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LHAASO-KM2A detector simulation using Geant4

radiation Detection Technology and Methods 2024年第3期8卷 1437-1447页

作者： Zhen cao F.Aharonian Q.An Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.j.Bi Y.j.Bi j.T.cai Q.cao W.Y.cao Zhe cao j.chang j.F.chang A.M.chen E.S.chen Liang chen Lin chen Long chen M.j.chen M.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen Y.chen n.cheng Y.D.cheng M.Y.cui S.W.cui X.H.cui Y.D.cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.H.Fan Y.Z.Fan j.Fang K.Fang c.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng S.Gabici B.Gao c.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.n.He j.Y.He X.B.He Y.He Y.K.Hor B.W.Hou c.Hou X.Hou H.B.Hu Q.Hu S.c.Hu D.H.Huang T.Q.Huang W.j.Huang X.T.Huang X.Y.Huang Y.Huang Z.c.Huang X.L.ji H.Y.jia K.jia K.jiang X.W.jiang Z.j.jiang M.jin M.M.Kang T.Ke D.Kuleshov K.Kurinov B.B.Li cheng Li cong Li D.Li F.Li H.B.Li H.c.Li H.Y.Li j.Li jian Li jie Li K.Li W.L.Li W.L.Li X.r.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.j.Lin B.Liu c.Liu D.Liu H.Liu H.D.Liu j.Liu j.L.Liu j.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.Liu Y.n.Liu r.Lu Q.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma j.r.Mao Z.Min W.Mitthumsiri H.j.Mu Y.c.nan A.neronov Z.W.Ou B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi Y.Q.Qi B.Q.Qiao j.j.Qin D.ruffolo A.Sáiz D.Semikoz c.Y.Shao L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.c.Song Yu.V.Stenkin V.Stepanov Y.Su Q.n.Sun X.n.Sun Z.B.Sun P.H.T.Tam Q.W.Tang Z.B.Tang W.W.Tian c.Wang c.B.Wang G.W.Wang H.G.Wang H.H.Wang j.c.Wang K.Wang L.P.Wang L.Y.Wang P.H.Wang r.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen c.Y.Wu H.r.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi j.Xia j.j.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu r.F.Xu r.X.Xu W.L.Xu L.Xue D.H.Yan j.Z.Yan T.Yan c.W.Yang F.Yang F.F.Yang H.W.Yang j.Y.Yang L.L.Yang M.j.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin n.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang j.L.Zhang L.X.Zhang Li Zhang P.F.Zhang P.P.Zhang r.Zhang S.B.Zh Key Laboratory of Particle Astrophysics&Experimental Physics Division&computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China University of chinese Academy of Sciences Beijing100049China TIAnFU cosmic ray research center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institute for nuclear Physics 69029Heidelberg103980Germany State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of china Hefei230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu610031SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing210023JiangsuChina center for Astrophysics Guangzhou UniversityGuangzhou510006GuangdongChina Hebei normal University Shijiazhuang050024HebeiChina Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for research in Galaxies and cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of cosmic rays(Tibet University) Ministry of EducationLhasa 850000TibetChina national Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityGuangzhouZhuhai 510275519000GuangdongChina School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina APc UniversitéParis CitéCNRS/IN2P3CEA/IRFUObservatoire de ParisParis 11975205France Department of Engineering Phys

KM2A is one of the main sub-arrays of LHAASO,working on gamma ray astronomy and cosmic ray physics at energies above 10 *** simulation is the important foundation for estimating detector performance and data *** is a big challenge to simulate the KM2A detector in the framework of Geant4 due to the need to track numerous photons from a large number of detector units(>6000)with large altitude difference(30)and huge coverage(1.3).In this paper,the design of the KM2A simulation code G4KM2A based on Geant4 is *** process of G4KM2A is optimized mainly in memory consumption to avoid memory *** simplifications are used to significantly speed up the execution of *** running time is reduced by at least 30 times compared to full detector *** particle distributions and the core/angle resolution comparison between simulation and experimental data of the full KM2A array are also presented,which show good agreement.

关键词： LHAASO KM2A Simulation GEAnT4

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Prospects for a multi-TeV gamma-ray sky survey with the LHAASO water cherenkov detector array

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chinese Physics c 2020年第6期44卷 123-132页

作者： F.Aharonian V.Alekseenko Q.An Axikegu L.X.Bai Y.W.Bao D.Bastieri9 X.j.Bi H.cai Zhe cao Zhen cao j.chang j.F.chang X.c.chang S.P.chao B.M.chen j.chen L.chen L.chen M.L.chen M.j.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen n.cheng Y.D.cheng S.W.cui X.H.cui Y.D.cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu B.D'Ettorre Piazzoli j.Fang j.H.Fan Y.Z.Fan c.F Feng L.Feng S.H.Feng Y.L.Feng B.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He j.c.He M.Heller S.L.He Y.He c.Hou D.H.Huang Q.L.Huang W.H.Huang X.T.Huang H.B.Hu S.Hu H.Y.jia K.jiang F.ji c.jin X.L.ji K.Levochkin E.W.Liang Y.F Liang cheng Li cong Li F.Li H.Li H.B.Li H.c.Li H.M.Li j.Li K.Li W.L.Li X.Li X.r.Li Y.Li Z.Li Z.Li B.Liu c.Liu D.Liu H.D.Liu H.Liu j.Liu j.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.n.Liu Z.X.Liu W.j.Long r.Lu H.K.Lv B.Q.Ma L.L.Ma j.r.Mao A.Masood X.H.Ma W.Mitthumsiri T.Montaruli Y.c.nan P.Pattarakijwanich Z.Y.Pei B.Q.Qiao M.Y.Qi D.ruffolo V.rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng j.r.Shi Y.Stenkin V.Stepanov Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian D.D.Volpe c.Wang H.Wang H.G.Wang j.c.Wang L.Y.Wang W.Wang W.Wang X.G.Wang X.Y.Wang X.j.Wang Y.D.Wang Y.j.Wang Y.n.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei j.j.Wei T.Wen c.Y.Wu H.r.Wu S.Wu W.X.Wu X.F.Wu G.M.Xiang G.Xiao G.G.Xin Y.Xing r.X.Xu L.Xue D.H.Yan c.W.Yang F.F.Yang L.L.Yang M.j.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin n.Yin X.H.You Z.Y.You Q.Yuan Y.H.Yu Z.j.jiang H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha B.B.Zhang H.M.Zhang H.Y.Zhang j.L.Zhang j.W.Zhang L.Zhang P.F.Zhang P.P.Zhang S.r.Zhang S.S.Zhang X.Zhang X.P.Zhang Yi Zhang Yong Zhang Y.F.g Zhang B.Zhao j.Zhao L.Zhao L.Z.Zhao F.Zheng Y.Zheng j.n.Zhou P.Zhou r.Zhou X.X.Zhou c.G.Zhu F.r.Zhu H.Zhu K.j.Zhu X.Zuo Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Beijing 100049China TIAnFU cosmic ray research center ChengduShichuanChina University of Science and Technology of china 230026 HefeiAnhuiChina Tsinghua University 100084 BeijingChina national Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina national Space Science center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina Sun Yat-sen University 519000 ZhuhaiGuangdongChina Shool of Physics and Technology Guangxi University530004 NanningGuangxiChina Hebei normal University 050024 ShijiazhuangHebeiChina School of Physics and Engineering Zhengzhou University450001 ZhengzhouHenanChina nanjing University 210023 NanjingJiangsuChina Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210034 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Shanghai Astronomical Observatory Chinese Academy of Sciences200030 ShanghaiChina School of Physical Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina Sichuan University 610065 ChengduSichuanChina Key Laboratory of cosmic rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of physics and technology Wuhan university430072 WuhanChina Yunnan University 650091 KunmingYunnanChina Yunnan Astronomical Observatories Chinese Academy of Sciences650216 KunmingYunnanChina Institute for nuclear research Russian Academy of SciencesMoscowRussia Département de Physique nucléaire et corpusculaire Facultéde SciencesUniversitéde GenéveGenevaSwitzerland Department of Physics Faculty of ScienceMahidol UniversityBangkokThailand Dublin Institute for Advanced Studies 31 Fitzwilliam PlaceDublin 2Ireland Max-Planc

The Water cherenkov Detector Array(WcDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WcDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WcDA, we present a projection of the one-year sensitivity of WcDA to TeV γ-ray sources from TeVcat using an all-sky approach. Out of 128 TeVcat sources observable by WcDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic nuclei(AGn).

关键词： TeVγ-ray astronomy observational prospect LHAASO-WcDA

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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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chinese Physics c 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara n.Akopov A.Aloisio F.Ameli L.Andricek n.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett j.Baudot A.Beaulieu j.Becker P.K.Behera j.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini n.Braun T.E.Browder A.Budano S.Bussino M.campajola L.cao G.casarosa c.cecchi D.Červenkov M.-c.chang P.chang r.cheaib V.chekelian Y.Q.chen Y.-T.chen B.G.cheon K.chilikin H.-E.cho K.cho S.cho S.-K.choi S.choudhury D.cinabro L.corona L.M.cremaldi S.cunliffe T.czank F.Dattola E.De La cruz-Burelo G.De nardo M.De nuccio G.De Pietro r.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di capua S.Di carlo j.Dingfelder Z.Doležal I.Domínguez jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez r.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich j.Gemmler T.Geßler r.Giordano A.Giri B.Gobbo r.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald c.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii c.Hearty M.T.Hedges I.Heredia de la cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.c.Hill H.Hirata M.Hoek S.Hollitt T.Hotta c.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia j.Irakkathil jabbar A.Ishikawa r.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.jackson W.W.jacobs D.E.jaffe E.-j.jang H.B.jeon S.jia Y.jin c.joo j.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi c.Kiesling B.H.Kim c.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita c.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov n.Kovalchuk T.M.G.Kraetzschmar P.Križan r.Kroeger j.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar r.Kumar K.Kumara S.Kurz A.Kuzmin Y.-j.Kwon S.Lacaprara Y.-T.Lai c.La Licata K.Lalwani L.Lanceri j.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven national Laboratory UptonNew York 11973 Budker Institute of nuclear Physics SB rAS Novosibirsk 630090 centro de Investigacion y de Estudios Avanzados del Instituto Politecnico nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague chiba University Chiba 263-8522 consejo nacional de ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake research Institute University of TokyoTokyo 113-0032 Forschungszentrum jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKEnDAI) Hayama 240-0193 Gyeongsang national University Jinju 52828 Department of Physics and Institute of natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator research Organization(KEK) Tsukuba 305-0801 j-PArc Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica corpuscular Paterna 46980 InFn Laboratori nazionali di Frascati I-00044 Frascati InFn Sezione di napoli I-80126 Napoli InFn Sezione di Padova I-35131 Padova InFn Sezione di Perugia I-06123 Perugia

From April to july 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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Potential Prebiotic relevance of Glycine Single crystals Enclosing Fluid Inclusions: An Experimental and computer Simulation with Static Magnetic Fields

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Advances in Biological chemistry 2020年第5期10卷 140-156页

作者： E. Angeles-camacho j. cruz-castañeda A. Meléndez M. colín-García K. cervantes de la cruz S. ramos-Bernal A. negrón-Mendoza G. Garza-ramos P. rodríguez-Zamora c. camargo-raya A. Heredia Instituto de ciencias nucleares Universidad Nacional Autónoma de México Mexico City México Facultad de Química Universidad Nacional Autónoma de México Ciudad Universitaria Mexico City México Programa de Maestría y Doctorado en ciencias Químicas UNAM. Cd. Universitaria Mexico City México Instituto de Geología Universidad Nacional Autónoma de México Mexico City México Departamento de Física Coordinación de Ciencias de la Tierra Facultad de Ciencias Universidad Nacional Autónoma de México Mexico City México Departamento de Bioquímica Facultad de Medicina Universidad Nacional Autónoma de México Mexico City México Instituto de Física-UnAM Circuito de la Investigación Científica Ciudad Universitaria Mexico City México

Glycine crystallizes into three different polymorphs called α, β and γ under standard physicochemical conditions. They have different features depending on their structural variations. The possible interaction of glycine with magnetic minerals in meteorites and comets or in the ancient Earth, paves the way to study the self-assembly and molecular behavior under irradiation and magnetic conditions. The magnetic field might induce the formation of a specific polymorph of glycine. To gain insight on the consequences of gamma irradiation with a gradient of static magnetic fields (0.06 T, 0.3 T, 0.42 T and 0.6 T) on the self-assembly of single macroscopic glycine crystals, we gamma irradiated the powdered amino acid and then assembled single crystals from water solutions. The preliminary results showed a stable formation of fluid inclusions in the single crystals and no straightforward effect on the self-assem- bly process after glycine gamma irradiation and interaction with static magnetic fields. The α glycine polymorph single crystals formed at 55° from the magnetic longitudinal axis and seemed to be enhanced by gamma radiation. n>The γn style="font-family:Verdana;">-glycine single crystals presented L and D circular dichroism signals,

关键词： Glycine Polymorphs Fluid Inclusions Gamma Irradiation chemical Evolution FT-Ir circular Dichroism chiral crystals

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novel Tandem Three consecutive reactions: Aza-Wittig, Imine condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

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International journal of Organic chemistry 2021年第2期11卷 55-71页

作者： julio c. González-rodríguez carlos González-romero Erick cuevas-Yáñez juan j. Mejía Vega christopher K. jankowski David corona-Becerril centro conjunto de Investigación en Química Sustentable (ccIQS) UAEM-UnAM Universidad Autónoma del Estado de México Unidad San Cayetano Toluca de Lerdo México Departamento de Química Orgánica Facultad de Química Universidad Autónoma del Estado de México Paseo Colón/Paseo Tollocan s/n Toluca Estado de México México Department de chimie et Biochimie Université de Moncton Moncton Canadá

reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde was used in novel Tandem three consecutive reactions: aza-Wittig, imine c... 详细信息

reactionn> of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde wn>as used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.

关键词： Iminophosphorane Tandem reaction Indolizine Synthesis

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Glass formation,thermal and mechanical properties of ZrcuAlni bulk metallic glasses

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Transactions of nonferrous Metals Society of china 2018年第6期28卷 1157-1165页

作者： c.E.BOrjA I.A.FIGUErOA O.LOZADA-FLOrES M.ESTrADA G.A.LArA-rOdrIguez j.A.VErDUZcO Instituto de Investigacion en Metalurgia y Materiales Universidad Michoacana de San Nicolfis de Hidalgo (UMSNH)Fco. J. Mujica S/N Col. Felicitas del Rio C.P. 58030 Morelia Mich. Mexico Instituto de Investigaciones en Materiales Universidad Nacional Autonoma de Mdxico (UNAM) Circuito Exterior S/N Cd. Universitaria C.P. 04510 Cd. Mx. Mexico

The glass forming ability, thermal and mechanical properties of some Zr cu Al ni bulk metallic glasses were analyzed. The compositions of the alloys were theoretically determined with the dense packing and kinetic fragility index models. cylindrical and conical ingots were produced by copper mould suction-casting under Ar atmosphere. The conical ingots were characterized by means of X-ray diffraction in order to determine the glassy structure. It was found that both alloys have a critical glassy diameter, Dc, of 3 mm. Thermal behaviours were investigated by differential scanning calorimetry at heating rates of 0.5, 0.67 and 0.83 K/s. The gamma parameter γ, supercooled liquid region ΔTx, and reduced glass transition temperature Trg, of the experimentally obtained glasses indicated high glass forming ability. The glassy compositions showed a fragility index of ~40 GPa. The compression test of the investigated alloys was carried out at a strain rate of 0.016 s^-1, obtaining a elastic modulus of ~83 GPa, total deformation of ~5%, yield strength of 1.6 GPa and hardness of 4 GPa. It was concluded that the use of the dense packing and kinetic fragility index models helped to predict glass-forming compositions in the family alloy investigated.

关键词： bulk metallic glass glass formation ability fragility index packing efficiency suction casting

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培美曲塞加铂类联合或不联合帕博利珠单抗对初治转移性非鳞状nScLc患者的疗效与安全性分析：KEYnOTE-189研究方案指定的最终分析

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中国肺癌杂志 2022年第6期25卷 443-456页

作者：周彩存 Delvys rOdríguez-ABrEU S.F.POWELL M.j.HOcHMAIr S.GAD GEEL E.ESTEBAn E.FELIP G.SPErAnZA F.De AnGELIS M.DóMInE S.Y.cHEnG H.G.BIScHOFF n.PELED M.rEcK r.HUI E.B.GArOn M.BOYEr T.KUrATA j.YAnG M.c.PIETAnZA F.SOUZA M.c.GArASSInO 同济大学附属上海市肺科医院肿瘤科 Medical Oncology Complejo Hospitalario Universitario Insular Materno-Infantil de Gran CanariaUniversidad de Las Palmas de Gran Canaria Oncology Sanford Health 4. Department of Respiratory and Critical Care MedicineKarl Landsteiner Institute of Lung Research and Pulmonary Oncology Thoracic Oncology Karmanos Cancer InstituteWayne State University Department of Medical Oncology Hospital Universitario Central de Asturias Medical Oncology Department Vall d'Hebron UniversityVall d'Hebron Institute of Oncology (VHIO) 8. Centre Integre de Cancerologie de la MontérégieH?pital Charles-Le Moyne 9. Medical Oncology DepartmentHospital Universitario Fundacidn Jiménez DiazIIS-FJD Sunnybrook Health Sciences centre Thoraxklinik Heidelberg Department of Oncology Shaare Zedek Medical Center Lungenclinic Airway Research Center NorthGerman Center for Lung Research Department of Medical Oncology Westmead Hospital and University of Sydney Department of Medicine David Geffen School of Medicine at UCLA Department of Medical Oncology Chris O'Brien Lifehouse Department of Thoracic Oncology Kansai Medical University Hospital Merck & co. Inc. Fondazione IrccS Istituto nazionale dei Tumori University of chicago Medicine & Biological Sciences Knapp Center for Biomedical Discovery

背景在KEYnOTE-189此项Ⅲ期研究(ncT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,nScLc)患者的总生存期(over... 详细信息

背景在KEYnOTE-189此项Ⅲ期研究(ncT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,nScLc)患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。本研究报告了研究方案指定的最终分析的疗效结局,包括从培美曲塞-铂类交叉至帕博利珠单抗治疗的患者,以及完成35个周期(约2年)帕博利珠单抗治疗组的疗效。方法符合条件的患者以2:1随机分配至帕博利珠单抗,每3周一次,200 mg (n=410)或安慰剂(n=206)(共35周期,约2年),加上4个周期的培美曲塞(500 mg/m~2)和由研究者选择的每3周顺铂(75 mg/m~2)或卡铂(曲线下面积5 mg/min/mL)治疗,随后使用培美曲塞直至疾病进展。若符合纳入标准,分配至安慰剂联合培美曲塞加铂类治疗的患者可在疾病进展时转向帕博利珠单抗治疗。主要研究终点为OS和PFS。结果中位随访31.0个月,无论PD-L1的表达水平如何,与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类治疗可使患者的OS[风险比(hazard ratio,Hr)为0.56;95%可信区间(confidence interval,cI) 0.46-0.69]和PFS (Hr=0.49;95%cI:0.41-0.59)显著获益。接受帕博利珠单抗联合培美曲塞-铂类治疗的患者客观缓解率(objective response rate,Orr)(48.3%vs 19.9%)和第二次/后续无进展生存期(PFS2;Hr=0.50;95%cI:0.41-0.61)均得到改善。安慰剂联合培美曲塞-铂类组的84例患者(40.8%)交叉至帕博利珠单抗治疗组。72.1%的接受帕博利珠单抗联合培美曲塞-铂类的患者和66.8%的接受安慰剂联合培美曲塞-铂类的患者发生了3级-5级不良事件。56例患者完成了35个周期(约2年)的帕博利珠单抗治疗;Orr为85.7%,53例(94.6%)患者存活至数据截止时间。结论与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类可持续提高疗效,且安全性可控。该研究结果支持将帕博利珠单抗联合培美曲塞-铂类作为初治转移性非鳞状nScLc患者的一线治疗方案。

关键词：帕博利珠单抗化疗非鳞状非小细胞肺癌

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Diamonds and Highly reduced Minerals from chromitite of the ray-iz Ophiolite of the Polar Urals: Deep Origin of Podiform chromitites and Ophiolitic Diamonds

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Acta Geologica Sinica(English Edition) 2015年第A2期89卷 107-107页

作者： YAnG j.S WIrTH r WIEDEnBEcK M GrIFFIn W.L MEnG F.c cHEn S.Y BAI W.j XU X.X MAKEEYEV A.B BrYAncHAnInIOVA n.I cArMA State Key Laboratory of Continental Tectonics and Dynamics Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China GFZ Helmholtz Zentrum Potsdam 14473 Potsdam Germany ccFS/GEMOc Earth and Planetary Sciences Macquarie University NSW 2109 Australia Institute of Geology Komi Scientific Center of Ural Division RAS Syktyvkar 167982 Russia

The Uralide orogenic belt suture zone extending more is a major early Paleozoic than 3000 km in a n-S direction, and geographically divides Europe from Asia （chemenda et al., 1997）. Ophiolites, podiform chromitites and high pressure metamorphic rocks are well developed in the orogenic belt （Leech and Ernst, 2000）.

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First and Second Law Analysis of a LiBr-Water Absorption cycle with recovering condensation Heat for Generation

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Frontiers in Heat and Mass Transfer 2024年第6期22卷 1719-1741页

作者： j.L.rodríguez-Muñoz j.S.Pacheco-cedeño j.F.Ituna-Yudonago j.j.ramírez-Minguela I.j.González-Hernández Department of Mechanical Engineering Escuela Superior de Ciudad SahagúnUniversidad Autónoma del Estado de HidalgoCiudad SahagúnCarretera Cd.Sahagún-Otumba s/nZona IndustrialHidalgoC.P.43998México Departamento de Ingeniería en Aeronáutica Universidad Politécnica Metropolitana de HidalgoBoulevard Acceso a Tolcayuca 1009Ex Hacienda de San Javier TolcayucaHidalgoC.P.43860México Department of chemical Engineering University of GuanajuatoDCNECol.Noria Alta s/nGuanajuatoGto.C.P.36050México Department of Industrial Engineering Escuela Superior de Ciudad SahagúnUniversidad Autónoma del Estado de HidalgoCiudad SahagúnHidalgoC.P.43998México

In conventional absorption refrigeration systems(ArS),the heat from the condenser is usually rejected by the environment in place to be used in the system,so recuperating this is a good alternative to enhance the system’s *** instance,in this paper,an alternative ArS in which LiBr/Water is used as a refrigerant mixture,where part of condensing heat is recovered via the solution heat recovery generator absorption cycle(Hr-ArS)was energy and exergy *** influence of generator,condenser and evaporator temperatures,as well as the efficiency of the solution heat exchanger on the coefficient of performance,exergy performance and exergy destroyed of the Hr-ArS system,were analyzed and compared with the traditional ArS system at the same working *** results showed an increase between 5.8%–6.3%on the cOP and 3.7%–9.5%in the exergy efficiency when condenser/absorber temperature was reduced from 40℃ to 30℃.However,when the evaporation temperature rose from 5℃ to 15℃,the cOP(coefficient of performance)increased by around 8%,although this could be increased by 2.3%–6.3%if the generator temperature decreases from 100℃ to 80℃.Moreover,the cOP and exergetic performance for the Hr-ArS is more significant at the lowest generator,condenser and evaporator temperatures,as well as at high efficiency in the solution heat exchanger,in comparison to ArS ***,the cOP and exergy performance for the Hr-ArS system was improved by 2.57%to 3.11%and 0.22%to 0.7%,respectively,while the recovering condensation heat for generation is around 1.51%–3.76%lower than with the *** also was found that for all ranges of evaporator and condenser temperatures,the cOP for the Hr-ArS system is around 3%higher than that obtained with the ArS at the three different generator temperatures here analyzed,while when the solution heat exchanger effectiveness was increased from 0.7–1.0,the total exergy destruction for the Hr-ArS resulted be 3.24%–5.01%smaller than the ArS

关键词： Absorption refrigeration system recovery condensation heat energy and exergy analysis LiBr-H_(2)O

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co-microencapsulation of Lactobacillus rhamnosus and krill oil by spray-drying

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Food Bioscience 2022年第6期50卷 1587-1595页

作者： E.Bonilla Zavaleta L.I.Lozano coavichi L.c.Velasco rodríguez E.Flores Andrade Hugo S.García M.P.rascón Díaz Facultad de ciencias Químicas Universidad VeracruzanaProlongación Oriente 6C.P.94340OrizabaVeracruzMexico UnIDA Tecnológico Nacional de México/IT de VeracruzM.A.de Quevedo2779 Col.Formando HogarVeracruzVer91897Mexico

co-microcapsules were prepared through spray drying of double emulsions of *** and krill oil,using whey protein as wall *** all tested drying process temperatures,viability of the microcapsules and co-microcapsules above 1×1010 cFU/mL was *** main phospholipid detected in the co-microcapsules were *** fatty acids profile of the co-microcapsules revealed a low content of saturated fatty acids(SFA)and a high content of monounsaturated fatty acids(MUFA)and polyunsaturated fatty acids(PUFA).The survivability of *** was evaluated during the storage of the co-microcapsules at different temperatures(4 and 25°c)and relative humidities(10–93%).It was found that increasing the storage temperature decreases the range of water activity in which the viability of the probiotic remains stable in the *** co-microencapsulates developed provide omega-3 fatty acids and probiotics with less impact on its functional properties.

关键词： Probiotics Fatty acids Phospholipid Microencapsulation Storage stability

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