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北喜马拉雅萨迦穹窿中苦堆和萨迦淡色花岗岩的U-Pb年龄及其地质意义

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科学通报 2004年第20期49卷 2090-2094页

作者：张宏飞 n.harris R.Parrish 张利赵志丹中国地质大学地球科学学院武汉430074 Department of Earth Sciences The Open UniversityMilton KeynesMK76AAUK nERC Isotope Geosciences Laboratory British Geological SurveyNottinghamNG125GGUK 中国地质大学地球和资源学院北京100083

利用TIMS方法，对产于北喜马拉雅萨迦穹窿中的苦堆和萨迦淡色花岗岩锆石、独居石和磷钇矿进行了U-Pb定年．结果表明，苦堆淡色花岗岩的岩浆结晶年龄为27．5±0．5Ma，而萨迦淡色花岗岩的岩浆结晶年龄为14．4±0．2Ma，因此将北喜马拉雅... 详细信息

利用TIMS方法，对产于北喜马拉雅萨迦穹窿中的苦堆和萨迦淡色花岗岩锆石、独居石和磷钇矿进行了U-Pb定年．结果表明，苦堆淡色花岗岩的岩浆结晶年龄为27．5±0．5Ma，而萨迦淡色花岗岩的岩浆结晶年龄为14．4±0．2Ma，因此将北喜马拉雅淡色花岗岩形成的时间跨度从原有的15～10Ma扩展到27．5～10Ma，并据此对北喜马拉雅淡色花岗岩的成因机制进行了年代学制约，指出北喜马拉雅淡色花岗岩有着多样的成因机制．

关键词：淡色花岗岩喜马拉雅 U-Pb年龄地质意义穹窿岩浆成因机制方法学制利用

Rootstock effects on scion phenotypes in a‘Chambourcin’experimental vineyard

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Horticulture Research 2019年第1期6卷 992-1004页

作者： ZoëMigicovsky Zachary n.harris Laura LKlein Mao Li Adam McDermaid Daniel H.Chitwood Anne Fennell Laszlo G.Kovacs Misha Kwasniewski Jason P.Londo Qin Ma Allison J.Miller Department of Plant and Animal Sciences Faculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada Department of Biology Saint Louis University3507 Laclede AvenueSt.LouisMO 63103-2010USA Donald Danforth Plant Science Center 975 North Warson RoadSt.LouisMO 63132-2918USA Department of Math&Statistics BioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Department of Computational Mathematics Science and EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Agronomy Horticulture&Plant ScienceBioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Department of Biology Missouri State University901S.National AvenueSpringfieldMO 65897USA Department of Food Science University of Missouri221 Eckles HallColumbiaMO 65211USA United States Department of Agriculture Agricultural Research Service:Grape Genetics Research Unit630 West North StreetGenevaNY 14456-1371USA

Understanding how root systems modulate shoot system phenotypes is a fundamental question in plant biology and will be useful in developing resilient agricultural *** is a common horticultural practice that joins the roots(rootstock)of one plant to the shoot(scion)of another,providing an excellent method for investigating how these two organ systems affect each *** this study,we used the French-American hybrid grapevine‘Chambourcin’(Vitis L.)as a model to explore the rootstock–scion *** examined leaf shape,ion concentrations,and gene expression in‘Chambourcin’grown ungrafted as well as grafted to three different rootstocks(‘SO4’,‘1103P’and‘3309C’)across 2 years and three different irrigation *** found that a significant amount of the variation in leaf shape could be explained by the interaction between rootstock and *** ion concentrations,the primary source of variation identified was the position of a leaf in a shoot,although rootstock and rootstock by irrigation interaction also explained a significant amount of variation for most ***,we found rootstock-specific patterns of gene expression in grafted plants when compared to ungrafted ***,our work reveals the subtle and complex effect of grafting on‘Chambourcin’leaf morphology,ionomics,and gene expression.

关键词： Root grafted irrigation

The flattening of spacetime hierarchy of the n,n-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES) framework

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national Science Review 2024年第5期11卷 46-55页

作者： Jakub Vohryzek Joana Cabral Christopher Timmermann Selen Atasoy Leor Roseman David J.nutt Robin L.Carhart-harris Gustavo Deco Morten L.Kringelbach Centre for Eudaimonia and Human Flourishing Linacre CollegeDepartment of Psychiatry University of Oxford Department of Psychiatry University of Oxford Center for Music in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health Sciences Research Institute School of MedicineUniversity of Minho ICVS/3B's-PT Government Associate Laboratory Centre for Psychedelic Research Department of Brain Sciences Imperial College London Departments of neurology and Psychiatry University of California San Francisco Institució Catalana de la Recerca i Estudis Avan?ats (ICREA) Department of neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological Sciences Monash University

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic n,n-dimethyltryptamine(DMT) with the Harmonic Decomposition of Spacetime(HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition(DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES'dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关键词： spatio-temporal brain dynamics DMT harmonic modes

Exploring the associations between skeletal muscle echogenicity and physical function in aging adults:A systematic review with meta-analyses

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Journal of Sport and Health Science 2024年第6期13卷 820-840页

作者： Dustin J.Oranchuk Stephan G.Bodkin Katie L.Boncella Michael O.harris-Love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Department of Physical Therapy

Background:Assessment and quantification of skeletal muscle within the aging population is vital for diagnosis,treatment,and injury/disease *** clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting ***,relationships between muscle echogenicity and clinical functional assessments require authoritative ***,we aimed to(a) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older adults(≥60 years),(b) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function,and(c) perform sub-analyses to determine between-muscle ***:CInAHL,Embase,MEDLInE,PubMed,and Web of Science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older ***-of-bias assessments were conducted along with funnel plot ***-analyses with and without sub-analyses for individual muscles were performed utilizing Fisher's Z transformation for the most common measures of physical ***'s Z was back-transformed to Pearson's r for ***:Fifty-one articles(n=5095,female=~2759,male=~2301,72.5± 5.8 years,mean±SD(1 study did not provide sex descriptors))were extracted for review,with previously unpublished data obtained from the authors of 13 *** rectus femoris(n=34) and isometric knee extension strength(n=22) were the most accessed muscle and physical qualities,*** relationship between quadriceps echogenicity and knee extensor strength was moderate(n=2924,r=-0.36(95% confidence interval:-0.38 to-0.32),p nalyses(grip strength,walking speed,sit-to-stand,timed up-and-go) resulting in slightly weaker correlations(r:-0.34 to-0.23,all p nalyses determined minimal differences in predicti

关键词： Correlations Echo intensity Elderly Intramuscular fat Strength

Estimating ancestral distributions of lineages with uncertain sister groups:a statistical approach to Dispersal-Vicariance Analysis and a case using Aesculus L.(Sapindaceae) including fossils

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Journal of Systematics and Evolution 2009年第5期47卷 349-368页

作者： A.J.harris north Carolina State University Department of Plant Biology

We propose a simple statistical approach for using Dispersal-Vicariance Analysis(DIVA) software to infer biogeographic histories without fully bifurcating *** this approach,ancestral ranges are first optimized for a sample of Bayesian *** probability P of an ancestral range r at a node is then calculated as P(rY) = n t=1 F(rY)t Pt where Y is a node,and F(rY) is the frequency of range r among all the optimal solutions resulting from DIVA optimization at node Y,t is one of n topologies optimized,and Pt is the probability of topology *** Y is a hypothesized ancestor shared by a specific crown lineage and the sister of that lineage "x",where x may vary due to phylogenetic uncertainty(polytomies and nodes with posterior probability ng this method,the ancestral distribution at Y can be estimated to provide inference of the geographic origins of the specific crown group of *** approach takes into account phylogenetic uncertainty as well as uncertainty from DIVA *** is an extension of the previously described method called Bayes-DIVA,which pairs Bayesian phylogenetic analysis with biogeographic analysis using ***,we show that the probability P of an ancestral range at Y calculated using this method does not equate to pp*F(rY) on the Bayesian consensus tree when both variables are nd F(rY) is the frequency of range r for the node containing the specific crown *** tested our DIVA-Bayes approach using Aesculus L.,which has major lineages unresolved as a *** inferred the most probable geographic origins of the five traditional sections of Aesculus and of Aesculus californica *** examined range subdivisions at parental nodes of these ***,we used the DIVA-Bayes data from Aesculus to quantify the effects on biogeographic inference of including two wildcard fossil taxa in phylogenetic *** analysis resolved the geographic ranges of the pare

关键词： Aesculus biogeography DIVA fossil wildcards MrBayes phylogenetic uncertainty.

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Cryogenic wedges on the nE Qinghai-Tibet and Ordos Plateaus:Their characteristics,origin and OSL dating

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Research in Cold and Arid Regions 2021年第6期13卷 463-473页

作者： Stuart A.harris Department of Geography University of CalgaryCalgaryAlbertaT2N 1N4Canada

Cryogenic wedges developed due to very cold,rather arid conditions during the maximum of the last cold event when the drying up of the neighboring China Sea resulted in the failure of the East Asian *** the climate ameliorated and the Monsoon rains reappeared,ice-wedges *** warming permitted thawing of the ice infillings accompanied by replacement of the ice by sediments partly from the host ground as well as from the surface by wind or sheet *** cases of extreme surface water flow on slopes after 10 ka B.P.,small baydjarakhs typically c.50 cm high developed,only to have the resulting hollows infilled by sediments carried by wind and/or sheet *** shallow structures form a network on top of many of the cryogenic *** complex history makes dating the ages of the wedges difficult using OSL ***,past field work ignored the problem of the angle of the cut face to the direction of the wedge infilling when sampling the contents of the narrow wedges,resulting in potential contamination of the samples with the host *** of the larger deposits should be alright,but the likelihood of contamination makes the interpretation of the resulting OSL dates from the narrow wedges *** wedges consisting of primary mineral infillings should still have similar OSL dates with depth for a given wedge,but the distinction between ice-wedge infillings and soil wedges is difficult since both can exhibit older dates of the infillings with *** available data suggests that ice-wedges were significantly more common than sediment-filled primary wedges.A protocol to avoid having to obtain large numbers of OSL dates by more careful field sampling and the use of grain size determinations is provided in the Appendix.

关键词： cryogenic wedges OSL dating nE Qinghai-Tibet Plateau differentiation of primary and secondary wedges baydjarakhs in arid climates

Strong observability as a sufficient condition for non-singularity and lossless convexification in optimal control with mixed constraints

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Control Theory and Technology 2022年第4期20卷 475-487页

作者： Sheril Kunhippurayil Matthew W.harris Torc Robotics Inc.405 Partnership DriveBlacksburg 24060VirginiaUSA Department of Mechanical and Aerospace Engineering Utah State University4130 Old Main HillLogan 84322UtahUSA

This paper analyzes optimal control problems with linear time-varying dynamics defined on a smooth manifold in addition to mixed constraints and pure control *** main contribution is the identification of sufficient conditions for the optimal controls to be non-singular,which enables exact(or lossless)convex relaxations of the control *** problem is analyzed in a geometric framework using a recent maximum principle on manifolds,and it is shown that strong observability of the dual system on the cotangent space is the key *** minimum time problems are analyzed and solved.A minimum fuel planetary descent problem is then analyzed and relaxed to a convex *** enables its efficient solution in less than one second without any initial guess.

关键词： Optimal control Strong observability Lossless convexification

Multi-commodity Optimization of Peer-to-peer Energy Trading Resources in Smart Grid

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 29-39页

作者： Olamide Jogunola Bamidele Adebisi Kelvin Anoh Augustine Ikpehai Mohammad Hammoudeh Georgina harris Manchester Metropolitan University ManchesterUK Department of Electrical and Electronic Engineering University of BoltonBoltonUK Department of Engineering and Mathematics Sheffield Hallam UniversitySheffieldUK Department of Computing and Mathematics Manchester Metropolitan UniversityManchesterUK School of Science Engineering and EnvironmentUniversity of SalfordSalfordUK

Utility maximization is a major priority of prosumers participating in peer-to-peer energy trading and sharing(P2P-ETS).However,as more distributed energy resources integrate into the distribution network,the impact of the communication link becomes *** present a multi-commodity formulation that allows the dual-optimization of energy and communication resources in *** one hand,the proposed algorithm minimizes the cost of energy generation and communication *** the other hand,it also maximizes the global utility of prosumers with fair resource *** evaluate the algorithm in a variety of realistic conditions including a time-varying communication network with signal delay signal *** results show that the convergence is achieved in a fewer number of time steps than the previously proposed *** is further observed that the entities with a higher willingness to trade the energy acquire more satisfactions than others.

关键词： Distributed algorithm social welfare peer-to-peer energy trading and sharing multi-commodity networks economic dispatch packet loss peer-to-peer energy trading distributed dual-gradient(DDG)