检索结果-南通市图书馆

Science China Materials 2018年第6期61卷 895-904页

作者： Charlene ng Jung-Ho Yun Hui Ling Tan Hao Wu Rose Amal Yun Hau ng Particles and Catalysis Research Group School of Chemical Engineering The University of New South Wales

The utilization of na2S/na2SO3 mixture as the electrolyte solution to stabilize sulfide anode in a photoelectrochemical cell for hydrogen evolution generally compromises the current-to-hydrogen efficiency（ηcurrent） of the system. Here, the employment of a dual-electrolyte system,that is, na2S/na2SO3 mixture and p H-neutral na2SO4 as the respective electrolyte solutions in the anode and cathode chambers of a water splitting cell is demonstrated to suppress the photocorrosion of CuInS2-In2O3-TiO2 nanotube（CISIn2O3-TNT） heterostructure, while simultaneously boosts theηcurrent. Although n-type CIS and In2O3 nanoparticles can be easily formed on TNT array via facile pulse-assisted electrodeposition method, conformal deposition of the nanoparticles homogeneously on the nanotubes wall with preservation of the TNT hollow structure is shown to be essential for achieving efficient charge generation and separation within the heterostructure. In comparison to na2S/na2SO3 solution as the sole electrolyte in both the anode and cathode chambers, introduction of dual electrolyte is shown to not only enhance the photostability of the CIS-In2O3-TNT anode, but also lead to near-unity ηcurrentas opposed to the merely 20% ηcurrentof the single-electrolyte system.

关键词： dual-electrolyte hydrogen generation photoelectrochemical TiO2 nanotubes CuInS2

基于Notch信号通路研究雷公藤多苷对体外培养小鼠卵巢生殖干细胞的毒性作用及机制研究

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第6期49卷 1594-1601页

作者：杜寒倩郭丽赵元李源李泽辉李佳珊徐盼瑜林娜徐颖中国中医科学院中药研究所北京100700 深圳市中医院中药制剂中心广东深圳518033

以优化培养体系中生长状态良好的卵巢生殖干细胞(ovarian germline stem cells,OGSCs)为研究对象,观察雷公藤多苷(Tripterygium glycosides,TG)对OGSCs的影响,并从Notch信号通路探讨其生殖毒性的作用机制。采用cell counting kit⁃8(CCk⁃8)检测3.75、7.5、15μg·mL^(-1) TG对体外培养小鼠OGSCs活力的影响;免疫荧光技术和逆转录聚合酶链式反应(reverse transcription⁃polymerase chain reaction,RT⁃PCR)检测3.75μg·mL^(-1) TG给药后OGSCs标志物VASA基因同源类似物(mouse vasa homologue,MVH)、八聚体结合转录因子4(octamer⁃binding transcription factor 4,Oct4)蛋白和基因的表达;RT⁃PCR检测Notch信号通路关键分子神经源性基因Notch同源蛋白1(neurogenic locus Notch homolog protein 1,Notch1)、Hes家族BHLH转录因子1(Hes family BHLH transcription factor 1,Hes1)、锯齿典型Notch配体1(jagged canonical Notch ligand 1,Jagged1)基因表达;提取Rna进行转录组学分析TG干预OGSCs的作用机制。3.75μg·mL^(-1) TG配伍40 ng·mL^(-1) Notch信号通路γ⁃促分泌酶激动剂jagged canonical Notch ligand(Jagged)联合给药,采用CCk⁃8检测OGSCs活力水平;免疫荧光双标法检测MVH与Hes1、Notch1、Jagged1蛋白共表达。结果显示,与空白组比较,TG给药后均显著抑制OGSCs活力(P<0.01或P<0.001);显著降低OGSCs标志物MVH、Oct4蛋白和基因表达(P<0.05,P<0.01或P<0.001);显著抑制Notch1、Hes1、Jagged1基因表达(P<0.001)。转录组学分析提示,TG通过干预Notch信号通路相关配体Jagged1影响OGSCs的生长增殖。实验验证结果表明,配伍Notch信号通路γ⁃促分泌酶激动剂Jagged可显著缓解TG所致OGSCs活力的降低(P<0.001);并与TG组比较,显著升高MVH/Hes1、MVH/Notch1、MVH/Jagged1蛋白共表达(P<0.01或P<0.001)。综上可知,TG可发挥γ⁃促分泌酶抑制剂样作用,通过下调OGSCs标志物MVH、Oct4和Notch信号通路分子Notch1、Hes1、Jagged1参与OGSCs途径介导Notch信号通路诱发生殖毒性。

关键词：雷公藤多苷生殖毒性卵巢生殖干细胞 Notch信号通路 γ⁃促分泌酶激动剂

根据计算结构因子重新指定镍(II)8-羟基喹啉的两个络合物(英文)

在线全文

学校读者我要写书评

暂无评论

物理化学学报 2001年第11期17卷 1040-1044页

作者： ng Seikweng 胡盛志马来亚大学研究生院厦门大学化学系厦门361005

晶体学研究曾认为分子式是naNiQ2HQCLO4的结构并不含有钠而应为H3ONiQCLO4.相似地,稀土-Ni络合物YQHQ2NiQ3CLO4也不含有钇而应为H3ONi2Q3CLO4.晶体结构描述的修正系根据文献报导的原子坐标计算结构因子所导出的结果.

关键词：结构修正镍(Ⅱ)络合物计算结构因子 8-羟基喹啉

Decarboxylated osteocalcin,a possible drug for type 2 diabetes,triggers glucose uptake in MG63 cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第7期12卷 1102-1115页

作者： Shi Jin Xiao-Cen Chang Jing Wen Jing Yang na Ao ke-Ying Zhang Lin-na Suo Jian Du Department of Endocrinology The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina Department of Endocrinology The Fifth People’s Hospital of ShenyangShenyang 110023Liaoning ProvinceChina

BACkGROUND Uncarboxylated osteocalcin(GluOC)has been reported to improve glucose metabolism,prevent type 2 diabetes,and decrease the severity of obesity in mice with type 2 *** can increase glucose uptake in a variety of *** metabolism is the main source of energy for osteoblast proliferation and *** hypothesized that decarboxylated osteocalcin(dcOC),a kind of GluOC,can increase glucose uptake in MG63 cells(osteoblast-like osteosarcoma cells)and influence their proliferation and *** To investigate the effects of dcOC on glucose uptake in human osteoblast-like osteosarcoma cells and the possible signaling pathways *** MG63 cells(human osteoblast-like osteosarcoma cells)were treated with dcOC(0,0.3,3,10,or 30 ng/mL)for 1 and 72 h,and glucose uptake was measured by flow *** effect of dcOC on cell proliferation was measured with a CCk-8 assay,and alkaline phosphatase(ALP)enzyme activity was ***3k was inhibited with LY294002,and hypoxia-inducible factor 1 alpha(HIF-1α)was silenced with ***,GPRC6A(G protein-coupled receptor family C group 6 subtype A),total Akt,phosphorylated Akt,HIF-1α,and glucose transporter 1(GLUT1)levels were measured by Western blot to elucidate the possible pathways by which dcOC modulates glucose *** The glucose uptake of MG63 cells was significantly increased compared with that of the paired control cells after short-term(1 h)treatment with dcOC at different concentrations(0.3,3,and 10 ng/mL groups,Png/mL group,Pke of MG63 cells was significantly increased compared with that of the paired control cells after long-term(72 h)treatment with dcOC at different concentrations(0.3,3,and 10 ng/mL groups,Png/mL group,Pkt phosphorylation in a dose-dependent manner,and the most effective stimulatory concentration of dcOC for short-term(1 h)was 3 ng/mL(P<0.01).LY294002 abolished the dcOC-mediated(1 h)

关键词： Decarboxylated osteocalcin Osteoblast Glucose uptake Glucose transporter 1 Type 2 diabetes

FeCo alloy@N-doped graphitized carbon as an efficient cocatalyst for enhanced photocatalytic H2 evolution by inducing accelerated charge transfer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第1期30卷 92-101,I0004页

作者： Sibo Chen Yun Hau ng Jihai Liao Qiongzhi Gao Siyuan Yang Feng Peng Xinhua Zhong Yueping Fang Shengsen Zhang key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510643GuangdongChina School of Energy and Environment City University of Hong KongHongkong 999077China Department of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina

Cocatalysts play important roles in improving the activity and stability of most *** is of great significance to develop economical,efficient and stable ***,using na2CoFe(CN)6 complex as precursor,a novel noble-metal-free FeCo@ngC cocatalyst(nano-FeCo alloy@N-doped graphitized carbon) is fabricated by a simple pyrolysis *** with g-C3 N4, the optimal FeCo@ngC/g-C3N4 receives a boosted visible light driven photocatalytic H2 evolution rate of 42.2 μmol h-1, which is even higher than that of 1.0 wt% Pt modified g-C3N4 *** on the results of density functional theory(DFT) calculations and practical experiment measurements,such outstanding photocatalytic performance of FeCo@ngC/g-C3N4 is mainly attributed to two *** is the accelerated charge transfer behavior,induced by a photogene rated electrons secondary transfer performance on the surface of FeCo alloy *** other is related to the adjustment of H adsorption energy(approaching the standard hydrogen electrode potential) by the presence of external ngC thin *** factors play key roles in the H2 evolution *** outstanding performance highlights an enormous potential of developing noble-metal-free bimetallic nano-alloy as inexpensive and efficient cocatalysts for solar applications.

关键词： FeCo alloy nanoparticles Cocatalyst N-doped graphitized carbon g-C3N4 Visible light Hydrogen evolution

Liver decompensation after rapid weight loss from semaglutide in a patient with non-alcoholic steatohepatitis -associated cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew Peverelle Jonathan ng James Peverelle Ryan D.Hirsch Adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (naSH). remains a paucity of safety data in the vulnerable naSHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with naSHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver Disease-na (MELD-na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELD-na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists Weight loss

急性白血病患儿造血干细胞移植后血清LDH、sIL-2R、GDF15水平变化及其临床意义

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海南医学 2024年第19期35卷 2797-2802页

作者：苏于泰毛彦娜马平刘炜郑州大学附属儿童医院&河南省儿童医院郑州儿童医院血液肿瘤科河南郑州450018

目的检测急性白血病患儿造血干细胞移植后血清乳酸脱氢酶(LDH)、可溶性白细胞介素-2受体(sIL-2R)、生长分化因子15(GDF15)水平,并探讨其临床意义。方法回顾性分析2022年1月至2023年6月河南省儿童医院收治的78例急性白血病患儿的临床诊... 详细信息

目的检测急性白血病患儿造血干细胞移植后血清乳酸脱氢酶(LDH)、可溶性白细胞介素-2受体(sIL-2R)、生长分化因子15(GDF15)水平,并探讨其临床意义。方法回顾性分析2022年1月至2023年6月河南省儿童医院收治的78例急性白血病患儿的临床诊治资料,所有患儿均进行造血干细胞移植,检测患儿移植前后的血清LDH、sIL-2R、GDF15水平。依据患儿移植后6个月的预后情况分为预后良好组(n=64)和预后不良组(n=14)。比较两组患儿的基线资料及移植前后的血清LDH、sIL-2R、GDF15水平,采用偏相关性系数分析血清LDH、sIL-2R、GDF15水平与移植预后的偏相关性,采用受试者工作特征(ROC)曲线分析血清LDH、sIL-2R、GDF15单独及联合预测移植预后的效能,并比较各预测方案的预测效能。结果移植后,患儿的血清LDH、sIL-2R、GDF15水平分别为(224.83±65.27)U/L、(257.41±80.26)U/mL、(0.87±0.26)ng/mL,明显低于移植前的(418.96±135.22)U/L、(492.83±140.47)U/mL、(1.39±0.45)ng/mL,差异均有统计学意义(Png/mL,明显高于预后良好组患儿的26.56%、(202.37±65.87)U/L、(237.19±75.17)U/mL、(0.80±0.26)ng/mL,差异均有统计学意义(P<0.05);偏相关性分析结果显示,在控制移植前未达到CR等因素后,移植后血清LDH(偏相关性系数=0.894,95%CI:1.415~3.029)、sIL-2R(偏相关性系数=0.875,95%CI:1.374~2.982)、GDF15(偏相关性系数=0.902,95%CI:1.692~3.047)水平仍与移植预后不良显著相关(P<0.05);ROC分析结果显示,移植后血清LDH、sIL-2R、GDF15单独预测移植预后的曲线下面积(AUC)分别为0.747、0.787、0.844,LDH+sIL-2R、LDH+GDF15、sIL-2R+GDF15及三者联合预测预后的AUC分别为0.884、0.886、0.898、0.949;成对对比分析结果显示,移植后血清三者联合预测AUC最大(0.949),预测效能明显优于各指标单独及两两联合预测价值。结论血清LDH、sIL-2R、GDF15与急性白血病患儿造血干细胞移植预后密切相关,且三者联合检测对预后不良具有一定预测价值,可作为临床预测预后的辅助指标,并指导临床防治工作。

关键词：急性白血病造血干细胞移植乳酸脱氢酶可溶性白细胞介素-2受体生长分化因子15 预后预测

维普期刊数据库博看期刊

基于3D-QSAR的多氟烷基磷酸二酯对斑马鱼的脂毒性预测

在线全文

学校读者我要写书评

暂无评论

环境工程 2024年第2期42卷 247-254页

作者：陈朋宇胡宇熙陈庚赵娜窦志超河海大学海洋学院江苏省海洋生物资源可持续利用工程研究中心南京210024 河海大学浅水湖泊综合治理与资源开发教育部重点实验室南京210024 中国科学院上海药物研究所上海201203

为研究多氟烷基磷酸二酯(DiPAPs)对斑马鱼的脂毒性作用,构建15种全氟化合物与过氧化物酶体增殖物激活受体β(PPARβ)结合的三维定量构效关系模型(3D-QSAR),分别对6∶2和8∶2的DiPAPs与PPARβ结合亲和力进行预测;基于分子对接分别研究6∶... 详细信息

为研究多氟烷基磷酸二酯(DiPAPs)对斑马鱼的脂毒性作用,构建15种全氟化合物与过氧化物酶体增殖物激活受体β(PPARβ)结合的三维定量构效关系模型(3D-QSAR),分别对6∶2和8∶2的DiPAPs与PPARβ结合亲和力进行预测;基于分子对接分别研究6∶2和8∶2 DiPAPs与PPARβ的相互作用;分别考察6∶2和8∶2 DiPAPs暴露对斑马鱼Pparβ表达的影响,对3D-QSAR预测结果进行验证。结果表明,6∶2和8∶2 DiPAPs的半数竞争效应浓度(pIC_(50))的预测值分别为3.73,3.63 mol/L,说明二者可能均具有过氧化物酶体增殖活性;6∶2和8∶2 DiPAPs主要通过氢键和疏水作用与PPARβ结合,且6∶2 DiPAP结合活性更强;二者分别暴露后,PPARβ表达量均显著上调,且50 ng/L 6∶2 DiPAP组比50 ng/L 8∶2 DiPAP组的表达量更高,与模型预测结果一致。综上,6∶2和8∶2 DiPAPs可通过影响斑马鱼PPARβ的表达,产生脂毒性。研究结果可为评估DiPAPs这类新型全氟/多氟烷基化合物在水环境中的生态风险提供理论依据。

关键词：多氟烷基磷酸二酯三维定量构效关系分子对接脂毒性过氧化物酶体增殖物激活受体

颅内动脉瘤性蛛网膜下腔出血患者血清CTRP3和CCL2与脑血管痉挛的关系

在线全文

学校读者我要写书评

暂无评论

中国临床神经科学 2024年第3期32卷 268-274页

作者：周真真王琦张旋马美娜沧州市中心医院日间手术治疗科沧州061000 沧州市中心医院麻醉科沧州061000 沧州市中心医院科研处沧州061000

目的探讨颅内动脉瘤性蛛网膜下腔出血(aSAH)患者血清补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)、CC趋化因子配体2(CCL2)水平与脑血管痉挛(CVS)的关系。方法选取2018年10月至2022年1月收治的120例aSAH患者,按aSAH患者术后3周内是否并发CVS... 详细信息

目的探讨颅内动脉瘤性蛛网膜下腔出血(aSAH)患者血清补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)、CC趋化因子配体2(CCL2)水平与脑血管痉挛(CVS)的关系。方法选取2018年10月至2022年1月收治的120例aSAH患者,按aSAH患者术后3周内是否并发CVS分为无CVS组(87例)和CVS组(33例),另纳入同期120例健康体检者为对照组。采用ELISA法检测血清CTRP3和CCL2水平;用Logistic回归分析aSAH患者并发CVS的影响因素;采用ROC曲线评估血清CTRP3、CCL2判断aSAH并发CVS的价值。结果无CVS组和CVS组患者血清CCL2水平均高于对照组(均Png·mL^(-1))、0.871(截断值:206.65pg·mL^(-1)),敏感度均为87.9%,特异度分别为79.3%和80.5%;且CTRP3联合CCL2判断aSAH并发CVS的AUC为0.937,敏感度为84.8%,特异度为94.3%。结论aSAH患者血清CTRP3水平较低,CCL2水平较高,CTRP3、CCL2均可作为评估aSAH并发CVS的辅助指标,且两者联合评估可更好的判断a SAH并发CVS,是临床预防aSAH并发CVS的新方向。

关键词：脑血管痉挛 CC趋化因子配体2 动脉瘤性蛛网膜下腔出血补体C1q/肿瘤坏死因子相关蛋白3

在线全文

学校读者我要写书评

暂无评论

12例胃肝样腺癌临床病理特征及预后分析

宁夏医科大学学报 2024年第6期46卷 640-646页

作者：肖雯苏利君苗亚萍罗娜陈萍宁夏医科大学第一临床医学院银川750004 宁夏医科大学总医院肿瘤医院肿瘤内二科宁夏医科大学第一临床医学院银川750004

目的总结12例胃肝样腺癌(HAS)患者临床资料,探讨胃肝样腺癌的临床病理特征及预后。方法回顾性分析2016年1月至2022年12月宁夏医科大学总医院收治的12例HAS患者的临床病理学资料,病理及免疫组化结果由两位病理科医师复阅肿瘤组织切片判... 详细信息

目的总结12例胃肝样腺癌(HAS)患者临床资料,探讨胃肝样腺癌的临床病理特征及预后。方法回顾性分析2016年1月至2022年12月宁夏医科大学总医院收治的12例HAS患者的临床病理学资料,病理及免疫组化结果由两位病理科医师复阅肿瘤组织切片判定。通过描述性统计方法总结患者的人口统计学和肿瘤特征。运用COX单因素和多因素回归分析胃肝样腺癌患者预后。结果12例患者中男性9例、女性3例,男女比例为3∶1;疾病中位诊断年龄为60岁;最常见发病部位为胃窦(41.7%),病变类型以BorrmannⅢ型(溃疡型)为主(45.5%),Lauren分型以弥漫型为主(58.3%),肿瘤分化程度多呈低分化(83.3%);8例患者血清癌胚抗原(CEA)≥5 ng·mL^(-1),6例患者进行血清甲胎蛋白(AFP)检测,其中4例(66.7%)升高,1例(16.7%)AFP≥300 ng·mL^(-1)。11例患者进行了手术治疗,术前远处转移5例,其中4例同时发生肝脏、腹膜后淋巴结转移;1例仅发生腹膜后淋巴结转移。10例患者(83.3%)发生脉管浸润,7例患者(58.3%)发生神经侵犯。根据肝样分化区所占比例不同,4例患者(33.3%)为单纯型HAS、8例患者(66.7%)为混合型HAS。临床分期:Ⅰ期1例、Ⅱ期1例、Ⅲ期5例、Ⅳ期5例。12例患者中位生存期为16个月,1、3、5年存活率分别为83.0%、41.0%、20.0%。根据单因素分析结果,不排除CEA水平、临床分期、肝样腺癌类型、是否行根治性手术、是否存在远处转移、远处转移是否为肝转移HepPar-1是否表达与患者预后可能有关。结论HAS是一种罕见的异质性肿瘤,常伴血清AFP升高及部分肝细胞癌标记物表达,易发生脉管浸润、淋巴结及远处转移,预后极差。

关键词：胃肝样腺癌临床病理特征免疫组化预后