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影响口腔扁平苔藓伴发胃食管反流病的因素

川北医学院学报 2024年第4期39卷 516-519页

作者：赵润哲韩金鹏刘英川北医学院附属医院口腔科川北医学院口腔医学系四川南充637000

目的:探讨影响口腔扁平苔藓(OLP)伴发胃食管反流病(GERD)的因素。方法:选取1205例口腔扁平苔藓患者为研究对象,根据是否伴发GERD分为OLP伴发GERD组(n=182)和OLP不伴发GERD组(n=1023)。比较两组患者一般资料,分析影响OLP伴发GERD的因素... 详细信息

目的:探讨影响口腔扁平苔藓(OLP)伴发胃食管反流病(GERD)的因素。方法:选取1205例口腔扁平苔藓患者为研究对象,根据是否伴发GERD分为OLP伴发GERD组(n=182)和OLP不伴发GERD组(n=1023)。比较两组患者一般资料,分析影响OLP伴发GERD的因素。结果:1205例OLP患者中,OLP伴发GERD组共182例,GERD的发病率为15.1%(182/1205)。OLP伴发GERD组的发病年龄低于OLP不伴发GERD组(P<0.05)。OLP患者中,中年人伴发GERD的占比高于青年人和老年人(P<0.05)。OLP伴发GERD组的斑纹型和充血萎缩型占比高于OLP不伴发GERD组(P<0.05),糜烂型占比低于OLP不伴发GERD组(P<0.05)。OLP伴发GERD组中糜烂型OLP患者年龄高于斑纹型OLP(P<0.05);REU评分高于斑纹型和充血萎缩型(P<0.05)。多因素Logistic回归分析显示,年龄较小(OR=0.972,95%CI:0.967~0.978,P<0.001)、REU评分较低(OR=0.824,95%CI:0.733~0.926,P=0.001)、伴有焦虑(OR=2.388,95%CI:1.606~3.550,P<0.001)为OLP患者伴发GERD的危险因素。结论:OLP人群中GERD的发病率较高,且中年人发病率高于青年人和老年人;OLP伴发GERD患者中伴有焦虑和不伴有焦虑患者的性别构成比存在明显差异,与男性相比,女性伴发GERD患者的焦虑发病率更高;年龄较小、伴有焦虑、REU评分较低为OLP患者伴发GERD的危险因素。

关键词：口腔扁平苔藓胃食管反流病回顾性研究

前列腺癌早期筛查风险预测模型的建立与验证研究

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中国全科医学 2024年第20期27卷 2483-2490页

作者：李宏基赵晓龙胡伟韩东晖王安辉秦卫军空军军医大学第一附属医院泌尿外科陕西省西安市710032 空军军医大学军事预防医学系流行病学教研室陕西省西安市710032

背景前列腺癌作为常见的恶性肿瘤,威胁中老年男性生命健康,其预后与初诊时肿瘤级别与分期密切相关。前列腺特异性抗原(PSA)是前列腺癌早期筛查的重要分子,但非肿瘤负荷的前列腺良性疾病或操作也会引起PSA升高,盲目穿刺常导致过度诊疗。... 详细信息

背景前列腺癌作为常见的恶性肿瘤,威胁中老年男性生命健康,其预后与初诊时肿瘤级别与分期密切相关。前列腺特异性抗原(PSA)是前列腺癌早期筛查的重要分子,但非肿瘤负荷的前列腺良性疾病或操作也会引起PSA升高,盲目穿刺常导致过度诊疗。依据患者穿刺活检前的临床指标构建前列腺癌风险预测模型,可以为早筛可疑患者是否进行穿刺活检提供重要参考。目的寻找前列腺穿刺活检阳性的独立危险因素,构建前列腺癌发生的风险预测模型,预测前列腺癌发生风险。方法选取2011年1月—2023年6月于空军军医大学第一附属医院泌尿外科住院并进行前列腺穿刺活检的患者1138例,排除351例临床数据不完整病例后,剩余787例病例通过R语言split函数随机分为训练集(n=548)与验证集(n=239)(划分比例为7∶3)。收集患者的基本信息以及穿刺活检前生化检查指标,依据患者穿刺活检病理结果判断是否发生前列腺癌。应用LASSO回归筛选前列腺癌发生的独立危险因素,对独立危险因素进行多因素Logistic回归分析,利用分析结果构建前列腺癌早期筛查的风险预测模型并绘制列线图。依据训练集与验证集数据对模型进行验证。结果使用LASSO回归分析筛选出6个预测变量,包括年龄、总PSA(tPSA)、碱性磷酸酶、总蛋白、钙、尿素。多因素Logistic回归分析结果显示,年龄≥60岁(OR=3.769,95%CI=2.393~5.937)、tPSA≥10μg/L(OR=2.259,95%CI=1.419~3.596)、碱性磷酸酶≥45 U/L[45~<125 U/L:OR=20.136,95%CI=4.419~91.752;≥125 U/L:OR=45.691,95%CI=9.199~226.951]是前列腺癌的危险因素(P<0.05),总蛋白≥65 g/L(OR=0.086,95%CI=0.031~0.236)、钙≥2.11 mmol/L(OR=0.148,95%CI=0.054~0.403)、尿素≥9.5mmol/L(OR=0.069,95%CI=0.019~0.252)是前列腺癌的保护因素(P<0.05)。依据有统计学差异的6个预测变量绘制列线图,建立预测模型。预测模型预测训练集前列腺癌发生的ROC曲线下面积(AUC)为0.778(95%CI=0.740~0.816),灵敏度为53.2%,特异度为85.5%,验证集前列腺癌发生的AUC为0.770(95%CI=0.708~0.832),灵敏度为61.2%,特异度为80.0%。拟合优度检验显示训练集P=0.543,验证集P=0.372,具有较好的拟合度。决策曲线分析(DCA)显示训练集高风险阈值<10%,验证集的高风险阈值约为15%,在临床实践中有一定的指导意义。结论本研究建立了包含年龄、tPSA、碱性磷酸酶、总蛋白、钙、尿素共6项穿刺前指标的前列腺癌列线图风险预测模型,可用于预测早期筛查可疑患者的前列腺癌发生风险。

关键词：前列腺肿瘤前列腺增生筛查危险因素列线图

THE KACAnOV METHOD FOR A nOnLInEAR VAriaTIOnAL InEQUALITY OF THE SECOnD KInD ARISInG In ELASTOPLASTICITY

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Chinese Annals of Mathematics,Series B 1996年第2期17卷 129-138页

作者： han WEIMIn S. JEnSEn Department of Mathematics University of Iowa Iowa City IA 52242 U.S.A.Department of Mathematics University of Maryland Baltimore County Baltimore MD 21228 U.S.A.

The authors first prove a convergence result on the Kacanov method for solving generalnonlineax vafiational inequalities of the second kind and then apply the Kacanov method tosolve a nonlinear variational inequality of the second kind arising in elastoplastieity. In additionto the convergence result, an a posteriori error estimate is shown for the Kacanov iterates. Ineach step of the Kacanov iteration, one has a (linear) variational inequality of the secondkind, which can he solved by uaing a regularization technique. The Kacanov iteration and the regularization technique together provide approximations which can be readily computednumerically. An a posteriori error estimate is derived for the combined effect of the Kacanoviteration and the regularization.

关键词： KACAnOV法二型非线性变换不等式收敛性正则化后验误差估计

静息心率对超高危动脉粥样硬化性心血管疾病患者全因死亡风险的影响

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中国循环杂志 2024年第2期39卷 140-147页

作者：刘士贺韩旭刘倩刘红敏赵海燕陈朔华吴寿岭吴云涛华北理工大学临床医学院唐山063000 开滦总医院心内科唐山063000 天津医科大学临床医学院天津300070 兰州大学临床医学院兰州730000

目的:探讨静息心率对超高危动脉粥样硬化性心血管疾病(ASCVD)患者全因死亡风险的影响。方法:从2006~2020年开滦研究队列中纳入3645例超高危ASCVD[采用《中国血脂管理指南(2023年)》中的定义]患者,排除602例静息心率数据缺失者后,最终分... 详细信息

目的:探讨静息心率对超高危动脉粥样硬化性心血管疾病(ASCVD)患者全因死亡风险的影响。方法:从2006~2020年开滦研究队列中纳入3645例超高危ASCVD[采用《中国血脂管理指南(2023年)》中的定义]患者,排除602例静息心率数据缺失者后,最终分析纳入3043例患者,根据确诊ASCVD后首次健康体检时的静息心率四分位水平,将其分为n组(n=744)、68~74次/min组(n=786)、75~80次/min组(n=760)、≥81次/min组(n=753)。采用Cox比例风险回归模型比较不同静息心率水平及静息心率每升高10次/min对全因死亡风险的影响。采用限制性立方样条回归模型探讨静息心率与全因死亡风险之间的剂量-反应关系。采用寿命表法计算四组患者中的累积全因死亡率,并通过log-rank检验进行比较。结果:中位随访5.81(3.46,9.64)年期间,772例(25.37%)患者死亡。控制主要混杂因素后,分析结果显示:与静息心率n组患者相比,75~80次/min组、≥81次/min组患者的全因死亡风险分别增加24%(HR=1.24,95%CI:1.01~1.52,P=0.047)和47%(HR=1.47,95%CI:1.20~1.81,Pn组患者的全因死亡风险差异无统计学意义(HR=1.06,95%CI:0.86~1.31,P=0.625)。此外,静息心率每升高10次/min,全因死亡风险增加13%(HR=1.13,95%CI:1.07~1.19,Pn时,女性患者的全因死亡风险高于男性患者,non-linear)=0.933),且静息心率>70次/min时全因死亡风险显著增加。结论:静息心率升高与超高危ASCVD患者全因死亡风险增加相关,且二者呈线性关联。超高危ASCVD患者静息心率的合适干预切点可能为>75次/min。

关键词：超高危动脉粥样硬化性心血管疾病静息心率全因死亡队列研究

Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors

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World Journal of Gastroenterology 2017年第45期23卷 7945-7951页

作者： Ahmad Al-Hader Rami n Al-Rohil Haiyong han Daniel Von Hoff Division of Hematology/Oncology Indiana University School of Medicine Department of Pathology Vanderbilt University School of Medicine Molecular Medicine Division Translational Genomics Research Institute (TGen)

Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma(PACC),pancreatoblastoma,and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than pancreatic neuroendocrine tumors. Reports of overall survival range from 18 to 47 mo. A literature review on PACCs included comprehensive genomic profiling and whole exome sequencing on a series of more than 70 patients as well as other diagnostic studies including immunohistochemistry. Surgical resection of PACC is the preferred treatment for localized and resectable tumors. The efficacy of adjuvant treatment is unclear. Metastatic PACCs are generally not curable and treated with systemic chemotherapy. They are moderately responsive to chemotherapy with different regimens showing various degrees of response in case reports/series. Most of these regimens were developed to treat patients with pancreatic ductal adenocarcinomas or colorectal adenocarcinomas. Review of PACC's molecular profiling showed a number of gene alterations such as: SMAD4,BRAF,BRCA2,TP53,RB1,men1,JAK-1,BRCA-1,BRCA-2,and DnA mismatch repair abnormalities. PACCs had multiple somatic mutations with some targetable with available drugs. Therefore,molecular profiling of PACC should be an option for patients with refractory PACC.

关键词：胰腺的 acinar 房间癌分子的介绍指向的治疗

Turning Industrial Waste into a Valuable Bioproduct:Starch from Mango Kernel Derivative to Oil Industry Mango Starch Derivative in Oil Industry

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Journal of Renewable Materials 2019年第2期7卷 139-152页

作者： nívia do nascimento Marques Caroline Suzy do nascimento Garcia Liszt Yeltsin Coutinho Madruga Marcos Antônio Villetti men de SáMoreira de Souza Filho Edson noriyuki Ito Rosangela de Carvalho Balaban Instituto de Química Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil Departamento de Física Universidade Federal de Santa Maria-UFSMSanta Maria97105900Brazil Embrapa Agroindústria Tropical Fortaleza60511-110Brazil Departamento de Engenharia de Materiais Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil

After industrial mango processing,tons of residues such as peels and kernels are discarded as ***,almost 60% of the mango kernel is due to starch on a dry weight ***,starch from mango(Manguifera Indica L.)kernel was applied to obtain a starch fatty ester with vinyl laurate,in DMSO,under basic ***,1H and 13C nMR confirmed that a starch ester with a degree of modification of 2.6 was *** showed that the modified starch has higher thermal stability than its precursors and higher than a vinyl laurate/starch physical *** data showed that granular shape and smooth surface on mango starch changed after chemical modification to a continuous and shapeless *** industrial reject derivative behaved as an efficient alternative environmentally friendly fluid loss controller in oil drilling fluids,even in conditions of high temperatures and high pressures(HTHP)drilling.

关键词： Mango Starch oil drilling fluid transesterification vinyl laurate

影像组学特征预测周围型肺癌Ki-67水平的CT研究

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影像诊断与介入放射学 2024年第1期33卷 31-36页

作者：魏伟韩冬贾永军雷雨欣于楠于勇樊丽华陕西中医药大学附属医院医学影像科陕西咸阳712000

目的周围型肺癌的影像组学特征与Ki-67表达水平之间的关系尚不清楚。本研究建立基于CT增强动脉期图像的影像组学标签预测周围型肺癌的Ki-67表达情况。方法回顾性收集2017年5月—2020年11月行胸部CT增强扫描并在检查后2周内经病理证实、... 详细信息

目的周围型肺癌的影像组学特征与Ki-67表达水平之间的关系尚不清楚。本研究建立基于CT增强动脉期图像的影像组学标签预测周围型肺癌的Ki-67表达情况。方法回顾性收集2017年5月—2020年11月行胸部CT增强扫描并在检查后2周内经病理证实、行Ki-67表达水平检测的117例周围型肺癌患者,其中男43例,女74例,年龄35~79岁(中位年龄54岁)。经手术病理证实,Ki-67高表达组54例,Ki-67低表达组63例,以7∶3的比例将患者分为训练组(n=82)和验证组(n=35)。使用ITK-SnAP于CT动脉期图像上手动勾画肺癌全肿瘤容积数据,A.K软件提取影像组学特征。采用LASSO回归模型进一步筛选特征并构建影像组学标签,并计算每例患者的影像组学评分,然后结合临床信息进行多因素Logistic回归分析,筛选出预测Ki-67水平的独立危险因素。在验证组和训练组中使用受试者工作特征曲线及曲线下面积(AUC)评价影像组学标签的预测性能。根据Hosmer-Lemeshow检验评估影像组学标签的校准度。采用决策曲线分析法(DCA)评估影像组学标签的临床价值。结果从396个特征中选择7个影像组学特征,建立与Ki-67表达水平显著相关的影像组学标签。该模型在训练组中AUC为0.844(95%CI:0.725~0.964),敏感度93%,特异度71%,校准度0.709。在验证组中,AUC为0.881(95%CI:0.756~0.954),敏感度91%,特异度75%,校准度0.950。单因素Logistic回归分析显示Ki-67高表达与低表达两组间性别、年龄和吸烟差异均无统计学意义(P>0.05)。使用多因素Logistic回归模型,影像组学评分被认为是预测周围型肺癌Ki-67表达情况的独立预测因素。DCA显示阈值概率在0.03%~0.63%时,影像组学标签预测周围型肺癌Ki-67表达水平效能较优。结论基于增强CT动脉期图像建立的影像组学标签有助于预测周围型肺癌病灶Ki-67的表达,无创评估肿瘤侵袭性和预后。

关键词：影像组学周围型肺癌 Ki-67增殖指数体层摄影术,X线计算机

Efficacy of contrast-enhanced ultrasound-guided percutaneous core needle biopsy in anterior mediastinal masses

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Journal of Interventional Medicine 2022年第3期5卷 159-165页

作者： Peili Fan Jiaying Cao Yunjie Jin Hong han Wenping Wang Huixiong Xu Zhengbiao Ji Department of Ultrasound Zhongshan HospitalFudan UniversityNo.180 Fenglin RoadXuhui District200032ShanghaiChina Shanghai Institute of Medical Imaging No.180 Fenglin RoadXuhui District200032ShanghaiChina Instiute of Ultrasound Medicine and Engineering Fudan UniversityNo.180 Fenglin RoadXuhui District Shanghai200032China

Objective:To evaluate the efficacy and safety of percutaneous core needle biopsy(PCnB)using ultrasound(US)-guided and contrast-enhanced ultrasound(CEUS)-guided procedures for anterior mediastinal masses(AMMs).Methods:In total,284 consecutive patients(166 men,118 women;mean age,43.0±18.4 years)who underwent PCnB for AMMs were *** were divided into the US-guided group(n=133)and the CEUS-guided group(n=151).PCnB was performed using a core needle(16-gauge or 18-gauge).Internal necrosis,diagnostic yield,and diagnostic accuracy were compared between the two ***:The predominant final diagnosis of the cases in this study was thymoma(29.7%),lymphoma(20.5%),thymic carcinoma(13.3%),and germ cell tumour(13.3%),*** was no significant difference in patient age,sex,number of percutaneous biopsies,or display rate of internal necrosis on conventional US between the two *** rate of internal necrosis of the lesions was significantly higher after contrast agent injection(72.2%vs.41.7%;Piagnostic yield than the US-guided group(100%vs.89.5%,Pno significant difference between the diagnostic accuracy of the CEUSguided and US-guided groups(97.3%vs.97.4%;P=1.000).none of the patients experienced adverse reactions or complications after US-guided or CEUS-guided ***:CEUS-guided PCnB can improve the diagnostic yield by optimizing the biopsy procedure.

关键词： Biopsy Ultrasound Contrast agent Core needle Mediastinal neoplasm

Effects of mild/asymptomatic COVID-19 on semen parameters and sex-related hormone levels in men:a systematic review and meta-analysis

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Asian Journal of Andrology 2023年第3期25卷 382-388页

作者： Bang-Wei Che Pan Chen Ying Yu Wei Li Tao Huang Wen-Jun Zhang Sheng-han Xu Jun He Miao Liu Kai-Fa Tang Department of Urology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China

Coronavirus disease 2019(COVID-19)has yet to be proven to alter male reproductive function,particularly in the majority of mild/asymptomatic *** purpose of this study was to explore whether mild/asymptomatic COVID-19 affects semen quality and sex-related hormone *** find suitable comparative studies,a systematic review and meta-analysis was done up to January 22,2022,by using multiple databases(Web of Science,PubMed,and Embase).Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines were used to identify and choose the ***-analysis was used to examine the semen parameters and sex-related hormones of mild/asymptomatic COVID-19 patients before and after *** effects of semen collection time,fever,and intensity of verification on semen following infection were also investigated.A total of 13 studies(n=770)were included in the analysis,including three case-control studies,six pre-post studies,and four single-arm studies.A meta-analysis of five pre-post studies showed that after infection with COVID-19,sperm concentration(I^(2)=0;P=0.003),total sperm count(I^(2)=46.3%;P=0.043),progressive motility(I^(2)=50.0%;Pnd normal sperm morphology(I^(2)=0;P=0.001)***,a systematic review of 13 studies found a significant relationship between semen collection time after infection,inflammation severity,and semen parameter values,with fever having only bearing on semen ***,there was no significant difference in sex-related hormone levels before and after infection in mild/asymptomatic ***/asymptomatic COVID-19 infection had a significant effect on semen quality in the short *** is recommended to avoid initiating a pregnancy during this period of time.

关键词： coronavirus disease 2019 male infertility meta-analysis semen quality severe acute respiratory syndrome coronavirus 2