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四川蝙蝠核型的进一步研究(英文)

广州大学学报（自然科学版） 2006年第4期5卷 20-24页

作者：吴毅原田正史石红艳刘昊广州大学生命科学学院广东广州510006 大阪市立大学医学部动物实验中心绵阳师范学院生物学系四川绵阳621000

报道了含中国特有种大足鼠耳蝠(Myotis ricketti)在内的、四川地区6种蝙蝠的核型.菊头蝠科2种,即大耳菊头蝠(Rhinolophus macrotis),核型为2n=62,Fn=60;云南菊头蝠(***),核型较为特殊,2n=46,Fn=58.蹄蝠科1种,即普氏蹄蝠(Hipposideros pratti),核型为2n=32,Fn=60;蝙蝠科鼠耳蝠属3种,即中华鼠耳蝠(Myotis chinensis),核型为2n=44,Fn=50;大足鼠耳蝠为2n=44,Fn=52;西南鼠耳蝠(***)为2n=44,Fn=50.其中云南菊头蝠的核型为中国第1次报道.

关键词：核型蝙蝠菊头蝠鼠耳蝠四川

纤瘦成人256排探测器CT肝脏动态扫描的低对比剂和低辐射剂量方案:低管电压和混合迭代重建算法对影像质量的影响

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国际医学放射学杂志 2012年第5期 485-485页

作者： T.nakaura S.nakamura n.Maruyama Y.Funama K.Awai K.harada 倪玲 Department of Diagnostic Radiology Amakusa Medical CenterKameba 854-1AmakusaKumamoto 863-0046Japan

摘要目的评估利用低管电压、混合迭代重建算法和256排探测器的腹部动态CT扫描低对比剂剂量和低辐射剂量方案与对影像质量的影响。方法本前瞻性研究获得机构审查委员会批准,且所有病人在实验前签署知情同意书。74例行肝动态CT扫描病人随... 详细信息

摘要目的评估利用低管电压、混合迭代重建算法和256排探测器的腹部动态CT扫描低对比剂剂量和低辐射剂量方案与对影像质量的影响。方法本前瞻性研究获得机构审查委员会批准,且所有病人在实验前签署知情同意书。74例行肝动态CT扫描病人随机分配到以下两个方案之一中:39例病人行常规的120kV管电压扫描,而其他35例病人行80kV管电压和降低40%的对比剂剂量的扫描。80kV获得的影像通过混合迭代重建算法进行后处理。

关键词：低管电压迭代重建算法低辐射剂量影像质量对比剂探测器动态扫描 CT

胼胝体的角度在诊断特发性正常压力脑积水中的临床影响

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国际医学放射学杂志 2009年第1期32卷 93-93页

作者： K. Ishii T. Kanda A. harada n. Miyamoto T. Kawaguchi K. Shimada 李志明 Department of Radiology and nuclear Medicine HyogoBrain and Heart Center 520 Saisho -Ko Himeji Hyogo 670 -0981 Japan

研究胼胝体角度的测量在诊断特发性正常压力脑积水（InPH）中的价值。对34例InPH病人、34例阿尔茨海默病（AD）病人及34例正常对照组（nC）受试者进行三维MRI检查。在后联合垂直于前后联合平面的冠状位MRI上测量所有受试者胼胝体的角度... 详细信息

研究胼胝体角度的测量在诊断特发性正常压力脑积水（InPH）中的价值。对34例InPH病人、34例阿尔茨海默病（AD）病人及34例正常对照组（nC）受试者进行三维MRI检查。在后联合垂直于前后联合平面的冠状位MRI上测量所有受试者胼胝体的角度。InPH组病人的胼胝体角度（平均值±标准差：66°±14°）显著小于AD组（104°±15°）及nC组（121°±11°）。

关键词：胼胝体角度特发性正常压力脑积水 MRI 阿尔茨海默病

Resolutive Results with Oral Corticosteroids for Patients with COVID-19 in Pulmonary Inflammatory Phase. Successful Outpatient Experience during the Collapse of Belem Do Para Health System—Brazil

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Health 2021年第8期13卷 830-838页

作者： Roberto S. Zeballos Luciana n. L. Cruz Vânia C. R. Brilhante Adriana V. Lima Carlliane L. L. P. Martins Karla n. A. Lima Michele C. G. L. Leão Belinete L. Cruz Alessandra B. Dysarz Paulo C. B. Lobato Erika S. Almeida Rute A. P. Costa Klevison C. Araújo Augusto C. C. Almeida Leônidas B. D. Junior Kathia O. harada Rita H. V. S. Araújo Elaine X. Prestes Ivete M. S. Souza Avany M. P. Pereira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carvalho Paulo M. P. Melo Clinical Care Sao Paulo Brazil Instituto de Ciencias da Saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publica Estadual Hospital de Clinicas Gaspar Vianna Belem Brazil Hospital da Policia Militar do Para Belem Brazil Imunoclinic Belem Brazil Universidade Estadual do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Clinica Barros Cirurgia Plastica Belem Brazil Secretaria de Estado de Saude Publica Castanhal Brazil Centro de Tratamento Oncologico Belem Brazil Sociedade Brasileira de Valorizaç ã o das Sociedades Medicas—SOBEMED S&#227 o Paulo Brazil Clinica de nutrologia Sao Luiz Brazil Hospital nipo Brasileiro de Olhos Belem Brazil Centro de Ciencias Biologicas e da Saude Universidade do Estado do Para Belem Brazil Hospital Regional do Baixo Amazonas Santarem Brazil Clinica Vallinoto Secretaria de Saude de Barcarena Barcarena Brazil Estrategia Saude da Familia Secretaria Municipal de Saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. P. Endocrinologia Belem Brazil Instituto Avertano Rocha Belem Brazil Departamento de neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itself in order to contain and control epidemics, such as the one we have recently faced, COVID-19, a disease with a wide spectrum of clinical severity. A new moment has been established, since the application of well-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COVID-19. Thereunto, studies with early intervention are needed, which can change the unfavorable outcome of patients. In this article, we report the successful experience using an oral strategy during the collapse of Belem (Para, Brazil) Health System. Two hundred and ten patients were diagnosed with respiratory failure due to COVID-19, with no option of hospital treatment due to lack of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisolone, 40 mg enoxaparin and macrolides (500 mg clarithromycin, 500 mg axetylcefuroxime) associated and followed in outpatient facilities. Two hundred and eight patients had an excellent therapeutic response and there were only two fatalities. These results push research boundaries, valuing outpatient treatment with early use of prednisolone in the initial pulmonary phase, preventing severe COVID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospitalization, as well as lethality, with social robust benefits and incalculable economic savings since involves the use of accessible, safe and not expensive medications.

关键词： COVID-19 Corticosteroids Pulmonary Inflammatory Phase Collapse Brazil

卵巢肿瘤n-乙酰1共振活体质子3T MR波谱的前期观察及临床价值

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国际医学放射学杂志 2012年第1期 102-102页

作者： M.Takeuchi K.Matsuzaki M.harada 刘靖 Department of Radiology University of Tokushima3-18-15Kuramoto-choTokushima 7708503Japan

目的回顾性评价n-乙酰1在2ppm(ppm表示10-6)时活体质子MR波谱鉴别卵巢占位病人黏液和非黏液肿瘤的临床意义。方法对病理诊断卵巢肿瘤的病人进行3TMR波谱成像。从围绕卵巢肿块的单个感兴趣立方体采集单

关键词： MRI MR波谱卵巢肿瘤 n-乙酰黏液化合物定量评估

坩埚下降法生长BSO(Bi_4Si_3O_(12))闪烁晶体

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人工晶体学报 2000年第S1期29卷 10-页

作者： M.Ishii 1, K.harada 1, Y.Hirose 1, n.Senguttuvan 1, M.Kobayashi 2, I.Yamaga 3, F.Shiji 4, F.Yiting 4 (1.SIT,Shonan Institute of Technology,Fujisawa,251 8511,Japan 2.KEK,High Energy Accelerator res.Organization,Tsukuba,30 0801,Japan 3.Futec

While the light output of BSO crystals is only 20% of the output of currently used BGO(Bi 4Ge 3O 12 )scintillation crystals,the decay time is one third(100ns).It is considered as promising for application as radiation detectors for high energy physics *** on this advantage,we have been proceeding with our development of large crystals to use *** this paper,we will review our results of crystal growth of BSO by Bridgman method and characterization on its scintillation performance. High purity raw materials of Bi 2O 3 and SiO 2 were mixed together,fired at 850℃,re mixed and sintered at 950℃.The charge was then fed into a Pt crucible of 25mm in *** crystal growth,the crucible was lowered at 0.5mm/h in a furnace temperature gradient of about 10℃/cm.

关键词： BSO crystal Bridgman method radiation detector

寻常天疱疮体外角质形成细胞分离测定评估抗桥粒核心糖蛋白3IgG自身抗体的病原性

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 22-22页

作者： Ishii K. harada R. Matsuo I. 阎小宁 Department of Dermatology University of Pennsylvania School of Medicine Philadelphia PA United States Dr.

Patients with pemphigus vulgaris (PV) have circulating antidesmoglein (Dsg) 3 immunoglobulin G (IgG) autoantibodies that induce blister formation. We developed an in vitro quantitative assay to evaluate the pathogenic strength of anti-Dsg3IgG autoantibodies in blister formation. To obtain intercellular adhesion mediated dominantlyby Dsg3,we used primary cultured normal human keratinocytes expressing low level of Dsg2 in the presence of exfoliative toxin A that specifically digests Dsg1. After incubation with various antibodies, monolayers released by dispase were subjected to mechanical stress by pipetting,and the number of cell fragments were counted. When anti-Dsg3 monoclonal antibodies (mAb) obtained from pemphigus model mice were tested, pathogenic AK23 mAb yielded significantly higher number of cell fragments than AK7 or AK20 non-pathogenic mAb. Dissociation scores, defined with AK23 mAb as the positive control, were significantly higher with active stage PVsera(n =10,77.4 ±21.4)thancontrols(n=11,16.0±9.6;p = 0.003). When pair sera obtained from 6 PV patients in active stage and in remission were compared, the dissociation scores reflected well the disease activity as those in active stage were four to 17 times higher than those in remission. When sera from different patients showing similar ELISA scores but different clinical severity were tested (n = 6), the dissociation scores with sera from severe disease activity were significantly higher than those with sera in remission. These findings indicate that this dissociation assay will provide a simple and objective biological method to measure the pathogenic strength of pemphigus autoantibodies.

关键词：寻常天疱疮角质形成细胞自身抗体 IgG 病原性桥粒水疱形成原代培养寻常性天疱疮分散酶

停用皮质类固醇后重症非典型中心性浆液性脉络膜视网膜病变的视力改变

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 52-53页

作者： Sharma T. Shah n. Rao M. 张磊 Shri Bhagwan Mahavir V. Sanka ra Nethralaya Vision Research Foundation Chennai India Dr.

Purpose To elucidate the effect of discontinuation of corticosteroids in patie nts with atypical severe central serous chorioretinopathy (CSC) on retinal reatt achment, resolution of retinal pigment epithelium (RPE) leaks, and improvement i n visual acuity (VA). Design Prospective, noncomparative, observational case ser ies. Participants Twenty-four eyes of 17 patients who were being treated with c orticosteroids for atypical severe CSC. Of these 17 patients, 16 were treated in appropriately with corticosteroids for their ocular condition; presumably, these patients’conditions were misdiagnosed, and they were thought to have choroidit is, harada’s syndrome, or similar entities, and not central serous chorioretino pathy. Intervention Observation or laser photocoagulation. Main outcome measures Reattachment of the retina, obliteration of RPE leaks on fundus fluorescein ang iography, and improvement in Snellen VA. Results Discontinuation of corticostero ids resulted in reattachment of the retina in 21 eyes (87.5%), with median time to reattachment of 49 days (range, 32-400); only 3 eyes required laser photoco agulation. Fundus fluorescein angiography showed obliteration of RPE leaks at a median period of 75 days (range, 32-400) in the observed eyes; the median VA im proved from 20/80 to 20/30. The mean follow-up was 16.5 months. ConclusionsDisc ontinuation of corticosteroids in atypical CSC helped in obliteration of RPE lea ks and retinal reattachment in 87.5%of the eyes without laser treatment, and im provement in VA was observed.

关键词：皮质类固醇视网膜色素上皮浆液性脉络膜激光光凝术中心性视网膜病视网膜脱离视网膜复位脉络膜炎比较性

Vogt-小柳原田病的患者血清中甘油醛衍生的晚期糖基化终末产物减少

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世界核心医学期刊文摘(眼科学分册) 2006年第3期 28-29页

作者： Kitamura M Kitaichi n Takeuchi M. 王海燕 Department of Ophthalmology and Visual Sciences Hokkaido University Graduate School of Medicine Sapporo JapanDr.

Background/aims: Advanced glycation end products (AGEs)-are considered to act as mediators of both age related pathologies and diabetic complications. It was recently reported that glyceraldehyde derived AGE (AGE-2) has a strong biological effect on various diseases. The aim of this study was to investigate the serum AGE-2 levels in Vogt-Koyanagi-harada (VKH) disease. Methods: Sera were obtained from 31 patients with active VKH. 20 of these 31 patients were treated with systemic corticosteroids. As controls, 33 healthy volunteers were also examined. The serum AGE-2 levels were determined with a competitive enzyme linked immunosorbent assay using AGE-2 polyclonal antibody. Results: The mean AGE-2 level in the sera of patients with VKH disease was 4.91 (SD 2.23) U/ml, which was significantly lower than that of the healthy control subjects (8.32 (2.94), p nificantly increased to 13.49 (2.17) U/ml after the patients were treated with systemic corticosteroids (p nclusions: These results suggest that AGE-2 may be involved in the onset of VKH disease.

关键词：甘油醛多元醛小柳原田病 Vogt 晚期糖基化终末产物血清患者