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High-current pulsed electron beam modification on microstructure and performance of Cu/CuW diffusion bonding joints

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Rare Metals 2024年第6期43卷 2819-2831页

作者： na-na tian Cong-Lin Zhang Peng Lyu Jin-Tong Guan Jie Cai Qing-Feng Guan Shun Guo School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Material Science and Engineering Yancheng Institute of TechnologyYancheng 221051China Engineering Institute of Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

This study investigates the influence of high-current pulsed electron beam(HCPEB)modification on the microstructure and shear strength of Cu/CuW *** solid-state diffusion bonding of modified-Cu(MCu)and modified-CuW(M-CuW)was achieved by HCPEB modification pretreatment at a temperature of 800-900℃and a pressure of 5 MPa for 10-50 *** demonstrate that HCPEB modification facilitates the dissolution of W and Cu,resulting in the formation of a Cu_(0.4)W_(0.6)solid solution and thus enhancing the uniform distribution of ***,HCPEB-induced defects play a beneficial role in promoting the diffusion process by providing fast diffusion paths for *** optimal joints with the maximum shear strength of 213.7 MPa were obtained through bonding M-Cu and M-CuW at 900℃and 5 MPa for 30 min,which attributes to the combined effects of fine-grained strengthening and solid solution ***,the application of HCPEB modification showcases its effectiveness in promoting element diffusion and enhancing the mechanical performance of the joints.

关键词： HCPEB Element diffusion Shear strength Crystal defects Surface modification

Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

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Military Medical Research 2024年第1期11卷 148-151页

作者： Hui-Juan Duan Hong-Qian Chu Ting-Ming Cao Guang-Ming Dai na tian Gang Sheng Zhao-Gang Sun Beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China

Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)*** studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH ***,in this study,we revealed the comprehensive characteristics of DTH by single-cell Rna sequencing(scRna-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)].

关键词： Tuberculin skin test Delayed-type hypersensitivity Single-cell Rna sequencing

Variations, effectiveness and its associated factors of a nationwide web-based hypertension management training project in China: insights from a government-led campaign for 1.2 million lay health workers

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Journal of Geriatric Cardiology 2024年第7期21卷 733-750页

作者： Wei WANG Hai-Bo ZHANG Jia-Min LIU Yan LI na tian Lei YAN Jin-Xiao SONG Mei-Li LI Yue PENG Jing LI national Primary Health Care Hypertension Management Office National Clinical Research Center for Cardiovascular DiseasesNHC Key Laboratory of Clinical Research for Cardiovascular MedicationsFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To evaluate the effectiveness of a large-scale,web-based,in-service hypertension management training project among lay health workers(LHWs)at primary care health(PHC)settings in China,and to examine the factors contributing to the of *** METHODS We used data from a web-based national hypertension management training project implemented in 2018,it was designed to facilitate LHWs to learn,understand,and apply the relevant knowledge and skills in hypertension management through providing training courses by use of the web-based platform with unified *** LHWs were required to parti-cipate in the exams before and after training to acquire scores for the use of evaluating their performance of hypertension man-agement *** first used descriptive analysis to present the variations of effectiveness in hypertension management knowledge among LHWs by important ***,we used multilevel logistic regression to examine the individual regional factors contributing to the variations and quantify the magnitude of how these factors affected training *** RESULTS There were 1,208,610 LHWs who completed training and were ***,the scores of LHWs in-creased significantly from 62.87±21.14 out of 100 in the pre-test to 88.30±11.31 in the post-test by 25.43(95%confidence interval[CI]:25.40-25.47).Training contents involved in antihypertensive medication showed the lowest score(54.36)in the pre-test and soared the most after training,up to 84.22 by 54.94%.Individual factors associated with disparities in the knowledge of hyperten-sion management decreased substantially after training,which included sex,age,education,practice type,professional level,and hierarchy of working *** variations were shown at the provincial level,with the majority of them being ex-by factors at the regional *** CONCLUSIONS Accessible web-based training modality,government efforts,accompanie

关键词： hypertension workers nationwide

A 128×128 SPAD LiDAR sensor with column-parallel 25 ps resolution TA-ADCs

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Journal of Semiconductors 2024年第8期45卷 34-40页

作者： na tian Zhe Wang Kai Ma Xu Yang nan Qi Jian Liu nanjian Wu Runjiang Dou Liyuan Liu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

This paper presents a design of single photon avalanche diode(SPAD)light detection and ranging(LiDAR)sensor with 128×128 pixels and 128 column-parallel time-to-analog-merged-analog-to-digital converts(TA-ADCs).Unlike the conventional TAC-based SPAD LiDAR sensor,in which the TAC and ADC are separately implemented,we propose to merge the TAC and ADC by sharing their capacitors,thus avoiding the analog readout noise of TAC’s output buffer,improving the conversion rate,and reducing chip *** reverse start-stop logic is employed to reduce the power of the *** in a 180 nm CMOS process,our prototype sensor exhibits a timing resolution of 25 ps,a DNL of+0.30/−0.77 LSB,an INL of+1.41/−2.20 LSB,and a total power consumption of 190 mW.A flash LiDAR system based on this sensor demonstrates the function of 2D/3D imaging with 128×128 resolution,25 kHz inter-frame rate,and sub-centimeter ranging precision.

关键词： 3D imaging CMOS imagers direct time-of-flight(dTOF) time-to-analog converter(TAC)

基于Dna指纹图谱的水牛角真伪及掺杂鉴别方法研究

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中国中药杂志 2024年第7期49卷 1826-1833页

作者：熊辕陈天韵张恬田娜蒋超中国中医科学院、中药资源中心、道地药材品质保障与资源持续利用全国重点实验室北京100700

是否存在掺杂是中药鉴定的难点问题。水牛角主要以水牛角丝或水牛角粉2种形态流通于药材市场,缺乏明显的鉴定特征,存在掺杂风险。然而目前水牛角的掺杂鉴定方法缺失。为解决中药水牛角的真伪及掺杂问题,控制药材水牛角的质量,保证临床... 详细信息

是否存在掺杂是中药鉴定的难点问题。水牛角主要以水牛角丝或水牛角粉2种形态流通于药材市场,缺乏明显的鉴定特征,存在掺杂风险。然而目前水牛角的掺杂鉴定方法缺失。为解决中药水牛角的真伪及掺杂问题,控制药材水牛角的质量,保证临床用药的真实性。使用Dna指纹图谱对来自药材企业和药材市场的43批样品进行鉴定,筛选出可鉴定水牛角和牦牛角的荧光Dna指纹图谱扩增引物,利用荧光毛细管分型技术获得水牛角的Dna指纹图谱。并检测了荧光毛细管分型技术对不同掺杂比例的鉴别效果。筛选出了2对可区分水牛角和牦牛角的荧光STR分型引物16Sa和CRc,建立Dna指纹图谱鉴别方法,牦牛角16Sa迁移峰为223.4~223.9 bp、水牛角为225.5~226.1 bp,牦牛角CRc迁移峰为518.8~524.8 bp、水牛角为535.9~542.5 bp。通过迁移峰的峰高可对掺伪比例在50%以下的掺杂品进行初步定量,定量结果与掺入比例相似。该研究建立了一种简单快捷,可用于中药水牛角及其掺杂品的通用Dna指纹图谱鉴别方法,能够实现对药材水牛角鉴定的同时对掺杂品进行半定量。

关键词：水牛角掺杂 Dna指纹图谱 STR分型分子鉴别动物药

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汤河水库洪水预报分析

黑龙江水利科技 2024年第7期52卷 65-68页

作者：田娜辽宁省辽阳水文局辽宁辽阳111000

为解决汤河流域大中水库预报调度、洪水监测中的问题,研究选取汤河干流防洪库容偏小、山洪沟道密集、暴雨频发的汤河水库为例,通过构建HEC-HMS水文模型预报分析了汤河水库洪水过程。经率定验证,该模型模拟洪峰流量场次的合格率达到80%,... 详细信息

为解决汤河流域大中水库预报调度、洪水监测中的问题,研究选取汤河干流防洪库容偏小、山洪沟道密集、暴雨频发的汤河水库为例,通过构建HEC-HMS水文模型预报分析了汤河水库洪水过程。经率定验证,该模型模拟洪峰流量场次的合格率达到80%,对于水库洪水预报模拟能够达到乙级精度要求,实用性和可靠性较好。

关键词：汤河水库 HEC-HMS模型参数分析率定验证

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辽阳市山洪灾害风险评价

水利科学与寒区工程 2024年第5期7卷 80-82页

作者：田娜辽宁省辽阳水文局辽宁辽阳111000

本文以辽阳市为研究对象,利用后果逆向扩散法选择9个典型指标,利用随机森林算法计算评价辽阳市山洪灾害风险区,通过与历史山洪灾害发生点相比较验证该方法的可行性。结果表明:中等及以上风险等级发生地所占比例81.20%,本文方法对于较小... 详细信息

本文以辽阳市为研究对象,利用后果逆向扩散法选择9个典型指标,利用随机森林算法计算评价辽阳市山洪灾害风险区,通过与历史山洪灾害发生点相比较验证该方法的可行性。结果表明:中等及以上风险等级发生地所占比例81.20%,本文方法对于较小空间尺度山洪灾害风险评价准确度较高,可为区域防洪减灾管理和山洪灾害防御预案编制提供科学依据。

关键词：随机森林算法山洪灾害风险评价辽阳市

转运体介导的纳米递送系统促进药物口服吸收的研究进展

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中国实验方剂学杂志 2024年第2期30卷 254-266页

作者：田娜张彦青李卫房雷雷解军波天津商业大学生物技术与食品科学学院天津300134 天津中医药大学中药学院天津301617

口服给药是一种最为便利的给药方式,但由于肠道屏障的存在,药物的口服生物利用度普遍较低,尤其对于水溶性低、渗透性差和大分子药物更为明显。几十年来,研究者们已证明纳米递送系统是解决这一问题最有效的策略之一,但纳米递送系统对药... 详细信息

口服给药是一种最为便利的给药方式,但由于肠道屏障的存在,药物的口服生物利用度普遍较低,尤其对于水溶性低、渗透性差和大分子药物更为明显。几十年来,研究者们已证明纳米递送系统是解决这一问题最有效的策略之一,但纳米递送系统对药物的口服生物利用度提高有限。为此,研究者们提出利用转运体介导的纳米递送系统来促进药物的口服吸收。摄取营养物质(如葡萄糖、寡肽、胆汁酸等)的转运体在肠道上高度表达,是口服递药系统的优良靶点,将其底物修饰在纳米递送系统上,通过转运体靶向的作用可以使负载药物更高效地跨过肠道屏障进入体循环。目前越来越多的证据支持转运体在口服递药系统领域的潜力,现将肠道转运体介导纳米递送系统促进药物口服吸收的研究进行梳理,包括肠道上转运体的分布、转运体底物修饰的3种策略,以及不同类型转运体的转运特性及其介导纳米递送系统促进药物口服吸收或治疗疾病的效果,以期为开发肠道靶向纳米递送系统提供重要的理论参考。

关键词：纳米递送系统肠道转运体介导药物口服生物利用度修饰策略

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中日美马拉松发展特征的跨文化比较研究

浙江体育科学 2024年第1期46卷 7-12,66页

作者：赵天娜章宏浙江大学传媒与国际文化学院浙江杭州310022

运用文本分析和田野调查的研究方法,基于集体主义和个人主义的文化价值观维度视角,分析并比较中国、日本和美国马拉松发展的文化特征。研究表明,美国马拉松文化以个人主义为核心,发展出注重参与和休闲的消费跑者群体。日本马拉松文化基... 详细信息

运用文本分析和田野调查的研究方法,基于集体主义和个人主义的文化价值观维度视角,分析并比较中国、日本和美国马拉松发展的文化特征。研究表明,美国马拉松文化以个人主义为核心,发展出注重参与和休闲的消费跑者群体。日本马拉松文化基于以制度集体主义为核心的“和”的精神,发展出注重团体竞技的驿传。中国马拉松文化结合群内集体主义和传统文化,催生出具有拟亲属关系的跑团与独特的创意跑步风尚。在三国的马拉松发展中,大众媒体与运动社交类新媒体等媒介因素均起到重要的推动作用。基于美国和日本马拉松的发展经验,结合当代中国马拉松的发展现状,未来中国马拉松应重视发展更具有中国特色的马拉松,以进一步推动中国马拉松产业化、本土化和大众化。

关键词：马拉松集体主义个人主义跨文化视角中国