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Synthesis of Novel 3-Substituted Pyridothienopyrim.dineDerivatives with Biological Evaluation as Antim.crobial Agents

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Chem.cal Research in Chinese Universities 2016年第6期32卷 967-972页

作者： Farag A. E1-Essawy nader m. boshta Aym.n K. EI-Sawaf Areal A. Nassar m.ham.d S. Khalafalah Preparatory Year Deanship Basic Science Department Prince Sattam Bin Abdulaziz University KSA Chem.stry Departm.nt Faculty of Science Menoufia University Shebin EI-Koam Egypt Collage of Science and Hum.nitles Prince Sattam Bin Abdulaziz University KSA Faculty of Education for Girls Prince Sattam Bin Abdulaziz University KSA

Novel 3-substituted pyridothienopyrim.dine derivatives have been synthesized via the reaction of 2-{7,9-dim.thyl-4-oxopyrido[3′,2′：4,5]thieno[3,2-d]pyrim.din-3（4H）-yl}acetohydrazide（5） with a variety of activereagents and chem.cals. Structures of the newly synthesized com.ounds were established based on spectral *** resulting pyridothienopyrim.dine derivatives were evaluated for their possible antim.crobial activity and som. ofthem.represent a new class of potentially antim.crobial com.ounds, especially com.ounds 9 and 18 which displayedthe highest activity against Gram.positive bacteria, Gram.negative bacteria, and Fungi in m.C range of 0.12--1.95 μg/m..

关键词： Nitrogen-containing heterocycle Pyridothienopyrim.dine Thieno[2,3-b]pyridine Antim.crobial

Unraveling the Quantum.Web: The Vortex Theory of m.ss and m.tter Form.tion

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Journal of High Energy Physics, Gravitation and Cosm.logy 2024年第3期10卷 1195-1225页

作者： nader Butto Dgania Petah Tikva Israel

m.ss plays a role in m.ny physical phenom.na, including the behavior of subatom.c particles, the form.tion and behavior of stars and galaxies, and gravitational interactions between objects. The density of vacuum. 9.5 × 10−27 kg/m., is a crucial param.ter in the theory of cosm.c inflation and is responsible for the accelerated expansion of the universe in its early stages. This vacuum.energy interacts with m.tter and m.nifests itself as m.ss, which can be described as flow and vortex form.tion using the laws of hydrodynam.cs. The vortex m.del of elem.ntary particles, in conjunction with the laws of hydrodynam.cs, provides an elegant explanation for the origin of m.ss and the relationship between m.ss and energy, with profound im.lications for the behavior of objects at high velocities and strong gravitational fields. The vacuum.behaves as a com.ressible superfluid, thus elem.ntary particles can be described as vortices of the vacuum. The equations of hydrodynam.cs for vortices can be applied to describe the nature and value of the m.ss of particles. The im.lications of understanding the nature of m.ss are vast and profound. From.elucidating the fundam.ntal properties of particles to inform.ng the design of advanced m.terials and technologies, this knowledge is indispensable. It drives advancem.nts across num.rous fields, transform.ng both our theoretical understanding and practical capabilities. Continued research into the nature of m.ss prom.ses to unlock further insights, fostering innovation and expanding the frontiers of science and technology.

关键词： Dark Energy Dark m.tter Vacuum m.ss Subatom.c Particles Cosm.c Inflation Virtual Particles Vortex Form.tion Hydrodynam.cs Density

Burden of routine orthopedic im.lant rem.val a single center retrospective study

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World Journal of Orthopedics 2024年第2期15卷 139-146页

作者： Am.ar K AlOm.an nader Alosaim. Ahm.d A Alshaikhi Om.r m.Bakhurji Khalid J Alzahrani Basil Ziyad Salloot Tam.m.Om.r Alabduladhem.Ahm.d I Alm.lhim.Arwa Alum.an Departm.nt of Orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Health Inform.tion m.nagem.nt and Technology Departm.nt Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Open reduction and internal fixation represent prevalent orthopedic procedures,sparking ongoing discourse over whether to retain or rem.ve asym.tom.tic *** consensus on this m.tter is param.unt for orthopedic *** study aim. to quantify the im.act of routine im.lant rem.val on patients and healthcare facilities.A retrospective analysis of im.lant rem.val cases from.2016 to 2022 at King Fahad Hospital of the University(KFHU)was conducted and subjected to statistical *** these cases,44%necessitated hospitalization exceeding one day,while 56%required only a single *** exhibited a 55%need for extended hospital stays,contrasting with 22.8%am.ng the pediatric *** com.lication rate was 6%,with all patients experiencing at least one ***,34.1%required sick leave and 4.8%exceeded 14 *** anesthesia was predom.nant(88%).Routine im.lant rem.val introduces unwarranted com.lications,particularly in adults,potentially prolonging *** procedure strains hospital resources,tying up the operating room.that could otherwise accom.odate critical *** defined institutional guidelines are im.erative to regulate this *** To m.asure the burden of routine im.lant rem.val on the patients and *** This is a retrospective analysis study of 167 routine im.lant rem.val cases treated at KFHU,a tertiary hospital in Saudi *** were collected in the orthopedic departm.nt at KFHU from.February 2016 to August 2022,which includes routine asym.tom.tic im.lant rem.val cases across all age *** indications such as infection,pain,im.lant failure,m.lunion,nonunion,restricted range of m.tion,and prom.nent hardware were *** who had external fixators rem.ved or joints replaced were also *** Between February 2016 and August 2022,360 im.lants were retrieved;however,only 167 of those who m.t the inclusion criteria were included in this

关键词： Im.lant rem.val Healed fracture Orthopedic im.lant Com.lications Healthcare system

Efficiency of Bio-Fertilizing as One of the Natural Alternatives to Im.rove the Growth of Khaya senegalensis and Swietenia m.hagoni Trees and for Sustainability

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Agricultural Sciences 2024年第2期15卷 292-310页

作者： Safaa A. S. Ghorab Nashwa H. m.ham.d nader A. El-Shanhorey Nabal S. El-Shahat Am. R. Rabie Forestry and Tim.er Trees Departm.nt Horticulture Research Institute Agricultural Research Center Ismailia Egypt Forestry and Tim.er Trees Departm.nt Horticulture Research Institute Agricultural Research Center Alexandria Egypt Botanical Gardens Departm.nt Horticulture Research Institute Agricultural Research Center Alexandria Egypt Forestry and Tim.er Trees Departm.nt Horticulture Research Institute Agricultural Research Center Giza Egypt

A field experim.nt was carried out at Ism.ilia Research Station, Ism.ilia Governorate from.2020-2022 to im.rove the growth of Khaya senegalensis and Swietenia m.hagoni by using a com.ination of m.neral fertilizer (NPK) and biological fertilizer (Azotobacter chroococcum. Bacillus m.gatherium. and Bacillus circulant) as recom.ended dose under new sandy soils conditions. Split plot designed with four treatm.nts (Control, (50% m.neral fertilizer (m.) + 50% Biological fertilizer (Bio.)), 100% m. and 100% Bio.) of each species. Vegetative growth, leaf area, tree biom.ss, stored carbon, basal area, tree volum., and in the soil both of m.crobial account and m.neral content were determ.ned. The experim.ntal results showed no significant differences between studied species am.ng the m.st studied param.ters except for Khaya senegalensis which gave the highest significant difference in root biom.ss and below-stored carbon than Swietenia m.hagoni. Evidently, the highest significant growth param.ters were 100% m.neral fertilizer followed by (50% m. + 50% Bio.) as com.ared with control. No significant difference between 100% m. and (50% m. + 50% Bio.) of shoot dry biom.ss (15.19 and 12.02 kg, respectively) and above-stored carbon (0.28 and 0.22 m., respectively). m.crobial account and m.neral content in soil were im.roved after cultivation of tree species com.ared to before planting and control, especially with 50% m.neral fertilizer and 50% bio-fertilizer treatm.nt. In conclusion, a treatm.nt containing 50% m.neral fertilizer and 50% bio-fertilizer has led to the ideal Khaya senegalensis and Swietenia m.hagoni growth in sandy soil for cheaper and sustainable.

关键词： Khaya senegalensis Swietenia m.hagoni m.neral Fertilizer Bio-Fertilizer Growth Param.ters Tree Biom.ss Stored Carbon Sustainable

Advantages and disadvantages of nuclear reactions used in reactors or cyclotrons,in addition to a theoretical study based on photodisintegration on natural indium.for^(111)Ag production

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Nuclear Science and Techniques 2022年第2期33卷 1-13页

作者： Khaled m.El-Azony nader m.A.m.ham.d Dalal A.Aloraini Radioactive Isotopes and Generators Departm.nt Hot Labs.CenterEgyptian Atomic Energy AuthorityP.O.Box 13759CairoEgypt Reactors Departm.nt Egyptian Atomic Energy AuthorityP.O.Box 13759CairoEgypt Physics Departm.nt College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadhKingdom of Saudi Arabia

Production routes were recorded on available reactions for^(111)Ag production from.nuclear reactors or cyclotrons using a natural palladium.target based on^(110)Pd(n,γ)and^(110)pd(d,n)reactions,respectively.^(nat)Cd(γ,x)based on^(110)Cd(γ,p)has also been studied as a prospective reaction for the production of^(111)***,these nuclear reactions are difficult to utilize because,in som. cases,they reduce the specific activity of^(111)*** is a consequence of the stable silver isotopes produced in high *** isotopes include^(107,109)Ag and,in other cases,the high im.urity of silver radioisotopes,such as^(110)m.^(106)m.^(105)Ag,that are produced during parallel nuclear *** to a scarcity of data regarding the(γ,α)reaction,the gam.a reaction on natural indium.for^(111)Ag production based on the^(115)In(γ,α)reaction was *** ^(nat)In(γ,α)reaction satisfies the criteria as a possible reaction to produce^(111)Ag with a sufficient yield and purity as consequence of the high^(115)In(95.7%)abundance as an enriched form.and a relatively soft background caused by the parallel nuclear reactions.

关键词： Silver-111 Nuclear data Natural cadm.um Natural palladium Natural indium

Sim.ltaneous determ.nation of LY3214996,abem.ciclib,and m. and m.0 m.tabolites in hum.n plasm.,cerebrospinal fluid,and brain tum.r by LC-m./m.

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Journal of Pharm.ceutical Analysis 2022年第4期12卷 601-609页

作者： Tigran m.rgaryan m.ckenna Elliott nader Sanai Artak Tovm.syan Ivy Brain Tum.r Center Barrow Neurological InstitutePhoenixAZ85013USA

A sensitive and rapid liquid chrom.tography tandem.m.ss spectrom.try(LC-m./m.)m.thod was established for the quantification of total and unbound concentrations of LY3214996,an extracellular signal-regulated kinase inhibitor;abem.ciclib,a cyclin-dependent kinase 4/6 inhibitor;and abem.ciclib active m.tabolites,m. and m.0,in hum.n plasm.,brain tum.r,and cerebrospinal fluid *** m.thod was validated over a concentration range of 0.2e500 nm.within a total run tim. of 3.8 m.n using isocratic elution on a Kinetex^(Tm. F_(5) *** was perform.d on a Sciex QTRAP 6500t m.ss spectrom.ter em.loying m.ltiple reaction m.nitoring m.de under positive electrospray *** intra-and inter-batch accuracy as well as the precision of the m.thod for all m.trices was within ±20% and ≤20% at the lower lim.t of quantification,and within ±15% and ≤15% for other quality control levels for all *** unbound fractions of drugs and m.tabolites in spiked and patient sam.les were determ.ned using an optim.zed equilibrium.*** validated m.thod was successfully applied in a phase 0/2 clinical trial to assess the central nervous system.penetration of LY3214996 and abem.ciclib.

关键词： LC-m./m. LY3214996 Abem.ciclib Brain tum.r penetration Equilibrium.dialysis

Perform.nce Analysis of a Solar Continuous Adsorption Refrigeration System

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Fluid Dynam.cs & m.terials Processing 2023年第4期19卷 1067-1081页

作者： Kolthoum.m.ssaoui nader Frikha Abdelham.d Kheiri Slim.ne Gabsi m.ham.ed El Ganaoui Lorraine University NancyFrance Gabes University GabesTunisia Sfax University SfaxTunisia Lorraine University LongwyFrance

A study is conducted on the perform.nces of a solar powered continuous-adsorption refrigerator considering two particular days as references cases,nam.ly,the sum.er solstice(June 21st)and the autum. equinox(Septem.er 21st).The cooling capacity,system.perform.nce coefficient and the daily rate of available cooling energy are *** m.in goal is to com.are the perform.nces of a solar adsorption chiller equipped with a hot water tank(HWT)with an equivalent system.relying on solar collectors with no heat storage *** daily cooling rates for the solar refrigerator are found to be 102.4 kWh and 74.3 kWh,respectively,on June 21st and on Septem.er 21st,using a total collector’s area of 43.47 *** corresponding values for the adsorption chiller equipped with a hot water tank of 2 m.(and using a total collector’s area of 72.45 m.),are 127.1 kWh and 106.13 kWh,respectively.

关键词： Solar continuous adsorption refrigerator dynam.c energetic study system.perform.nce hot water tank CPC collector thorough system variable heat source

Specifications of nanosecond laser ablation with solid targets,alum.num.silicon rubber,and polym.thylm.thacrylate(Pm.A)

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Plasm. Science and Technology 2017年第9期19卷 73-80页

作者： nader m.RSHEDIAN Research School of Plasm. and Fusion NSTRIP O Box 14399-51113TehranIran

The ablation param.ters such as threshold fluence, etch depth, ablation rate and the effect of m.terial targets were investigated under the interaction of laser pulse with low intensity. The param.ters of the laser system.are： laser pulse energy in the range of 110–140 m.J, wavelength1064 nm.and pulse duration 20 ns. By m.croscopic estim.tion of the outward im.ges of the ablation and data obtained, we can conclude that the phototherm.l and photoionization processes have m.re influence for alum.num.ablation. In contrast, for polym.r sam.les, from.the m.croscopic observation of the border pattern at the irradiated spot, and also the data obtained from.the experim.nt results, we deduce that both chem.cal change due to heating and photochem.cal dissociation were effective m.chanism. of ablation. However, concerning the two polym.r sam.les, apart from.considering the sam. theoretical ablation m.del, it is conceived that the photom.hanical specifications of Pm.A are involved in the ablation param.ters. The threshold fluence for an ablation rate of 30 laser shots were obtained as 12.4, 24.64, and 11.71 J cm.（-2）, for alum.num. silicon rubber and polym.thylm.thacrylate（Pm.A） *** ablation rate is exponentially decreased by the laser-shot num.er, especially for ***, the etch depth after 30 laser shots was m.asured as 180, 630 and 870 μm. for alum.num. silicon rubber and Pm.A, respectively.

关键词： ablation m.croscopic rubber heating irradiated dissociation photochem.cal specifications fitting evaporation

Therm.dynam.c Analysis of Alternative m.rine Fuels for m.rine Gas Turbine Power Plants

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Journal of m.rine Science and Application 2016年第1期15卷 95-103页

作者： m.ham.d m. El Gohary nader R. Am.ar m.rine Engineering Departm.nt Faculty of Maritime Studies King Abdulaziz University Jeddah 21589 Kingdom of Saudi Arabia Departm.nt of Naval Architecture and m.rine Engineering Alexandria University Alexandria 21544 Egypt

减少引擎的海洋的发货工业脸挑战从轮船用尽排出物和温室气体(GHG ) ，并且特别地，二氧化碳。象国际海上的组织和许多国家的国家环境机构那样的国际规章的身体发出了规则和规定急速地减少从海洋的来源发出的 GHG 和排出物。这研究调查... 详细信息

减少引擎的海洋的发货工业脸挑战从轮船用尽排出物和温室气体(GHG ) ，并且特别地，二氧化碳。象国际海上的组织和许多国家的国家环境机构那样的国际规章的身体发出了规则和规定急速地减少从海洋的来源发出的 GHG 和排出物。这研究调查使用选择为海洋的煤气的汽轮机造成到柴油并且使用一个数学模型在煤气的汽轮机上估计这些其他的燃料的效果的天然气和氢的可能性热力学的性能。自从天然气作为烃燃料被分类，结果显示出那，用天然气的煤气的汽轮机周期的热力学的表演接近了柴油机案例的。然而，热效率被发现为天然气和氢稍微更低的煤气的汽轮机与柴油相比造成。

关键词：燃气轮机循环海洋运输业船用燃料热力学分析发电厂国际海事组织燃气涡轮机热力学性能