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Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis

World Journal of Gastroenterology 2022年第10期28卷 1024-1054页

作者： Cristina M Hagen Eva Roth Theresia Reding Graf François Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini nadège poncet Simone Mafalda Rodrigues Camargo Institute of Physiology University of ZurichZurich 8057ZHSwitzerland Swiss Hepato-Pancreato-Biliary Center Department of Visceral and Transplantation SurgeryZurich University HospitalZurich 8091ZHSwitzerland Institute of Veterinary Pathology University of ZurichZurich 8057ZHSwitzerland

BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains ***1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer *** mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet *** To evaluate the role of LAT1 in the development of and recovery from *** AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and *** The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the ***,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout *** in females,we observed less mTOR reactivation and dysfunctional *** later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day *** contrast,pancreas morphology had returned to normal in wild-type *** LAT1 supports the regeneration of acinar cells after *** mice lacking LAT1 exh

关键词： Acute pancreatitis Amino acid transporter LAT1 Metabolism Regeneration Fibrosis

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Blasius flow and heat transfer of fourth-grade fluid with slip

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Applied Mathematics and Mechanics(English Edition) 2013年第12期34卷 1465-1480页

作者： B.SAHOO S.poncet Department of Mathematics National Institute of Technology Laboratoire de Mecanique Modelisation and Procedes PropresAix-Marseille Universite

This investigation deals with the effects of slip, magnetic field, and non- Newtonian flow parameters on the flow and heat transfer of an incompressible, electrically conducting fourth-grade fluid past an infinite porous plate. The heat transfer analysis is carried out for two heating processes. The system of highly non-linear differential equations is solved by the shooting method with the fourth-order Runge-Kutta method for moderate values of the parameters. The effective Broyden technique is adopted in order to improve the initial guesses and to satisfy the boundary conditions at infinity. An exceptional cross-over is obtained in the velocity profile in the presence of slip. The fourth-grade fluid parameter is found to increase the momentum boundary layer thickness, whereas the slip parameter substantially decreases it. Similarly, the non-Newtonian fluid parameters and the slip have opposite effects on the thermal boundary layer thickness.

关键词： Blasius flow partial slip fourth-grade fluid shooting method Broyden'smethod

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Recent trends in the treatment of well-differentiated endocrine carcinoma of the small bowel

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World Journal of Gastroenterology 2010年第14期16卷 1696-1706页

作者： Gilles poncet Jean-Luc Faucheron Thomas Walter Department of Digestive Surgery Edouard Herriot Hospital 69437 Lyon cedex 03 France Department of Colorectal Surgery Michallon Hospital 38043 Grenoble cedex France Department of Medical Oncology Pavillon H Edouard Herriot Hospital 69437 Lyon Cedex 03 France

Well-differentiated endocrine carcinomas of the small bowel are fairly rare neoplasms that present many clinical challenges. They secrete peptides and neuroamines that may cause carcinoid syndrome. However, many are clinically silent until late presentation with major effects. Initial treatment aims to control carcinoid syndrome with somatostatin analogs. Even if there is metastatic spread, surgical resection of the primitive tumor should be discussed in cases of retractile mesenteritis, small bowel ischemia or subocclusive syndrome in order to avoid any acute complication, in particular at the beginning of somatostatin analog treatment. The choice of treatment depends on the symptoms, general health of the patient, tumor burden, degree of uptake of radionuclide, histological features of the tumor, and tumor growth. Management strategies include surgery for cure (which is rarely achieved) or for cytoreduction, radiological interventions (transarterial embolization or radiofrequency ablation), and chemotherapy (interferon and somatostatin analogs). New biological agent and radionuclide targeted therapies are under investigation. Diffuse and non-evolving lesions should also be simplymonitored. Finally, it has to be emphasized that it is of the utmost importance to enroll these patients with a rare disease in prospective clinical trials assessing new therapeutic strategies.

关键词： Gastrointestinal neoplasms Neuroendocrine carcinoma Carcinoid tumor Somatostatin analogs Therapeutic chemoembolization Surgery

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单U型地埋管换热器的热性能

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Journal of Central South University 2021年第11期28卷 3580-3598页

作者： Seyed Soheil MOUSAVI AJAROSTAGHI Hossein JAVADI Seyed Sina MOUSAVI Sébastien poncet Mohsen POURFALLAH Faculty of Mechanical Engineering Babol Noshirvani University of TechnologyBabol 47148-71167Iran Faculty of Mechanical Engineering Mazandaran University of Science and TechnologyBabol 47166-85635Iran Faculty of Civil Engineering Babol Noshirvani University of TechnologyBabol 47148-71167Iran Department of Mechanical Engineering Universitéde Sherbrooke2500 Boulevard de l'UniversitéSherbrookeQuébecJ1K 2R1Canada

本文采用数值模拟的方法对单U型垂直地埋管换热器的热工性能进行了研究,计算了土壤孔隙率、充填材料的体积热容量、导热系数、入口体积流量和入口流体温度等参数对换热器热工性能的影响。从换热率的变化、有效热阻的变化以及地埋管换热... 详细信息

本文采用数值模拟的方法对单U型垂直地埋管换热器的热工性能进行了研究,计算了土壤孔隙率、充填材料的体积热容量、导热系数、入口体积流量和入口流体温度等参数对换热器热工性能的影响。从换热率的变化、有效热阻的变化以及地埋管换热器的效率等方面进行了讨论。结果表明,入口体积流量、入口流体温度和回填材料导热系数对地埋管换热器的热性能有显著影响,通过降低入口体积流量、提高回填材料导热系数和入口流体温度,出口流体温度明显降低。土壤孔隙率和回填材料容积热容对所研究的地埋管换热器热性能的影响可以忽略不计。当流体入口温度最低时,钻孔和土壤的有效热阻最大,传热速率和效率最低。此外,采用多元线性回归分析以建立预测单U型地埋管换热器热性能的最可行模型。

关键词：单U型地埋管换热器数值模拟换热率效率多元线性回归分析

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When Exchange-rate Volatility Affects Trade

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中国对外贸易（英文版） 2013年第2期 26-27页

作者： Jér(o)me Héricourt Sandra poncet Assistant Professor at EQUIPPE University of Lille Professor at the University of Paris Ⅰ and scientific advisor at CEPII

The increasing volatility of exchange rates after the fall of the Bretton Woods agreements has been a constant source of concern for both policymakers and *** countries fought hard in the 1980s to limit US dollar fluctuation (one thinks of the Plaza and Louvre's agreements,respectively in 1985 and 1987),and some European countries took an even more radical decision by giving up their national currency for the euro in 1999.

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BLAST INJURY TO THE EARS

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中华创伤杂志 1994年第6期 307-311页

作者： $$$$Y.F. Cudennec,J.L. poncet,P. BuffeDepartment of ENT and Cervico-Facial Surgery, Army Hospital Begin, 00498, Armees, France.

ＢＬＡＳＴＩＮＪＵＲＹＴＯＴＨＥＥＡＲＳＹ．Ｆ．Ｃｕｄｅｎｎｅｃ，Ｊ．Ｌ．Ｐｏｎｃｅｔ，Ｐ．ＢｕｆｆｅＤｅｐａｒｔｍｅｎｔｏｆＥＮＴａｎｄＣｅｒｖｉｃｏ－ＦａｃｉａｌＳｕｒｇｅｒｙ，ＡｒｍｙＨｏｓｐｉｔａｌＢｅｇｉｎ... 详细信息

ＢＬＡＳＴＩＮＪＵＲＹＴＯＴＨＥＥＡＲＳＹ．Ｆ．Ｃｕｄｅｎｎｅｃ，Ｊ．Ｌ．Ｐｏｎｃｅｔ，Ｐ．ＢｕｆｆｅＤｅｐａｒｔｍｅｎｔｏｆＥＮＴａｎｄＣｅｒｖｉｃｏ－ＦａｃｉａｌＳｕｒｇｅｒｙ，ＡｒｍｙＨｏｓｐｉｔａｌＢｅｇｉｎ，００４９８，Ａｒｍｅｅｓ，Ｆｒａ...

关键词： BLAST INJURY TO THE EARS

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附录C

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现代图书情报技术 1986年第S1期 65-66页

作者： Joel poncet

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先天性耳畸形的听力重建

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昆明医学院学报 1983年第S3期 72-73页

作者： E.poncet 秦家凤

本文报告5年中125例先天性耳畸形病人的治疗结果,125例中除几例颌面畸形及少数骨导高音下降外,都是50—70分贝的传导性耳聋。其中双耳畸形占25％。手术应解决两个问题,一是打开鼓室产生新的外耳道,其直径以1厘米为适合,一是建立双窗的... 详细信息

本文报告5年中125例先天性耳畸形病人的治疗结果,125例中除几例颌面畸形及少数骨导高音下降外,都是50—70分贝的传导性耳聋。其中双耳畸形占25％。手术应解决两个问题,一是打开鼓室产生新的外耳道,其直径以1厘米为适合,一是建立双窗的压差以提高听力,其方法有三,即水平半规管开窗术、常规的鼓室成形术及鼓膜-听小骨移植术。目前水平半规管开窗术仅用于不能作鼓室成形术或鼓膜-听小骨移植术的病人,特别

关键词：半规管开窗术鼓膜鼓室成形术听力提高听小骨先天性耳畸形

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头皮屑抑制剂的发展趋势

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日用化学品科学 1984年第4期 52-53页

作者： gerard A.Francois-poncet 谌山涛

有效的抑制头皮屑洗发剂上市已二十年了,第一个含有机锌盐"的头皮屑抑制剂在1963年由Procter&Gamble公司投入市场。这种商品名为Head&Shoulders的产品立即获得了成功,最后控制了抑制头皮屑洗发剂市场。后来,其他一些含有机锌盐的洗发剂... 详细信息

有效的抑制头皮屑洗发剂上市已二十年了,第一个含有机锌盐"的头皮屑抑制剂在1963年由Procter&Gamble公司投入市场。这种商品名为Head&Shoulders的产品立即获得了成功,最后控制了抑制头皮屑洗发剂市场。后来,其他一些含有机锌盐的洗发剂也投入美国及国外市场。 1973年,含一硫化硒的Selsun Blue进入头皮屑抑制剂市场。在过去十年中,曾很快地受到欢迎的抑制头皮屑洗发剂在

关键词：头皮屑抑制剂浮选药剂

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AB032. Exploring the effects of a retinal prosthesis on visual hallucinations related to Charles Bonnet syndrome

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Annals of Eye Science 2019年第1期 207-207页

作者： Vincent Moore Marie Courchesne Mathieu Carignan Sylvie Cantin Frédérique poncet Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre LongueuilQCCanada Centre de Recherche Interdisciplinaire en Readaptation du Montreal Metropolitain MontréalQCCanada Concordia University MontréalQCCanada

Background:A first occurrence in the province of Quebec(Canada)of the use of a retinal prosthesis system(RPS)by a patient with a Charles Bonnet syndrome(CBS)provides a rare opportunity to explore the effects of this system on visual hallucinations(VH)related to *** that the RPS artificially induces a visual perception and that VH related to CBS occur in cases of significant vision loss,this study aimed to explore whether the recovery of a visual perception could affect the nature and frequency of VH related to ***:This is a case study with time series and repeated experimentation:a pre-intervention measure to establish the baseline level,two implant activation periods(A1 and A2)and a post-intervention measure(3 for each activation).The study is based on a 65-year-old man with retinitis *** has been functionally blind for about ten years and was completely blind at the time of the *** began to perceive VH corresponding to the CBS after a significant decrease of his visual *** the time of the study,these VH were frequent and often *** receiving the Argus II RPS,he participated,along with INLB staff,in an intensive rehabilitation program aiming at optimizing the use of the *** explore the effects of the RPS,we collected visual,cognitive,and mood-related data and documented the VH using the Charles Bonnet Syndrome Screening Questionnaire(Cantin et al.,2018).Results:The visual acuity and visual field measurements show a significant improvement with the use of the RPS(visual acuity of 2.3 logMAR and visual fields of 12 degrees).Measurements of cognitive functions have shown high,stable,and close to the maximum *** data revealed low and relatively stable depression and anxiety scores over the course of the *** documented VH showed the characteristic features of *** nature and frequency of VH have varied widely over the study ***:The RPS improved the visual perceptions of the

关键词： Retinal prosthesis Charles Bonnet syndrome(CBS) visual impairment

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