检索结果-南通市图书馆

Urine Metabonomic Analysis of Interventions Effect of Soy Isoflavones on Rats Exposed to Di-(2-ethylhexyl) Phthalate

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第2期33卷 77-88页

作者： DONG Xin Wen YAO San Qiao WU Hao Yu ZHANG Yun Bo WANG Cheng na xiao lin WU Wei Dong Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

Objective Di-(2-ethylhexyl) phthalate(DEHP) is a ubiquitous environmental *** an endocrine disruptor,it seriously threatens human health and ecological environmental *** study examines the impact of intervention with soybean isoflavones(SIF) on DEHP-induced toxicity using a metabonomics *** Rats were randomly divided into control(H),SIF-treated(A,86 mg/kg body weight),DEHP-treated(B,68 mg/kg),and SIF plus DEHP-treated(D) *** were given SIF and DEHP daily through diet and gavage,*** 30 d of treatment,rat urine was tested using UPLC/MS with multivariate *** changes were also evaluated using biochemical *** Metabolomics analyses revealed that p-cresol glucuronide,methyl hippuric acid,N1-methyl-2-pyridone-5-carboxamide,lysophosphatidycholine [18:2(9 Z,12 Z)] {lyso PC [18:2(9 Z,12 Z)]},lyso PC(16:0),xanthosine,undecanedioic acid,and N6-acetyl-l-lysine were present at significantly different levels in control and treatment *** SIF supplementation partially protects rats from DEHP-induced metabolic abnormalities by regulating fatty acid metabolism,antioxidant defense system,amino acid metabolism,and is also involved in the protection of mitochondria.

关键词： Di-(2-ethylhexyl) phthalate Soy isoflavones Metabonomics UPLC-QTOF-MS/MS Urine

Maternal Genistein Intake Can Reduce Body Weight in Male Offspring

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2015年第10期28卷 769-772页

作者： ZHANG Yun Bo YAN Jing Dong YANG Su Qing GUO Ji Peng ZHANG xiao SUN xiao Xi na xiao lin DAI Shao Chun Department of Environmental Hygiene Public Health CollegeHarbin Medical University The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Department of Ultrasonography Harbin Medical University Cancer Hospital

The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in ute... 详细信息

关键词： In body Maternal Genistein Intake Can Reduce Body Weight in Male Offspring

Influence of Soy Isoflavone on lindane Cumulant in Sprague-Dawley Rats

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2014年第8期27卷 637-640页

作者： YANG Yang ZHANG Yun Bo SHENG Wei FU Zheng Hai WANG Zhe WANG xiao GUAN Si Yuan na xiao lin Department of Environmental Hygiene Public Health College Harbin Medical University Department of Chemistry Zhejiang University

Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause the uterus hyperplasia. lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat＇s body. lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat＇s uterus.

关键词：雌二醇大鼠 Sprague-Dawley 激素类林丹脑鼠科异黄酮类子宫动物女(雌)性

Hepatitis E virus re-infection accelerates hepatocellular carcinoma development and relapse in a patient with liver cirrhosis:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2020年第12期12卷 1358-1366页

作者： xiao-na lin Qiu-Xiong lin Shu-Mei Li Ke-Ping Xie Jun Hou Ren Chen The Laboratory of Computational Medicine and Systems Biology School of MedicineSouth China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Department of Infectious Disease Guangdong General Hospital&Guangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Hepatitis E virus(HEV)superinfection is a suspected promoting factor for hepatocellular carcinoma(HCC)in patients with chronic hepatitis and ***,to date,very few cases of HEV-related HCC have been ***,the role of HEV re-infection in cirrhotic liver without other chronic hepatitis infections has rarely been *** SUMMARY A 53-year-old male farmer was diagnosed with liver cirrhosis and splenomegaly in August 2016,accompanied with negative HEV-IgM and positive *** evidence of hepatitis B virus or hepatitis C virus infection was *** then the patient was evaluated for liver function and viral parameters every 3 *** June 2017,the patient presented severe fatigue with whole body itching and was diagnosed with *** this patient experienced quick HCC development,progression,relapse,and metastasis in the following 8 mo,and presented persistent dual positivity of HEV-IgM and *** patient had a long history of smoking and alcohol *** This unique case invokes the importance of HEV surveillance and treatment among cirrhotic patients,HCC cases,and blood donors.

关键词： Hepatitis E virus Re-infection Hepatocellular carcinoma Cirrhosis Case report

Effect of Soy Isoflavone Crude Extract Supplementation on High Fat Diet-induced Insulin Resistance in Ovariectomized Rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2014年第1期27卷 49-51页

作者： ZHANG Yun Bo LI Li na ZHAO Xin Yu CHEN Wen Hua GUO Jing Jing FU Zheng Hai YANG Yang na xiao lin Department of Environmental Hygiene School of Public HealthHarbin Medical University Human Resources School of Public HealthHarbin Medical University

Female Wister rats aged 8 weeks were randomly divided into sham operation group, ovariectomized （OVX） control group, and 20VX groups fed with soy isoflavone crude extract supplementation. The rats had free access to high fat diet and water for 9 weeks. No significant difference was found in body weight （BW）, total abdominal fat, food intake and food utilization rate between OVX control group and 20VX groups. However, the fasting blood glucose and blood lipid levels were significantly higher in 20VX groups than in OVX control group （P〈0.05）. Intraperitoneal glucose tolerance test （IGTI＂） showed that the area under AUC was smaller in 20VX groups than in OVX control group （P〈0.05）. These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.

关键词： Effect of Soy Isoflavone Crude Extract Supplementation on High Fat Diet-induced Insulin Resistance in Ovariectomized Rats than

Decentralized Optimal Control and Stabilization of Interconnected Systems With Asymmetric Information

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 698-707页

作者： na Wang xiao Liang Hongdan Li xiao Lu the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266000China the School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China the College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266000China

The paper addresses the decentralized optimal control and stabilization problems for interconnected systems subject to asymmetric *** with previous work,a closed-loop optimal solution to the control problem and sufficient and necessary conditions for the stabilization problem of the interconnected systems are given for the first *** main challenge lies in three aspects:Firstly,the asymmetric information results in coupling between control and estimation and failure of the separation ***,two extra unknown variables are generated by asymmetric information(different information filtration)when solving forward-backward stochastic difference ***,the existence of additive noise makes the study of mean-square boundedness an *** adopted technique is proving and assuming the linear form of controllers and establishing the equivalence between the two systems with and without additive noise.A dual-motor parallel drive system is presented to demonstrate the validity of the proposed algorithm.

关键词： Asymmetric information decentralized control forwardbackward stochastic difference equations interconnected system stalibization

Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu lin-na Wu Yuan Zhang Te Ba xiao-feng Zhao Acupuncture and Moxibustion Department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China national Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

Background:Electroacupuncture is often used to treat ***:To evaluate the efficacy and safety of electroacupuncture for *** strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China national Knowledge Infrastructure,Wanfang Data and VIP Fulltext e-Journals Database were searched up to January 15,*** criteria:Randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,publication year,diagnostic criteria,sample size,population characteristics,interventions and *** above steps were performed independently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was reported when the same scale was *** dichotomous variables (clinical response rate and adverse events),a meta-analysis was performed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacupuncture was more effective in improving insomnia compared with the control group (sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];P<0.001).There was no significant difference in the incidence of adverse events between the EA and control groups (sham acupuncture and no treatment or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addition,the regression results revealed t

关键词： Electroacupuncture Insomnia Systematic review Meta-analysis

Long-term Di-(2-ethylhexyl) phthalate Exposure Disturbs the Lipid Metabolism Profiles and Hepatic Enzymes in Male Rats:A UPLC-MS-based Serum Metabolomics Analysis

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第11期34卷 920-925页

作者： DONG Xin Wen WU Wei Dong YAO San Qiao ZHANG Yun Bo WANG Cheng WU Hao Yu na xiao lin Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e... 详细信息

关键词： Lipid Metab Serum

A Review on the Mullins Effect in Tough Elastomers and Gels

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第2期37卷 181-214页

作者： lin Zhan Shaoxing Qu Rui xiao MOE Key Lab of Disaster Forecast and Control in Engineering College of Mechanics and Construction EngineeringJinan UniversityGuangzhou510632China State Key Laboratory of Fluid Power and Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceDepartment of Engineering MechanicsZhejiang UniversityHangzhou310027China

Tough elastomers and gels have garnered broad research interest due to their wide-ranging potential ***,during the loading and unloading cycles,a clear stress softening behavior can be observed in many material systems,which is also named as the Mullins *** this work,we aim to provide a complete review of the Mullins effect in soft yet tough materials,specifically focusing on nanocomposite gels,double-network hydrogels,and multi-network *** first revisit the experimental observations for these soft *** then discuss the recent developments of constitutive models,emphasizing novel developments in the damage mechanisms or network *** phenomenological models will also be briefly *** attention is then placed on the anisotropic and multiaxial modeling *** is demonstrated that most of the existing models fail to accurately predict the multiaxial data,posing a significant challenge for developing future anisotropic models tailored for tough gels and elastomers.

关键词： Mullins effect Double-network hydrogels nanocomposite gels Multi-network elastomers Anisotropic damage model Multiaxial model