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Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng Bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang Gu Yuxiang Wang lulu Zhang Yue Zhao na lu State Key Laboratory of natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRna and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRna stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2135-2144页

作者： lu-na Bai lu-Xian Zhang Department of Radiology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many *** early detection and diagnosis of CRC are crucial for improving treatment success and patient survival ***,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(MRI)and spiral computed tomography(SCT)playing a significant role in enhancing diagnostic and treatment *** To explore the effectiveness of MRI and SCT in the preoperative staging of CRC and the prognosis of laparoscopic *** Ninety-five individuals admitted to Zhongshan Hospital Xiamen University underwent MRI and SCT and were diagnosed with *** precision of MRI and SCT for the presurgical classification of CRC was assessed,and pathological staging was used as a *** operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with *** Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,*** were 39 cases at the N0 stage,22 at N1,34 at N2,44 at M0 stage,and 51 at *** pathological findings as the benchmark,the combined use of MRI and SCT for preoperative TNM staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(Pnalysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volu

关键词： Magnetic resonance imaging Spiral computed tomography Colorectal cancer Prognosis Receiver operating characteristic curve Retrospective study

Exploring mechanism of hidden,steep obliquely inclined bedding landslides using a 3DEC model:A case study of the Shanyang landslide in Shaanxi Province,China

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China Geology 2024年第2期7卷 303-314,I0001-I0003页

作者： Jia-yun Wang Zi-long Wu Xiao-ya Shi Long-wei Yang Rui-ping Liu na lu Xi’an Center of China Geological Survey/Northwest China Center for Geoscience Innovation Xi’an 710119China Xi’an University of Science and Technology Xi’an 710054China Wuhan Design&Research Institute Co. Ltd.of China Coal Technology&Engineering GroupWuhan 430064China

Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily *** phenomenon has become a focal point in landslide ***,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding *** study investigated the Shanyang landslide in Shaanxi Province,*** field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such *** findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of *** landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip *** slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more ***,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the *** study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure *** insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.

关键词： Landslide Steep obliquely inclined bedding slope Failure mode Failure mechanism Apparent dip creep-buckling Lateral friction 3DEC model Landslide numerical model Geological hazards survey engineering

Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients

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World Journal of Diabetes 2024年第2期15卷 275-286页

作者： Ping Shi Yang Tian Feng Xu lu-na Liu Wan-Hong Wu Ying-Zhou Shi An-Qi Dai Hang-Yu Fang Kun-Xia Li Chao Xu Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Pediatric Yantai Yuhuangding Hospital Affiliated to Qingdao UniversityYantai 264099Shandong ProvinceChina

BACKGROUND Adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1(APPL1)plays a crucial role in regulating insulin signaling and glucose *** in the APPL1 gene have been associated with the development of maturity-onset diabetes of the young type 14(MODY14).Currently,only two mutations[c.1655T>A(***552*)and c.281G>A p.(Asp94Asn)]have been identified in association with this *** the limited understanding of MODY14,it is imperative to identify additional cases and carry out comprehensive research on MODY14 and APPL1 *** To assess the pathogenicity of APPL1 gene mutations in diabetic patients and to characterize the functional role of the APPL1 *** Patients exhibiting clinical signs and a medical history suggestive of MODY were screened for the *** exome sequencing was performed on the patients as well as their family *** pathogenicity of the identified APPL1 variants was predicted on the basis of bioinformatics *** addition,the pathogenicity of the novel APPL1 variant was preliminarily evaluated through in vitro functional ***,the impact of these variants on APPL1 protein expression and the insulin pathway were assessed,and the potential mechanism underlying the interaction between the APPL1 protein and the insulin receptor was further *** A total of five novel mutations were identified,including four missense mutations(Asp632Tyr,Arg633His,Arg532Gln,and Ile642Met)and one intronic mutation(1153-16A>T).Pathogenicity prediction analysis revealed that the Arg532Gln was pathogenic across all *** Asp632Tyr and Arg633His variants also had pathogenicity based on *** addition,multiple alignment of amino acid sequences showed that the Arg532Gln,Asp632Tyr,and Arg633His variants were conserved across different ***,in in vitro functional experiments,both the c.1894G>T(at Asp632Tyr)and c.1595G>A(at Arg532Gln)mutations

关键词： Adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1 Maturity-onset diabetes of the young Bioinformatics analysis Gene mutation Domain

16MnDR钢焊接接头组织特性及在氢氟酸环境中的腐蚀行为

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机械工程学报 2024年第8期60卷 196-203页

作者：顾玉芬鲁娜石玗孙青岭兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 中核兰州铀浓缩有限公司兰州730060

16MnDR钢中厚板核贫料储罐焊接接头采用脉冲钨极氩弧焊(P-TIG)打底和埋弧焊(SAW)填充及盖面工艺制造。只采用P-TIG焊接的打底层组织为针状铁素体+索氏体,但SAW填充后的打底层发生了组织转变,变为多边形铁素体+蠕虫状屈氏体。通过对焊接... 详细信息

16MnDR钢中厚板核贫料储罐焊接接头采用脉冲钨极氩弧焊(P-TIG)打底和埋弧焊(SAW)填充及盖面工艺制造。只采用P-TIG焊接的打底层组织为针状铁素体+索氏体,但SAW填充后的打底层发生了组织转变,变为多边形铁素体+蠕虫状屈氏体。通过对焊接接头在0.1 M氢氟酸中的浸泡腐蚀试验发现,SAW填充后的打底层的耐蚀性发生严重退化,其原因是蠕虫状屈氏体极细的片层结构在腐蚀溶液中发生了微电偶腐蚀,从而近表面的屈氏体就相当于一个块状的渗碳体,然后与周边多边形铁素体形成的大阴极小阳极的腐蚀电偶加速了铁素体的腐蚀溶解,进而屈氏体失去支撑,最终松动脱落并在宏观上形成了腐蚀坑。这一发现为核贫料储罐的安全服役奠定了理论基础,为后续工艺的优化设计指明了方向。

关键词： 16MnDR钢焊接显微组织热循环腐蚀

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继续教育服务老龄群体灵活就业的困境与突破

继续教育研究 2024年第1期 67-72页

作者：卢娜云南大学职业与继续教育学院云南昆明650091

继续教育服务老龄群体灵活就业既是其社会价值的体现,也是终身教育体系建设的重要内容。通过分析继续教育服务老龄群体灵活就业的现实需要,发现我国继续教育在服务老年群体灵活就业过程中存在顶层制度保障缺位、高校继续教育对老年个体... 详细信息

继续教育服务老龄群体灵活就业既是其社会价值的体现,也是终身教育体系建设的重要内容。通过分析继续教育服务老龄群体灵活就业的现实需要,发现我国继续教育在服务老年群体灵活就业过程中存在顶层制度保障缺位、高校继续教育对老年个体的赋能尚不充分、老年大学课程资源与“老有所为”契合度低、老龄群体封闭思想亟待转变等多重困境,并从“完善继续教育政策内核”“推动高校继续教育与‘老有所为’有机融合”“重构老年大学课程结构,兼顾‘所乐’与‘所为’”“转变老年个体观念,构建‘老年学习共同体’”等方面入手,试图为继续教育服务我国老龄群体的灵活就业问题找寻中国式现代化的突破路径。

关键词：继续教育老龄群体灵活就业

“文王征伐”故事的叙事转向:从颂扬武功到圣德书写

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阴山学刊 2024年第4期37卷 1-6页

作者：芦娜山东大学儒学高等研究院山东济南250000

周文王是周代历史文化遗存中被尊奉的显赫先祖,是儒家道统谱系中的重要一环,其施行的“文王之政”被后世君王奉为治政标杆。相较于“文王之政”,有关文王征伐之事的书写较为稀少。爬梳文献可知,周原甲骨中已记载有文王征伐之事,至东周,... 详细信息

周文王是周代历史文化遗存中被尊奉的显赫先祖,是儒家道统谱系中的重要一环,其施行的“文王之政”被后世君王奉为治政标杆。相较于“文王之政”,有关文王征伐之事的书写较为稀少。爬梳文献可知,周原甲骨中已记载有文王征伐之事,至东周,典籍中记载的文王征伐故事以文王德化邦国进行了文饰化处理。至两汉,汉人不仅绍继文王盛德的基调,而且将文王征伐之事融于文王圣德的书写中,以“文王有征伐之法”[1]评判。概言之,“文王征伐”故事书写的变迁展现了周人直至汉人对周文王文德记载的大力改塑过程。

关键词：周文王故事流变 “文王征伐”

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BIM数据安全管理方法研究

建筑科技 2024年第5期8卷 61-63页

作者：路娜黄浦区教育局校产管理站上海200011

随着《中华人民共和国数据安全法》的发布和实施,数据安全的重要性日益凸显。建筑工程是涉及国计民生的重要行业,其中的BIM数据重要性等级较高,但尚缺乏体系化的BIM数据安全管理方法可供参考。在参考数据安全政策及行业标准的基础上,充... 详细信息

随着《中华人民共和国数据安全法》的发布和实施,数据安全的重要性日益凸显。建筑工程是涉及国计民生的重要行业,其中的BIM数据重要性等级较高,但尚缺乏体系化的BIM数据安全管理方法可供参考。在参考数据安全政策及行业标准的基础上,充分考虑BIM数据的特殊性,提出相应的安全管理分类分级建议,为当前及未来的BIM数据安全管理提供参考。

关键词： BIM 数据安全分类分级

脓毒症患者的病原菌分布与其病情危重程度相关性研究进展

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中国病原生物学杂志 2024年第4期19卷 491-494页

作者：崔耀月冯友繁张萌芦娜甘肃卫生职业学院甘肃兰州730207 甘肃省人民医院血液科甘肃省中心医院风湿免疫肾病科甘肃省中心医院重症医学科

脓毒症是一种由感染引起的全身性炎症反应,其病情危重程度与病原菌分布密切相关。近年来,随着病原菌检测技术的进步和临床治疗的不断完善,对脓毒症患者的病原菌分布及其与病情危重程度的相关性有了更深入的认识。研究发现,革兰阴性菌和... 详细信息

脓毒症是一种由感染引起的全身性炎症反应,其病情危重程度与病原菌分布密切相关。近年来,随着病原菌检测技术的进步和临床治疗的不断完善,对脓毒症患者的病原菌分布及其与病情危重程度的相关性有了更深入的认识。研究发现,革兰阴性菌和革兰阳性菌是脓毒症的主要病原菌,而不同种类的病原菌感染患者的病情危重程度存在差异。同时,多重耐药菌感染的出现也给临床治疗带来了巨大挑战。因此,深入研究脓毒症患者的病原菌分布及其与病情危重程度的相关性,对于制定个性化治疗方案、提高治疗效果具有重要意义。本研究参考近年来学者研究,从脓毒症患者病原菌培养分布、脓毒症病情与病原菌类型相关性进行总结,旨在揭示不同类型和数量的病原菌对患者病情的影响,为临床医生评估患者病情和预后提供参考。

关键词：脓毒症病原菌分布病情危重程度相关性综述