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Chinese Journal of Polymer Science 2020年第10期38卷 1131-1140,I0007页

作者： yue Ming Wu Wei-Wei Zhang Rui-Yi Zhou Qi Chen Chen-yu Xie Heng-Xue Xiang Bin Sun Mei-Fang Zhu Run-Hui Liu State KeyLaboratory of Bioreactor Enginering East China Uniersity of Science and TechnologyShanghai 200237China State Key Laboratory for Modification of Chemical Fibers and Polymer Materals College of Materias Science and EngineringDonghua UniversityShanghai 201620China Key Laboratory of Specally Functional Polymeric Materials and Related Technology(ECUST)Ministry of Education Key Laboratory for Ultrafine Materials of Ministry of EducationResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Polypeptides have been widely utilized in the fields of biomaterials and *** since n-carboxyanhydride(nCA)was reported by Hermann Leuchs in 1906,ring-opening polymerization of nCAS has been extensively used to prepare *** continuous innovations,it is still challenging to synthesize polypeptides in high molecular weight *** address this challenge,we developed KHMDS/naHMDS initiated fast nCA polymerization that is also moisture tolerant,open-flask amenable and terminal *** nCA polymerization was able to proceed in most common solvents and meet the solubility requirement of variable nCA monomers and corresponding *** can initiate r benzy-L glutamate-n carboxyanhydride(BLG nCA)polymerization in a reaction rate 92 times faster than does hexylamine and 80 times faster than does *** nCA polymerization also demonstrated easy and fast synthesis of gram-scale long chain polypeptides in an open flask.

关键词： nCA polymerization Polypeptide Open vessel Fast polymerization High Mw

β-Secretase inhibitor increases amyloid-β precursor protein level in rat brain cortical primary neurons induced by okadaic acid

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Chinese Medical Journal 2008年第15期121卷 1439-1444页

作者： yu Chun-Jiang WAnG Wei-zhi LIU Wei Department of neurology the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Department of neurology Hai-Dian Hospital Beijing100080 China

Background Senile plaques and neurofibrillary tangles （nFTs） represent two of the major histopathological hallmarks of Alzheimer＇s disease （AD）. The plaques are primarily composed of aggregated amyloid β （Aβ） peptides. The processing of amyloid-β precursor protein （AβPP） in okadaic acid （OA）-induced tau phosphorylation primary neurons was studied. Methods Primary cultures of rat brain cortical neurons were treated with OA and β-secretase inhibitor. neurons＇ viability was measured. AβPP processing was examined by immunocytochemistry and Western blotting with specific antibodies against the AβPP-n-terminus （nT） and AβPP-C-terminus （CT）. Results Ten nmol/L OA had a time-dependent suppression effect on primary neurons＇ viability. The suppression effect was alleviated markedly by pretreatment with β-secretase inhibitor. After OA treatment, both AβPP and β-C-terminal fragment （βCTF） were significantly increased in neurons. AβPP level was increased further in neurons pretreated with β-secretase inhibitor. Conclusions In OA-induced tau phosphorylation cell model, inhibition of β-secretase may protect neurons from death induced by OA. Because of increased accumulation of AβPP in neurons after OA treatment, more AβPP turns to be cleaved by β-secretase, producing neurotoxic βCTF. As a potential effective therapeutic target, β-secretase is worth investigating further.

关键词： tau phosphorylation amyloid-β precursor protein β-C-terminal fragment β-secretase inhibitor

Feasible fabrication of o-phenanthroline-based polymer adsorbent for selective capture of aqueous Ag(Ⅰ)

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Chinese Chemical Letters 2023年第3期34卷 191-194页

作者： Xuan Ding Wanjun yu Xin Sheng Hui Shi Deng You Mingming Peng Penghui Shao Liming Yang Lingling Liu Xubiao Luo Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China national-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China

Devising a desirable adsorbent for efficiently selective capture of Ag(Ⅰ) from wastewater has attracted much attention but faced with huge challenges. Herein, a novel linear o-phenanthroline-based polymer L-PRL was prepared via chemical oxidative polymerization for the adsorption of Ag(Ⅰ). The maximum adsorption capacity for Ag(Ⅰ) by L-PRL is 325.8 mg/g at pH 0. In addition, L-PRL owes ascendant selectivity for Ag(Ⅰ) from aqueous solutions containing various interfering metal ions of Pb(Ⅱ), Co(Ⅱ), ni(Ⅱ), Cd(Ⅱ)and Fe(Ⅲ). Multiple characterizations of FT-IR and XPS uncover that the n groups on L-PRL act as adsorption sites to coordinate with Ag(Ⅰ). Density functional theory(DFT) calculations further evidence the mechanism that L-PRL is provided with the admirable adsorptivity and selectivity for Ag(Ⅰ). It is mainly attributed to the most stable complexes of L-PRL with Ag(Ⅰ), which possesses shortest Ag-n bond length compared with other heavy metal ions. Furthermore, 93.5% of initial adsorption capacity is reserved after four continuous regeneration cycles, indicating that L-PRL is equipped with superior recyclability and durability, and L-PRL is capable of removing Ag(Ⅰ) in low-concentration actual Ag(Ⅰ)-containing wastewater completely. This study shed light on the rational design of polymer adsorbents and in-depth insight into selective removal of aqueous Ag(Ⅰ).

关键词： Wastewater o-Phenanthroline Polymer Adsorbent Ag(Ⅰ) Selective capture

Linking changes of forage production and digestibility with grassland community assembly under nitrogen enrichment

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Ecological Processes 2021年第1期10卷 441-448页

作者： Xiao-Tao Lü Zhuo-Yi Liu Seeta Sistla Guo-Jiao Yang Yan-yu Hu Zhi-Wei Zhang Shuang-Li Hou Cong Ding Erguna Forest-Steppe Ecotone Research Station CAS Key Laboratory of Forest Ecology and ManagementInstitute of Applied EcologyChinese Academy of SciencesShenyang 110016China natural Resources Management and Environmental Sciences California Polytechnic State UniversitySan Luis ObispoCA 93407USA Institute of Ecology and Biodiversity School of Life ScienceShandong UniversityQingdao 266237China.

Background:Forage production is the fundamental ecosystem service of *** forage consumption occurs at community level,most studies focused on species-level changes of forage *** quantitative and qualitative changes of forage production are driven by species-specific trait,intra-specific plasticity,and species *** examined the changes in forage production and digestibility after 5-year factorial treatments of nitrogen(n)addition and mowing in a temperate steppe and linked such changes to community assembly under the Price equation ***:nitrogen addition significantly reduced species richness,increased forage production,but did not change forage digestibility(indicated by the total Ca+Mg concentrations).Mowing did not affect forage production and *** positive effects of n addition on forage production were driven by the enhancement of abundance of the remaining species following n enrichment,rather than by species loss or species *** species identity effects could offset the effects of species richness loss or gain on forage production and ***:Our results highlight the importance of a community perspective in addressing the quantitative and qualitative changes of forage production under global change pressure of n *** identity is important in determining the contribution of different processes of community assembly to ecosystem services.

关键词： Community composition nitrogen deposition Species turnover Price equation Primary productivity

Optimized Pt-MnO_(x) interface in Pt-MnO_(x)/3DOM-Al_(2)O_(3)catalysts for enhancing catalytic soot combustion

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Chinese Chemical Letters 2021年第4期32卷 1447-1450页

作者： Jing Xiong Zhenguo Li Peng Zhang Qi yu Kaixiang Li Yilin Zhang Zhen Zhao Jian Liu Jianmei Li yuechang Wei national Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.Ltd.Tianjin 300300China State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China

The catalysts of three-dimensionally ordered macroporous(3 DOM)Al_(2)O_(3)-supported core-shell structured Pt@MnOx nanoparticles(3 DOM-Pt@MnO_(x)/Al_(2)O_(3))were successfully prepared by the gas bubbling-assisted membrane reduction-precipitation(GBMR/P)***@MnO_(x)core-shell nanoparticles(nPs)are highly dispersed on the inner surface of 3 DOM-Al_(2)O_(3)***@MnOx/3 DOM-Al_(2)O_(3)catalysts,which combine both advantages of high-efficiency soot-catalyst contact by 3 DOM-Al_(2)O_(3)structure and the abundant active sites by the optimized Pt-MnO_(x)interface,exhibit high catalytic activities for soot combustion,and the catalytic activities are strongly dependent on the thickness of MnO_(x)*** the catalysts,3 DOM-Pt@MnO_(x)/Al_(2)O_(3)-1 catalyst with optimized Pt-MnO_(x)interface shows the highest catalytic activity for soot combustion,i.e.,its values of T_(50)and S_(CO_(2))^(m) are 351℃and98.6%,*** highest density of Pt-MnO_(x)active sites for adsorptio n-activation of gaseous O_(2)is responsible for enhancing catalytic activity for soot ***@MnOx/3 DOM-Al_(2)O_(3)catalysts are promising to practical applications for the emission reduction of soot particles.

关键词： 3DOM material Platinum Manganese oxide Strong metal-oxide interaction Soot combustion

B-n covalent bond-involved π-extension of multiple resonance emitters enables high-performance narrowband electroluminescence

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national Science Review 2024年第6期11卷 243-253页

作者： Xingyu Huang Jiahui Liu yulin Xu Guohao Chen Manli Huang Mingxin yu Xialei Lv Xiaojun Yin Yang Zou Jingsheng Miao Xiaosong Cao Chuluo Yang Shenzhen Key Laboratory of new Information Display and Storage Materials College of Materials Science and EngineeringShenzhen University College of Physics and Optoelectronic Engineering Shenzhen University

Multi-boron-embedded multiple resonance thermally activated delayed fluorescence（MR-TADF） emitters show promise for achieving both high color-purity emission and high exciton utilization ***, their development is often impeded by a limited synthetic scope and excessive molecular weights,which challenge material acquisition and organic light-emitting diode（OLED） fabrication by vacuum deposition. Herein, we put forward a B–n covalent bond-involved π-extension strategy via post-functionalization of MR frameworks, leading to the generation of high-order B/n-based motifs. The structurally and electronically extended π-system not only enhances molecular rigidity to narrow emission linewidth but also promotes reverse intersystem crossing to mitigate efficiency roll-off. As illustrated examples, ultra-narrowband sky-blue emitters（full-width at half-maximum as small as 8 nm in n-hexane）have been developed with multi-dimensional improvement in photophysical properties compared to their precursor emitters, which enables narrowband OLEDs with external quantum efficiencies(EQEmax) of up to 42.6%, in company with alleviated efficiency decline at high brightness, representing the best efficiency reported for single-host OLEDs. The success of these emitters highlights the effectiveness of our molecular design strategy for advanced MR-TADF emitters and confirms their extensive potential in high-performance optoelectronic devices.

关键词： narrowband electroluminescence thermally activated delayed fluorescence (TADF) multiple resonance emitters ultra-high external quantum efficiency

Curcumin Reduces Cardiac Fibrosis by Inhibiting Myofibroblast Differentiation and Decreasing Transforming Growth Factor β1 and Matrix Metalloproteinase 9/Tissue Inhibitor of Metalloproteinase 1

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Chinese Journal of Integrative Medicine 2017年第5期23卷 362-369页

作者： MA Jin MA Shi-yu DInG Chun-hua Cardiac Electrophysiology Research Lab Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou 510006 China Department of Critical Care Medicine Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510006 China Arrhythmia Center Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510006 China

Objective： To study the effect of curcumin on fibroblasts in rats with cardiac fibrosis. Methods： The rats were randomly divided into 4 groups（n=12 in each group）： the normal control, isoproterenol（ISO）, ISO combined with low-dose curcumin（ISO＋Cur-L）, and ISO combined with high-dose curcumin（ISO＋Cur-H） groups. ISO＋Cur-L and ISO＋Cur-H groups were treated with curcumin（150 or 300 mg·kg-1·day-1） for 28 days. The primary culture of rat cardiac fibroblast was processed by trypsin digestion method in vitro. The 3rd to 5th generation were used for experiment. Western blot method was used to test the expression of collagen type Ⅰ/Ⅲ, α-smooth muscle actin（α-SMA）, transforming growth factor（TGF）-β1, matrix metalloproteinase（MMP）-9 and tissue inhibitor of metalloproteinase（TIMP）-1. 3-（4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetr-azolium bromide（MTT） assay was applied to test the proliferation of fibroblast. Result： Curcumin significantly decreased interstitial and perivascular myocardial collagen deposition and cardiac weight index with reducing protein expression of collagen type Ⅰ/Ⅲ in hearts（P〈0.05）. In addition, curcumin directly inhibited angiotensin（Ang） Ⅱ-induced fibroblast proliferation and collagen type Ⅰ/Ⅲ expression in cardiac fibroblasts（P〈0.05）. Curcumin also inhibited fibrosis by inhibiting myofibroblast differentiation, decreased TGF-β1, MMP-9 and TIMP-1 expression（P〈0.05） but had no effects on Smad3 in Ang Ⅱ incubated cardiac fibroblasts. Conclusions： Curcumin reduces cardiac fibrosis in rats and Ang Ⅱ-induced fibroblast proliferation by inhibiting myofibroblast differentiation, decreasing collagen synthesis and accelerating collagen degradation through reduction of TGF-β1, MMPs/TIMPs. The present findings also provided novel insights into the role of curcumin as an anti-fibrotic agent for the treatment of cardiac fibrosis.

关键词： curcumin fibrosis myofibroblast transforming growth factor matrix metalloproteinase

Preparation of quaternarized n-halamine-grafted graphene oxide nanocomposites and synergetic antibacterial properties

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Chinese Chemical Letters 2021年第11期32卷 3509-3513页

作者： Danlin Bu yu Zhou Chang Yang Hengyu Feng Chunxia Cheng Mengjie Zhang Zice Xu Linghan Xiao yujing Liu Zhenai Jin Jilin Province Key Laboratory of Carbon Fiber Development and Application College of Chemistry and Life ScienceChangchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Department of Pediatrics Affiliated Hospital of Yanbian UniversityYanji 133000China

At present,frequent outbreaks of bacteria and viruses have seriously affected people's normal ***,the study of broad-spectrum antibacterial nanocomposites is very ***,most antibacterial materials have some disadvantages,such as single bactericidal mechanisms and unrepeatable *** on the current situation,a kind of nanocomposite with three structures of graphene oxide(GO),quaternary ammonium salt(QAs)and n-halamine was prepared,which showed synergistic effect to improve antibacterial activity and combined with a variety of sterilization ***,GO can provide richer ways of sterilization and high specific surface area,which is conducive to the grafting of quaternarized *** advantages of physical sterilization of GO,charge adsorption of QAs,reuse of n-halamine and efficient sterilization are fully *** results showed that the quaternarized n-halamine-grafted GO was obtained *** grafted with quaternarized n-halamine polymer showed strong speedy bactericidal activity against Escherichia coli(***)and Staphylococcus aureus(***)(99%).It had good storage and regeneration properties.

关键词： n-Halamine Quaternary ammonia salt Graphene oxide Synergetic sterilization nanocomposite

Low-temperature processed solar cells with formamidinium tin halide perovskite/fullerene heterojunctions

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nano Research 2016年第6期9卷 1570-1577页

作者： Meng Zhang Miaoqiang Lyu Jung-Ho yun Mahirnoori Xiaojing Zhou nathan A. Cooling Qiong Wang Hua yu Paul C. Dastoor Lianzhou Wang nanomaterials Centre School of Chemical Engineering and AIBN The University of Queensland St Lucia Brisbane QLD 4072 Australia Centre for Organic Electronics University of Newcastle Callaghan NSW 2308 Australia

A new type of lead-free, formamidinium （FA）-based halide perovskites, FASnf2Br, are investigated as light-harvesting materials for low-temperature processed p-i-n heterojunction solar cells with different configurations. The FASnlaBr perovskite, with a band-gap of 1.68 eV, exhibits optimal photovoltaic performance after low-temperature annealing at 75 ~C. By using C60 as electron-transport layer, the device yields a hysteresis-less power conversion efficiency of 1.72%. The possible use of an inorganic MoO~ film as a new type of independent hole-transport layer for the present tin-based perovskite solar cells is also demonstrated.

关键词： lead-free perovskite perovskite solar cells low-temperature process fullerene molybdenum oxide

岷江冷杉和紫果云杉对增加温度和CO_(2)浓度的物种特异性的生长、形态和生理响应

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Journal of Plant Ecology 2023年第1期16卷 214-228页

作者： Haojie Dong Zongdi Huang Wen Li Lei yu Department of Ecology College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China

尽管许多研究评估了植物对增加的大气二氧化碳浓度(CO_(2))和增温的生理生态响应,但探究这两个因素交互作用的研究较少,尤其是更敏感的高海拔树种。为了解决这个问题,我们选用岷江冷杉(Abies faxoniana)和紫果云杉(Picea purpurea)幼苗... 详细信息

尽管许多研究评估了植物对增加的大气二氧化碳浓度(CO_(2))和增温的生理生态响应,但探究这两个因素交互作用的研究较少,尤其是更敏感的高海拔树种。为了解决这个问题,我们选用岷江冷杉(Abies faxoniana)和紫果云杉(Picea purpurea)幼苗来评估增加CO_(2)浓度(CeTa,700 ppm)、增温(CaTe,高于环境温度2°C)以及增加CO_(2)浓度和增温(CeTe)交互作用对植物生长、形态和生理的影响。我们的研究发现CaTe处理下,这两种针叶树总干重、比根长、净光合速率以及^(15)nH_(4)+和^(15)nO_(3)−的转运速率均升高,但CeTe处理下植株的响应更强烈(岷江冷杉的净光合速率除外)。这些结果表明,增加CO_(2)浓度加剧了增温对植物生长和生理反应的影响。此外,CeTe对紫果云杉生理特征的影响更大,其总干重、比叶面积、水分利用效率(δ^(13)C)、δ^(15)nO_(3)^(−)-n水平、15nH4+和15nO3−的转运速率和非结构碳水化合物浓度均高于岷江冷杉。总体而言,这些研究结果表明,在评估针叶树种对未来气候的响应时,应考虑CO_(2)×温度的交互作用。

关键词：增温增加CO_(2)浓度非结构性碳水化合物 15n 示踪针叶树