检索结果-南通市图书馆

Deploying Hybrid EnsembleMachine Learning Techniques for Effective Cross-Site Scripting (XSS) Attack Detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials and Continua 2024年第1期81卷 707-748页

作者： Bacha n.u. Lu S. ur Rehman A. Idrees M. Ghadi Y.Y. Alahmadi T.J. School of Cyber Science and Engineering Huazhong University of Science and Technology Wuhan 430073 China Department of Computer Science and Engineering University of Engineering and Technology Lahore 54000 Pakistan Department of Computer Science and Software Engineering Al Ain University Al Ain Abu Abu Dhabi 12555 United Arab Emirates Department of Information Systems College of Computer and Information Sciences Princess Nourah bint Abdulrahman University Riyadh 84428 Saudi Arabia

Cross-Site Scripting (XSS) remains a significant threat to web application security, exploiting vulnerabilities to hijack user sessions and steal sensitive data. Traditional detection methods often fail to keep pace with the evolving sophistication of cyber threats. This paper introduces a novel hybrid ensemble learning framework that leverages a combination of advanced machine learning algorithms-Logistic Regression (LR), Support Vector Machines (SVM), eXtreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), and Deep n.u.al networks (Dnn). utilizing the XSS-Attacks-2021 dataset, which comprises 460 instances across various real-world trafficrelated scenarios, this framework significantly enhances XSS attack detection. Our approach, which includes rigorous feature engineering and model tuning, not only optimizes accuracy but also effectively minimizes false positives (FP) (0.13%) and false negatives (Fn) (0.19%). This comprehensive methodology has been rigorously validated, achieving an.u.precedented accuracy of 99.87%. The proposed system is scalable and efficient, capable of adapting to the increasing number of web applications and user demands without a decline in performance. It demonstrates exceptional real-time capabilities, with the ability to detect XSS attacks dynamically, maintaining high accuracy and low latency even.u.der significant loads. Furthermore, despite the computational complexity introduced by the hybrid ensemble approach, strategic use of parallel processing and algorithmtuning en.u.es that the system remains scalable and performs robustly in real-time applications. Designed for easy integration with existing web security systems, our framework supports adaptable Application Programming Interfaces (APIs) and a modular design, facilitating seamless augmentation of current defenses. This innovation represents a significant advancement in cybersecurity, offering a scalable and effective solution for securing modern web applications a

关键词： Cross-site scripting hybrid learning machine learning stacking ensemble learning XSS detection

可逆实正规矩阵中的零项性质研究及酉矩阵的补全

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

可逆实正规矩阵中的零项性质研究及酉矩阵的补全

作者：蒋衍赫长春工业大学

学位级别：硕士

酉矩阵和正规矩阵在数学和物理学中起着重要的作用。在数学领域中,已有很多充分的研究,如酉矩阵的有向图,典型的形式和不变量的相似性等。在物理领域中,酉矩阵的应用有最小通用二量子位控制的非基电路,多粒子纠缠及其应用密码等。正规... 详细信息

酉矩阵和正规矩阵在数学和物理学中起着重要的作用。在数学领域中,已有很多充分的研究,如酉矩阵的有向图,典型的形式和不变量的相似性等。在物理领域中,酉矩阵的应用有最小通用二量子位控制的非基电路,多粒子纠缠及其应用密码等。正规矩阵是非常重要的一类矩阵,具有很多好的性质,并且在各种数学领域都有着广泛的应用。包含许多零项的矩阵是稀疏矩阵,这类矩阵在数学和工程问题中很容易处理;同时在过去的几十年里,对酉矩阵这类矩阵的研究已有很多结果,然而关于酉矩阵的补全,结果并不是很多。本文主要研究并给出了酉矩阵及其子阵的关系,得出各子阵间的关系为Im(X)=Ker(u1*),Ker(X)=Im(u4*),Im(Y)=Ker(u4*)且Ker(Y)=Im(u1*).同时,本文也研究了可逆实正规矩阵中的零项个数所满足的一些性质,给出了零项个数构成的集合中元素的最大值、运算以及其他性质,最后证明了零项个数与维数的关系为:ζn={0,1,…,n2-n-1,n2-n}(n≥6).

关键词：正规矩阵可逆矩阵零项酉矩阵矩阵补全

长牡蛎腺苷脱氨酶CgADAR1调节类干扰素表达的作用研究

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

长牡蛎腺苷脱氨酶CgADAR1调节类干扰素表达的作用研究

作者：赫倩倩大连海洋大学

学位级别：硕士

腺苷脱氨酶(adenosine deaminase that act on RnA,ADAR)是一种能将双链RnA(ds RnA)的腺苷脱氨成为肌苷的RnA编辑酶,这一过程被称为A-to-I编辑,是真核动物中最普遍的转录后修饰之一。ADAR1能够编辑细胞内源性或者是病毒ds RnA,使其逃避... 详细信息

腺苷脱氨酶(adenosine deaminase that act on RnA,ADAR)是一种能将双链RnA(ds RnA)的腺苷脱氨成为肌苷的RnA编辑酶,这一过程被称为A-to-I编辑,是真核动物中最普遍的转录后修饰之一。ADAR1能够编辑细胞内源性或者是病毒ds RnA,使其逃避抗黑色素瘤分化相关基因5(melanoma differentiation-associated gene 5,MDA5)/维甲酸诱导基因-Ⅰ(retinoic acid-in.u.ible gene I,RIG-Ⅰ)等传感器的检测,进而抑制干扰素(Interferon,IFn)的产生。本研究从长牡蛎(Crassostrea gigas)ADAR1出发,采用基因克隆、免疫荧光和RnA干扰等多种分子生物学技术手段,探究了ADAR1对长牡蛎类干扰素蛋白(IFn-like protein,IFnLP)合成的调节机制。本文主要研究了长牡蛎CgADAR1基因,其开放阅读框(open reading frame,ORF)全长3444 bp,编码一个包含1147个氨基酸,分子量为126.1 k Da的多肽。CgADAR1包含四个结构域:n端两个Zα结构域、一个DSRM结构域和一个ADEAMc结构域。进化树分析表明CgADAR1与软体动物加州双斑章鱼(Octopus bimaculoides)的ADAR1亲缘关系较近,随后与棘皮动物紫色球海胆(Strongylocentrotus purpuratus)和红海星(Asterias rubens)的ADAR1聚为一大支。CgADAR1的m RnA在长牡蛎的闭壳肌、唇瓣、鳃、外套膜、肝胰腺、性腺等组织及血淋巴细胞中均有表达,在外套膜和鳃中表达量较高。CgADAR1蛋白主要定位于长牡蛎血淋巴细胞的细胞质中。Poly(A:u)刺激24 h和36 h后,血淋巴细胞中CgADAR1的m RnA表达水平均显著升高,分别是对照组的6.03倍(pu)刺激48 h后,长牡蛎血淋巴细胞中CgRIG-Ⅰ、CgIRF8和CgIFnLP的m RnA表达量相比于对照组均显著升高,分别是对照组的4.36倍(pnA干扰技术抑制CgADAR1的表达后,与对照组相比,CgMDA5、CgRIG-Ⅰ、CgTBK1、CgIRF8和CgIFnLP m RnA表达量都显著升高,分别是对照组的11.88倍、11.51倍、2.22倍、2.85倍和2.52倍(pu)刺激,并通过抑制CgMDA5/CgRIG-Ⅰ的表达,进而抑制IFnLP的表达。本研究探究了长牡蛎CgADAR1负向调控CgIFnLP表达的分子机制,研究结果有助于揭示CgADAR1对长牡蛎类干扰素系统的调节作用,深入认识软体动物干扰素系统的复杂分子机制。

关键词：腺苷脱氨酶长牡蛎干扰素黑色素瘤分化相关基因5 维甲酸诱导基因Ⅰ

血清白细胞介素-35、乳酸脱氢酶在骨髓增生异常综合征120例中的临床意义

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

安徽医药 2024年第1期28卷 105-110页

作者：王宁匡歆赫宁宁青岛市胶州中心医院检验科山东青岛266300

目的分析血清白细胞介素(IL)-35、乳酸脱氢酶(LDH)在骨髓增生异常综合征(MDS)中的临床意义,为探究MDS的潜在靶点提供参考依据。方法选取青岛市胶州中心医院2019年5月至2020年5月收治的128例MDS病人作为研究对象,所有病人均根据指南在医... 详细信息

目的分析血清白细胞介素(IL)-35、乳酸脱氢酶(LDH)在骨髓增生异常综合征(MDS)中的临床意义,为探究MDS的潜在靶点提供参考依据。方法选取青岛市胶州中心医院2019年5月至2020年5月收治的128例MDS病人作为研究对象,所有病人均根据指南在医院接受个体化治疗,于治疗6个月疗程时评估病人治疗效果,分为治疗失败组(n=28)和治疗有效组(n=92)。于治疗前检测研究相关指标[白细胞(WBC)、血小板(PLT)、中性粒细胞绝对计数(AnC)、红细胞(RBC)、血红蛋白(Hb)、IL-35、LDH]并统计病人临床资料,分析血清IL-35、LDH与MDS病人治疗效果的关系,并检验IL-35、LDH联合预测MDS病人治疗失败的最佳阈值。结果128例MDS病人随访期间共剔除8例,120例MDS病人,治疗6个疗程时,治疗失败占23.33%(28/120),治疗有效组占76.67%(92/120);治疗失败组WHO分型预后积分系统(WPSS)评分、修订的国际预后积分系统(IRSS-R)均高于治疗有效组,较高危病人占比多于治疗有效组(PnC,血浆Hb、PLT低于治疗有效组,血清IL-35、LDH表达量高于治疗有效组(PnC,血浆Hb、PLT低表达,血清IL-35、LDH高表达有关(Png/L、324.28 u/L。限制性立方样条分析显示,血清IL-35、LDH与MDS病人治疗失败风险呈线性剂量反应关系。结论血清IL-35、LDH水平与MDS病人治疗失败风险呈线性剂量反应关系,检测血清IL-35、LDH有助于预测MDS病人治疗失败风险。

关键词：骨髓增生异常综合征治疗结果白细胞介素-35 乳酸脱氢酶中性粒细胞血红蛋白类

Polio eradication surveillance in Sri Lanka,2019-2023

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando n.S.Madarasinghe C.Rangana n.Weerasinghe D.C.u.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPCR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,en.u.ing timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.nagahawatta n.M.Liyanage Thilina u.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MnPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MnPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Bandara Tithira Lakkana Shanika Jayasinghe David Woodbury Arun Dayanandan B.M.P.Singhakumara Xiangcheng Mi I.A.u.n.Gunatilleke C.V.S.Gunatilleke Mark SAshton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:no studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 Mg·ha^(-1).no differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult over wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific gravity

Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第6期13卷 764-779页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Pedro Lopez Chris Bishop Anna Maria Markarian Valentina natalucci Jin-Soo Kim Robert u.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Pleural Medicine unit Institute for Respiratory HealthPerthWA 6009Australia Medical School Faculty of Health&Medical SciencesUniversity of Western AustraliaPerthWA 6009Australia Grupo de Pesquisa em Exercicio para Populacoes Clinicas(GPCLIn) Universidade de Caxias do SulCaxias do SulRio Grande do Sul 95070-560Brazil London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK Department of Pathophysiology and Transplantation University of MilanMilan 20133Italy School of Human Movement and nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully *** muscle secretes myokines,which mediate muscleorgan *** regulate satellite-cell proliferation and migration,inflammatory cascade,in.u.in secretion,angiogenesis,fatty oxidation,and cancer *** date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be *** is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical ***:A systematic search was undertaken in PubMed,MEDLInE,CInAHL,Embase,SPORTDiscus,andWeb of Science in April *** studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of ***:Sixty-two studies were included(n=1193).Overall,exercise appeared to in.u.e small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically *** aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across *** levels returned to baseline levels within 180 min to 24 h ***,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be ***:Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic *** research is required to investigate the effects of different exercise modes at multiple time points on myok

关键词： Myokine Resistance exercise Aerobic exercise Cytokine Systemic circulation

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

在线全文

学校读者我要写书评

暂无评论

n.u.al Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan Laboratory of n.u.obiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades n.u.odegenerativas(CIBERnED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of n.u.obiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,n.u.ological,and n.u.odegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can in.u.e enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in n.u.odegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of n.u.onal arbo rization and spine density,as well as an increase in brain-derived n.u.otrophic factor(BDnF).A knockdown of BDnF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of n.u.onal structural plasticity and in the prevention of ORM *** findings suggest that BDnF-mediated n.u.onal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of n.u.onal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived n.u.otrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling