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The new era of cardiovascular research:revolutionizing cardiovascular research with 3D models in a dish

Medical Review 2024年第1期4卷 68-85页

作者： Yuan Yang Hao Yang Fedir n.Kiskin Joe Z.Zhang Institute of neurological and Psychiatric Disorders Shenzhen Bay LaboratoryShenzhenGuangdong ProvinceChina Institute of neurological and Psychiatric Disorders Shenzhen Bay LaboratoryShenzhen 518132Guangdong ProvinceChina

Cardiovascular research has heavily relied on studies using patient samples and animal ***,patient studies often miss the data from the crucial early stage of cardiovascular diseases,as obtaining primary tissues at this stage is *** animal models can offer some insights into disease mechanisms,although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their *** recent years,a promising breakthrough has emerged in the form of in vitro three-dimensional(3D)cardiovascular models utilizing human pluripotent stem *** innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled *** advancement is pivotal as it addresses the existing gaps in cardiovascular research,allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin *** this review,we first outline various approaches employed to generate these *** then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular ***,we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and *** their immense potential,challenges persist,particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real ***,overcoming these challenges could revolutionize cardiovascular *** has the potential to offer comprehensive mechanistic insights into human-specific disease processes,ultimately expediting the development of personalized therapies.

关键词： pluripotent stem cells three-dimensional(3D)models cardiac microtissues cardiac organoids vessel organoids organ-on-a-chip

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Effect of bone loss in anterior shoulder instability

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World Journal of Orthopedics 2015年第5期6卷 421-433页

作者： Grant H Garcia Joseph n Liu David M Dines Joshua S Dines Department of Orthopedic Surgery Hospital for Special Surgery

Anterior shoulder instability with bone loss can be a difficult problem to treat. It usually involves a component of either glenoid deficiency or a Hill-Sachs lesion. Recent data shows that soft tissue procedures alone are typically not adequate to provide stability to the shoulder. As such, numerous surgical procedures have been described to directly address these bony deficits. For glenoid defects, coracoid transfer and iliac crest bone block procedures are popular and effective. For humeral head defects, both remplissage and osteochondral allografts have decreased the rates ofrecurrent instability. Our review provides an overview of current literature addressing these treatment options and others for addressing bone loss complicating anterior glenohumeral instability.

关键词： Latarjet Remplissage Glenoid deficiency Hill-Sachs lesion Anterior instability

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Best operating conditions to produce hydroxyapatite nanoparticles by means of a spinning disc reactor

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 156-160页

作者： A. F. D' Intino B. de Caprariis M.L. Santarelli n. Verdone A. Chianese Department of Chemical Engineering Sapienza University via Eudossiana 00184 Rome Italy

In this work, Mg2＋ doped hydroxyapatite （Mg-HAP） nanoparticles were produced by a reactionprecipitation process by using a spinning disc reactor （SDR） at high rotational speed. The production process of these nanoparticles consisted of the neutralization reaction between two aqueous solutions of calcium chloride and ammonia orthophosphate at room temperature. By operating at pH = 10, a high purity Mg-HAP nanoparticles were obtained. In particular, they were 51 nm in average size when the two reagents were fed over the disc symmetrically at 3 cm from the disc center and a rotational speed of the disc reactor equal to 1400 r/min was adopted.

关键词： hydroxyapatite nanoparticles spinning discreactor

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Experimental and numerical investigation of controlled disturbances development from two sources in supersonic boundary layer

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Advances in Aerodynamics 2019年第1期1卷 288-300页

作者： G.L.Kolosov A.D.Kosinov A.n.Semenov A.A.Yatskikh Khristianovich Institute of Theoretical and Applied Mechanics SB RAS Novosibirsk 630090Russia

The paper presents the experimental results and the results of direct numerical simulation of the development and interaction of two wave trains from two point sources of controlled disturbances in a supersonic boundary layer on a flat plate with an incident flow Mach number of *** were located parallel to the leading edge of the *** the introduction of controlled disturbances into the boundary layer,the normal component of the mass flow rate was varied in the *** the experiment,periodic glow discharges at a frequency of 20 kHz were *** both cases,the disturbances sources worked *** flow rate pulsations were measured and recorded in sections,parallel to the leading edge of the model,near the maximum of disturbances along the boundary *** the experiment,a constanttemperature hot-wire anemometer was *** performing a discrete Fourier transform,the spatial distributions of disturbances,the beta-spectra were determined,and the wave characteristics of the development of disturbances downstream were *** addition,direct numerical simulation of the downstream development of disturbances from a single source was *** work presents a comparison of experimental and theoretical calculated *** paper discusses the effects inherent in the interaction of unstable traveling controlled disturbances from two sources operating synchronously.

关键词： :DnS Computational modeling Supersonic boundary layer Compressibility Discharge Flat plate Hot-wire anemometer Instability Turbulence

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高阶有限体积法研究

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西北工业大学学报 2001年第3期19卷 327-331页

作者：杨永陈宝 K.Pahke n.Kroll 西北工业大学翼型研究中心陕西西安710072 德国宇航院布伦瑞克设计气动所

在有限体积法的基础上 ,提出了几种基于 Cartesian坐标系下的空间显式、隐式高阶离散格式和高阶解重构算法。采用高阶紧致滤波替代二阶、四阶人工耗散抑制 Euler方程计算中的非线性高频振荡现象。以 Sculley涡在二维均匀无粘流场中的非... 详细信息

在有限体积法的基础上 ,提出了几种基于 Cartesian坐标系下的空间显式、隐式高阶离散格式和高阶解重构算法。采用高阶紧致滤波替代二阶、四阶人工耗散抑制 Euler方程计算中的非线性高频振荡现象。以 Sculley涡在二维均匀无粘流场中的非定常传输为算例。

关键词：高阶格式重构算法高阶紧致滤波 Euler方程计算流体力学非线性高频振荡

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Hybrid Excitation Flux Switching Motor with Permanent Magnet Placed at Middle of Field Coil Slots and High Filling Factor Windings

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CES Transactions on Electrical Machines and Systems 2019年第3期3卷 248-258页

作者： T.Okada H.Matsumori T.Kosaka n.Matsui Department of Electrical and Mechanical Engineering Graduate School of EngineeringNagoya Institute of TechnologyGokisoShowaNagoya466-8555 Japan Frontier Research Institute for Information Science Nagoya Institute of TechnologyGokisoShowaNagoya466-8555 Japan nagoya Institute of Technology GokisoShowaNagoya466-8555 Japan.

Design and experimental studies on a hybrid excitation flux switching motor as a traction motor for hybrid electric vehicles drive are presented.A stator body of the motor consists of not only laminated silicon-iron electromagnetic steel and three-phase armature windings,but also both of field excitation coils and permanent magnets working together as a variable field magnetomotive force *** the other hand,a rotor is composed of just laminated silicon-iron electromagnetic steel with salient poles like switched reluctance *** bring out the best in drive performances of the hybrid excitation flux switching motor as a variable flux motor for the application,each material adopted for the stator and rotor body should be designed properly in terms of motor efficiency,maximum torque and power densities and so *** some of them,in this paper,thinner silicon-iron electromagnetic steel sheet and permanent magnets with high remanent and low amount of Dysprosium used are applied for achieving higher motor ***,all coils wound flatwise and edgewise using rectangular wires are introduced to realizing high filling factor for reduced copper *** tests using a 60kW prototype of the motor demonstrates the designed motor has good motor efficiency under frequent operating points expected for the target vehicle drive.

关键词： Hybrid electric vehicle hybrid excitation flux switching motor rectangular wire traction motor variable flux motor.

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Cis-[Pd(en)(H_2O)_2](nO_3)_2与n-AcCysMe反应动力学研究

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科学通报 1996年第2期41卷 140-143页

作者：陈晓华朱龙根燕红游效曾 n.M.Kosti 南京大学配位化学研究所配位化学国家重点实验室南京210093 Dept.of

近年来,人工限制性蛋白水解酶的研究引起很多化学家的兴趣,最近我们发现,Pd(Ⅱ)配合物具有选择性水解多肽中含硫氨基酸残基羧端酰胺键的功能,对快的水解反应其半衰期t_(1/2)仅10多分钟.在用[Pd(en)(H_2O)_2]^(2+)作为促进剂时,在酰胺键... 详细信息

近年来,人工限制性蛋白水解酶的研究引起很多化学家的兴趣,最近我们发现,Pd(Ⅱ)配合物具有选择性水解多肽中含硫氨基酸残基羧端酰胺键的功能,对快的水解反应其半衰期t_(1/2)仅10多分钟.在用[Pd(en)(H_2O)_2]^(2+)作为促进剂时,在酰胺键水解过程中同时发现有游离的乙二胺从Pd(Ⅱ)上释放出来,而且我们又发现,Pd(Ⅱ)的含硫氨基酸及肽的配合物本身对水解肽键也很有效.因此,我们用~1H nMR跟踪技术较详细地研究了n-AcCysMe与Cis-[Pd(en)(H_2O)_2]^(2+)的反应以及乙二胺的释放动力学.这对深入了解Pd(Ⅱ)与含硫氨基酸之间的作用以及Cis-[Pd(en)(H_2O)_2]^(2+)促进酰胺键的选择性水解机理均具有一定意义.

关键词：多肽 n-AcCysMe 动力学钯配合物蛋白质水解酶

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Potential traces of earthquakes in the ancient city of Kytaia, Kerch Peninsula, Crimea

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Geodesy and Geodynamics 2019年第4期10卷 331-338页

作者： E.A.Molev A.M.Korzhenkov A.n.Ovsyuchenko A.S.Larkov Federal State Autonomous Educational Institution of Higher Education N.I.Lobachevsky State UniversityNizhny NovgorodRussian Federation Institute of Physics of the Earth RASMoscowRussian Federation

In this paper, the authors studied the traces of destruction in the fortress walls and houses of the Bosporan city of Kytaia. The study of this city has been ongoing since 1970. Over the past time, numerous damages have been identified at different sites of the ancient settlement. In the article, an attempt is made to compare some of them with the results of earthquakes on the Bosporus, about which the data of ancient authors were preserved.

关键词： The Bosporan city of Kytaia Traces of destruction Ancient earthquakes

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THE BURST OF InDIAn SUMMER MOnSOOn AS REVEALEDBY GOES SATELLITE DURInG MQnEX 1979

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Advances in Atmospheric Sciences 1986年第4期3卷 514-519页

作者： P.n.Mahajan,V.R.Mujumdar,S.P.Ghanekar Indian Institute of Tropical Meteorology Pune-411005 India Indian Institute of Tropical Meteorology Pune-411005 India Indian Institute of Tropical Meteorology Pune-411005 India

During FGGE year 1979, low-level air flow over the western Indian Ocean was determined from the analysis of GOES images (5-20 June). The wind pattern shows sudden change in low-level air circulation over western Indian Ocean during the initial burst of summer monsoon. The burst of monsoon is characterized by sudden establishment of low-level jet and strong cross-equatorial flow. This abrupt change signals the beginning of southwest monsoon over India and it is associated with the first monsoon rainfall over the southern part of western coast of India. Sudden change in low-level air flow is followed by the burst of monsoon within 3-5 days.

关键词： GOES In THE BURST OF InDIAn SUMMER MOnSOOn AS REVEALEDBY GOES SATELLITE DURInG MQnEX 1979 over

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Buffer Standards for Physiological pH of the Buffer n-(2-Acetamido)-2-aminoethanesulfonic Acid from 5°C to 55°C

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Open Journal of Physical Chemistry 2011年第3期1卷 118-123页

作者： Blake M. Bodendorfer Zachary M. Downs Isaac B. Henson Lakshmi n. Roy Rabindra n. Roy Jessica M. Stegner Jaime A. Veliz Joshua T. Wollen 不详

Electromotive force (emf) measurements of the Cell Pt(s), H2(g)|ACES(m1) + naACES(m2) + naCl (m3)| AgCl, Ag(s) have been carried out from 5°C to 55°C . The agreement of pH values between two calculated (extended Debye-Hückel and liquid junction correction) is very good. Two buffer solutions without the chloride ion and seven buffer solutions with naCl, at an ionic strength (I = 0.16 ***-1) similar to that of physiological fluids, have been studied. The pH values for these buffer solutions have been evaluated in the temperature range of 5°C to 55°C using the extended Debye-Hückel equation of the Bates-Guggenheim convention. Values of the residual liquid junction potential (δEj) between the ACES solutions and the saturated KCl calomel electrode solution have been estimated at 25°C and 37°C from the previously determined Ej values using the flowing junction cell to determine the operational pH values at 25°C and 37°C. These ACES buffer solutions are recommended as secondary standard reference solutions for pH measurements in the range of physiological applicati on at I = 0.16 ***-1.

关键词： Buffer Emf pH Zwitterionic

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