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Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo Yi hua Lu Xu Cong-Ying Zhao Li-hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(InD group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

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Seasonal response of nitrogen exchange fluxes to crab disturbance at sediment-water interface in coastal tidal wetlands

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Water Science and Engineering 2024年第2期17卷 129-138页

作者： Guo-fen.hua Shang-qing Liu Xiang-dong Liu Jin-li Li Yue Fang Wen-ting Xie Xiang Xu College of Water Conservancy and Hydroelectric Power Hohai UniversityNanjing 210098China College of Renewable Energy Hohai UniversityNanjing 210098China

Coastal wetlands are hotspots for nitrogen(n)cycling,and crab burrowing is known to transform n in intertidal marsh ***,the underlying mechanisms remain *** study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat *** results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and *** to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without *** summer,nH-n showed a positive flux from the sediment to the overlying water,but nO2-n and nOg-n showed positive fluxes from the sediment to the overlying water only in early *** winter,nH-n showed a positive flux from the sediment to the overlying water,but nO-n and nO,-n both exhibited positive and negative *** results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.

关键词： Coastal tidal flat wetland Crab disturbance nitrogen flux nitrification Denitrification Sediment-water interface

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Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

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World Journal of Diabetes 2024年第8期15卷 1734-1741页

作者： Yang-Zhou Zhang hua Gong Juan Yang Ji-Pu Bu Hui-Ling Yang Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Xingsheng HospitalYiyang 413200Hunan ProvinceChina Department of Ophthalmology Boshi Eye HospitalLiuyang 410300Hunan ProvinceChina Department of Ophthalmology Hunan Children‘s HospitalChangsha 410007Hunan ProvinceChina

BACKGROUnD non-proliferative diabetic retinopathy(nPDR)poses a significant challenge in diabetes management due to its microvascular changes in the *** photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in nPDR *** Forty-nine nPDR patients(86 eyes)treated between September 2020 and July 2022 were *** were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)*** outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 *** reactions were also *** Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(Pnd CMT improvements were noted in the multi-spot group at one-month posttreatment(Pn incidence was similar between groups(P>0.05).COnCLUSIOn While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for nPDR patients,with reduced laser-induced damage.

关键词： Panretinal laser photocoagulation non-proliferative diabetic retinopathy Efficacy comparison Multipoint Single point Treatment assessment

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Impact of early refined nursing program on prognosis of middleaged and elderly patients with cognitive dysfunction combined with cerebral infarction

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World Journal of Psychiatry 2024年第7期14卷 1034-1042页

作者： Hui-Lian Xiong Zhi-Xin Li Xin Lu Yan.hua Lu Ping Zhong Ganzhou City Central Blood Station Ganzhou 341000Jiangxi ProvinceChina Department of Rehabilitation Medicine Ganzhou People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUnD Cerebral infarction is a local or extensive necrosis of brain ***,the corresponding neurological deficits *** incidence of cerebrovascular diseases in China is increasing *** the onset of cerebrovascular disease,the most common sequelae include movement disorders,language disorders,and cognitive *** To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive *** A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group(n=32)and a control group(n=28).The experimental group received early intensive care every day,and the control group received daily routine *** scores of the Mini-Mental State Examination(MMSE)and the Trail Making Test(TMT),as well as the latency and amplitude of the event-related potential P300,were used as main indicators to evaluate changes in cognitive function,and changes in BDnF,TGF-β,and GDnF expression were used as secondary *** Both groups experienced notable enhancements in MMSE scores,with the experi-mental group demonstrating higher scores than the control group(experimental:28.75±2.31;control:25.84±2.87).Moreover,reductions in TMT-A and TMT-B scores were observed in both groups(experimental:TMT-A 52.36±6.18,TMT-B 98.47±10.23;control:TMT-A 61.48±7.92,TMT-B 112.63±12.55),with the experimental group displaying lower scores.P300 Latency decreased(experimental:270.63 ms±14.28 ms;control:285.72 ms±16.45 ms),while amplitude increased(experimental:7.82μV±1.05μV;control:6.35μV±0.98μV)significantly in both groups,with superior outcomes in the experimental ***,the levels of the growth factors BDnF,TGF-β1,and GDnF surged(experimental:BDnF 48.37 ng/mL±5.62 ng/mL,TGF-β152.14 pg/mL±4.28 pg/mL,GDnF 34.76 ng/mL±3.89 ng/mL;control:BDnF 42.58 ng/mL±4.73 ng/mL,TGF-β146.23 pg/m

关键词： Early refined nursing program Cerebral infraction Cognitive impairment Psychiatry Trajectory test

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Dietary supplementation with succinic acid improves growth performance and flesh quality of adult nile tilapia(Oreochromis niloticus)fed a high-carbohydrate diet

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Animal nutrition 2024年第3期18卷 390-407页

作者： Manxia Cao ningning Xie Jianmin Zhang Ming Jiang Feng huang Lixue Dong Xing Lu hua Wen Juan Tian Key Laboratory of Freshwater Biodiversity Conservation Ministry of AgricultureYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Key Laboratory for Animal nutrition and Feed Science of Hubei Province Wuhan Polytechnic UniversityWuhan 430023China

To evaluate the effects of dietary supplementation with succinic acid on growth performance,flesh quality,glucose,and lipid metabolism of nile tilapia(Oreochromis niloticus)fed a high-carbohydrate diet(HCD),five iso-nitrogenous and iso-lipidic diets were prepared as follows:HCD(control group)consisting of 55%corn starch and HCD supplemented with 0.5%,1.0%,2.0%,and 4.0%succinic acid,*** with an initial body weight of 204.90±1.23 g randomly assigned to 15 tanks with 3 replicates per group and 10 fish per tank fed for 8 *** dietary succinic acid supplementation resulted in significant second-order polynomial relationship in the weight gain rate(WGR),specific growth rate(SGR),feed conversion ratio(FCR),protein efficiency rate(PER),viscerosomatic index,condition factor,and contents of muscular crude lipid and glycogen(Pndex,mesenteric fat index,liver glycogen content and crude lipid contents of the whole-body and liver demonstrated significantly linear and second-order polynomial relationship(Pnalysis based on WGR,SGR,PER,and FCR demonstrated that optimal supplementation with succinic acid in the HCD of nile tilapia ranged from 1.83%to 2.43%.Fish fed with 1.0%succinic acid had higher muscular hardness,increased the contents of alkali-soluble hydroxyproline in collagen,docosahexaenoic acid(DHA)and n-3 polyunsaturated fatty acid(n-3PUFA)in muscle,and lower total fatty acid content in muscle(Pntrol *** to the control group,dietary supplementation with 1.0%succinic acid significantly increased the contents of total bounding amino acid(arginine,histidine,isoleucine,lysine,methionine,alanine,proline),total flavor amino acid(free aspartic acid),the catalase(CAT)activity and total antioxidant capacity,and the mRnA relative expression levels of CAT,superoxide dismutase(SOD),and nuclearfactor erythroidderived 2-like 2(nrf2)in muscle(Pni

关键词： Oreochromis niloticus High-carbohydrate diet Succinic acid Antioxidant capacity Muscular nutritional value Muscle growth

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Characteristics and risk factor analyses of high-grade intraepithelial neoplasia in older patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4129-4137页

作者： Xin Zhang Ying Wang Tong Zhu Jian Ge Jun.hua Yuan Department of Geriatric Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUnD According to the degree of intradermal neoplasia in the colorectal exhalation,it can be divided into two grades:Low-grade intraepithelial neoplasia(LGIn)and high-grade intraepithelial neoplasia(HGIn).Currently,it is difficult to accurately diagnose LGIn and HGIn through imaging,and clinical diagnosis depends on postoperative histopathological diagnosis.A more accurate method for evaluating HGIn preoperatively is urgently needed in the surgical treatment and nursing intervention of colorectal *** To explore the characteristics and risk factors of HGIn in older patients with colorectal *** We selected 84 older patients diagnosed with HGIn as the HGIn group(n=95 colonic polyps)and 112 older patients diagnosed with LGIn as the LGIn group(n=132 colonic polyps)from Shandong Provincial Hospital Affiliated to Shandong First Medical *** endoscopic features,demographic characteristics,and clinical manifestations of the two patient groups were compared,and a logistic regression model was used to analyze the risk factors for HGIn in these *** The HGIn group was older and had a higher number of sigmoid colon polyps,rectal polyps,pedunculated polyps,polyps≥1.0 cm in size,polyps with surface congestion,polyps with surface depression,and polyps with villous/tubular adenomas,a higher proportion of patients with diabetes and a family history of colorectal cancer,patients who experienced rectal bleeding or occult blood,patients with elevated carcinoembryonic antigen(CEA)and cancer antigen 199(CA199),and lower nutritional levels and higher frailty *** polyp location(in the sigmoid colon or rectum),polyp diameter(≥1.0 cm),pathological diagnosis of(villous/tubular adenoma),family history of colorectal cancer,rectal bleeding or occult blood,elevated serum CEA and CA199 levels,lower nutritional levels and higher frailty levels also are independent risk factors for *** The occurrence of high-grade neoplastic transformat

关键词： Elderly Colorectal polyps High-grade intraepithelial neoplasia Low-grade intraepithelial neoplasia Risk factors

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Uninvolved liver dose prediction in stereotactic body radiation therapy for liver cancer based on the neural network method

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4146-4156页

作者： huai-Wen Zhang You-hua Wang Bo Hu Hao-Wen Pang Department of Radiotherapy Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Oncology Gulin People’s HospitalLuzhou 646500Sichuan ProvinceChina Key Laboratory of nondestructive Testing(Ministry of Education) Nanchang Hang Kong UniversityNanchang 330063Jiangxi ProvinceChina Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUnD The quality of a radiotherapy plan often depends on the knowledge and expertise of the plan *** To predict the uninvolved liver dose in stereotactic body radiotherapy(SBRT)for liver cancer using a neural network-based *** A total of 114 SBRT plans for liver cancer were used to test the neural network ***-organs of the uninvolved liver were automatically *** between the volume of each sub-organ,uninvolved liver dose,and neural network prediction model were established using *** the cases,70%were selected as the training set,15%as the validation set,and 15%as the test *** regression R-value and mean square error(MSE)were used to evaluate the *** The volume of the uninvolved liver was related to the volume of the corresponding *** all sets of Rvalues of the prediction model,except for D_(n0)which was 0.7513,all R-values of D_(n10)-D_(n100)and D_(nmean)were>*** MSE of the prediction model was also *** We developed a neural network-based method to predict the uninvolved liver dose in SBRT for liver *** is simple and easy to use and warrants further promotion and application.

关键词： Dose prediction Sub-organ Machine learning Stereotactic body radiotherapy Liver cancer

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Metal-free two-dimensional phosphorene-based electrocatalyst with covalent P-n heterointerfacial reconstruction for electrolyte-lean lithium-sulfur batteries

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Carbon Energy 2024年第5期6卷 175-185页

作者： Jiangqi Zhou Chengyong Shu Jiawu Cui Chengxin Peng Yong Liu Weibo hua Laura Simonelli Yuping Wu Shi Xue Dou Wei Tang School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghaiChina CELLS-ALBA Synchrotron BarcelonaSpain School of Energy and Environment Southeast UniversityNanjingChina

The use of lithium-sulfur batteries under high sulfur loading and low electrolyte concentrations is severely restricted by the detrimental shuttling behavior of polysulfides and the sluggish kinetics in redox ***-dimensional(2D)few layered black phosphorus with fully exposed atoms and high sulfur affinity can be potential lithium-sulfur battery electrocatalysts,which,however,have limitations of restricted catalytic activity and poor electrochemical/chemical *** resolve these issues,we developed a multifunctional metal-free catalyst by covalently bonding few layered black phosphorus nanosheets with nitrogen-doped carbon-coated multiwalled carbon nanotubes(denoted c-FBP-nC).The experimental characterizations and theoretical calculations show that the formed polarized P-n covalent bonds in c-FBP-nC can efficiently regulate electron transfer from nC to FBP and significantly promote the capture and catalysis of lithium polysulfides,thus alleviating the shuttle ***,the robust 1D-2D interwoven structure with large surface area and high porosity allows strong physical confinement and fast mass ***,with c-FBP-nC as the sulfur host,the battery shows a high areal capacity of 7.69 mAh cm^(−2) under high sulfur loading of 8.74 mg cm^(−2) and a low electrolyte/sulfur ratio of 5.7μL mg^(−1).Moreover,the assembled pouch cell with sulfur loading of 4 mg cm^(−2) and an electrolyte/sulfur ratio of 3.5μL mg^(−1) shows good rate capability and outstanding *** work proposes an interfacial and electronic structure engineering strategy for fast and durable sulfur electrochemistry,demonstrating great potential in lithium-sulfur batteries.

关键词： black phosphorus electronic structure high sulfur loading interfacial covalent bonds lean electrolyte

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The alarming link between neonicotinoid insecticides and kidney injury

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Emerging Contaminants 2024年第3期10卷 318-328页

作者： Zhanpeng Zhang Longbin Shen Mei Chen Biao huang Zhuoqi Wei Weiguo Xu hua Zhang Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou510632China Department of Dermatology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong510632China Department of Rehabilitation Medicine The First Affiliated Hospital of Jinan UniversityGuangzhou510632China Department of Interventional The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou510400China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhaiGuangdong519000China

neonicotinoid insecticides(nEOs)have been extensively approved for application in agricultural production both in China and *** studies indicated that human exposure to nEOs would have adverse health ***,studies on occurrences of nEOs in kidney injury patients and their association with nephrotoxicity are *** study investigates the potential correlation between exposure to nEOs and kidney injury within a subset(n=224)of the population residing in South *** of 8 nEOs and 5 metabolites were quantified in blood samples obtained from both the 110 healthy and 114 kidney injury cohorts in South *** found that target analytes were frequently detected in samples from the healthy and kidney injury cohorts(61%-100%).Dinotefuran is the predominant nEO in the healthy(42.3%)and kidney injury cohort(49.6%).Significantly positive(pns between blood nEO concentrations and kidney injury were found,indicating that these pollutants may increase the odds of human kidney injury *** multilinear regression analysis,it was observed that the concentrations of various nEOs exhibited a significant association(pnked to *** study represents the pioneering investigation examining the relationships between nEOs and kidney injury,thereby offering novel insights into the nephrotoxicity associated with these *** discovery carries significant implications for public health policies and environmental conservation practices.

关键词： neonicotinoid insecticides Metabolites Human exposure Kidney injury

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Synergistic effect between Er-doped MoS_(2)nanosheets and interfacial Mo-n coupling phases for enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第3期43卷 1301-1308页

作者： nian-Peng Li Lei Zhang hua Zhang Fan-Fei Min Lei Wang Sam Toan Xi-Jun Liu Guang-Zhi Hu State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines School of Materials Science and EngineeringAnhui University of Science and TechnologyHuainan232001China Donghai Laboratory Zhoushan316021China Department of Chemical Engineering University of Minnesota-DuluthDuluthMN55812USA School of Ecology and Environmental Science Institute for Ecological Research and Pollution Control of Plateau LakesYunnan UniversityKunming650504China MOE Key Laboratory of new Processing Technology for non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China

Hydrogen production via electrochemical water splitting is a promising and green *** one of the most representative transition metal sulfides layered materials,Molybdenum disulfide(MoS_(2))has immense potential for the hydrogen evolution reaction(HER).We successfully prepared a nitrogen-doped carbon(nC)in situ-grown erbium-doped MoS_(2)polyhedral structure(Er-MoS_(2)/nC)that incorporates an interfacial Mo-n coupling phase.

关键词： hydrogen interfacial coupling

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