUdI department of mechanical Engineering Babol University of Technology Babol Iran department of mechanical Engineering Sari Branch Islamic AzadUniversity Sari Iran department of Electrical and Computer Engineering Babol Universityof Technology Babol Iran department of mechanical Engineering College of Mechanic TehranScience and Research Branch Islamic Azad University Darnavand Iran

An analysis has been performed to study the problem of magneto-hydrodynamic （mHd） squeeze flow of an electrically conducting fluid between two infinite, parallel disks. The analytical methods called Homotopy Analysis method （ham） and Homotopy Perturbation method （HPm） have been used to solve nonlinear differential equations. It has been attempted to show the capabilities and wide-range applications of the proposed methods in comparison with a type of numerical analysis as Boundary Value Problem （BVP） in solving this problem. Also, the velocity fields have been computed and shown graphically for various values of physical parameters. The objective of the present work is to investigate the effect of squeeze Reynolds number, Hartmann number and the suction/injection parameter on the velocity field. Furthermore, the results reveal that ham and HPm are very effective and convenient.

关键词： Homotopy Analysis method Homotopy Perturbation method incompressible flow magneto-hydrodynamic flow parallel disks

multi-redox phenazine/non-oxidized graphene/cellulose nanohybrids as ultrathick cathodes for high-energy organic batteries

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Nano Research 2021年第5期14卷 1382-1389页

作者： Youngjin ham Vitalii Ri Jin Kim Yeoheung Yoon Jinho Lee Kisuk Kang Ki-Seok An Chunjoong Kim Seokwoo Jeon department of materials Science and Engineering Advanced Battery CenterKorea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea department of materials Science and Engineering Chungnam National UniversityDaejeon34134Republic of Korea Thin Film materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon34114Republic of Korea department of materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea

Various redox-active organic molecules can serve as ideal electrode materials to realize sustainable energy storage systems. Yet, to be more appropriate for practical use, considerable architectural engineering of an ultrathick, high-loaded organic electrode with reliable electrochemical performance is of crucial importance. Here, by utilizing the synergetic effect of the non-covalent functionalization of highly conductive non-oxidized graphene flakes (NOGFs) and introduction of mechanically robust cellulose nanofiber (CNF)-intermingled structure, a very thick (≈ 1 mm), freestanding organic nanohybrid electrode which ensures the superiority in cycle stability and areal capacity is reported. The well-developed ion/electron pathways throughout the entire thickness and the enhanced kinetics of electrochemical reactions in the ultrathick 5,10-dihydro-5,10-dimethylphenazine/NOGF/CNF (dmPZ-NC) cathodes lead to the high areal energy of 9.4 mWh·cm−2 (= 864 Wh·kg−1 at 158 W·kg−1). This novel ultrathick electrode architecture provides a general platform for the development of the high-performance organic battery electrodes.

关键词： energy storage organic electrodes batteries graphene cellulose nanofibers

Fundamental principles and development of proximity-field nanopatterning toward advanced 3d nanofabrication

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Nano Research 2021年第9期14卷 2965-2980页

作者： Sang-Hyeon Nam Gayea Hyun donghwi Cho Seonggon Han Gwangmin Bae Haomin Chen Kisun Kim Youngjin ham Junyong Park Seokwoo Jeon department of materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea department of mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of materials Science and Engineering Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea department of Energy Engineering Convergence Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea KAIST Institute for NanoCentury(KINC) KAISTDaejeon 34141Republic of Korea

Three-dimensional(3d)nanoarchitectures have offered unprecedented material performances in diverse applications like energy storages,catalysts,electronic,mechanical,and photonic *** outstanding performances are attributed to unusual material properties at the nanoscale,enormous surface areas,a geometrical uniqueness,and comparable feature sizes with optical *** the practical use of the unusual nanoscale properties,there have been developments for macroscale fabrications of the 3d nanoarchitectures with process areas over centimeter *** the many fabrication methods for 3d structures at the nanoscale,proximity-field nanopatterning(PnP)is one of the promising techniques that generates 3d optical holographic images and transforms them into material structures through a lithographic *** conformal and transparent phase masks as a key factor,the PnP process has advantages in terms of stability,uniformity,and reproducibility for 3d nanostructures with periods from 300 nm to several *** merits of realizing precise 3d features with sub-100 nm and rapid processes are attributed to the interference of coherent light diffracted by phase *** this review,to report the overall progress of PnP from 2003,we present a comprehensive understanding of PnP,including its brief history,the fundamental principles,symmetry control of 3d nanoarchitectures,material issues for the phase masks,and the process area expansion to the wafer-scale for the target ***,technical challenges and prospects are discussed for further development and practical applications of the PnP technique.

关键词： proximity-field nanopatterning three-dimensional(3d)nanostructures phase mask interference lithography