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High Risk Factors of Pancreatic Carcinoma

Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第3期36卷 295-304页

作者： Soriba naby Camara 殷涛杨明李响龚琼周静赵刚杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍宁辛熊炯新陶京钦琪周伟崔静黄敏郭尧勾善淼王博刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah naby laye moussa keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory keita naby Daouda Camara Dusabe Emmanuel 吴河水王春友 Department of General Surgery Pancreatic disease InstituteUnion Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Breast and.Thyroid Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Planning Family and Reproductive Institute Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of General Medicine Sir Seewoosagur Ramgoolam National Hospital of PamplemoussesMauritius 21017Mauritius Department of Thoracic Surgery Friendship Hospital Sino-Guinea of Kipe Department of General Surgery National Hospital of Ignace DeenConakry 1147Guinea Department of Gastroenterology and Hepatology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Nephrology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Dermatology Friendship Hospital Sino-Guinea of Kipe Department of Internal Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Biochemistry University Gamal Abdel Nasser of ConakryConakryl147Guinea Department of Neurosurgery Friendship Hospital Sino-Guinea of Kipe Department of Medical Imaging Good Shepherd Medical CenterThe University of TexasLongview 75601USA Department of Visceral Surgery National Hospital of Donka Department of Gynecology and Obstetrics National Hospital of Donka Department of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer（PC） is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists.

关键词： high risk factors pancreatic cancer treatment epidemiology pathogenesis etiology

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Successful Separation of Conjoined Twins at the Conakry University Hospital Center

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Open Journal of Pediatrics 2022年第3期12卷 514-521页

作者： Mamadou Alpha Touré Balla keita Balla moussa Touré naby Fofana Ibrahima Kalil Dioubaté Thiero Mamadou Aliou Touré Pediatric Surgery Department Donka National Hospital Conakry Guinea Pediatric Surgery Unit General Surgery Department Ignace Deen Hospital Conakry Guinea Institute of Nutrition and Health for Children Conakry Guinea

Introduction: The birth of conjoined twins is an event extremely rare that offers unique therapeutic challenges and circumstances. We must examine each situation with the many questions that arise and which sometimes require a long reflection. We report a case of separation of pygopages conjoined twins as well as a review of the literature. Patients and Observations: a pair of conjoined twins aged 11 days, weighing 3080 g between them, was referred to the neonatology department from the Faranah prefecture, 300 km from Conakry, for care. The mother, a 30-year-old housewife, multipara, eight gestures and nine parities, had not followed any prenatal consultation. The delivery took place at home in a village with the death of the mother immediately postpartum. The clinical and paraclinical investigation had concluded with the diagnosis of Siamese type pygopage. After multidisciplinary consultation, the surgical treatment by separation of the twins was carried out at the age of 50 days with success and preservation of the physiological functions. Conclusion: The birth of conjoined twins is extremely rare. Each pair of Siamese is different and the surgical strategy must be adapted according to the shared organs. The perfect multidisciplinary work of the medical staff has been the main contributor to our success.

关键词： Siamese Twins Pygopages Multidisciplinarity Separation Conakry Hospital and University Center

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Thyroid Disease at the University Hospital of Conakry, Guinea

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Open Journal of Internal Medicine 2019年第4期9卷 105-111页

作者： Amadou Kaké Mamadou Mansour Diallo Djibril Sylla Alpha Mamadou Diallo Ibrahima Camara Abdoulaye keita Thierno Amadou Wann Kadija Dieng Mamadou Alpha Diallo Elhadj Zaï noul Bah Mohamed Yakharé Camara Abdoulaye Bayo naby moussa Baldé Department of Endocrinology and Metabolic Diseases Donka University Hospital Conakry Guinea Department of Internal Medicine Donka University Hospital Conakry Guinea Department of ENT Donka University Hospital Conakry Guinea.

Objectives: To describe the epidemiological, clinical and therapeutic characteristics of thyroid disease at the University Hospital of Conakry, Guinea. Methods: This was a descriptive study with prospective data collection, carried out over the period of December 2016 to April 2019 at the endocrinology outpatient consultation at the University Hospital of Conakry. All the epidemiological, clinical and therapeutic data of the patients followed-up for thyroid disease were collected, analyzed and classified according to the epidemiological, clinical and therapeutic profile. The functional, morphological and autoimmune aspects of the thyroid gland were studied. Results: Out of a total of 3.517 endocrinology consultations during the study period, 204 patients were diagnosed with thyroid disease (180 women and 24 men, F/H ratio: 7.5). The average age was 47 ± 16 years. A total of 90 patients (44.33%) had hyperthyroidism, including 52 cases of Graves-Basedow disease (57.6%) and 24 cases of toxic multi-nodular goiter (32.6%). Hypothyroidism was confirmed in 25 patients (11%);about half (48%) of them had a complete thyroid surgery. The treatment of hyperthyroidism was exclusively done by synthetic antithyroid drugs, except 5 cases of Hashimoto disease with transient initial hyperthyroidism phase. Hypothyroidism was treated by hormone replacement therapy. Thyroidectomy, partial (n = 5) or total (n = 12), was performed for aesthetic discomfort (n = 6), cervical compression (n = 8) and suspicion of thyroid cancer (n = 3). Follow-up was considered regular in 40 cases (44%). Conclusion: Thyroid disease was frequent in this study conducted in Conakry and its clinical features were very diverse, dominated by hyperthyroidism mainly due to Grave disease. However, diagnostic and therapeutic strategies were hindered by the limitation in availability of biological and morphological explorations.

关键词： Goiter Hyperthyroidism Hypothyroidism Guinea

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