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Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine‑resistant treatment‑refractory schizophrenia:a 12‑week randomized,double‑blind,placebo‑controlled trial

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军事医学研究:英文版 2023年第4期10卷 431-443页

作者： Ming‑Huan zhu Zhen‑Jing Liu Qiong‑Yue Hu Jia‑Yu Yang Ying Jin na zhu Ying Huang Dian‑Hong Shi Min‑Jia Liu Hong‑Yang Tan Lei Zhao Qin‑Yu Lv Zheng‑Hui Yi Feng‑Chun Wu Ze‑Zhi Li Clinical Research Center for Mental Disorders School of MedicineShanghai Pudong New Area Mental Health CenterTongji UniversityShanghai 200124China Qingdao Mental Health Center Qingdao 266034ShandongChina Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Department of Psychiatry the Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders Guangzhou 510370China

Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to *** main purpose of this randomized,double-blind,placebocontrolled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia(CTRS)***:A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride(amisulpride group)or clozapine plus placebo(placebo group).Positive and Negative Syndrome Scale(PANSS),Scale for the Assessment of Negative Symptoms(SANS),Clinical Global Impression(CGI)scale scores,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Treatment Emergent Symptom Scale(TESS),laboratory measurements,and electrocardiograms(ECG)were performed at baseline,week 6,and week ***:Compared with the placebo group,amisulpride group had a lower PANSS total score,positive subscore,and general psychopathology subscore at week 6 and week 12(PBonferroni<0.01).Furthermore,compared with the placebo group,the amisulpride group showed an improved RBANS language score at week 12(PBonferroni<0.001).Amisulpride group had a higher treatment response rate(P=0.04),lower scores of CGI severity and CGI efficacy at week 6 and week 12 than placebo group(PBonferroni<0.05).There were no differences between the groups in body mass index(BMI),corrected QT(QTc)intervals,and laboratory *** study demonstrates that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients.

关键词： Schizophrenia Clozapine-resistant treatment-refractory schizophrenia Clozapine Amisulpride Augmentation

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Lead Determination on MWNT/nafion Composite Modified Glassy Carbon Electrodes

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Chinese Journal of Chemistry 2005年第11期23卷 1510-1514页

作者： XU, Qin LIU, Ni-na zhu, Jun-Jie Key Labororatory of Analytical Chemistry for Life Science Department of Chemistry Nanjing University Nanjing Jiangsu 210093 China

A composite material of nitric acid oxidized multiwalled carbon nanotube （MWNT） and nation was prepared. Such composite was modified on a glassy carbon electrode to determine trace of lead by differential pulsed voltammetry. In pH=6.47 naNO3 solution, Pb^2＋ ions were accumulated on the modified electrode at -0.4 V. Compared with a bare and a nation film coated electrode, the composite coated GC electrode can reduce the accumulating potential and eliminate the toxic character of mercury. The calibration plots were linear at low concentration of 5.0× 10^-9-2.0× 10^-8 mol/L and high concentration of 2.5× 10^-8-5.0× 10^-6 mol/L. The performances characteristics indicate that the electrode can be used to determine trace Pb^2＋ ions.

关键词： composite lead electrochemistry differential pulsed voltammetry

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Two Novel Antifungal Saponins from Tibetan Herbal Medicine Clematis tangutica

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Chinese Chemical Letters 2003年第7期14卷 707-710页

作者： Zhi Zhi DU na zhu Yue Mao SHEN Kunming Institute of Botany Chinese Academy of SciencesKunming 650204

Antifungal assay-guided isolation of the ethanol extract of the aerial parts of Clematis tangutica yielded two novel triterpene saponins. Their structures were determined to be 3-O-a-L-arabinopyranosyl hederagenin 28-O-a-L-rhamnopyranosyl ester (1) and 3-O-b-D- glucopyranosyl(14)-a-L-arabinopyranosyl hederagenin 28-O-a-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical reactions.

关键词： Clematis tangutica triterpene saponins hederagenin antifungal assay.

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Mild spring temperature rising affects the anti-oxidation and immune functions of Asian Short-toed Larks

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Avian Research 2020年第2期11卷 115-121页

作者： na zhu Tingting Liu Fei Wang Wei Liang Shuping Zhang College of Life and Environment Sciences Minzu University of ChinaBeijing 100081China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikou 571158China.

Background:Predicting the possibility of severe effects of global warming on animals is important for understanding the ecological consequences of climate change on *** is the season during which birds have to physiologically prepare for the subsequent breeding period,and unusual spring temperature rising probably becomes a heat stress to the birds which have adapted to the low spring ***,it is necessary to understand the physiological effect of spring warming on the temperate ***:Using the activities of blood anti-oxidative enzymes(SOD,CAT,GPx)and the concentrations of serum immunogloblins(IgA,IgY,IgM)as indicators,we compared the anti-oxidative and immune functions of Asian Shorttoed Larks(Calandrella cheleensis)captured between 10 and 15 March,2015 and housed under conditions of 21°C and 16°***:The SOD activities of birds in 21°C group were significantly lower than those in 16°C group on all the treatment *** CAT activities of the birds in 21°C group were significantly lower than those in 16°C group on the 1 st,5 th,13 th,17 treatment *** GPx activities of the birds in 21°C group were signifthicantly lower than those in 16°C group on the 1 st,13 th and 17 th,but significantly higher on the 21 st treatment *** IgA,IgY and IgM concentrations of birds in 21°C group were significantly lower than those in 16°C group on all the treatment ***:This study shows that spring temperature rising negatively influences antioxibative and humoral immune functions,which indicates that spring climate warming might reduce the fitness of the temperate passerine birds which have adapted to the low spring temperature.

关键词： Mild temperature rising Anti-oxidant capacity Immunity Asian Short-toed Larks Spring

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The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zhao Jing-Jing Guo Feng zhu na-na Zhang Xiao-Feng Li Hai-Tao Liu Fei Wang Yong-Qiang Deng Cheng-Feng Qin College of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Guaico Culex virus(GCXV)is a newly identified segmented Jingmenvirus from Culex *** in Central and South *** genome of GCXV is composed of four or five single-stranded positive Rna ***,the infection kinetics and transmission capability of GCXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GCXVs(4S and 5S)that contained four and five Rna segments,respectively,in C6/36 *** in vitro characterization revealed that the two GCXVs exhibited comparable replication kinetics,protein expression and viral ***,GCXV Rnas were detected in the bodies,salivary glands,midguts and ovaries of Culex quinquefasciatus at 4–10 days after oral *** addition,two GCXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GCXVs with four or five Rna segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico Culex virus(GCXV) Jingmenvirus Culex quinquefasciatus Vertical transmission

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Spatiotemporal characteristics of water exchange between the Andaman Sea and the Bay of Bengal

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Acta Oceanologica Sinica 2024年第5期43卷 1-15页

作者： Yihao Wang Feng Zhou Xueming zhu Ruijie Ye Yingyu Peng Zhentao Hu Haoran Tian na Li Ocean College Zhejiang UniversityZhoushan 316021China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural ResourcesZhoushan 316022China Southern Marine Science and Engineering Guangdong Laboratory(zhuhai) Zhuhai 519080China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China School of Marine Sciences Sun Yat-sen UniversityZhuhai 519080China

A high-resolution customized numerical model is used to analyze the water transport in the three major water passages between the Andaman Sea(AS)and the Bay of Bengal,i.e.,the Preparis Channel(PC),the Ten Degree Channel(TDC),and the Great Channel(GC),based on the daily averaged simulation results ranging from 2010 to *** analysis and Empirical Orthogonal Function(EOF)methods are employed to investigate the spatiotemporal variability of the water exchange and controlling *** results of model simulation indicate that the net average transports of the PC and GC,as well as their linear trend,are opposite to that of the *** indicates that the PC and the GC are the main inflow channels of the AS,while the TDC is the main outflow channel of the *** transport variability is most pronounced at surface levels and between 100 m and 200 m depth,likely affected by monsoons and circulation.A 182.4-d semiannual variability is consistently seen in all three channels,which is also evident in their second principal *** on sea level anomalies and EOF analysis results,this is primarily due to equatorial winds during the monsoon transition period,causing eastward movement of Kelvin waves along the AS coast,thereby affecting the spatiotemporal characteristics of the flow in the *** first EOF of the PC flow field section shows a split at 100 m deep,likely due to *** first EOF of the TDC flow field section is steady but has potent seasonal oscillations in its time ***,the first EOF of the GC flow field section indicates a stable surface inflow,probably influenced by the equatorial Indian Ocean’s eastward current.

关键词： Andaman Sea water exchange Regional Ocean Modeling Systems(ROMS) Kelvin waves spatiotemporal characteristics

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Lower extremity peripherally inserted central catheter placement ectopic to the ascending lumbar vein:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1430-1436页

作者： Xiao-Ju zhu Ling Zhao na Peng Jia-Min Luo Shui-Xia Liu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Peripherally inserted central catheters(PICCs)are an essential infusion route for oncology patients receiving intravenous treatments,but lower extremity veni-puncture is the preferred technique for patients with superior vena cava syndrome(SVCS).We report the case of a patient with a lower extremity PICC ectopic to the ascending lumbar vein,to indicate and verify PICC catheterisation in the lower extremity is safe and *** hope to provide different per-spectives for clinical PICC venipuncture to get the attention of *** SUMMARY On 24 August 2022,a 58-year-old male was admitted to our department due to an intermittent cough persisting for over a month,which worsened 10 d *** and laboratory investigations suggested the patient with pulmonary malignancy and *** was not an absolute contraindication in this *** extremity venipuncture is the preferred technique because administering upper extremity venous transfusion to patients with SVCS can exacerbate oedema in the head,neck,and upper *** patient and his family were informed about the procedure,and informed consent was *** successful puncture and prompt treatment,the patient was discharged,experiencing some relief from *** Inferior vena cava catheterisation is rare and important for cancer patients with SVCS,particularly in complex situations involving ectopic placement.

关键词： Superior vena cava syndrome Peripherally inserted central catheter Ascending lumbar vein Complications Case report

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Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with W substrate

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China Foundry 2024年第4期21卷 352-359页

作者： Zhen Zhang Lin-na Feng Jin-he Wang Zheng-kun Li Hua-meng Fu Hong Li Zheng-wang zhu Hai-feng Zhang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110004China

The infiltration casting method is widely employed for the preparation of ex-situ composite ***,the production of composite materials using this method must necessitates a comprehensive understanding of the wettability and interface characteristics between the reinforcing phase and the bulk metallic glasses(BMGs).This work optimized the composition of Zr-based BMGs through microalloying methods,resulting in a new set of Zr-based BMGs with excellent glass-forming *** experiments between the Zr-based BMGs melts and W substrates were conducted using the traditional sessile drop method,and the interfaces were characterized utilizing a scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS).The work demonstrates that the microalloying method substantially enhances the wettability of the Zr-based BMGs ***,the incorporation of Nb element impedes the formation of W-Zr phases,but the introduction of Nb element does not alter the extent of interdiffusion between the constituent elements of the amorphous matrix and W element,indicating that the influence of Nb element on the diffusion of individual elements is minute.

关键词： Zr-based BMGs infiltration casting method wettability interface characteristics W-Zr phases

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-na Yang Shuang-Shuang Yang Yi-zhu Lyu Bing Zhang Kai-Wen Liu na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China national Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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An interface-reconstruction effect for rechargeable aluminum battery in ionic liquid electrolyte to enhance cycling performances

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Green Energy & Environment 2018年第1期3卷 71-77页

作者： Feng Wu na zhu Ying Bai Yaning Gao Chuan Wu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and Engineering Beijing Institute of Technology Collaborative Innovation Center of Electric Vehicles in Beijing

Aluminum(Al) metal has been regarded as a promising anode for rechargeable batteries because of its natural abundance and high theoretical specific capacity. However, rechargeable aluminum batteries(RABs) using A1 metal as anode display poor cycling performances owing to interface problems between anode and electrolyte. The solid-electrolyte interphase(SEI) layer on the anode has been confirmed to be essential for improving cycling performances of rechargeable batteries. Therefore, we immerse the Al metal in ionic liquid electrolyte for some time before it is used as anode to remove the passive film and expose fresh Al to the electrolyte. Then the reactions of exposed Al, acid, oxygen and water in electrolyte are occurred to form an SEI layer in the cycle. Al/electrolyte/V_2 O_5 full batteries with the thin, uniform and stable SEI layer on Al metal anode perform high discharge capacity and coulombic efficiency(CE). This work illustrates that an SEI layer is formed on Al metal anode in the cycle using a simple and effective pretreatment process and results in superior cycling performances for RABs.

关键词： Rechargeable aluminum battery Aluminum anode Ionic liquid electrolyte Solid-electrolyte interphase

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