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Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer

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World Journal of Gastroenterology 2010年第19期16卷 2428-2434页

作者： Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key laboratory of Oncology in South China, department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key laboratory of Oncology in South China, department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key laboratory of Oncology in South China, department of Experimental research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China State Key laboratory of Oncology in South China Biotherapy Center Sun Yat-sen University 651 Dongfeng R E Guangzhou 510060 Guangdong Province China.

AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3n1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. COnCLUSIOn: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer.

关键词： Calreticulin Tumor-infiltrating lymphocyte Colon cancer Immune escape

Preparation of grain size controlled boron-doped diamond thin films and their applications in selective detection of glucose in basic solutions

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Science China Chemistry 2010年第6期53卷 1378-1384页

作者： ZHAO JianWen1,2,WAnG JinLiang3,ZHI JinFang3 & ZHAnG ZhiMing4 1College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China 2Schools of materials Science and Engineering,nanyang Technological University,639798,Singapore 3laboratory of Organic Optoelectronic Functional materials and Molecular Engineering,Technical Institute of Physics and Chemistry & Graduate University of Chinese Academy of Sciences,Beijing 100080,China 4research Institute of Micro-nano Science and Technology,Shanghai Jiao Tong University,Shanghai 200030,China College of Chemistry and Chemical Engineering Jishou University Jishou China Schools of materials Science and Engineering Nanyang Technological University Singapore Singapore laboratory of Organic Optoelectronic Functional materials and Molecular Engineering Technical Institute of Physics and Chemistry & Graduate University of Chinese Academy of Sciences Beijing China research Institute of Micro-nano Science and Technology Shanghai Jiao Tong University Shanghai China

Boron-doped diamond (BDD) thin films with different crystal grain sizes were prepared by controlling the reacting gas pressure using hot filament chemical vapor deposition (HFCVD).The morphologies and structures of the prepared diamond thin films were characterized by scanning electron microscopy (SEM) and Raman *** electrochemical responses of K4Fe(Cn)6 on different BDD electrodes were *** results suggested that electron transfer was faster at the boron-doped nanocrystalline diamond (BDnD) thin film electrodes in comparison with that at other BDD thin film *** prepared BDD thin film electrodes without any modification were used to directly detect glucose in the basic *** results showed that the as-prepared BDD thin film electrodes exhibited good selectivity for detecting glucose in the presence of ascorbic acid (AA) and uric acid (UA).The higher sensitivity was observed on the BDnD thin film grown on the boron-doped microcrystalline diamond (BDMD) thin film surface,and the linear response range,sensitivity and the low detection limit were 0.25–10 mM,189.1 μA mmol-1 cm-2 and 25 μM (S/n=3) for glucose in the presence of AA and UA,respectively.

关键词： diamond thin films electrochemical properties selective glucose detection

Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard

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Zoological research 2024年第3期45卷 464-467页

作者： Hai-Meng Li Bo-Yang Liu Min-Hui Shi Le Zhang Shang-Chen Yang Sunil Kumar Sahu Liang-Yu Cui Shan-Lin Liu nicolas Dussex Yue Ma Dan Liu Wei-Yao Kong Hao-Rong Lu Yue Zhao Love Dalén Huan Liu Tian-Ming Lan Guang-Shun Jiang Yan-Chun Xu College of Wildlife and Protected Area Northeast Forestry UniversityHarbinHeilongjiang 150040China State Key laboratory of Agricultural Genomics BGI ResearchShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China BGI research WuhanHubei 430074China department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China Centre for Palaeogenetics Svante Arrhenius väg 20CStockholm 10691Sweden department of Zoology Stockholm UniversityStockholm 10691Sweden department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholm 10691Sweden Heilongjiang Siberian Tiger Park HarbinHeilongjiang 150000China Jinlin Provincial Academy of Forestry Science ChangchunJilin 130033China China national GeneBank BGI ResearchShenzhenGuangdong 518120China Guangdong Provincial Key laboratory of Genome Read and Write BGI ResearchShenzhenGuangdong 518083China BGI Life Science Joint research Center Northeast Forestry UniversityHarbinHeilongjiang 150040China Feline research Center of national Forestry and Grassland Administration College of Wildlife and Protected AreaNortheast Forestry UniversityHarbinHeilongjiang 150040China national Forestry and Grassland Administration research Center of Engineering Technology for Wildlife Conservation and Utilization HarbinHeilongjiang 150040China

DEAR EDITOR,Big cats,such as Amur tigers(Panthera tigris altaica)and Amur leopards(*** orientalis),are apex predator and have evolved specialized traits for hunting and carnivory(Moya et al.,2022),thus playing a crucial role in maintaining biodiversity and ecosystem integrity by regulating prey-predator ***,human-induced pressures,habitat fragmentation,and environmental alterations have restricted these species in small and isolated ***,all extant big cats are categorized as endangered or threatened according to their conservation *** tigers and Amur leopards share overlapping geographic ranges,habitats,and certain prey species in the forests of northeast Asia(Jiang et al.,2015).To reduce interspecies conflict,these carnivores exhibit differentiated dietary and temporal *** tigers predominantly prey on large ungulates,while Amur leopards hunt small to medium-sized animals(Sugimoto et al.,2016).Additionally,they occupy different temporal niches,with tigers being active at night and leopards more active during the *** spatial and temporal niche partitioning,interspecific competition between these two species is ***,benefiting from their greater size,have a competitive advantage over leopards,which can manifest in occasional leopard predation by tigers and declines in leopard populations with increasing tiger density(Jiang et al.,2015).Tigers also displace leopards from marginal habitats in nature reserves where they coexist.

关键词： habitat Panthera resolved

Electroluminescent properties of three ternary europium complexes with different phenanthroline derivatives

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Science China Chemistry 2004年第4期47卷 326-334页

作者： BIAn Zuqiang1,2, GAO Deqing1, GUAn Min1, XIn Hao1, LI Fuyou1, HUAnG Chunhui1, WAnG Kezhi2 & JIn Linpei2 1. State Key laboratory of Rare Earth materials Chemistry and Applications, Peking University, Beijing 100871, China 2. department of Chemistry, Beijing normal University, Beijing 100875, China State Key laboratory of Rare Earth materials Chemistry and Applications Peking University Beijing China department of Chemistry Beijing Normal University Beijing China

Three ternary Eu(III) complexes with general formula of Eu(DBM)3Ln (DBM = dibenzoylmethanate, and Ln (n = 13 ) stand for three different 1,10-phenanthroline derivatives) have been synthesized for vacuum deposition films-based electroluminescent devices. The complex Eu(DBM)3L3 (L3 = 2-phenyl-3-[3-(carbazol-9-yl)propyl]imidazo[4,5-f]1,10-phenan- throline) was designed with an effort to combine the electron-transporting phenanthroline plat-form and the hole-transporting carbazole group into one molecule expecting to improve both electron and hole transporting properties simultaneously. The results show that the variation of the neutral ligands in Eu(III) mixed ligand complexes is a simple and effective approach to the improvement in the thermal stability, PL and EL properties of materials. A double-layer device with the configuration of ITO/TPD (50 nm)/Eu(DBM)3L3 (50 nm)/Mg0.9Ag0.1 (200 nm)/Ag (100 nm) exhibited Eu(III)-based pure red emission with a maximum brightness of 561 cd/m2 at 16 V, and an onset driving voltage of 8 V. A device with the configuration of ITO/TPD (50 nm)/[Eu(DBM)3L3 (5 nm):BCP (5 nm)]4/BCP (20 nm)/AlQ (10 nm) Mg0.9Ag0.1 (110 nm)/Ag (100 nm) gave high effi-cient and pure red light emission with a luminance of 1419 cd/m2.

关键词： dibenzoylmethane electroluminescence lanthanide n ligands

Sharpness on the Lower Bound of the Lifespan of Solutions to nonlinear Wave Equations

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Chinese Annals of Mathematics,Series B 2011年第4期32卷 521-526页

作者： Yi ZHOU 1 Wei HAn 2 1 nonlinear Mathematical Modeling and Methods laboratory Shanghai Key laboratory for Contem- porary Applied Mathematics School of Mathematical Sciences, Fudan University, Shanghai 200433, China. 2 School of Mathematical Sciences, Fudan University, Shanghai 200433, China department of Mathematics, north University of China, Taiyuan 030051, China. nonlinear Mathematical Modeling and Methods laboratory Shanghai Key laboratory for Contemporary Applied Mathematics School of Mathematical Sciences Fudan University Shanghai China School of Mathematical Sciences Fudan University Shanghai China department of Mathematics North University of China Taiyuan China

This paper is devoted to proving the sharpness on the lower bound of the lifespan of classical solutions to general nonlinear wave equations with small initial data in the case n = 2 and cubic nonlinearity (see the results of T. T. Li and Y. M. Chen in 1992). For this purpose, the authors consider the following Cauchy problem:{□ u = (ut ) 3 , n = 2, t = 0 : u = 0, u t = εg(x), x ∈ R 2 , where □= 2t- sum from i=1 to n 2 xi is the wave operator, g(x) ≡ 0 is a smooth non-negative function on R 2 with compact support, and ε > 0 is a small parameter. It is shown that the solution blows up in a finite time, and the lifespan T (ε) of solutions has an upper bound T (ε) ≤ exp(Aε-2 ) with a positive constant A independent of ε, which belongs to the same kind of the lower bound of the lifespan.

关键词：非线性波动方程寿命锐度立方非线性柯西问题古典解清晰度时间

Anticancer Drugs ( Ⅳ )——new Derivatives of Podophyllotoxin

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Chemical research in Chinese Universities 1993年第2期9卷 116-120页

作者： TIAn Xuan, LI Jin-xin, ZHAnG Ya-li CHEn Yao-zu (national laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000)LI Wen-guang (department of Pharmacology, Lanzhou Medicine College, Lanzhou, 730000)

Four new derivatives of podophyllotoxin, n'-podophyllic acid-n-[3-(2, 2, 5, 5-te-tramethyl-pyrrolinenyloxy)] semicarbazide(GP-11, 6), podophyllic acid [3-(2,2,5,5-te-tramethyl-pyrrolinenyloxy)]hydrazone (GP-12, 7), podophyllic acid-[4-(2, 2, 6, 6-tetramethyl-1-hydroxy piperidine)]hydrazone(GP-1-OH, 8) and podophyllic acid[4-(2,2, 6, 6-tetramethyl piperidine)]hydrazone(GP-1-H, 9) were synthesized. The inhibition effect of the four new compounds on L-1210 cells were determined. The antitumor activity and toxicity of GP-1(2), GP-1-OH(8), GP-1-H(9) and VP-16-213(1) were discussed.

关键词： Podophyllotoxin Anticancer drugs nitroxyl radical

Syntheses, properties and structures of copper and nickel complexes of 6,7-dihydro-5H-1,4-dithiepin-2,3-dithiolate

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Chinese Journal of Chemistry 1994年第3期12卷 248-257页

作者： YAO, Tian-Ming YOU, Xiao-ZengCoordination Chemistry Institute, State Key laboratory of Coordination Chemistry, nanjing University,nanjing 210008, ChinaYAnG, Qing-ChuanChemistry department, Beijing University, Beijing 100871, China Coordination Chemistry Institute State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210008 China Chemistry department Beijing University Beijing 100871 China

The reaction of CuCl2-2H2O or niCl2.6H2O with K2(C5H6S4) [potassium salt of 6,7-dihydro-5H-1,4-dithiepin-2,3-dithiolate] under nitrogen atmosphere resulted in the isolation of [Cu(C5H6S4)2]- or [ni(C5H6S4)2]- as the tetrabutylammonium salt. Both complexes show characteristic IR and UV-Vis absorptions of transition metal dithiolenes. Cyclic voltammograms contain two waves indicating a two step electrochemical procedure [M(C5H6S4)2]0 = [M(C5H6S4)2]1-= [M(C5H6S4)2]2-. Single crystal structure study has been carried out on the nickel complex. Crystal of [Bu4n][ni(C5H6S4)2] belongs to monoclinic space group P21/c with a=17.576(5), 6=10.883(2), c=17.773(4) A,B=91.07(2)0, Z=4, and o(calcd.)=1.348 g/cm3. Final result is R=0.059 for 2959 reflections. The niS4 core exhibits square planar coordination with average ni-S bond length of 2.134(5) A. There are not anion pairs in crystal. The anions stack along a and c axes while the cations intercalate in them. The nearest S-S contact is 4.429 A. The solid powder ESR spectrum of the nickel complex shows three broadening signals at g1=2.097, g2=2.042, g3=2.022. Magnetic susceptibility data for [Bu4n][ni(CgH6S4)2] reveal enhanced anti-ferromagnetic interaction.

关键词： Dithiolene complex copper nickel single crystal.

Catalytic Asymmetric[3+2]Cycloaddition of Exocyclic Enol Ethers for the Synthesis of Spiroketals

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Precision Chemistry 2023年第7期1卷 423-428页

作者： Fengcai Zhang Yuqiao Zhou hansen Zhao Long Chen Weidi Cao Xiaoming Feng Key laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China

An efficient synthesis of chiral benzannulated spiroketals via catalytic asymmetric[3+2]cycloaddition of exocyclic enol ethers with p-quinones was *** transformation was enabled by a chiral n,n′-dioxides/Tm^(Ⅲ)complex as the Lewis acid catalyst and afforded a series of enantiomerically enriched benzannulated spiroketal derivatives in good yields(up to 99%)and enantioselectivities(up to 98%ee).Topographic steric maps and distribution of the buried volumes of the catalysts via Cavallo’s SambVca 2 tool were used to elucidate the enantioinduction raised by the ligands and the metal ions.

关键词： asymmetric catalysis [3+2]-cycloaddition spiroketals exocyclic enol ethers quinones

Half-lives and fine structure for the α decay of deformed even-even nuclei

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 24-31页

作者： nI DongDong1,2 & REn ZhongZhou1,2,3 1department of Physics, nanjing University, nanjing 210093, China 2Kavli Institute for Theoretical Physics China, Beijing 100190, China 3Center of Theoretical nuclear Physics, national laboratory of Heavy-Ion Accelerator, Lanzhou 730000, China department of Physics Nanjing University Nanjing China Kavli Institute for Theoretical Physics China Beijing China Center of Theoretical nuclear Physics National Laboratory of Heavy-Ion Accelerator Lanzhou China

The α-decay properties of well-deformed even-even nuclei are systematically calculated within the multichannel cluster model (MCCM). Instead of working in the WKB framework, the quasibound solution to the coupled Schro¨dinger equation is presented with outgoing wave boundary conditions, and the coupling potential is taken into full account in terms of the general quantum theories. The calculated α-decay half-lives are found to agree well with the experimental data with a mean factor of less than 2. The fine structure observed in α decay is also well reproduced by the four-channel microscopic calculation. Very strikingly, the MCCM can give relatively precise descriptions of the branching ratio to excited 4+ states, which is often overestimated in the usual WKB calculations. We expect it to be a significant development of theoretical models toward quantitative descriptions of α transitions to high-spin daughter states.

关键词： α decay half-lives cluster model coupled channel approach