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A simple technique of tissue collection after morcellation during holmium laser enucleation of the prostate

Advances in Entomology（昆虫学） 2024年第3期 195页

作者： n.Akhter M.Z.Alam M.A.Rahaman M.R.U.Miah I.H.Mian M.A.Latif

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Asian Journal of Urology 2020年第1期7卷 68-69页

作者： Pankaj n.Maheshwari Saurabh Patil nick Okwi Anant Pore Department of Urology Fortis Hospital MulundMumbaiMaharashtraIndia Department of Surgery Busitema University of Health SciencesMbaleUganda

Holmium laser enucleation of the prostate(HoLEP)has stood the test of time for management of benign enlarge-ment of prostate[1].Multiple studies since 1990 have shown good results with HoL EP,which are comparable to t... 详细信息

关键词： nucleation prostate collection

Last decade update for three-finger toxins: newly emerging structures and biological activities

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World Journal of Biological Chemistry 2019年第1期10卷 17-27页

作者： Yuri n Utkin Laboratory of Molecular Toxinology Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Three-finger toxins(TFTs) comprise one of largest families of snake venom toxins. While they are principal to and the most toxic components of the venoms of the Elapidae snake family, their presence has also been detected in the venoms of snakes from other families. The first TFT, α-bungarotoxin, was discovered almost 50 years ago and has since been used widely as a specific marker of the α7 and muscle-type nicotinic acetylcholine receptors. To date, the number of TFT amino acid sequences deposited in the UniProt Knowledgebase free-access database is more than 700, and new members are being added *** structural variations among the TFTs are not numerous, several new structures have been discovered recently; these include the disulfide-bound dimers of TFTs and toxins with nonstandard pairing of disulfide bonds. new types of biological activities have also been demonstrated for the well-known TFTs, and research on this topic has become a hot topic of TFT studies. The classic TFTs α-bungarotoxin and α-cobratoxin, for example, have now been shown to inhibit ionotropic receptors of γ-aminobutyric acid, and some muscarinic toxins have been shown to interact with adrenoceptors. new, unexpected activities have been demonstrated for some TFTs as well, such as toxin interaction with interleukin or insulin receptors and even TFT-activated motility of sperm. This minireview provides a summarization of the data that has emerged in the last decade on the TFTs and their activities.

关键词： Three-finger toxins Snake Venom Structure Biological activity

Modification of the newtonian Dynamics in &#923FRW-Cosmology an Alternative Approach to Dark Matter and Dark Energy

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Journal of Modern Physics 2013年第8期4卷 10-18页

作者： nelson Falcón Department of Physics FACYT University of Carabobo Valencia Venezuela

Modified newtonian Dynamics (MonD) is an empirically motivated modification of newtonian gravity at largest scales, to explain rotation curves of galaxies, as an alternative to nonbaryonic dark matter. But MonD theories can hardly connect to the formalism of relativistic cosmology type Friedmann-Robertson-Walker. Presently work intends the existence of one scalar potential, with non gravitational origin, that would solve these problems. This potential Yukawa type inverse is build starting from a specular reflection of the potential of Yukawa: null in very near solar system, slightly attractiveness in ranges of interstellar distances, very attractiveness in distance ranges comparable to galaxies cluster and repulsive to cosmic scales. The consequences of this potential are discussed, through Cosmological Model Tipe Friedmann-Roberston-Walker with cosmological term in function of the distance (lambda like function of r). In the cosmological model so raised the critical density of matter is consistent with the observed density does not include dark matter, MonD theory is deduced for interstellar scales and consequently would explain rotation curves. Also it is shown that Yukawa type inverse does not alter the predictions of the Cosmic Microwave Background neither the primordial nucleosynthesis in early universe;and can be explain the large-scale structure formation.

关键词： Dark Matter ΛFRW Cosmology MonD

Characterization of Peaks and Valleys of Electricity Demand. Application to the Spanish Mainland System in the Period 2000-2020

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Energy and Power Engineering 2011年第4期3卷 537-546页

作者： Fermín Moreno Division of Inspections Liquidations and Compensations Comisión Nacional de Energía (CNE)

Energy planning must anticipate the development and strengthening of power grids, power plants construction times, and the provision of energy resources with the aim of increasing security of supply and its quality. This work presents a methodology for predicting power peaks in mainland Spain’s system in the decade 2011-2020. Forecasts of total electricity demand of Spanish energy authorities set the boundary conditions. The accuracy of the results has successfully been compared with records of demand (2000-2010) and with various predictions published. Three patterns have been observed: 1) efficiency in the winter peak;2) increasing trend in the summer peak;3) increasing trend in the annual valley of demand. By 2020, 58.1 GW and 53.0 GW are expected, respectively, as winter and summer peaks in a business-as-usual scenario. If the observed tendencies continue, former values can go down to 55.5 GW in winter and go up to 54.7 GW in summer. The annual minimum valley of demand will raise 5.5 GW, up to 23.4 GW. These detailed predictions can be very useful to identify the types of power plants needed to have an optimum structure in the electricity industry.

关键词： Peaks Of Demand Security Of Supply Demand Forecasting

CAn catalyzed one-pot synthesis and docking study of some novel substituted imidazole coupled 1,2,4-triazole-5-carboxylic acids as antifungal agents

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Chinese Chemical Letters 2015年第1期26卷 108-112页

作者： Anna Pratima G.nikalje Mangesh S.Ghodke Firoz A.Kalam Khan Jaiprakash n.Sangshetti Department of Pharmaceutical Chemistry Y.B.Chavan College of PharmacyDr.Rafiq Zakaria CampusAurangabad 431001MSIndia

The present work describes a facile,one-pot three component synthesis of a series of 3-[（4,5-diphenyl-2-substituted aryl/heteryl）-1H-imidazol-1-yl]-1H-1,2,4-triazole-5-carboxylic acid derivatives M（1-15）.Benzil,aromatic aldehydes and 3-amino-l,2,4-triazole-5-carboxylic acid was refluxed in ethanol using cerric ammonium nitrate（CAn） as a catalyst to give the title compounds in good *** compounds were evaluated for their in vitro antifungal and antibacterial *** M1,M9,and M15 were found to be equipotent against Candida albicans when compared with *** M2.M5,and M14 showed higher activity against Streptococcus *** coli and Streptococcus pyogenes,respectively,compared with *** study of the newly synthesized compounds was performed,and the results showed good binding mode in the active sites of C albicans enzyme cytochrome P450 lanosterol 14α-*** results of in vitro antifungal activity and docking study showed that synthesized compounds had potential antifungal activity and can be further optimized and developed as a lead compound.

关键词： 1,2,4-Triazole Imidazole Ceric ammonium nitrate Antifungal activity Antibacterial activity Docking study

Biomass derived oligosaccharides for potential leather tanning

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Collagen and Leather 2023年第4期5卷 64-66页

作者： Zhicheng Jiang Wei Ding Jiajun Fan Yuhe Liao Javier Remón Bi Shi College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China national Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065China China Leather and Footwear Research Institute Co.Ltd. Beijing 100015China Department of Chemistry Green Chemistry Centre of ExcellenceUniversity of YorkYork YO105DDUK Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China Thermochemical Processes Group Aragón Institute for Engineering Research(13A)University of ZaragozaC/Mariano Esquillor s/n50018 ZaragozaSpain

The global demand for renewable and affordable feed-stocks,combined with the worldwide targets for reduc-ing carbon emissions,is the driving force behind a breakthrough in resource revolution and GreenTech innovations[1].Owing to the vast reserves and short growing cycle,utilizing lignocellulosic biomass as an alternative to petroleum and environmentally friendly feedstock to furnish bioenergy and biomaterials is key to building a more sustainable *** mainly contains three biopolymers,i.e.,cellulose,hemicellulose and *** the centuries,utilization of lignocellu-lose has crossed its possible molecular scale ranging from 101 m,as the original matrix,to 10-10 m,as a mono-meric molecule.

关键词： cellulose breakthrough utilizing

美国智能电网和分布式发电重点方向的调研分析

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电力系统自动化 2010年第9期34卷 12-16页

作者：卢永甘德强 John n.JIAnG 浙江大学电气工程学院浙江省杭州市310027 The University of Oklahoma 美国

通过研究美国能源部向国会提交的《智能电网系统报告》及其近年所有与智能电网相关的资助声明及投资,对美国智能电网发展的真正重点及近期目标,尤其是分布式发电在美国智能电网中的地位及发展趋势进行了较为全面细致的分析调研。基于所... 详细信息

通过研究美国能源部向国会提交的《智能电网系统报告》及其近年所有与智能电网相关的资助声明及投资,对美国智能电网发展的真正重点及近期目标,尤其是分布式发电在美国智能电网中的地位及发展趋势进行了较为全面细致的分析调研。基于所提出的领域分类和影响指标,对智能电网发展趋势及投资比重的研究结果显示美国智能电网在保证电力系统稳定和安全的前提下,主要投资用于解决与配电相关的一系列技术问题。

关键词：智能电网分布式发电配电系统电力系统

Detection of KRAS G12D in colorectal cancer stool by droplet digital PCR

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World Journal of Gastroenterology 2017年第39期23卷 7087-7097页

作者： Susana Olmedillas-López Dennis César Lévano-Linares Carmen Laura Aúz Alexandre Luz Vega-Clemente Edurne León Sánchez Alejandro Villagrasa Jaime Ruíz-Tovar Mariano García-Arranz Damián García-Olmo Foundation Health Research Institute-Fundación Jiménez Díaz University Hospital Department of Surgery School of Medicine Universidad Autónoma de Madrid Department of Surgery Rey Juan Carlos University Hospital Department of Pathology Fundación Jiménez Díaz University Hospital Department of Biomedicine and Biotechnology Universidad de Alcalá Department of Surgery Fundación Jiménez Díaz University Hospital

AIMTo assess KRAS G12D mutation detection by droplet digital PCR (ddPCR) in stool-derived DnA from colorectal cancer (CRC) *** this study, tumor tissue and stool samples were collected from 70 patients with stage I-IV CRC diagnosed by preoperative biopsy. KRAS mutational status was determined by pyrosequencing analysis of DnA obtained from formalin-fixed paraffin-embedded (FFPE) tumor tissues. The KRAS G12D mutation was then analyzed by ddPCR in FFPE tumors and stool-derived DnA from patients with this point mutation. Wild-type (WT) tumors, as determined by pyrosequencing, were included as controls; analysis of FFPE tissue and stool-derived DnA by ddPCR was performed for these patients as *** the total 70 patients included, KRAS mutations were detected by pyrosequencing in 32 (45.71%), whereas 38 (54.29%) had WT tumors. The frequency of KRAS mutations was higher in left-sided tumors (11 located in the right colon, 15 in the left, and 6 in the rectum). The predominant point mutation was KRAS G12D (14.29%, n = 10), which was more frequent in early-stage tumors (I-IIA, n = 7). In agreement with pyrosequencing results, the KRAS G12D mutation was detected by ddPCR in FFPE tumor-derived DnA, and only a residual number of mutated copies was found in WT controls. The KRAS G12D mutation was also detected in stool-derived DnA in 80% of all fecal samples from CRC patients with this point *** is a reliable and sensitive method to analyze KRAS G12D mutation in stool-derived DnA from CRC patients, especially at early stages. This non-invasive approach is potentially applicable to other relevant biomarkers for CRC management.

关键词： Droplet digital PCR KRAS Stool Formalin-fixed paraffin-embedded Pyrosequencing Colorectal cancer

Dirac Equation with a new Tensor Interaction under Spin and Pseudospin Symmetries

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Communications in Theoretical Physics 2018年第9期69卷 294-298页

作者： C.A.Onate M.C.Onyeaju A.n.Ikot O.Ebomwonyi J.O.A.Idiodi Physics Programme Department of Physical SciencesLandmark UniversityPMB 1001Omu-AranNigeria Theoretical Physics Group Physics DepartmentUniversity of Port HarcourtNigeria Department of Physics University of BeninBenin CityNigeri

The approximate analytical solutions of the Dirac equation under spin and pseudospin symmetries are examined using a suitable approximation scheme in the framework of parametric nikiforov-Uvarov *** a tensor interaction in the Dirac equation removes the energy degeneracy in the spin and pseudospin doublets that leads to atomic stability,we study the Dirac equation with a Hellmann-like tensor potential newly proposed in this *** newly proposed tensor potential removes the degeneracy from both the spin symmetry and pseudospin symmetry *** proposed tensor potential seems better than the Coulomb and Yukawa-like tensor potentials.

关键词： wave equation eigensolutions Dirac equation nikiforov-Uvarov method tensor interaction